Browsing Articles publicats (Pedagogia i Psicologia) by Author "Estivill Torrús, Guillermo"
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Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA1 receptor results in increased alcohol consumption
Castilla Ortega, Estela; Pavón, Francisco Javier; Sanchez Marín, Laura; Estivill Torrús, Guillermo; Pedraza, Carmen; Blanco Calvo, Eduardo; Suárez, Juan; Santín, Luis; Rodríguez de Fonseca, Fernando; Serrano, Antonia (Elsevier, 2016-04-01)BACKGROUND: Lysophosphatidic acid species (LPA) are lipid bioactive signaling molecules that have been recently implicated in the modulation of emotional and motivational behaviors. The present study investigates the ... -
Glutaminase and MMP-9 downregulation in cortex and hippocampus of LPA1 receptor null mice correlate with altered dendritic spine plasticity
Peñalver, Ana; Campos-Sandoval, José A.; Blanco Calvo, Eduardo; Cardona,Carolina; Castilla,Laura; Martín-Rufián,Mercedes; Estivill Torrús, Guillermo; Sánchez-Varo,Raquel; Alonso, Francisco J.; Pérez-Hernández,Mercedes; Colado, María I.; Gutiérrez,Antonia; Rodríguez de Fonseca, Fernando; Márquez,Javier (Frontiers Media S.A., 2017)Lysophosphatidic acid (LPA) is an extracellular lipid mediator that regulates nervous system development and functions acting through G protein-coupled receptors (GPCRs). Here we explore the crosstalk between LPA1 receptor ... -
Pharmacological reduction of adult hippocampal neurogenesis modifies functional brain circuits in mice exposed to a cocaine conditioned place preference paradigm
Castilla Ortega, Estela; Blanco Calvo, Eduardo; Serrano, Antonia; Ladrón de Guevara-Miranda, David; Pedraz, María; Estivill Torrús, Guillermo; Pavón, Francisco Javier; Rodríguez de Fonseca, Fernando; Santín Núñez, Luis Javier (John Wiley & Sons, 2015-03-14)We investigated the role of adult hippocampal neurogenesis in cocaine-induced conditioned place preference (CPP) behaviour and the functional brain circuitry involved. Adult hippocampal neurogenesis was pharmacologically ... -
Reduced wheel running and blunted effects of voluntary exercise in LPA1-null mice: the importance of assessing the amount of running in transgenic mice studies
Castilla Ortega, Estela; Rosell del Valle, Cristina; Blanco Calvo, Eduardo; Pedraza Benitez, Carmen; Chun, Jerold; Rodríguez de Fonseca, Fernando; Estivill Torrús, Guillermo; Santín Núñez, Luis Javier (Elsevier, 2013-09-19)This work was aimed to assess whether voluntary exercise rescued behavioral and hippocampal alterations in mice lacking the lysophosphatidic acid LPA1 receptor (LPA1-null mice), studying the potential relationship between ...