Now showing items 1-4 of 4

    • Antiprotozoal effect of saponins in the rumen can be enhanced by chemical modifications in their structure 

      Ramos-Morales, Eva; de la Fuente Oliver, Gabriel; Duval, Stéphane; Wehrli, Christof; Bouillon, Marc E.; Lahmann, Martina; Preskett, David; Braganca, Radek; Newbold, C. Jamie (Frontiers Media, 2017-02-27)
      The antiprotozoal effect of saponins is transitory, as when saponins are deglycosylated to the sapogenin by rumen microorganisms they become inactive. We postulated that the substitution of the sugar moiety of the saponin ...
    • Improving the antiprotozoal effect of saponins in the rumen by combination with glycosidase inhibiting iminosugars or by modification of their chemical structure 

      Ramos-Morales, Eva; de la Fuente Oliver, Gabriel; Nash, Robert J.; Braganca, Radek; Duval, Stéphane; Bouillon, Marc E.; Lahmann, Martina; Newbold, C. Jamie (Public Library of Science, 2017)
      The antiprotozoal effect of saponins is transitory, as when saponins are deglycosylated to sapogenins by rumen microorganisms they become inactive. We hypothesised that the combination of saponins with glycosidase-inhibiting ...
    • Not all saponins have a greater antiprotozoal activity than their related sapogenins 

      Ramos-Morales, Eva; Lyons, Laura; de la Fuente Oliver, Gabriel; Braganca, Radek; Newbold, C. Jamie (Oxford University Press, 2019-07-04)
      The antiprotozoal effect of saponins varies according to both the structure of the sapogenin and the composition and linkage of the sugar moieties to the sapogenin. The effect of saponins on protozoa has been considered ...
    • The role of ciliate protozoa in the rumen 

      Newbold, C. Jamie; de la Fuente Oliver, Gabriel; Belanche, A.; Ramos-Morales, Eva; McEwan, Neil (Frontiers, 2015-11-09)
      First described in 1843, Rumen protozoa with their striking appearance were assumed to be important for the welfare of their host. However, despite contributing up to 50% of the bio-mass in the rumen, the role of protozoa ...