Now showing items 1-6 of 6

    • Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers 

      Laplana Lafaja, Marina; Bieg, Matthias; Faltus, Christian; Melnik, Svitlana; Bogatyrova, Olga; Gu, Zuguang; Muley, Thomas; Meister, Michael; Dienemann, Hendrik C.; Herpel, Esther; Amos, Christopher I.; Schlesner, Matthias; Eils, Roland; Plass, Christoph; Risch, Angela (Taylor & Francis, 2021-02-17)
      Genome-wide association studies (GWAS) have identified SNPs linked with lung cancer risk. Our aim was to discover the genes, non-coding RNAs, and regulatory elements within GWAS-identified risk regions that are deregulated ...
    • Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients 

      Laplana Lafaja, Marina; Yuguero Torres, Oriol; Fibla Palazón, Joan (2020)
      Background The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its derivatives in COVID-19 in Spanish individuals. Methods We performed a survey addressed ...
    • Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients 

      Laplana Lafaja, Marina; Yuguero Torres, Oriol; Fibla Palazón, Joan (Public Library of Science, 2020)
      Background The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its derivatives in COVID-19 in Spanish individuals. Methods We performed a survey addressed ...
    • Resilience effects of SGK1 and TAP1 DNA markers during PRRSV outbreaks in reproductive sows 

      Laplana Lafaja, Marina; Estany Illa, Joan; Fraile Sauce, Lorenzo José; Pena i Subirà, Ramona Natacha (MDPI, 2020-05-22)
      The porcine reproductive and respiratory syndrome virus (PRRSV) is a major infectious stressor that causes serious health problems and productivity drops. Based on previous genome-wide analyses, we selected SGK1 and TAP1 ...
    • The role of a functional variant of TYK2 in vasculitides and infections 

      Ortiz-Fernández, L.; López-Mejias, R.; Carmona, F. D.; Castaño-Nuñez, A. L.; Spanish GCA Study Group; IgAV Study Group; AAV Study Group; HIV Study Group; Lyons, P. A.; Caruz, Antonio; Gónzalez-Escribano, M. F.; Smith, K. G. C.; González-Gay, M. A.; Martin, J.; Laplana Lafaja, Marina (Clinical and Experimental Rheumatology S.A.S., 2020-09-01)
      Objective The TYK2 gene encodes a tyrosin kinase which is involved in multiple immune functions. A functional variant of this gene has been identified to play a protective role in multiple autoimmune diseases. The goal of ...
    • Toll Like Receptor 2 promoter -196 to -174 deletion affects CD4 levels along HIV infection progression 

      Laplana Lafaja, Marina; Bravo, M. J.; Fernández-Fuertes, M.; Ruiz-García, C.; Alarcón-Martin, E.; Colmenero, J. D.; Caruz, Antonio; Fibla Palazón, Joan; Real, Luis M.; Royo Sánchez-Palencia, José Luis (Infectious Diseases Society of AmericaOxford University Press, 2020-06-09)
      TLR2 plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter Insertion/Deletion polymorphism with contradictory data about its role in HIV-1 infection. ...