Browsing by Subject "p53"
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2-phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53
(Elsevier, 2014)2-Phenylethynesulfonamide (PES) or pifithrin-μ is a promising anticancer agent with preferential toxicity for cancer cells. The type of cell death and the molecular cascades activated by this compound are controversial. ... -
Pharmacological Modulation of Reactive Oxygen Species in Cancer Treatment
(Bentham Science, 2015-01-01)Aerobic metabolism of mammalian cells leads to the generation of reactive oxygen species (ROS). To cope with this toxicity, evolution provided cells with effective antioxidant systems like glutathione. Current anticancer ... -
(R)-roscovitine (CYC202, Seliciclib) sensitizes SH-SY5Y neuroblastorna cells to nutlin-3-induced apoptosis
(Elsevier, 2006)In this study, we have analyzed the consequences, on several neuroblastoma cell lines, of combined treatments with (R)-roscovitine (CYC202, Seliciclib), a CDK inhibitory drug, and nutlin-3, a p53 activating drug. Both ...