Now showing items 1-7 of 7

    • Analysis of oxidative stress-induced protein carbonylation using fluorescent hydrazides 

      Tamarit Sumalla, Jordi; Hoogh, Anouk de; Obis Monné, Èlia; Alsina Obiols, David; Cabiscol Català, Elisa; Ros Salvador, Joaquim (Elsevier, 2012)
      Protein carbonyl detection has been commonly used to analyze the degree of damage to proteins under oxidative stress conditions. Most laboratories rely on derivatization of carbonyl groups with dinitrophenylhydrazine ...
    • Redox control of yeast Sir2 activity is involved in acetic acid resistance and longevity 

      Vall-llaura Espinosa, Núria; Mir, Noèlia; Garrido, Lourdes; Vived Maza, Celia; Cabiscol Català, Elisa (Elsevier, 2019-06)
      Yeast Sir2 is an NAD-dependent histone deacetylase related to oxidative stress and aging. In a previous study, we showed that Sir2 is regulated by S-glutathionylation of key cysteine residues located at the catalytic domain. ...
    • Regulation of small GTPase activity by G1 cyclins 

      Pedraza González, Neus; Cemeli, Tània; Monserrat Monserrat, Maria Ventura; Garí Marsol, Eloi; Ferrezuelo, Francisco (Taylor & Francis, 2017-01-27)
      Together with a cyclin-dependent kinase (CDK) partner G1 cyclins control cell cycle entry by phosphorylating a number of nuclear targets and releasing a transcriptional program at the end of G1 phase. Yeast G1 cyclins also ...
    • Sir2 is induced by oxidative stress in a yeast model of Huntington disease and its activation reduces protein aggregation 

      Sorolla Bardají, Maria Alba; Nierga, Clara; Rodríguez Colman, Maria José; Reverter Branchat, Gemma; Arenas, Alicia; Tamarit Sumalla, Jordi; Ros Salvador, Joaquim; Cabiscol Català, Elisa (Elsevier, 2011)
      Huntington disease (HD) is a neurodegenerative disorder caused by expansion of CAG trinucleotide repeats, leading to an elongated polyglutamine sequence (polyQ) in the huntingtin protein. Misfolding of mutant polyQ ...
    • Sumoylation of Smc5 Promotes Error-free Bypass at Damaged Replication Forks 

      Zapatka, Mariel; Pociño Merino, Irene; Heluani-Gahete, Hayat; Bermúdez López, Marcelino; Tarrés, Marc; Ibars, Eva; Solé-Soler, Roger; Gutiérrez-Escribano, Pilar; Apostolova, Sonia; Casas Herranz, Celia; Aragon, Luis; Wellinger, Ralf Erik; Colomina i Gabarrella, Neus; Torres Rosell, Jordi (Elsevier, 2019)
      Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms to tolerate DNA lesions. The Smc5/6 complex, together with the Nse2/Mms21 SUMO ligase, plays essential ...
    • Yeast as a model system to study metabolic impact of selenium compounds 

      Herrero Perpiñán, Enrique; Wellinger, Ralf Erik (Shared Science Publishers, 2015)
      Inorganic Se forms such as selenate or selenite (the two more abundant forms in nature) can be toxic in Saccharomyces cerevisiae cells, which constitute an adequate model to study such toxicity at the molecular level ...