Now showing items 1-9 of 9

    • Advanced lipoprotein profle disturbances in type 1 diabetes mellitus: a focus on LDL particles 

      Amor, Antonio J.; Castelblanco Echavarría, Esmeralda; Hernández García, Marta; Gimenez, Marga; Granado Casas, Minerva; Blanco, Jesús; Soldevila, Berta; Esmatjes, Enric; Conget, Ignacio; Alonso, Núria; Ortega, Emilio; Mauricio Puente, Dídac (BioMed Central, 2020)
      Background: Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profle in T1DM individuals, and analysed ...
    • Assessment of Inner Retinal Layers and Choroidal Thickness in Type 1 Diabetes Mellitus: A Cross-Sectional Study 

      Carbonell, Marc; Alonso, Núria; Castelblanco Echavarría, Esmeralda; Real, Jordi; Ramírez-Morros, Anna; Simó, Rafael; Hernández, Cristina; Jurjo Campo, Carmen; Traveset Maeso, Alicia; Valldeperas, Xavier; Mauricio Puente, Dídac (MDPI, 2019)
      Recent studies have shown that retinal neurodegeneration may precede visible vascular changes in diabetic retinopathy (DR). In addition, the relationship of choroidal thickness (CT) with DR stage is not well defined. To ...
    • B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes 

      Egia-Mendikute, Leire; Arpa i Puigdemont, Berta; Rosell Mases, Estela; Corral Pujol, Marta; Carrascal, Jorge; Carrillo, Jorge; Mora Giral, Concepció; Chapman, Harold; Panosa, Anaïs; Vives Pi, Marta; Stratmann, Thomas; Serreze, David; Verdaguer Autonell, Joan (Frontiers Media, 2019)
      Previous studies indicate that B-lymphocytes play a key role activating diabetogenic T-lymphocytes during the development of autoimmune diabetes. Recently, two transgenic NOD mouse models were generated: the NOD-PerIg and ...
    • CDK11 promotes cytokine-induced apoptosis in pancreatic beta cells independently of glucose concentration and is regulated by inflammation in the NOD mouse model 

      Sala Solé, Ester; Vived Maza, Celia; Luna Salinas, Júlia; Saavedra Ávila, Noemí Alejandra; Sengupta, Upasana; Castaño, A. Raúl; Villar-Pazos, Sabrina; Haba, Laura; Verdaguer Autonell, Joan; Ropero, Ana Belén; Stratmann, Thomas; Pizarro, Javier; Vázquez-Carrera, Manuel; Nadal, Ángel; Lahti, Jill M.; Mora Giral, Concepció (Frontiers, 2021-02-10)
      Background: Pancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D). We found that the Cdk11(Cyclin Dependent Kinase 11) is ...
    • Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice 

      Presa, Maximiliano; Zarama Ortiz, Angela; Garabatos, Nahir; Izquierdo, Cristina; Rivas, Elisa I.; Teyton, Luc; Mora Giral, Concepció; Serreze, David; Stratmann, Thomas (Wiley, 2013)
      The cholera toxin B subunit (CTB) has been used as adjuvant to improve oral vaccine delivery in type 1 diabetes. The effect of CTB/peptide formulations on Ag-specific CD4+ T cells has remained largely unexplored. Here, ...
    • Effect of Subcutaneous Insulin on Spirometric Maneuvers in Patients with Type 1 Diabetes: A Case-Control Study 

      Sánchez Peña, Enric; Mizab, Chadia; Sauret, Ariadna; Barbé Illa, Ferran; Martí, Raquel; López Cano, Carolina; Hernández García, Marta; Gutiérrez Carrasquilla, Liliana; Carmona, Paola; González, Jessica; Dalmases, Mireia; Hernández, Cristina; Simó, Rafael; Lecube Torelló, Albert (MDPI, 2020)
      In order to compare spirometric maneuvers in adults according to the presence of type 1 diabetes, a case-control study including 75 patients with type 1 diabetes and 75 controls matched by sex, age, and body mass index ...
    • Obesity in Patients with Type 1 Diabetes: Links, Risks and Management Challenges 

      Vilarrasa, Núria; San Jose, Patricia; Rubio, Miguel Ángel; Lecube Torelló, Albert (Dove Medical Press, 2021)
      Obesity affects large numbers of patients with type 1 diabetes (T1D) across their lifetime, with rates ranging between 2.8% and 37.1%. Patients with T1D and obesity are characterized by the presence of insulin resistance, ...
    • Poorer Quality of Life and Treatment Satisfaction is Associated with Diabetic Retinopathy in Patients with Type 1 Diabetes without Other Advanced Late Complications 

      Granado Casas, Minerva; Castelblanco Echavarría, Esmeralda; Ramírez-Morros, Anna; Martín, Mariona; Alcubierre Calvo, Núria; Martínez Alonso, Montserrat; Valldeperas, Xavier; Traveset Maeso, Alicia; Rubinat, Esther; Lucas-Martin, Ana; Hernández García, Marta; Alonso, Núria; Mauricio Puente, Dídac (MDPI, 2019-03-18)
      Diabetic retinopathy (DR) may potentially cause vision loss and affect the patient's quality of life (QoL) and treatment satisfaction (TS). Using specific tools, we aimed to assess the impact of DR and clinical factors on ...
    • Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes 

      Castelblanco Echavarría, Esmeralda; Betriu i Bars, M. Àngels; Hernández García, Marta; Granado Casas, Minerva; Ortega, Emilio; Soldevila, Berta; Ramírez-Morros, Anna; Franch-Nadal, Josep; Puig-Domingo, Manuel; Fernández i Giráldez, Elvira; Avogaro, Angelo; Alonso, Núria; Mauricio Puente, Dídac (MDPI, 2019-03-28)
      The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of ...