Now showing items 1-9 of 9

    • 7-Bromoindirubin-3'-oxime induces caspase-independent cell death 

      Ribas i Fortuny, Judit; Bettayeb, Karima; Ferandin, Yoan; Knockaert, Marie; Garrofé Ochoa, Xènia; Totzke, Frank; Schächtele, Christoph; Mester, Jan; Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Boix Torras, Jacint; Meijer, Laurent (Nature Publishing Group, 2006)
      Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) as well as an agonist of the aryl hydrocarbon receptor (AhR). Indirubin is the active ...
    • 7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death 

      Ribas i Fortuny, Judit; Yuste Mateos, Víctor J. (Víctor José); Garrofé Ochoa, Xènia; Meijer, Laurent; Esquerda Colell, Josep; Boix Torras, Jacint (Elsevier, 2008)
      The new 7-bromoindirubin-3′-oxime (7BIO) compound induces caspase-independent cell death in all cell lines tested to date. Irrespective of the cell line, a 25 μM treatment for 24 h is lethal for the entire cell population. ...
    • Cell death induced by 2-phenylethynesulfonamide uncovers a pro-survival function of BAX 

      Mattiolo, Paolo; Barbero-Farran A.; Amigó J.; Ripamonti M.; Ribas i Fortuny, Judit; Boix Torras, Jacint (Elsevier, 2014)
      PES (2-phenylethynesulfonamide) was initially identified as an inhibitor of p53 translocation to mitochondria and named Pifithrin-µ. Further studies showed that PES selectively killed tumour cells and was thus a promising ...
    • EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes 

      Zhang, Jisheng; Ye, Junmei; Altafaj, Albert; Cardona Colom, Maria; Bahi i Pla, Núria; Llovera i Tomàs, Marta; Cañas, Xavier; Cook, Stuart A.; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Public Library of Science (PLoS), 2011)
      Mitochondrial dysfunction, caspase activation and caspase-dependent DNA fragmentation are involved in cell damage in many tissues. However, differentiated cardiomyocytes repress the expression of the canonical apoptotic ...
    • Neuronal survival induced by neurotrophins requires calmodulin 

      Egea Navarro, Joaquim; Espinet Mestre, Carme; Soler i Tatché, Rosa Ma.; Dolcet Roca, Xavier; Yuste Mateos, Víctor J. (Víctor José); Encinas Martín, Mario; Iglesias Durán, Montserrat; Rocamora Ibars, Nativitat; Comella i Carnicé, Joan Xavier (Rockefeller University Press, 2001)
      It has been reported that phosphoinositide 3-kinase (PI 3-kinase) and its downstream target, protein kinase B (PKB), play a central role in the signaling of cell survival triggered by neurotrophins (NTs). In this report, ...
    • Pharmacological Modulation of Reactive Oxygen Species in Cancer Treatment 

      Ribas i Fortuny, Judit; Mattiolo, Paolo; Boix Torras, Jacint (Bentham Science, 2015-01-01)
      Aerobic metabolism of mammalian cells leads to the generation of reactive oxygen species (ROS). To cope with this toxicity, evolution provided cells with effective antioxidant systems like glutathione. Current anticancer ...
    • Polypyrimidine tract binding proteins (PTB) regulate the expression of apoptotic genes and susceptibility to caspase-dependent apoptosis in differentiating cardiomyocytes 

      Zhang, Jisheng; Bahi i Pla, Núria; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Nature Publishing Group, 2009)
      Cardiac morphologic abnormalities in mice deficient for key regulators of the caspase-dependent signaling underscored its role in heart development. However, the mechanisms regulating apoptotic gene expression in the ...
    • Relevance of death receptors in nervous system: role in the pathogenesis of neurodegenerative diseases and targets for therapy 

      Segura Ginard, Miguel Francisco; Comella i Carnicé, Joan Xavier (Institut d'Estudis Catalans. Secció de Ciències i Tecnologia, 2008)
      L’apoptosi és un procés fisiològic que controla el nombre de cèl·lules en organismes superiors. L’apoptosi està estrictament regulada i s’ha vist que està implicada en la patogènesi d’algunes malalties del sistema nerviós. ...
    • The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-κB signaling 

      Solé Serra, Carme; Dolcet Roca, Xavier; Segura Ginard, Miguel Francisco; Gutierrez, Humberto; Diaz Meco, Maria Teresa; Gozzelino, Raffaella; Sanchis, Daniel; Bayascas Ramírez, José Ramón; Gallego, Carme; Moscat, Jorge; Davies, Alun M.; Comella i Carnicé, Joan Xavier (Rockefeller University Press, 2004)
      Fas apoptosis inhibitory molecule (FAIM) is a protein identified as an antagonist of Fas-induced cell death. We show that FAIM overexpression fails to rescue neurons from trophic factor deprivation, but exerts a marked ...