Browsing by Subject "DKK"

Now showing items 1-1 of 1

Dickkopf-1 Inhibition Reactivates Wnt/beta-Catenin Signaling in Rhabdomyosarcoma, Induces Myogenic Markers In Vitro and Impairs Tumor Cell Survival In Vivo

Giralt, Irina; Gallo Oller, Gabriel; Navarro, Natalia; Zarzosa, Patricia; Pons, Guillem; Magdaleno, Ainara; Segura, Miguel F.; Sabado, Constantino; Hladun, Raquel; Arango, Diego; Sánchez de Toledo, José; Moreno, Lucas; Gallego, Soledad; Roma, Josep (MDPI, 2021)

The Wnt/β-catenin signaling pathway plays a pivotal role during embryogenesis and its deregulation is a key mechanism in the origin and progression of several tumors. Wnt antagonists have been described as key modulators ...