Browsing by Author "Trevijano Contador, Nuria"

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The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug

Mesa-Arango, Ana Cecilia; Trevijano Contador, Nuria; Román, Elvira; Sánchez Fresneda, Ruth; Casas Herranz, Celia; Herrero Perpiñán, Enrique; Argüelles, Juan Carlos; Pla, Jesús; Cuenca-Estrella, Manuel; Zaragoza, Oscar (American Society for Microbiology, 2014)

Amphotericin B (AMB) is an antifungal drug that binds to ergosterol and forms pores at the cell membrane, causing the loss of ions. In addition, AMB induces the accumulation of reactive oxygen species (ROS), and although ...