Browsing by Author "Mrsic-Flogel, Thomas D."

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Regulation of EphA4 Kinase Activity Is Required for a Subset of Axon Guidance Decisions Suggesting a Key Role for Receptor Clustering in Eph Function

Egea Navarro, Joaquim; Vig Nissen, Ulla; Dufour, Audrey; Sahin, Mustafa; Greer, Paul; Kullander, Klas; Mrsic-Flogel, Thomas D.; Greenberg, Michael E.; Kiehn, Ole; Vanderhaeghen, Pierre; Klein, Rüdiger (Elsevier, 2005)

Signaling by receptor tyrosine kinases (RTKs) is mediated by their intrinsic kinase activity. Typically, kinase-activating mutations result in ligand-independent signaling and gain-of-function phenotypes. Like other RTKs, ...