Now showing items 1-2 of 2

    • Multilayer OMIC data in medullary thyroid carcinoma identifies the STAT3 pathway as a potential therapeutic target in RETM918T tumors 

      Mancikova, Veronica; Montero Conde, Cristina; Perales Paton, Javier; Fernandez, Agustin F; Santacana Espasa, Maria; Jodkowska, Karolina; Inglada-Pérez, Lucía; Castelblanco Echavarría, Esmeralda; Borrego, Salud; Encinas Martín, Mario; Matias-Guiu, Xavier; Fraga, Mario; Robledo, Mercedes (American Association for Cancer Research., 2016-09-12)
      Purpose: Medullary thyroid carcinoma (MTC) is a rare disease with few genetic drivers, and the etiology specific to each known susceptibility mutation remains unknown. Exploiting multilayer genomic data, we focused our ...
    • Novel DNMT3A Germline Variant in a Patient with Multiple Paragangliomas and Papillary Thyroid Carcinoma 

      Mellid, Sara; Coloma, Javier; Calsina, Bruna; Monteagudo, María; Roldán Romero, Juan M.; Santos, María; Leandro García, Luis J.; Lanillos, Javier; Martínez Montes, Ángel M.; Rodríguez-Antona, Cristina; Montero Conde, Cristina; Martínez López, Joaquín; Ayala, Rosa; Matias-Guiu, Xavier; Robledo, Mercedes; Cascón, Alberto (MDPI, 2020)
      Over the past few years, next generation technologies have been applied to unravel the genetics of rare inherited diseases, facilitating the discovery of new susceptibility genes. We recently found germline DNMT3A ...