2024-03-28T15:52:59Zhttps://repositori.udl.cat/server/oai/requestoai:repositori.udl.cat:10459.1/483732022-05-06T13:09:22Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_66064col_10459.1_314col_10459.1_59998col_10459.1_66068
Laplana Lafaja, Marina
Royo Sánchez-Palencia, José Luis
Aluja Fabregat, Antón
López Ortega, Ricard
Heine-Suñer, Damià
Fibla Palazón, Joan
2015-06-23T08:17:32Z
2015-06-23T08:17:32Z
2014
Autism spectrum disorder (ASD) is a highly heritable disease (∼0.9) with a complex genetic etiology. It is initially characterized by
altered cognitive ability which commonly includes impaired language and communication skills as well as fundamental deficits in
social interaction. Despite the large amount of studies described so far, the high clinical diversity affecting the autism phenotype
remains poorly explained. Recent studies suggest that rare genomic variations, in particular copy number variation (CNV), may
account for a significant proportion of the genetic basis of ASD. The use of disease-discordant monozygotic twins represents a
powerful strategy to identify de novo and inherited CNV in the disorder. Here we present the results of a comparative genome
hybridization (CGH) analysis with a pair of monozygotic twins affected of ASD with significant differences in their clinical
manifestations that specially affect speech language impairment and communication skills. Array CGH was performed in three
different tissues: blood, saliva, and hair follicle, in an attempt to identify germinal and somatic CNV regions that may explain these
differences. Our results argue against a role of large CNV rearrangements as a molecular etiology of the observed differences.This
forwards future research to explore de novo point mutation and epigenomic alterations as potential explanations of the observed
clinical differences.
https://doi.org/10.1155/2014/516529
021653
2090-6544
http://hdl.handle.net/10459.1/48373
eng
Hindawi Publishing Corporation
Reproducció del document publicat a https://doi.org/10.1155/2014/516529
Case Reports in Genetics, 2014, vol. 2014, ID 516529, p. 1-9
cc-by, (c) Laplana et al., 2014
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Absence of substantial copy number differences in a pair of monozygotic twins discordant for features of autism spectrum disorder
article
publishedVersion
TEXT
021653.pdf.txt
021653.pdf.txt
Extracted Text
text/plain
31637
https://repositori.udl.cat/bitstreams/92f28023-ff37-49be-a447-ecc5327b0428/download
69ac3d7cb8f4012b0fe514e4b5b59980
MD5
7
ORIGINAL
021653.pdf
021653.pdf
application/pdf
2419152
https://repositori.udl.cat/bitstreams/f367bfad-65fa-4edc-be01-d80a13a0606b/download
75036c043ddccec2537ba33bad437023
MD5
1
THUMBNAIL
021653.pdf.jpg
021653.pdf.jpg
Generated Thumbnail
image/jpeg
4847
https://repositori.udl.cat/bitstreams/429c7127-b232-4c3a-a9a1-d52496002149/download
7b4d480d6c4b4f4b46ce7ce70a370d6d
MD5
6
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1232
https://repositori.udl.cat/bitstreams/848063e4-daff-4c40-a52e-a00964bcda41/download
b51f25f83cca752633b6ec4c418dbcc7
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/3b269a4b-60b1-46c2-9310-d38584cdcac0/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
10459.1/48373
oai:repositori.udl.cat:10459.1/48373
2022-05-06 13:09:22.877
http://creativecommons.org/licenses/by/3.0/es/
cc-by, (c) Laplana et al., 2014
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/3192020-07-14T08:39:35Zcom_10459.1_227com_10459.1_2col_10459.1_314
Vilaprinyo Terré, Ester
Alves, Rui
Sorribas Tello, Albert
2010-04-15T07:20:24Z
2010-04-15T07:20:24Z
2006
Background: Understanding the relationship between gene expression changes, enzyme activity shifts, and the corresponding physiological adaptive response of organisms to environmental cues is crucial in explaining how cells cope with stress. For example, adaptation of yeast to heat shock
involves a characteristic profile of changes to the expression levels of genes coding for enzymes of the glycolytic pathway and some of its branches. The experimental determination of changes in gene expression profiles provides a descriptive picture of the adaptive response to stress. However, it does not explain why a particular profile is selected for any given response.
Results: We used mathematical models and analysis of in silico gene expression profiles (GEPs) to understand how changes in gene expression correlate to an efficient response of yeast cells to heat shock. An exhaustive set of GEPs, matched with the corresponding set of enzyme activities, was
simulated and analyzed. The effectiveness of each profile in the response to heat shock was evaluated according to relevant physiological and functional criteria. The small subset of GEPs that lead to effective physiological responses after heat shock was identified as the result of the tuning
of several evolutionary criteria. The experimentally observed transcriptional changes in response to heat shock belong to this set and can be explained by quantitative design principles at the
physiological level that ultimately constrain changes in gene expression.
Conclusion: Our theoretical approach suggests a method for understanding the combined effect of changes in the expression of multiple genes on the activity of metabolic pathways, and consequently on the adaptation of cellular metabolism to heat shock. This method identifies quantitative design principles that facilitate understating the response of the cell to stress.
https://doi.org/10.1186%2F1471-2105-7-184
009118
1471-2105
http://hdl.handle.net/10459.1/319
eng
BioMed Central
Reproducció del document publicat a https://doi.org/10.1186%2F1471-2105-7-184
BMC Bioinformatics, 2006, vol. 7, núm. 184, p. 1-19
cc-by, (c) Vilaprinyo et al., 2006
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.0/es/deed.ca
Llevats -- Biotecnologia
Enginyeria genètica
Expressió genètica
Use of physiological constraints to identify quantitative design principles for gene expression in yeast adaptation to heat shock
article
publishedVersion
TEXT
1471-2105-7-184.pdf.txt
1471-2105-7-184.pdf.txt
Extracted Text
text/plain
98612
https://repositori.udl.cat/bitstreams/7491f89c-2aae-4c66-afc9-ee1c6dfca8e7/download
9437292320685658d45e0cf257c68b82
MD5
17
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1846
https://repositori.udl.cat/bitstreams/6fcfe8d3-bea6-4f59-8888-f8ee1ec09f5e/download
ecab73aad5dcfe5aa46da979074a46cf
MD5
5
ORIGINAL
1471-2105-7-184.pdf
1471-2105-7-184.pdf
application/pdf
812530
https://repositori.udl.cat/bitstreams/a60d5ed0-3bc8-486c-97d0-5248136f1875/download
5fbb0f296ef03a1ffb9c7c5c664a67c2
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
24637
https://repositori.udl.cat/bitstreams/008ca1fd-009d-455f-b5bf-5b12c3139d0e/download
0efe8f1eca8ecb2ed203a894608d7c09
MD5
7
license_text
license_text
text/html; charset=utf-8
20901
https://repositori.udl.cat/bitstreams/fcaf2d25-2225-4506-9c29-c0583b610263/download
1f2747d4709567dd87bd8f89348c86d4
MD5
8
license_url
license_url
text/plain; charset=utf-8
46
https://repositori.udl.cat/bitstreams/0763e772-f77a-40ac-801b-e16026bdde04/download
9f2020a497eacc3c6092de175e4836a8
MD5
9
THUMBNAIL
1471-2105-7-184.pdf.jpg
1471-2105-7-184.pdf.jpg
Generated Thumbnail
image/jpeg
5577
https://repositori.udl.cat/bitstreams/030fdc91-3c48-4162-9688-897d827c782a/download
6da3bc537c5847d0d77634391f28e417
MD5
16
10459.1/319
oai:repositori.udl.cat:10459.1/319
2020-07-14 08:39:35.213
http://creativecommons.org/licenses/by/2.0/es/deed.ca
cc-by, (c) Vilaprinyo et al., 2006
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
TGljZW5zZSBncmFudGVkIGJ5IFBpbGFyIFJpZ3VhbCBQdW50b3MgKHBpbGFyLnJpZ3VhbEBzYmQudWRsLmNhdCkgb24gMjAxMC0wNC0xNVQwNzoyMDoyNFogKEdNVCk6CgpOT1RFOiBQTEFDRSBZT1VSIE9XTiBMSUNFTlNFIEhFUkUKVGhpcyBzYW1wbGUgbGljZW5zZSBpcyBwcm92aWRlZCBmb3IgaW5mb3JtYXRpb25hbCBwdXJwb3NlcyBvbmx5LgoKTk9OLUVYQ0xVU0lWRSBESVNUUklCVVRJT04gTElDRU5TRQoKQnkgc2lnbmluZyBhbmQgc3VibWl0dGluZyB0aGlzIGxpY2Vuc2UsIHlvdSAodGhlIGF1dGhvcihzKSBvciBjb3B5cmlnaHQKb3duZXIpIGdyYW50cyB0byBEU3BhY2UgVW5pdmVyc2l0eSAoRFNVKSB0aGUgbm9uLWV4Y2x1c2l2ZSByaWdodCB0byByZXByb2R1Y2UsCnRyYW5zbGF0ZSAoYXMgZGVmaW5lZCBiZWxvdyksIGFuZC9vciBkaXN0cmlidXRlIHlvdXIgc3VibWlzc2lvbiAoaW5jbHVkaW5nCnRoZSBhYnN0cmFjdCkgd29ybGR3aWRlIGluIHByaW50IGFuZCBlbGVjdHJvbmljIGZvcm1hdCBhbmQgaW4gYW55IG1lZGl1bSwKaW5jbHVkaW5nIGJ1dCBub3QgbGltaXRlZCB0byBhdWRpbyBvciB2aWRlby4KCllvdSBhZ3JlZSB0aGF0IERTVSBtYXksIHdpdGhvdXQgY2hhbmdpbmcgdGhlIGNvbnRlbnQsIHRyYW5zbGF0ZSB0aGUKc3VibWlzc2lvbiB0byBhbnkgbWVkaXVtIG9yIGZvcm1hdCBmb3IgdGhlIHB1cnBvc2Ugb2YgcHJlc2VydmF0aW9uLgoKWW91IGFsc28gYWdyZWUgdGhhdCBEU1UgbWF5IGtlZXAgbW9yZSB0aGFuIG9uZSBjb3B5IG9mIHRoaXMgc3VibWlzc2lvbiBmb3IKcHVycG9zZXMgb2Ygc2VjdXJpdHksIGJhY2stdXAgYW5kIHByZXNlcnZhdGlvbi4KCllvdSByZXByZXNlbnQgdGhhdCB0aGUgc3VibWlzc2lvbiBpcyB5b3VyIG9yaWdpbmFsIHdvcmssIGFuZCB0aGF0IHlvdSBoYXZlCnRoZSByaWdodCB0byBncmFudCB0aGUgcmlnaHRzIGNvbnRhaW5lZCBpbiB0aGlzIGxpY2Vuc2UuIFlvdSBhbHNvIHJlcHJlc2VudAp0aGF0IHlvdXIgc3VibWlzc2lvbiBkb2VzIG5vdCwgdG8gdGhlIGJlc3Qgb2YgeW91ciBrbm93bGVkZ2UsIGluZnJpbmdlIHVwb24KYW55b25lJ3MgY29weXJpZ2h0LgoKSWYgdGhlIHN1Ym1pc3Npb24gY29udGFpbnMgbWF0ZXJpYWwgZm9yIHdoaWNoIHlvdSBkbyBub3QgaG9sZCBjb3B5cmlnaHQsCnlvdSByZXByZXNlbnQgdGhhdCB5b3UgaGF2ZSBvYnRhaW5lZCB0aGUgdW5yZXN0cmljdGVkIHBlcm1pc3Npb24gb2YgdGhlCmNvcHlyaWdodCBvd25lciB0byBncmFudCBEU1UgdGhlIHJpZ2h0cyByZXF1aXJlZCBieSB0aGlzIGxpY2Vuc2UsIGFuZCB0aGF0CnN1Y2ggdGhpcmQtcGFydHkgb3duZWQgbWF0ZXJpYWwgaXMgY2xlYXJseSBpZGVudGlmaWVkIGFuZCBhY2tub3dsZWRnZWQKd2l0aGluIHRoZSB0ZXh0IG9yIGNvbnRlbnQgb2YgdGhlIHN1Ym1pc3Npb24uCgpJRiBUSEUgU1VCTUlTU0lPTiBJUyBCQVNFRCBVUE9OIFdPUksgVEhBVCBIQVMgQkVFTiBTUE9OU09SRUQgT1IgU1VQUE9SVEVECkJZIEFOIEFHRU5DWSBPUiBPUkdBTklaQVRJT04gT1RIRVIgVEhBTiBEU1UsIFlPVSBSRVBSRVNFTlQgVEhBVCBZT1UgSEFWRQpGVUxGSUxMRUQgQU5ZIFJJR0hUIE9GIFJFVklFVyBPUiBPVEhFUiBPQkxJR0FUSU9OUyBSRVFVSVJFRCBCWSBTVUNICkNPTlRSQUNUIE9SIEFHUkVFTUVOVC4KCkRTVSB3aWxsIGNsZWFybHkgaWRlbnRpZnkgeW91ciBuYW1lKHMpIGFzIHRoZSBhdXRob3Iocykgb3Igb3duZXIocykgb2YgdGhlCnN1Ym1pc3Npb24sIGFuZCB3aWxsIG5vdCBtYWtlIGFueSBhbHRlcmF0aW9uLCBvdGhlciB0aGFuIGFzIGFsbG93ZWQgYnkgdGhpcwpsaWNlbnNlLCB0byB5b3VyIHN1Ym1pc3Npb24uCg==
oai:repositori.udl.cat:10459.1/832712022-05-13T00:08:21Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Sarlabous Uranga, Leonardo
Aquino Esperanza, Jose
Magrans, Rudys
de Haro, Candelaria
López-Aguilar, Josefina
Subirà, Carles
Batlle, Montserrat
Rué i Monné, Montserrat
Gomà Fernández, Gemma
Ochagavía, Ana
Fernández, Rafael
Blanch, Lluís
2022-05-12T10:26:23Z
2022-05-12T10:26:23Z
2020
Patient-ventilator asynchronies can be detected by close monitoring of ventilator screens by clinicians or through automated algorithms. However, detecting complex patient-ventilator interactions (CP-VI), consisting of changes in the respiratory rate and/or clusters of asynchronies, is a challenge. Sample Entropy (SE) of airway flow (SE-Flow) and airway pressure (SE-Paw) waveforms obtained from 27 critically ill patients was used to develop and validate an automated algorithm for detecting CP-VI. The algorithm’s performance was compared versus the gold standard (the ventilator’s waveform recordings for CP-VI were scored visually by three experts; Fleiss’ kappa = 0.90 (0.87–0.93)). A repeated holdout cross-validation procedure using the Matthews correlation coefficient (MCC) as a measure of effectiveness was used for optimization of different combinations of SE settings (embedding dimension, m, and tolerance value, r), derived SE features (mean and maximum values), and the thresholds of change (Th) from patient’s own baseline SE value. The most accurate results were obtained using the maximum values of SE-Flow (m = 2, r = 0.2, Th = 25%) and SE-Paw (m = 4, r = 0.2, Th = 30%) which report MCCs of 0.85 (0.78–0.86) and 0.78 (0.78–0.85), and accuracies of 0.93 (0.89–0.93) and 0.89 (0.89–0.93), respectively. This approach promises an improvement in the accurate detection of CP-VI, and future study of their clinical implications.
This work was funded by projects PI16/01606, integrated in the Plan Nacional de R+D+I and co-funded by the ISCIII- Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER). RTC-2017-6193-1 (AEI/FEDER UE). CIBER Enfermedades Respiratorias, and Fundació Parc Taulí.
https://doi.org/10.1038/s41598-020-70814-4
030748
2045-2322
http://hdl.handle.net/10459.1/83271
eng
Scientific Reports
Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-70814-4
Scientific Reports, 2020 , vol. 10, p. 1-12
cc-by (c) The Author 2020
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Enginyeria biomèdica
Marcadors bioquímics
Bases de dades
Aprenentatge automàtic
Estadística
Biomedical engineering
Biochemical markers
Database
Machine learning
Statistics
Development and validation of a sample entropy-based method to identify complex patient-ventilator interactions during mechanical ventilation
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://repositori.udl.cat/bitstreams/8c62b602-6347-49cd-86c4-3990b9858d03/download
0175ea4a2d4caec4bbcc37e300941108
MD5
2
THUMBNAIL
030748.pdf.jpg
030748.pdf.jpg
IM Thumbnail
image/jpeg
6838
https://repositori.udl.cat/bitstreams/56bb2c2e-4e0a-4bd9-85ba-972462e5fcf4/download
4dc7374c9f5a614b742cccc17a2c7250
MD5
5
ORIGINAL
030748.pdf
030748.pdf
application/pdf
5356344
https://repositori.udl.cat/bitstreams/ab23545f-294f-48c8-a7fd-0ac86fffc567/download
3539b5187e8461f6e50dc05ee5eed7c3
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/90a40c4a-6e87-4909-9f0d-b90514bcbafd/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
TEXT
030748.pdf.txt
030748.pdf.txt
Extracted text
text/plain
51813
https://repositori.udl.cat/bitstreams/e7e471ad-629a-4496-962d-f461edb55eae/download
b46feba5791493338954987851ff2e9b
MD5
4
10459.1/83271
oai:repositori.udl.cat:10459.1/83271
2022-05-13 00:08:21.748
http://creativecommons.org/licenses/by/4.0/
cc-by (c) The Author 2020
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/494282021-08-30T15:04:33Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Royo Sánchez-Palencia, José Luis
Pascual Pons, Mariona
Lupiañez, Arantxa
Sanchez Lopez, Isabel
Fibla Palazón, Joan
2016-02-02T19:08:03Z
2016-02-02T19:08:03Z
2025-01-01
2015
2016-02-02T19:08:04Z
Copy number variant (CNV) regions have been proven to have a significant impact on gene expression. Some of them have been also found to be associated to different human diseases. CNV genotyping is often prone to error and cross-validation with independent methods is frequently required. The platform of choice depends on whether it is a genome-wide discovery screening or a candidate CNV study, the cohort size and the number of CNVs included in the assay and, finally, the budget available. Here we illustrate a affordable approach to determine the CNV genotype using matrix-assisted laser desorption/ ionization mass spectrometry (MALDI-MS) and based on the quantitative determination of single nucleotide duplicated mismatches (SNDM) mapping the CNV region and a paralogue genomic region that is used as a two-copy reference. We have genotyped nsv436327, a common CNV mapping SIRPB1 intron 1 that has been associated to human personality behavior. SIRP cluster region was subjected to several ancestral duplication events what makes SIRPB1 CNV genotyping technically challenging. We designed three sets of primer pairs that amplified paralogue regions inside and outside the CNV, containing three SNDMs. Post-PCR extension analyses of sequencing oligonucleotides mapping immediately upstream each SNDM allowed us to quantify using MALDI-MS the proportion of PCR products derived from the CNV region versus the external reference. In contrast to other approaches, setting up this genotyping method requires an affordable investment.
application/pdf
https://doi.org/10.1016/j.mcp.2015.07.009
023182
0890-8508
http://hdl.handle.net/10459.1/49428
eng
Elsevier
Reproducció del document publicat a: https://doi.org/10.1016/j.mcp.2015.07.009
Molecular and Cellular Probes, 2015, vol. 29, núm. 6, p. 517-521
(c) Elsevier, 2015
info:eu-repo/semantics/restrictedAccess
SIRPB1
cnv
MALDI-TOF
genotyping-by-sequencing
Gens
Genes
Genotyping of common SIRPB1 copy number variant using Paralogue Ratio Test coupled to MALDI-MS quantification
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
jlroyo@cmb.udl.cat
Royo Sánchez-Palencia, José Luis
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/bf85c514-edbf-47a2-939a-bc8da243755d/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
ORIGINAL
023182.pdf
application/pdf
1052672
https://repositori.udl.cat/bitstreams/583e5286-e832-48ad-b426-a2847880abc5/download
e21da07cfa216f98b704e0e905a4f1df
MD5
1
SWORD
mets.xml
SWORD deposit package
application/octet-stream
825476
https://repositori.udl.cat/bitstreams/7d96a7b4-6899-4252-8fe4-0fa5335c1df5/download
31f1e711d9022cace65d6780af237e29
MD5
3
TEXT
023182.pdf.txt
023182.pdf.txt
Extracted Text
text/plain
27171
https://repositori.udl.cat/bitstreams/7319bf47-decf-4c3f-b60b-c3f9da590148/download
de35bb050dbbb733c38ee8c16ee2aee8
MD5
5
THUMBNAIL
023182.pdf.jpg
023182.pdf.jpg
Generated Thumbnail
image/jpeg
5538
https://repositori.udl.cat/bitstreams/87031aa4-1d7d-4284-8823-96c9d0ea9dd1/download
24fdaadd026790c2ee86b06d2a419237
MD5
6
10459.1/49428
oai:repositori.udl.cat:10459.1/49428
2021-08-30 15:04:33.568
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/570002021-08-30T15:04:33Zcom_10459.1_227com_10459.1_2col_10459.1_314
Puigpinós, R.
Borrell i Thió, Carme
Pasarín, M.I.
Montellà, N.
Pérez, G.
Plasència, A.
Rué i Monné, Montserrat
2016-05-10T07:19:45Z
2025-01-01
2000
Most of the studies of inequalities in mortality
carried out in Spain have been ecological, due
to the di culty of obtaining good quality socioeconomic
information at individual level. The objective
of this study was to describe inequalities in mortality
by social class, based on occupation, among men
residents of Barcelona in 1993. A representative
sample was obtained of men residents of Barcelona
who died during the year 1993, aged between 15 and
65 years. It was a retrospective interview given to
relatives of the deceased, or other closely related
persons. The variables analysed were: age, education
level, underlying cause of death, and social class
based on occupation (manual and non-manual
workers). Rates, relative risks (RRs) and their 95%
con®dence intervals (95% CIs) are presented by age
groups and cause of death. The main results show
that among young people, the excess of mortality due
to infectious diseases is notable (RR: 1.9; 95% CI:
1.6±2.2), and also due to external causes (RR: 2.1;
95% CI: 1.8±2.4) among manual workers with respect
to non-manual workers, mainly due to AIDS
and drug overdose. No signi®cant di erences were
found in mortality due to tumours. For respiratory
and cardiovascular causes, there is an increase in
mortality in the less favoured social classes, as also
occurs for mortality due to diseases of the digestive
system, particularly among young manual workers,
with an RR: 2.6 (95% CI: 1.5±3.6) compared to nonmanual
workers. This study shows that it is necessary
to continue exploring inequalities in health, but
above all it is necessary to implement e cient preventive
measures addressed mainly at young people
in situations of disadvantage, in order to avoid the
excess of avoidable mortality which is found.
https://doi.org/10.1023/A:1026706302783
009182
0393-2990
http://hdl.handle.net/10459.1/57000
eng
Springer Verlag
Reproducció del document publicat a https://doi.org/10.1023/A:1026706302783
European Journal of Epidemiology, 2000, vol. 16, núm. 8, p. 751-756
(c) Kluwer Academic Publishers, 2000
info:eu-repo/semantics/restrictedAccess
Barcelona
Inequalities
Mortality
Retrospective survey
Inequalities in mortality by social class in men in Barcelona, Spain
article
publishedVersion
montse.rue@cmb.udl.cat
Rué i Monné, Montserrat
THUMBNAIL
009182.pdf.jpg
009182.pdf.jpg
Generated Thumbnail
image/jpeg
5044
https://repositori.udl.cat/bitstreams/bbd270ec-35ec-476a-9107-d0401492d140/download
32657624fa42ccf1e84e11bbd7de7a0d
MD5
3
ORIGINAL
009182.pdf
009182.pdf
application/pdf
83262
https://repositori.udl.cat/bitstreams/b90ed65f-67f6-4e96-a3d6-a13e74405d86/download
9265bd9a4b34739f0ad4c4798860f843
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/101364ce-f202-42b2-89bf-53d47a21e6ea/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
TEXT
009182.pdf.txt
009182.pdf.txt
Extracted Text
text/plain
26443
https://repositori.udl.cat/bitstreams/f1ede4c8-64e8-45d4-b162-8e1d0018f454/download
7365e6734373d3b5ab90d525a7b83960
MD5
4
10459.1/57000
oai:repositori.udl.cat:10459.1/57000
2021-08-30 15:04:33.759
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=
oai:repositori.udl.cat:10459.1/571612021-08-30T15:04:28Zcom_10459.1_227com_10459.1_2com_10459.1_59159com_10459.1_47453col_10459.1_314col_10459.1_59160col_10459.1_59998col_10459.1_49291
Sorolla Bardají, Maria Alba
Reverter Branchat, Gemma
Tamarit Sumalla, Jordi
Ferrer, Isidre
Ros Salvador, Joaquim
Cabiscol Català, Elisa
2016-06-06T10:32:52Z
2025-01-01
2008
Huntington disease (HD) is a neurodegenerative disorder caused by expansion of CAG repeats in exon 1 of the
huntingtin gene, affecting initially the striatum and progressively the cortex. This work reports a proteomic
analysis of human brain postmortem samples obtained from striatum and cortex of patients with HD
compared to samples of age- and sex-matched controls. Antioxidant defense proteins that were strongly
induced in striatum, but also detectable in cortex, were identified as peroxiredoxins 1, 2, and 6, as well as
glutathione peroxidases 1 and 6. The activities of other antioxidant enzymes such as mitochondrial
superoxide dismutase and catalase were also increased in HD. Aconitase, a protein involved in energy
metabolism, showed decreased activities in striatum of HD patients. Protein carbonyls, used as markers of
oxidative stress, were increased in HD, and glial fibrillary acidic protein, aconitase, γ-enolase, and creatine
kinase B were identified as the main targets. Taken together, these results indicate that oxidative stress and
damage to specific macromolecules would participate in the disease progression. Also, these data support the
rationale for therapeutic strategies that either potentiate antioxidant defenses or avoid oxidative stress
generation to delay disease progression.
This work has been supported by Grants BFU2004-00593/BMC, BFU2007-66249, and CSD2007-20 Consolider Ingenio 2010 from the Ministerio de Educación y Ciencia (Spain) and SGR2005-00677 from the Generalitat de Catalunya. M. A. Sorolla is the recipient of a Ph.D. fellowship from the Ministerio de Educación y Ciencia (Spain)
https://doi.org/10.1016/j.freeradbiomed.2008.05.014
012451
0891-5849
http://hdl.handle.net/10459.1/57161
eng
Elsevier
MIECI/PN2004-2007/BFU2004-00593/BMC
MIECI/PN2004-2007/BFU2007-66249
Reproducció del document publicat a https://doi.org/10.1016/j.freeradbiomed.2008.05.014
Free Radical Biology and Medicine, 2008, vol. 45, núm. 5, p. 667-678
(c) Elsevier Inc., 2008
info:eu-repo/semantics/restrictedAccess
Huntington disease
Proteomic analysis
Oxidative stress
Protein carbonylation
Proteomic and oxidative stress analysis in human brain samples of Huntington disease
article
publishedVersion
elisa.cabiscol@cmb.udl.es
Cabiscol Català, Elisa
THUMBNAIL
012451.pdf.jpg
012451.pdf.jpg
Generated Thumbnail
image/jpeg
5397
https://repositori.udl.cat/bitstreams/808bb3e2-e099-483b-acc7-6a8b6348637a/download
c521a53c10c3d27a8c9acdf4a5841a7e
MD5
3
ORIGINAL
012451.pdf
012451.pdf
application/pdf
1379912
https://repositori.udl.cat/bitstreams/377c9bde-5727-4904-a252-0d5f1f0a05a2/download
2ce9964dca7e41f79de6b81fe9c76a90
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/69a9a702-fe31-410b-ad1a-80495b928be7/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
TEXT
012451.pdf.txt
012451.pdf.txt
Extracted Text
text/plain
71695
https://repositori.udl.cat/bitstreams/d316213d-77b5-4f87-8a03-25f34e8c6c1d/download
9e6926f67299ecb27999823733873445
MD5
4
10459.1/57161
oai:repositori.udl.cat:10459.1/57161
2021-08-30 15:04:28.93
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/455882023-01-27T19:50:26Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_49291
Salvadó López, Baldiri
Vilaprinyo Terré, Ester
Karathia, Hiren
Sorribas Tello, Albert
Alves, Rui
2012-06-18T10:49:05Z
2012-06-18T10:49:05Z
2012
Signal transduction systems mediate the response and adaptation of organisms to environmental changes. In prokaryotes, this signal transduction is often done through Two Component Systems (TCS). These TCS are phosphotransfer protein cascades, and in their prototypical form they are composed by a kinase that senses the environmental signals (SK) and by a response regulator (RR) that regulates the cellular response. This basic motif can be modified by the addition of a third protein that interacts either with the SK or the RR in a way that could change the dynamic response of the TCS module. In this work we aim at understanding the effect of such an additional protein (which we call ‘‘third component’’) on the
functional properties of a prototypical TCS. To do so we build mathematical models of TCS with alternative designs for their
interaction with that third component. These mathematical models are analyzed in order to identify the differences in dynamic behavior inherent to each design, with respect to functionally relevant properties such as sensitivity to changes in either the parameter values or the molecular concentrations, temporal responsiveness, possibility of multiple steady states, or stochastic fluctuations in the system. The differences are then correlated to the physiological requirements that impinge on the functioning of the TCS. This analysis sheds light on both, the dynamic behavior of synthetically designed TCS, and the conditions under which natural selection might favor each of the designs. We find that a third component that
modulates SK activity increases the parameter space where a bistable response of the TCS module to signals is possible, if
SK is monofunctional, but decreases it when the SK is bifunctional. The presence of a third component that modulates RR activity decreases the parameter space where a bistable response of the TCS module to signals is possible.
This work was partially supported by grants BFU2008-0196 to AS and BFU2010-17704 to RA, both from MICINN (Ministerio de Ciencia e Innovación, Spain). HK is funded by a Ph. D. fellowship and EV is funded by a Beatriu de Pinós Post-doctoral fellowship, both from AGAUR (Agència de Gestió d'Ajuts Universitaris i de Recerca, Catalunya). No additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
https://doi.org/10.1371/journal.pone.0031095
020994
1932-6203
http://hdl.handle.net/10459.1/45588
eng
Public Library of Science
info:eu-repo/grantAgreement/MICINN//BFU2008-0196/ES/
info:eu-repo/grantAgreement/MICINN//BFU2010-17704/ES/METRES (METABOLIC RECONSTRUCTION SERVER DESARROLLO Y APLICACION EN EN ESTUDIO DE PRINCIPIOS DE DISEÑO BIOLOGICO/
Reproducció del document publicat a https://doi.org/10.1371/journal.pone.0031095
PLoS ONE, 2012, vol. 7, núm. 2, p. 1-18
cc-by, (c) Salvado et al., 2012
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/es/deed.ca
Transducció de senyal cel·lular
Proteïnes
Two component systems: physiological effect of a third component
article
publishedVersion
ORIGINAL
journal.pone.0031095.pdf
journal.pone.0031095.pdf
application/pdf
2177116
https://repositori.udl.cat/bitstreams/d0f7c27a-353a-43fa-ab00-02c0042dd130/download
8b23e7937254d4753163e7a66177fda3
MD5
1
THUMBNAIL
journal.pone.0031095.pdf.jpg
journal.pone.0031095.pdf.jpg
Generated Thumbnail
image/jpeg
6102
https://repositori.udl.cat/bitstreams/bfcab67f-98bd-4d2b-9ebd-0f544619ebee/download
5d6b90fb0144dc6214b9fc64546b81a7
MD5
10
CC-LICENSE
license_url
license_url
text/plain; charset=utf-8
46
https://repositori.udl.cat/bitstreams/d09c2c5d-5fe6-409a-ae08-34dcd343da25/download
9f2020a497eacc3c6092de175e4836a8
MD5
2
license_text
license_text
text/html; charset=utf-8
20453
https://repositori.udl.cat/bitstreams/29d27810-eeee-4d79-a4b8-c3b6b3b061e0/download
c29898748122bf4bd3699c3a8d561864
MD5
3
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
21460
https://repositori.udl.cat/bitstreams/e55e6657-45fc-41e1-a56d-fc53d0d94b91/download
31b0756a06487998b0d2d46d5604477d
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/dd26ebad-11f9-4bca-b7ab-745e5ace8ed2/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
5
TEXT
journal.pone.0031095.pdf.txt
journal.pone.0031095.pdf.txt
Extracted Text
text/plain
88873
https://repositori.udl.cat/bitstreams/1365540b-262e-43e2-b9b3-76868405e955/download
7c32d0f8adbc5ab8a921af4a0b1219d8
MD5
11
10459.1/45588
oai:repositori.udl.cat:10459.1/45588
2023-01-27 19:50:26.306
http://creativecommons.org/licenses/by/2.5/es/deed.ca
cc-by, (c) Salvado et al., 2012
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/570542021-08-30T15:04:34Zcom_10459.1_227com_10459.1_2col_10459.1_314
Igoshin, Oleg A.
Alves, Rui
Savageau, Michael A.
2016-05-19T08:54:33Z
2025-01-01
2008
Bacterial two-component systems (TCS) are key
signal transduction networks regulating global
responses to environmental change. Environmental
signals may modulate the phosphorylation state of
sensor kinases (SK). The phosphorylated SK trans-
fers the phosphate to its cognate response regulator
(RR), which causes physiological response to the
signal. Frequently, the SK is bifunctional and, when
unphosphorylated, it is also capable of dephosphory-
lating the RR. The phosphatase activity may also be
modulated by environmental signals. Using the EnvZ/
OmpR system as an example, we constructed math-
ematical models to examine the steady-state and
kinetic properties of the network. Mathematical
modelling reveals that the TCS can show bistable
behaviour for a given range of parameter values
if unphosphorylated SK and RR form a dead-end
complex that prevents SK autophosphorylation. Addi-
tionally, for bistability to exist the major dephospho-
rylation flux of the RR must not depend on the
unphosphorylated SK. Structural modelling and pub-
lished affinity studies suggest that the unphosphory-
lated SK EnvZ and the RR OmpR form a dead-end
complex. However, bistability is not possible because
the dephosphorylation of OmpR
~
P is mainly done by
unphosphorylated EnvZ. The implications of this
potential bistability in the design of the EnvZ/OmpR
network and other TCS are discussed.
https://doi.org/10.1111/j.1365-2958.2008.06221.x
011508
0950-382X
http://hdl.handle.net/10459.1/57054
eng
Blackwell
Reproducció del document publicat a https://doi.org/10.1111/j.1365-2958.2008.06221.x
Molecular Microbiology, 2008, vol. 68, p. 1196-1215
(c) Blackwell, 2008
info:eu-repo/semantics/restrictedAccess
Hysteretic and graded responses in bacterial two-component signal transduction
article
publishedVersion
ralves@cmb.udl.cat
Alves, Rui
ORIGINAL
011508.pdf
011508.pdf
application/pdf
827191
https://repositori.udl.cat/bitstreams/7e2ee118-30a5-449f-bbb1-b347c1782cdb/download
e3f683aa2352014881cf5fa6e26ab3f6
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/ca6eae3d-6894-4907-819e-2c14fc2e5f19/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
TEXT
011508.pdf.txt
011508.pdf.txt
Extracted Text
text/plain
100130
https://repositori.udl.cat/bitstreams/dc4d2adb-12e8-4448-8bcc-daf94354a3fb/download
6fd016b94a856f0976055bd29abc27e2
MD5
4
THUMBNAIL
011508.pdf.jpg
011508.pdf.jpg
Generated Thumbnail
image/jpeg
5690
https://repositori.udl.cat/bitstreams/be5ef8d0-03fb-4df8-bb9c-328448e76c8e/download
4253148a632ad9e54c9c83e4d83fda6c
MD5
3
10459.1/57054
oai:repositori.udl.cat:10459.1/57054
2021-08-30 15:04:34.211
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/416672020-07-14T08:39:35Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Reveiz, Ludovic
Chan, An-Wen
Krleza-Jeric, Karmela
Granados, Carlos Eduardo
Pinart, Mariona
Etxeandia, Itziar
Rada, Diego
Martínez Alonso, Montserrat
Bonfill, Xavier
Cardona, Andrés Felipe
2011-10-31T10:13:12Z
2011-10-31T10:13:12Z
2010
Background: Although randomized clinical trials (RCTs) are considered the gold standard of evidence, their reporting is
often suboptimal. Trial registries have the potential to contribute important methodologic information for critical appraisal of study results.
Methods and Findings: The objective of the study was to evaluate the reporting of key methodologic study characteristics in trial registries. We identified a random sample (n = 265) of actively recruiting RCTs using the World Health Organization International Clinical Trials Registry Platform (ICTRP) search portal in 2008. We assessed the reporting of relevant domains from the Cochrane Collaboration’s ‘Risk of bias’ tool and other key methodological aspects. Our primary outcomes were the proportion of registry records with adequate reporting of random sequence generation, allocation concealment, blinding, and trial outcomes. Two reviewers independently assessed each record. Weighted overall proportions in the ICTRP search portal for adequate reporting of sequence generation, allocation concealment, blinding (including and excluding open label RCT) and primary outcomes were 5.7% (95% CI 3.0–8.4%), 1.4% (0–2.8%), 41% (35–47%), 8.4% (4.1–13%), and 66% (60–72%), respectively. The proportion of adequately reported RCTs was higher for registries that used specific methodological fields for describing methods of randomization and allocation concealment compared to registries that did not. Concerning other key methodological aspects, weighted overall proportions of RCTs with adequately reported items were as follows:
eligibility criteria (81%), secondary outcomes (46%), harm (5%) follow-up duration (62%), description of the interventions
(53%) and sample size calculation (1%).
Conclusions: Trial registries currently contain limited methodologic information about registered RCTs. In order to permit
adequate critical appraisal of trial results reported in journals and registries, trial registries should consider requesting details
on key RCT methods to complement journal publications. Full protocols remain the most comprehensive source of methodologic information and should be made publicly available.
https://doi.org/10.1371%2Fjournal.pone.0012484
016421
1932-6203
http://hdl.handle.net/10459.1/41667
eng
Public Library of Science (PLoS)
Reproducció del document publicat a https://doi.org/10.1371%2Fjournal.pone.0012484
PLoS ONE, 2010, vol. 5, núm. 8, e12484
cc-by, (c) Reveiz et al., 2010
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/es/deed.ca
Assaigs clínics
Medicina basada en l'evidència
Assaigs clínics -- Bases de dades
Reporting of methodologic information on trial registries for quality assessment: a study of trial records retrieved from the WHO search portal
article
publishedVersion
ORIGINAL
journal.pone.0012484.pdf
journal.pone.0012484.pdf
application/pdf
90760
https://repositori.udl.cat/bitstreams/54631279-e14b-4633-9f89-58170e0a8130/download
e0e6525ab8b6f384366401c76a26c0ae
MD5
1
CC-LICENSE
license_url
license_url
text/plain; charset=utf-8
46
https://repositori.udl.cat/bitstreams/e31eb6f4-5266-4c68-a4de-6d3d794ab443/download
9f2020a497eacc3c6092de175e4836a8
MD5
2
license_text
license_text
text/html; charset=utf-8
23858
https://repositori.udl.cat/bitstreams/f94ffb6d-48b7-48bd-a98f-772c55c3b743/download
d6c047d90a3b401186e0437ec1444977
MD5
3
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
21477
https://repositori.udl.cat/bitstreams/d3d36759-9f34-49d3-9218-b9654b1d700f/download
5ae8a691a00e184e412e9974f9719ed3
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1846
https://repositori.udl.cat/bitstreams/a22f7c1b-7229-40df-bf88-a47a28202641/download
9d17de354c4d3c2c02535606eec50b80
MD5
5
TEXT
journal.pone.0012484.pdf.txt
journal.pone.0012484.pdf.txt
Extracted Text
text/plain
36723
https://repositori.udl.cat/bitstreams/3de258d9-daf6-4268-b36d-760178cc176a/download
290f3f57b336929c3ba90b3cd4144d83
MD5
13
THUMBNAIL
journal.pone.0012484.pdf.jpg
journal.pone.0012484.pdf.jpg
Generated Thumbnail
image/jpeg
6032
https://repositori.udl.cat/bitstreams/765206a5-c7ff-4143-86dc-b8314c1f3340/download
860916fa618e702aa4567906ba55cb01
MD5
12
10459.1/41667
oai:repositori.udl.cat:10459.1/41667
2020-07-14 08:39:35.336
http://creativecommons.org/licenses/by/2.5/es/deed.ca
cc-by, (c) Reveiz et al., 2010
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/566622023-04-25T12:44:42Zcom_10459.1_227com_10459.1_2com_10459.1_463061com_10459.1_47453col_10459.1_314col_10459.1_463062col_10459.1_59998
Usié Chimenos, Anabel
Alves, Rui
Solsona Tehàs, Francesc
Vázquez, Miguel
Valéncia, Alfonso
2016-03-01T10:08:43Z
2016-03-01T10:08:43Z
2013
Motivation: Chemical named entity recognition is used to automatically
identify mentions to chemical compounds in text, and is the
basis for more elaborate information extraction. However, only a
small number of applications are freely available to identify such
mentions. Particularly challenging and useful is the identification of
IUPAC chemical compounds, which due to the complex morphology
of IUPAC names requires more advanced techniques than that of
brand names.
Results: We present CheNER, a tool for automated identification of
systematic IUPAC chemical mentions. We evaluated different systems
using an established literature corpus to show that CheNER
has a superior performance in identifying IUPAC names specifically,
and that it makes better use of computational resources.
Availability: http://metres.udl.cat/index.php/9-download/4-chener,
http://ubio.bioinfo.cnio.es/biotools/CheNER/
Supplementary information: Both web sites above include the
user manual for the software. Supplementary materials accompany
this publication.
AU is a Ph.D. scholar funded by Generalitat de Catalunya. AU, FS & RA are partially supported by the Spanish government (grants TIN2011-28689-C02-02 and BFU2010-17704) and Generalitat de Catalunya (research groups 2009SGR809 and 2009SGR145). MV & AV were supported by the Spanish Government (grant BIO2007-66855) and eTOX (grant IMI/115002).
https://doi.org/10.1093/bioinformatics/btt639
020206
1367-4803
http://hdl.handle.net/10459.1/56662
eng
Oxford University Press
Reproducció del document publicat a https://doi.org/10.1093/bioinformatics/btt639
Bioinformatics Advance Access, 2013, vol. 30, núm. 7, p. 1039-1040
cc-by-nc-nd, (c) Usié et al., 2013
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
CheNER: Chemical Named Entity Recognizer
article
publishedVersion
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1232
https://repositori.udl.cat/bitstreams/6a6be46c-5e32-444e-8547-65ac9d884cbb/download
b51f25f83cca752633b6ec4c418dbcc7
MD5
2
ORIGINAL
020206.pdf
020206.pdf
application/pdf
93418
https://repositori.udl.cat/bitstreams/1a307a97-9e7e-4c8f-885c-6a4c6b261465/download
294311e459c55ec8b2211a532fc784a5
MD5
4
THUMBNAIL
020206.pdf.jpg
020206.pdf.jpg
Generated Thumbnail
image/jpeg
6027
https://repositori.udl.cat/bitstreams/50171e1b-1c78-44eb-b0fe-cb0d54e75e3a/download
df9dda266129dd6029bbb2460a77444e
MD5
5
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/0e19c6e6-b187-444c-bd54-23150abcad64/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
TEXT
020206.pdf.txt
020206.pdf.txt
Extracted Text
text/plain
12062
https://repositori.udl.cat/bitstreams/7456f5aa-febd-4292-82fd-05e4065b416f/download
52737a827459bc0e830fe9610c27becc
MD5
6
10459.1/56662
oai:repositori.udl.cat:10459.1/56662
2023-04-25 12:44:42.761
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
cc-by-nc-nd, (c) Usié et al., 2013
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/604282022-01-12T12:23:51Zcom_10459.1_227com_10459.1_2com_10459.1_237com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_354col_10459.1_59998col_10459.1_333
Granado Casas, Minerva
Martínez Alonso, Montserrat
Alcubierre Calvo, Núria
Ramírez-Morros, Anna
Hernández García, Marta
Castelblanco Echavarría, Esmeralda
Torres Puig-gros, Joan
Mauricio Puente, Dídac
2017-11-06T19:23:31Z
2017-11-06T19:23:31Z
2017-10-18
2017-11-06T19:23:31Z
Objectives. Our main aim was to assess the quality of life (QoL) and treatment satisfaction (TS) of subjects with LADA (latent autoimmune diabetes of the adult) and compare these measures with those of patients with other diabetes types, i.e., type 1 (T1DM) and type 2 diabetes mellitus (T2DM). Methods. This was a cross-sectional study with a total of 48 patients with LADA, 297 patients with T2DM and 124 with T1DM. The Audit of Diabetes-Dependent Quality of Life (ADDQoL-19) questionnaire and the Diabetes Treatment Satisfaction Questionnaire (DTSQ) were administered. Relevant clinical variables were also assessed. The data analysis included comparisons between groups and multivariate linear models. Results. The LADA patients presented lower diabetes-specific QoL (p D 0:045) and average weighted impact scores (p D 0:007) than the T2DM patients. The subgroup of LADA patients with diabetic retinopathy (DR) who were treated with insulin had a lowerADDQoLaverage weighted impact score than the other diabetic groups. Although the overall measure of TS was not different between the LADA and T2DM (pD0:389) and T1DM (pD0:091) groups, the patients with LADA showed a poorer hyperglycemic frequency perception than the T2DM patients (p<0:001) and an improved frequency of hypoglycemic perception compared with the T1DM patients (pD0:021). Conclusions. The current findings suggest a poorer quality of life, especially in terms of DRand insulin treatment, among patients with LADA compared with those withT1DM and T2DM. Hyperglycemia frequency perception was also poorer in the LADA patients than in the T1DM and T2DM patients. Further research with prospective studies and a large number of patients is necessary.
This study was supported by grant PS09/01035 and PI12/00183 from the Instituto de Salud Carlos III, Ministry of Economy and Competitiveness, Spain. CIBERDEM is an initiative from Instituto de Salud Carlos III (Plan Nacional de I+D+I and Fondo Europeo de Desarrollo Regional). MGC holds a predoctoral fellowship from the Ministerio de
Educación, Cultura y Deporte (FPU15/03005).
application/pdf
https://doi.org/10.7717/peerj.3928
026046
2167-8359
http://hdl.handle.net/10459.1/60428
eng
PeerJ
Reproducció del document publicat a: https://doi.org/10.7717/peerj.3928
Peerj, 2017, 5:e3928
cc-by (c) Granado Casas, Minerva et al., 2017
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es
Diabetis
Qualitat de vida
Diabetes
Quality of life
Decreased quality of live and treatment satisfaction in patients with latent autoinmune diabetes of the adult
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
026046.pdf
application/pdf
219343
https://repositori.udl.cat/bitstreams/1c8d8f4b-3b82-4387-8d9e-e24e33284674/download
3cc7eccb4e0e4321113350e370fc3aeb
MD5
1
THUMBNAIL
026046.pdf.jpg
026046.pdf.jpg
Generated Thumbnail
image/jpeg
4937
https://repositori.udl.cat/bitstreams/9e959e5c-2394-4be9-b4b0-28c750088060/download
5d1100f66c38607caf51cc1ca696b739
MD5
7
TEXT
026046.pdf.txt
026046.pdf.txt
Extracted Text
text/plain
47370
https://repositori.udl.cat/bitstreams/d84d9005-6e3e-45eb-9518-7d1aaa69e5bb/download
923b7093a7dbe13f456675fb86fff90b
MD5
8
CC-LICENSE
license_url
application/octet-stream
43
https://repositori.udl.cat/bitstreams/b7c125c2-3e98-44d3-86a7-5c1341ad4549/download
5134edb0a80711cbbaa5247c36025151
MD5
2
license_text
text/html
23115
https://repositori.udl.cat/bitstreams/d8e34117-c9a8-4de3-8aac-e9f4e62c124f/download
ec3783401c55aba9b2c045380c0dd4b3
MD5
3
license_rdf
application/octet-stream
20337
https://repositori.udl.cat/bitstreams/b9900181-5533-40e5-bd89-7a8b3b7c0a0d/download
1485691ce20485471fe59ad1ac24bf0f
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/8a92a67d-dc34-4d22-a405-4a59db95e6c8/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
5
SWORD
mets.xml
SWORD deposit package
application/octet-stream
220308
https://repositori.udl.cat/bitstreams/90ee7e98-5a8a-4433-a57c-3dc057204db5/download
fb2fb293aaa7b8a1e68b1923a36e6d7f
MD5
6
10459.1/60428
oai:repositori.udl.cat:10459.1/60428
2022-01-12 12:23:51.774
http://creativecommons.org/licenses/by/3.0/es
cc-by (c) Granado Casas, Minerva et al., 2017
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/489932022-11-28T19:36:37Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_49291
Eritja Sánchez, Núria
Mirantes Barbeito, Cristina
Llobet Navàs, David
Masip Vilà, Gemma
Matias-Guiu, Xavier
Dolcet Roca, Xavier
2015-11-18T14:25:09Z
2015-11-18T14:25:09Z
2013
Most glandular tissues comprise polarized epithelial cells organized around a single central lumen. Although there is active research investigating the molecular networks involved in the regulation of lumenogenesis, little is known about the extracellular factors that influence lumen formation and maintenance. Using a three-dimensional culture system of epithelial endometrial cells, we have revealed a new role for pro-inflammatory cytokines such as TNF alpha and IL1 alpha in the formation and, more importantly, maintenance of a single central lumen. We also studied the mechanism by which glucocorticoids repress TNF alpha and IL1 alpha expression. Interestingly, regulation of pro-inflammatory cytokine expression and subsequent lumen formation is mediated by estrogen receptor alpha (ER alpha) but not by the glucocorticoid receptor. Finally, we investigated the signaling pathways involved in the regulation of lumen formation by pro-inflammatory cytokines. Our results demonstrate that activation of the ERK/MAPK signaling pathway, but not the PI3K/Akt signaling pathway, is important for the formation and maintenance of a single central lumen. In summary, our results suggest a novel role for ER alpha-regulated pro-inflammatory cytokine expression in lumen formation and maintenance.
Supported by grants from Fondo de Investigaciones Sanitarias (FIS) [grant numbers FISPI10/00604, FISPI070304, FISPI070276]; Ministerio de Ciencia e Innovacion [grant numbers SAF2002-10529-E, SAF2004-05250]; National Cancer Institute [grant number CA90400]; Marato de TV3 2005-47 (Fundacio la Marato de TV3), RD06/0020/1034 and RD06/0020/0013(Red Tematica de Investigacion Cooperativa en Cancer), 2009SGR794 (Grups Consolidats de Recerca) and 2004XT00090 (Xarxa Tematica); AECC, Catalunya contra el cancer and programa de intensificacion de la investigacion; and Instituto Carlos III. N.E. holds a fellowship from Fundacion Alicia Cuello de Merigo and a predoctoral fellowship from FIS [grant number FI08/0012]. Deposited in PMC for release after 12 months.
017679
0021-9533
http://hdl.handle.net/10459.1/48993
eng
Company of Biologists Ltd.
info:eu-repo/grantAgreement/MICYT//SAF2002-10529-E/ES/
info:eu-repo/grantAgreement/MEC//SAF2004-05250/ES/
Reproducció del document publicat a : https://doi.org/10.1242/jcs.095067
Journal of Cell Science, 2012, vol. 125, núm. 8, p. 1929-1944
(c) Company of Biologists Ltd., 2012
info:eu-repo/semantics/openAccess
Pro-inflammatory cytokines
Epithelial cell polarity
ER alpha
Citocines
Carcinoma
ER alpha-mediated repression of pro-inflammatory cytokine expression by glucocorticoids reveals a crucial role for TNF alpha and IL1 alpha in lumen formation and maintenance
article
publishedVersion
ORIGINAL
017679.pdf
017679.pdf
application/pdf
5907375
https://repositori.udl.cat/bitstreams/44a203a6-fdf9-47fb-9a06-52b3e441c26a/download
470c78523b2ce9175e6c6d8609ce3da1
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/9e5fc6de-fee6-4324-9ba8-95b9d9aa4e7b/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
017679.pdf.jpg
017679.pdf.jpg
Generated Thumbnail
image/jpeg
6290
https://repositori.udl.cat/bitstreams/c8829b8b-8223-41ef-b736-a588671ac37e/download
7ca56a8a284d990f760663d916b46fa8
MD5
4
TEXT
017679.pdf.txt
017679.pdf.txt
Extracted Text
text/plain
73741
https://repositori.udl.cat/bitstreams/94635a3a-b8f1-4ce6-8114-19c4f0f898b2/download
8f3b43cdd0f21331fff511a37f5d1c43
MD5
5
10459.1/48993
oai:repositori.udl.cat:10459.1/48993
2022-11-28 19:36:37.909
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/648382021-10-29T12:13:54Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
García de la Fuente, María Reyes
Santacana Espasa, Maria
Valls Marsal, Joan
Vilardell, Felip
Fernández Armenteros, José Manuel
Pujol Vallverdú, Ramón M.
Garí Marsol, Eloi
Casanova i Seuma, Josep M. (Josep Manel)
2018-10-08T10:54:29Z
2018-10-08T10:54:29Z
2018
Basal cell carcinoma (BCC) seems to originate from
ultraviolet light-induced mutations involving the bulge or the outer
sheath of the hair follicle cells. However, the etiopathogenic
mechanisms involved in the development of these tumors in
nonphotoexposed and in hairless areas remain unclear. The cytokeratin
(CK) profile (including CK5/6, CK7, CK14, CK15, CK17, and
CK19) from a series of different BCC subtypes developing in
sun-exposed and non–sun-exposed areas, including hairless regions,
was evaluated. The authors have observed that CK7 expression in
BCC is associated with the anatomical localization of the tumor and
its sun-exposition, but not with other factors such as histological
subtype. The expression of this CK is higher in BCCs located in
non–sun-exposed and nonhairy areas, such as the vulvar semimucosa
and the nipple. Because CK7 is a marker of simple glandular
epithelia, the authors suggest a glandular origin for BCCs located
in hairless and nonphotoexposed areas.
https://doi.org/10.1097/DAD.0000000000001042
026993
0193-1091
http://hdl.handle.net/10459.1/64838
eng
Wolters Kluwer Health, Inc.
International Society of Dermatopathology (ISDP)
Reproducció del document publicat a https://doi.org/10.1097/DAD.0000000000001042
The American Journal of Dermatopathology, 2018, vol. 40, núm. 5, p. 342–348
cc-by-nc-nd (c) María Reyes García de la Fuente et al., 2018
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Basal cell carcinoma
Cytokeratins
Hair follicle
Sebaceous gland
Photoexposition
Cytokeratin profile of basal cell carcinomas according to the degree of sun exposure and to the anatomical localization
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
TEXT
026993.pdf.txt
026993.pdf.txt
Extracted Text
text/plain
33412
https://repositori.udl.cat/bitstreams/535db57b-88d1-45f7-beae-bf2b7272b8ec/download
8ba3a656f467a9c1e27c003953a76c94
MD5
5
ORIGINAL
026993.pdf
026993.pdf
application/pdf
762000
https://repositori.udl.cat/bitstreams/53928aed-4e13-4b10-aa95-e7deca32e037/download
fa619d2cee280c2a302b02b2ecaefbda
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
805
https://repositori.udl.cat/bitstreams/3546f6b7-517f-407c-9f03-d84a3fb1af34/download
4460e5956bc1d1639be9ae6146a50347
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/8e031ccb-2949-44f0-8ebe-f7cf8717bed2/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
THUMBNAIL
026993.pdf.jpg
026993.pdf.jpg
Generated Thumbnail
image/jpeg
5643
https://repositori.udl.cat/bitstreams/1ae7f85d-1b17-4c96-ba82-e7afbea0dfc7/download
f642e021bd1916b15072cce23f1df967
MD5
4
10459.1/64838
oai:repositori.udl.cat:10459.1/64838
2021-10-29 12:13:54.763
http://creativecommons.org/licenses/by-nc-nd/4.0/
cc-by-nc-nd (c) María Reyes García de la Fuente et al., 2018
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/569442017-03-10T13:54:56Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Chiner, Eusebi
Llombart, Mónica
Valls Marsal, Joan
Pastor, Esther
Sancho-Chust, José
Luz Andreu, Ada
Sánchez de la Torre, Manuel
Barbé Illa, Ferran
2016-05-04T08:03:02Z
2016-05-04T08:03:02Z
2016
Background:
We hypothesized that obstructive sleep apnea (OSA) can predispose individuals to lower
airway infections and community-acquired pneumonia (CAP) due to upper airway microaspiration.
This study evaluated the association between OSA and CAP.
Methods:
We performed a case-control study that included 82 patients with CAP and 41 patients with
other infections (control group). The controls were matched according to age, sex and body
mass index (BMI). A respiratory polygraph (RP) was performed upon admission for patients
in both groups. The severity of pneumonia was assessed according to the Pneumonia
Severity Index (PSI). The associations between CAP and the Epworth Sleepiness Scale
(ESS), OSA, OSA severity and other sleep-related variables were evaluated using logistic
regression models. The associations between OSA, OSA severity with CAP severity were
evaluated with linear regression models and non-parametric tests.
Findings:
No significant differences were found between CAP and control patients regarding anthropometric
variables, toxic habits and risk factors for CAP. Patients with OSA, defined as individuals
with an Apnea-Hypopnea Index (AHI) 10, showed an increased risk of CAP (OR =
2 86, 95%CI 1 29–6 44, p = 0 01). Patients with severe OSA (AHI 30) also had a higher
risk of CAP (OR = 3 18, 95%CI 1 11–11 56, p = 0 047). In addition, OSA severity, defined
according to the AHI quartile, was also significantly associated with CAP (p = 0 007). Furthermore,
OSA was significantly associated with CAP severity (p = 0 0002), and OSA severity
was also associated with CAP severity (p = 0 0006).
Conclusions:
OSA and OSA severity are associated with CAP when compared to patients admitted to the
hospital for non-respiratory infections. In addition, OSA and OSA severity are associated with CAP severity. These results support the potential role of OSA in the pathogenesis of
CAP and could have clinical implications. This link between OSA and infection risk should
be explored to investigate the relationships among gastroesophageal reflux, silent aspiration,
laryngeal sensory dysfunction and CAP.
https://doi.org/10.1371/journal.pone.0152749
024336
1932-6203
http://hdl.handle.net/10459.1/56944
eng
Public Library of Science
Reproducció del document publicat a https://doi.org/10.1371/journal.pone.0152749
Plos One, 2016, vol. 11, núm. 4, e0152749
cc-by (c) Chiner, Eusebi et al., 2016
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Association between Obstructive Sleep Apnea and Community-Acquired Pneumonia
article
publishedVersion
ORIGINAL
Plos One, 2016,.PDF
Plos One, 2016,.PDF
024336
application/pdf
554252
https://repositori.udl.cat/bitstreams/dae12772-e168-437d-86c9-9c2e5cf80592/download
3d69e71c68a8566dbfcaee0843ee4d7b
MD5
1
THUMBNAIL
Plos One, 2016,.PDF.jpg
Plos One, 2016,.PDF.jpg
Generated Thumbnail
image/jpeg
5616
https://repositori.udl.cat/bitstreams/38819469-2b0d-4acf-890b-2e005de8a236/download
92a350763f810c88f70ff72721f25ab5
MD5
4
TEXT
Plos One, 2016,.PDF.txt
Plos One, 2016,.PDF.txt
Extracted Text
text/plain
39980
https://repositori.udl.cat/bitstreams/71cf8970-9634-48c9-9520-8a9f97a8bacb/download
1c84a39283d6b444c9230f685c79557d
MD5
5
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1370
https://repositori.udl.cat/bitstreams/1526cbb5-1248-482b-8436-0afc84852b0f/download
ac86fe33011bda956ed9b032abf4d402
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/3f815a5b-4de2-4925-b8d3-c6cdc2e96053/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
10459.1/56944
oai:repositori.udl.cat:10459.1/56944
2017-03-10 13:54:56.068
http://creativecommons.org/licenses/by/3.0/es/
cc-by (c) Chiner, Eusebi et al., 2016
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/694702020-09-09T00:19:35Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Alza, Lía
Visa Pretel, Anna
Herreros Danés, Judit
Cantí Nicolás, Carles
2020-09-08T09:27:00Z
2020-09-08T09:27:00Z
2020-04-07
2020-09-08T09:27:00Z
Hyperactivation of the Mitogen Activated Protein Kinase (MAPK) pathway is prevalent in melanoma, principally due to mutations in the B-Raf and NRas genes. MAPK inhibitors are effective only shortterm, and recurrence occurs due to functional redundancies or intertwined pathways. The remodeling of Ca2+ signaling is also common in melanoma cells, partly through the increased expression of T-type channels (TTCCs). Here we summarize current knowledge about the prognostic value and molecular targeting of TTCCs. Furthermore, we discuss recent evidence pointing to TTCCs as molecular switches for melanoma chemoresistance, which set the grounds for novel combined therapies against the advanced disease.
This work was funded by the Spanish Ministry of Science, Innovation & Universities (“Retos”
Program, grant RTI2018-094739-B-I00 to JH and CC). LA held a predoctoral fellowship from
University of Lleida (UdL) and AV from UdL and IRBLleida (Diputació de Lleida).
application/pdf
https://doi.org/10.1016/j.bbcan.2020.188364
029978
0304-419X
http://hdl.handle.net/10459.1/69470
eng
Elsevier
Versió postprint del document publicat a: https://doi.org/10.1016/j.bbcan.2020.188364
Biochimica et Biophysica Acta-Reviews on Cancer, 2020, vol. 1873, núm. 2, p. 188364
(c) Elsevier, 2020
info:eu-repo/semantics/openAccess
Melanoma
T-type channels
MAPK
RAF/RAS mutants
PTEN mutants
Macroautophagy
Chemotherapeutic resistance
The rise of T-type channels in melanoma progression and chemotherapeutic resistance
info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
ORIGINAL
029978.pdf
029978.pdf
preprint
application/pdf
832169
https://repositori.udl.cat/bitstreams/8de5fb07-dfa8-47d7-899f-422bf2e0b6af/download
9fa713bea9438ec70c93e1e5fd594068
MD5
7
CC-LICENSE
license_url
application/octet-stream
49
https://repositori.udl.cat/bitstreams/47250ad7-e7e7-4434-b145-24aa373548bf/download
fd26723f8d7edacdb29e3f03465c3b03
MD5
2
license_text
text/html
23276
https://repositori.udl.cat/bitstreams/e2b845f3-69b4-4222-b937-019e6db61baa/download
dee46d6d9b23aac7b2f1bf36a82cece7
MD5
3
license_rdf
application/octet-stream
23594
https://repositori.udl.cat/bitstreams/7d242866-e1ba-417b-8a7d-317e1f0f7cf3/download
f8dc1202367987bad3050a5dac12c346
MD5
4
SWORD
mets.xml
SWORD deposit package
application/octet-stream
774371
https://repositori.udl.cat/bitstreams/cf28a6f0-c23b-4970-88f3-52880bbaea96/download
da2bf850efcc4f5047657a3c22ddab84
MD5
6
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/e6f39d49-1a60-4bfb-b131-9c7a657251a5/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
5
THUMBNAIL
029978.pdf.jpg
029978.pdf.jpg
Generated Thumbnail
image/jpeg
2152
https://repositori.udl.cat/bitstreams/07f39660-ec3e-46e3-8aa4-0717ea21673c/download
1a1cc1517037b440862d63256dd3c1bc
MD5
8
TEXT
029978.pdf.txt
029978.pdf.txt
Extracted Text
text/plain
35357
https://repositori.udl.cat/bitstreams/7e35a3e2-cdc8-4865-aae3-a24c871303d2/download
9e24078d2b245dc02584c7cfe2c3aaca
MD5
9
10459.1/69470
oai:repositori.udl.cat:10459.1/69470
2020-09-09 00:19:35.848
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/566842023-06-26T09:53:56Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Barbé Illa, Ferran
Durán-Cantolla, Joaquín
Sánchez de la Torre, Manuel
Martínez Alonso, Montserrat
Carmona, Carmen
Barceló Bennasar, Antònia
Chiner, Eusebi
Masa, Juan Fernando
González, Mónica
Marín, J. M.
García-Río, Francisco
Díaz de Atauri, María Josefa
Terán, Joaquin
Mayós Pérez, Mercè
Peña, Mónica de la
Monasterio, Carmen
Campo, Félix del
Montserrat i Capdevila, Josep
2016-03-08T09:28:23Z
2016-03-08T09:28:23Z
2013
Context Continuous positive airway pressure (CPAP) is the first-line treatment for patients
with symptomatic obstructive sleep apnea (OSA). However, its indication for all
patients with sleep-disordered breathing, regardless of daytime symptoms, is unclear.
Objective To evaluate the effect of CPAP treatment on the incidence of hypertension
or cardiovascular events in a cohort of nonsleepy patients with OSA.
Design, Setting, and Patients Multicenter, parallel-group, randomized controlled
trial in 14 teaching hospitals in Spain. Between May 2004 and May 2006, 725
consecutive patients were enrolled who had an apnea-hypopnea index of 20 h−1 or
greater and an Epworth Sleepiness Scale score of 10 or less (scores range from 0-24,
with values 10 suggesting no daytime sleepiness). Exclusion criteria were previous
cardiovascular event, physical or psychological incapacity, chronic disease, or drug or
alcohol addiction. Follow-up ended in May 2009.
Intervention Patients were allocated to receive CPAP treatment or no active intervention.
All participants received dietary counseling and sleep hygiene advice.
Main Outcome Measures Incidence of either systemic hypertension (taking antihypertensive
medication or blood pressure greater than 140/90 mm Hg) or cardiovascular
event (nonfatal myocardial infarction, nonfatal stroke, transient ischemic attack,
hospitalization for unstable angina or arrhythmia, heart failure, or cardiovascular death).
Results Seven hundred twenty-three patients underwent follow-up for a median of 4
(interquartile range, 2.7-4.4) years (1 patient from each group did not receive allocated
treatment); 357 in the CPAP group and 366 in the control group were included in the
analysis. In the CPAP group there were 68 patients with new hypertension and 28 cardiovascular
events (17 unstable angina or arrhythmia, 3 nonfatal stroke, 3 heart failure,
2 nonfatal myocardial infarction, 2 transient ischemic attack, 1 cardiovascular death). In
the control group there were 79 patients with new hypertension and 31 cardiovascular
events (11 unstable angina or arrhythmia, 8 nonfatal myocardial infarction, 5 transient
ischemic attack, 5 heart failure, 2 nonfatal stroke). The hypertension or cardiovascular
event incidence density rate was 9.20 per 100 person-years (95% CI, 7.36-11.04) in
the CPAP group and 11.02 per 100 person-years (95% CI, 8.96-13.08) in the control
group. The incidence density ratio was 0.83 (95% CI, 0.63-1.1; P=.20).
Conclusions In patients with OSA without daytime sleepiness, the prescription of
CPAP compared with usual care did not result in a statistically significant reduction in
the incidence of hypertension or cardiovascular events. However, the study may have
had limited power to detect a significant difference.
This study was funded by the Instituto de Salud Carlos III (PI 04/0165) (Fondo de Investigaciones Sanitarios, Ministerio de Sanidad y Consumo, Spain), Spanish Respiratory Society (SEPAR) (Barcelona), Resmed (Bella Vista, Australia), Air Products–Carburos Metalicos (Barcelona), Respironics (Murrysville, Pennsylvania), and Breas Medical (Madrid, Spain).
https://doi.org/10.1001/jama.2012.4366
019356
0098-7484
http://hdl.handle.net/10459.1/56684
eng
American Medical Association
Reproducció del document publicat a https://doi.org/10.1001/jama.2012.4366
JAMA, 2013, vol. 307, núm. 20, p.2161-2168
(c) American Medical Association, 2013
info:eu-repo/semantics/openAccess
Effect of Continuous Positive Airway Pressure on the Incidence of Hypertension and Cardiovascular Eventsin Nonsleepy Patients With Obstructive Sleep Apnea
article
publishedVersion
TEXT
019356.pdf.txt
019356.pdf.txt
Extracted Text
text/plain
48639
https://repositori.udl.cat/bitstreams/39f0b3e9-750d-423c-97ab-eb42b4ee168c/download
66dea7de8789a9ca7f00e38a19a6f9fa
MD5
4
ORIGINAL
019356.pdf
019356.pdf
application/pdf
331976
https://repositori.udl.cat/bitstreams/671ffe54-a2be-4b43-b2f6-97c3b738b94e/download
1636386cb4030f9d1abcbe7a2ed545a9
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/f261411f-e55a-4fe6-9420-69c5d9039c3d/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
019356.pdf.jpg
019356.pdf.jpg
Generated Thumbnail
image/jpeg
5817
https://repositori.udl.cat/bitstreams/74e6e9fa-b821-4c3e-b0ed-24dd22be42c1/download
106263fc7df9b75ad3f056997a80e37f
MD5
3
10459.1/56684
oai:repositori.udl.cat:10459.1/56684
2023-06-26 09:53:56.306
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/4639652023-09-14T03:00:22Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Batlle Garcia, Jordi de
Benítez, Iván
Moncusí Moix, Anna
Androutsos, Odysseas
Barbastro, Rosana Angles
Antonini, Alessio
Arana, Eunate
Cabrera-Umpierrez, Maria Fernanda
Cea, Gloria
Dafoulas, George Ε.
Folkvord, Frans
Fullaondo, Ane
Giuliani, Francesco
Huang, Hsiao-Ling
Innominato, Pasquale F.
Kardas, Przemyslaw
Lou, Vivian W.Q.
Manios, Yannis
Matsangidou, Maria
Mercalli, Franco
Mokhtari, Mounir
Pagliara, Silvio
Schellong, Julia
Stieler, Lisa
Votis, Konstantinos
Currás, Paula
Arredondo, Maria Teresa
Posada, Jorge
Guillén, Sergio
Pecchia, Leandro
Barbé Illa, Ferran
Torres, Gerard
Fico, Giuseppe
2023-09-13T07:40:04Z
2023-09-13T07:40:04Z
2023
Background: The World Health Organization’s strategy toward healthy aging fosters person-centered integrated care sustained by eHealth systems. However, there is a need for standardized frameworks or platforms accommodating and interconnecting multiple of these systems while ensuring secure, relevant, fair, trust-based data sharing and use. The H2020 project GATEKEEPER aims to implement and test an open-source, European, standard-based, interoperable, and secure framework serving broad populations of aging citizens with heterogeneous health needs.
Objective: We aim to describe the rationale for the selection of an optimal group of settings for the multinational large-scale piloting of the GATEKEEPER platform.
Methods: The selection of implementation sites and reference use cases (RUCs) was based on the adoption of a double stratification pyramid reflecting the overall health of target populations and the intensity of proposed interventions; the identification of a principles guiding implementation site selection; and the elaboration of guidelines for RUC selection, ensuring clinical relevance and scientific excellence while covering the whole spectrum of citizen complexities and intervention intensities.
Results: Seven European countries were selected, covering Europe’s geographical and socioeconomic heterogeneity: Cyprus, Germany, Greece, Italy, Poland, Spain, and the United Kingdom. These were complemented by the following 3 Asian pilots: Hong Kong, Singapore, and Taiwan. Implementation sites consisted of local ecosystems, including health care organizations and partners from industry, civil society, academia, and government, prioritizing the highly rated European Innovation Partnership on Active and Healthy Aging reference sites. RUCs covered the whole spectrum of chronic diseases, citizen complexities, and intervention intensities while privileging clinical relevance and scientific rigor. These included lifestyle-related early detection and interventions, using artificial intelligence–based digital coaches to promote healthy lifestyle and delay the onset or worsening of chronic diseases in healthy citizens; chronic obstructive pulmonary disease and heart failure decompensations management, proposing integrated care management based on advanced wearable monitoring and machine learning (ML) to predict decompensations; management of glycemic status in diabetes mellitus, based on beat to beat monitoring and short-term ML-based prediction of glycemic dynamics; treatment decision support systems for Parkinson disease, continuously monitoring motor and nonmotor complications to trigger enhanced treatment strategies; primary and secondary stroke prevention, using a coaching app and educational simulations with virtual and augmented reality; management of multimorbid older patients or patients with cancer, exploring novel chronic care models based on digital coaching, and advanced monitoring and ML; high blood pressure management, with ML-based predictions based on different intensities of monitoring through self-managed apps; and COVID-19 management, with integrated management tools limiting physical contact among actors.
Conclusions: This paper provides a methodology for selecting adequate settings for the large-scale piloting of eHealth frameworks and exemplifies with the decisions taken in GATEKEEPER the current views of the WHO and European Commission while moving forward toward a European Data Space.
https://doi.org/10.2196/42187
033428
1438-8871
https://repositori.udl.cat/handle/10459.1/463965
eng
JMIR Publications
Reproducció del document publicat a: https://doi.org/10.2196/42187
Journal of Medical Internet Research, 2023, vol. 25, p. 1-13, article number e42187
cc-by (c) The autors, 2023
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Big data
Chronic diseases
eHealth
Healthy aging
Integrated care
Large-scale pilots
GATEKEEPER's Strategy for the Multinational Large-Scale Piloting of an eHealth Platform: Tutorial on How to Identify Relevant Settings and Use Cases
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
033428.pdf
033428.pdf
application/pdf
339203
https://repositori.udl.cat/bitstreams/b8f564a1-495f-4f17-8b63-60798bc12e7f/download
c064e7374386c1325fd9c51317f2aae8
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1019
https://repositori.udl.cat/bitstreams/ded96f13-00ad-4fba-8380-e82423f99599/download
313ea3fe4cd627df823c57a0f12776e5
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
639
https://repositori.udl.cat/bitstreams/a3a8992c-65c5-4765-88e3-cb73bca19e5d/download
15ec217096d63e7cd318d42eb888308c
MD5
3
TEXT
033428.pdf.txt
033428.pdf.txt
Extracted text
text/plain
64869
https://repositori.udl.cat/bitstreams/3a2853a8-66c0-45ad-852b-c6da4baabc49/download
d96ce4633b5735bce1968c4d3e154191
MD5
4
THUMBNAIL
033428.pdf.jpg
033428.pdf.jpg
Generated Thumbnail
image/jpeg
5855
https://repositori.udl.cat/bitstreams/5ef64036-15db-48af-81a7-bca0f9b48018/download
a8ed93bef2f0fb3c8dc0e78367bd9108
MD5
5
10459.1/463965
oai:repositori.udl.cat:10459.1/463965
2023-09-14 03:00:22.27
http://creativecommons.org/licenses/by/4.0/
cc-by (c) The autors, 2023
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/658262022-05-26T13:07:13Zcom_10459.1_56965com_10459.1_2com_10459.1_227com_10459.1_241com_10459.1_244col_10459.1_57707col_10459.1_314col_10459.1_30324col_10459.1_363col_10459.1_44504
Granado-Serrano, Ana Belén
Martín Garí, Meritxell
Sánchez, Virginia
Riart Solans, Marissa
Berdún Hernández, Rebeca
Ludwig, Iziar A.
Rubió Piqué, Laura
Vilaprinyo Terré, Ester
Portero Otín, Manuel
Serrano Casasola, José Carlos Enrique
2019-02-28T09:31:41Z
2019-02-28T09:31:41Z
2019
2019-02-28T09:31:47Z
Gut microbiota has been suggested to affect lipid metabolism. The objective of this study was to characterize the faecal microbiota signature and both short chain fatty acids (SCFAs) and bile acids (BA) profile of hypercholesterolemic subjects. Microbiota composition, SCFAs, BA and blood lipid profile from male volunteers with hypercholesterolemia (HC) and normocholesterolemia (NC) were determined by 16S rDNA sequencing, HPLC, GC and NMR, respectively. HC subjects were characterized by having lower relative abundance of Anaeroplasma (0.002% vs 0.219%, p-value = 0.026) and Haemophilus (0.041% vs 0.078%, p-value = 0.049), and higher of Odoribacter (0.51% vs 0.16%; p-value = 0.044). Correlation analysis revealed that Anaeroplasma and Haemophilus were associated to an unfavourable lipid profile: they correlated negatively to cholesterol and triglycerides related biomarkers and the ratio total to high density lipoprotein (HDL) cholesterol, and positively to HDL size. Odoribacter displayed an opposite behaviour. Faecal SCFAs profile revealed higher abundance of isobutyric (2.76% vs 0.82%, p-value = 0.049) and isovaleric acid (1.32% vs 0.06%, p-value = 0.016) in HC. Isobutyric acid correlated positively with Odoribacter and lipid parameters indicative of an unfavourable profile. BA profile did not show differences between groups. It was concluded that HC subjects showed a particular faecal bacterial signature and SCFAs profile associated with their lipid profile.
The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the Seventh Framework Programme of the European Union (FP7/2007-2013) under REA grant agreement No. 600388 (TECNIOspring Progamme) and from the Agency for Business Competitiveness of the Government of Catalonia ACCIÓ that support the fellowship given to Ana Belén Granado-Serrano (TECSPR14-0-0023). I.A.L enjoys a post-doctoral contract (2017PMF-POST2-19) from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement and from the Universitat Rovira i Virgili (URV).
application/pdf
https://doi.org/10.1038/s41598-019-38874-3
028252
2045-2322
http://hdl.handle.net/10459.1/65826
eng
Nature Research
Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-38874-3
Scientific Reports, 2019, vol. 9, núm. 1772, p. 1-13
info:eu-repo/grantAgreement/EC/FP7/600388
cc-by (c) Granado-Serrano, Ana Belén et al., 2019
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es
Hypercholesterolemia
Faecal bacteria
short chain fatty acids
Branched short chain fatty acids
Bile acids
Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
028252.pdf
application/pdf
3006494
https://repositori.udl.cat/bitstreams/78a46447-55e8-464d-a1d0-95c551d1911c/download
4f47b66810ebf59e1b170e02abd51622
MD5
1
THUMBNAIL
028252.pdf.jpg
028252.pdf.jpg
Generated Thumbnail
image/jpeg
5826
https://repositori.udl.cat/bitstreams/fd05a1e5-7d2d-4d9b-b581-d7a831bd2335/download
698f453019603cf48bb2c9df2926499a
MD5
7
CC-LICENSE
license_url
application/octet-stream
43
https://repositori.udl.cat/bitstreams/7d79cab4-527e-4d3d-a14c-8db6b7c74ffd/download
5134edb0a80711cbbaa5247c36025151
MD5
2
license_text
text/html
23115
https://repositori.udl.cat/bitstreams/97472207-ae5f-4564-b45a-e659eeabcabb/download
ec3783401c55aba9b2c045380c0dd4b3
MD5
3
license_rdf
application/octet-stream
20337
https://repositori.udl.cat/bitstreams/7e134fa7-c4db-4602-9cea-5c0f59d5b6e2/download
1485691ce20485471fe59ad1ac24bf0f
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/d11eedd0-f803-4a14-a31a-cd1413970a31/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
5
SWORD
mets.xml
SWORD deposit package
application/octet-stream
2666102
https://repositori.udl.cat/bitstreams/6aaf98ec-9e77-472e-93e4-19f2b5d7ae9b/download
a2e401b590a2ce5575ab47ff33c8b798
MD5
6
TEXT
028252.pdf.txt
028252.pdf.txt
Extracted Text
text/plain
63618
https://repositori.udl.cat/bitstreams/45a281b4-91df-47a9-bde2-598b6981c1d9/download
b6dac1d75d3a95757e7721aee944f809
MD5
8
10459.1/65826
oai:repositori.udl.cat:10459.1/65826
2022-05-26 13:07:13.529
http://creativecommons.org/licenses/by/3.0/es
cc-by (c) Granado-Serrano, Ana Belén et al., 2019
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/832752023-06-02T09:33:16Zcom_10459.1_227com_10459.1_2com_10459.1_237com_10459.1_47453com_10459.1_241com_10459.1_240col_10459.1_314col_10459.1_354col_10459.1_59998col_10459.1_30324col_10459.1_333
Cambray Carner, Serafí
Ibarz Escuer, Mercedes
Bermúdez López, Marcelino
Martí Antonio, Manuel
Bozić Stanojević, Milica
Fernández i Giráldez, Elvira
Valdivielso Revilla, José Manuel
2022-05-13T07:32:33Z
2022-05-13T07:32:33Z
2020
Classical risk factors of atherosclerosis in the general population show paradoxical effects in chronic kidney disease (CKD) patients. Thus, low low-density lipoprotein (LDL) cholesterol levels have been associated with worse cardiovascular outcomes. Magnesium (Mg) is a divalent cation whose homeostasis is altered in CKD. Furthermore, Mg levels have been associated with cardiovascular health. The present study aims to understand the relationships of Mg and lipid parameters with atherosclerosis in CKD. In this analysis, 1754 participants from the Observatorio Nacional de Atherosclerosis en Nefrologia (NEFRONA) cohort were included. Carotid intima media thickness (cIMT) was determined in six arterial territories, and associated factors were investigated by linear regression. cIMT correlated positively with being male, Caucasian, a smoker, diabetic, hypertensive, dyslipidemic and with increased age, BMI, and triglyceride levels, and negatively with levels of HDL cholesterol. First-order interactions in linear regression analysis showed that Mg was an effect modifier on the influence of lipidic parameters. Thus, cIMT predicted values were higher when triglycerides or LDL levels were high and Mg levels were low. On the contrary, when Mg levels were high, this effect disappeared. In conclusion, Mg acts as an effect modifier between lipidic parameters and atherosclerotic cardiovascular disease. Therefore, Mg levels, together with lipidic parameters, should be taken into account when assessing atherosclerotic risk.
This research was funded by Instituto de salud Carlos III; grants PI18/00610 and ISCIII-RETIC REDinRENRD016/009
https://doi.org/10.3390/nu12092631
032814
2072-6643
http://hdl.handle.net/10459.1/83275
eng
MDPI
Reproducció del document publicat: https://doi.org/10.3390/nu12092631
Nutrients, 2020, vol. 12, núm. 9,
cc-by (c) Authors, 2020
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Atherosclerosis
Cardiovascular risk
Cholesterol
First-order interaction
Magnesium
Magnesium Levels Modify the Effect of Lipid Parameters on Carotid Intima Media Thickness
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
032814.pdf
032814.pdf
application/pdf
647509
https://repositori.udl.cat/bitstreams/77ae308a-3ef2-4a3e-868e-9bab410f39fa/download
1277a32917ee917fe4731ea18427d535
MD5
1
TEXT
032814.pdf.txt
032814.pdf.txt
Extracted text
text/plain
47025
https://repositori.udl.cat/bitstreams/251da989-86cc-4352-99dd-d34adb9c317e/download
d83db4c8f4f7f559f739b0c2e3312238
MD5
4
THUMBNAIL
032814.pdf.jpg
032814.pdf.jpg
IM Thumbnail
image/jpeg
10325
https://repositori.udl.cat/bitstreams/f6fdb441-bae3-483c-b206-57df312264f5/download
58f9f6be18eaca47dd9828e6c5a2a225
MD5
5
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://repositori.udl.cat/bitstreams/e3b2f5ae-cf50-4508-b5f2-7a17abaaf8c2/download
0175ea4a2d4caec4bbcc37e300941108
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/6dd8bddc-aaf9-4a43-acbc-3eb5941bd78d/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
10459.1/83275
oai:repositori.udl.cat:10459.1/83275
2023-06-02 09:33:16.154
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Authors, 2020
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/626812023-03-15T12:36:12Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_241col_10459.1_314col_10459.1_59998col_10459.1_30324
Maiques Carlos, Oscar
Barceló Gómez, Carla
Panosa, Anais
Pijuan Marquilles, Jordi
Orgaz, Jose L.
Rodríguez Hernández, Irene
Matas Nadal, Clara
Tell, Gemma
Vilella, Ramón
Fabra, Angels
Puig, Susana
Sanz Moreno, Victoria
Matias-Guiu, Xavier
Cantí Nicolás, Carles
Herreros Danés, Judit
Martí Laborda, Rosa Ma.
Macià Armengol, Anna
2018-02-20T09:45:39Z
2019-02-18T23:24:51Z
2018
Melanoma is a malignant tumor derived from melanocytes. Once disseminated, it is usually highly resistant to chemotherapy and is associated with poor prognosis. We have recently reported that T-type calcium channels (TTCCs) are overexpressed in melanoma cells and play an important role in melanoma progression. Importantly, TTCC pharmacological blockers reduce proliferation and deregulate autophagy leading to apoptosis. Here, we analyze the role of autophagy during migration/invasion of melanoma cells. TTCC Cav3.1 and LC3-II proteins are highly expressed in BRAFV600E compared with NRAS mutant melanomas, both in cell lines and biopsies. Chloroquine, pharmacological blockade, or gene silencing of TTCCs inhibit the autophagic flux and impair the migration and invasion capabilities, specifically in BRAFV600E melanoma cells. Snail1 plays an important role in motility and invasion of melanoma cells. We show that Snail1 is strongly expressed in BRAFV600E melanoma cells and patient biopsies, and its expression decreases when autophagy is blocked. These results demonstrate a role of Snail1 during BRAFV600E melanoma progression and strongly suggest that targeting macroautophagy and, particularly TTCCs, might be a good therapeutic strategy to inhibit metastasis of the most common melanoma type (BRAFV600E).
Supported by grants from ISCIII/FEDER “Una manera de hacer Europa” (FIS-PI1200260 and PI1500711 to RMM, PI1301980 to JH and CIBERONC-CB16/12/00231 to XMG), Fundació la Marató de TV3 (FMTV 201331-30 to SP, -31 to RMM, and -32 to AF), Generalitat de Catalunya (2014/SGR138 to XMG); and Cancer Research UK grants C33043/A12065 and C33043/A24478 (VSM, JLO). OM holds a predoctoral fellowship from IRBLleida/Diputació de Lleida and CB a predoctoral fellowship from University of Lleida. AM holds a postdoctoral fellowship from AECC Scientific Foundation. IRH is supported by Marie Sklodowska-Curie Action (H2020-MSCA-IF-2014-EF-ST). Tumor samples were obtained with the support of Xarxa de Bancs de Tumors de Catalunya sponsored by Pla Director d'Oncologia de Catalunya (XBTC) and IRBLleida Biobank (B.0000682) and PLATAFORMA BIOBANCOS (PT17/0015/0027).
https://doi.org/10.1111/pcmr.12690
026992
1755-1471
http://hdl.handle.net/10459.1/62681
eng
Wiley
Versió postprint del document publicat a https://doi.org/10.1111/pcmr.12690
Pigment Cell and Melanoma Research, 2018, vol. 31, núm. 4, p. 484-495
(c) Wiley, 2018
info:eu-repo/semantics/openAccess
Melanoma
T-Type Calcium channels
Autophagy
Migration
Invasion
BRAFV600E
T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1
article
acceptedVersion
anna.macia@mex.udl.cat
Anna Macià
ORIGINAL
026992.pdf
026992.pdf
Postprint
application/pdf
1130470
https://repositori.udl.cat/bitstreams/6623721d-2033-458a-b272-5ac7b192fe8d/download
6a6661a4e9a3a613ad03241ead963963
MD5
6
THUMBNAIL
026992.pdf.jpg
026992.pdf.jpg
Generated Thumbnail
image/jpeg
1992
https://repositori.udl.cat/bitstreams/42b4d258-8fdd-4e23-828e-83921fe7bf2c/download
22178ba803802583440cc37993a208a1
MD5
7
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/c12c53af-1912-457d-9c54-1fe59891e1ed/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
TEXT
026992.pdf.txt
026992.pdf.txt
Extracted Text
text/plain
52897
https://repositori.udl.cat/bitstreams/59fb45c3-2933-4837-9187-e96c184f1214/download
1eac94eedc8438c7cc51109f66b6d3b3
MD5
8
10459.1/62681
oai:repositori.udl.cat:10459.1/62681
2023-03-15 12:36:12.529
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=
oai:repositori.udl.cat:10459.1/680252020-02-18T00:16:18Zcom_10459.1_227com_10459.1_2col_10459.1_314
Wang, Yufei
McKay, James D.
Rafnar, Thorunn
Wang, Zhaoming
Timofeeva, Maria N.
Broderick, Peter
Zong, Xuchen
Laplana Lafaja, Marina
Wei, Yongyue
Han, Younghun
Lloyd, Amy
Delahaye-Sourdeix, Manon
Chubb, Daniel
Gaborieau, Valerie
Wheeler, William
Chatterjee, Nilanjan
Thorleifsson, Gudmar
Sulem, Patrick
Liu, Geoffrey
Kaaks, Rudolf
Henrion, Marc
Kinnersley, Ben
Vallée, Maxime
LeCalvez-Kelm, Florence
Stevens, Victoria L.
Gapstur, Susan M.
Chen, Wei V.
Zaridze, David
Szeszenia-Dabrowska, Neonilia
Lissowska, Jolanta
Rudnai, Peter
Fabianova, Eleonora
Mates, Dana
Bencko, Vladimir
Foretova, Lenka
Janout, Vladimir
Krokan, Hans E.
Gabrielsen, Maiken Elvestad
Skorpen, Frank
Vatten, Lars
2020-02-17T13:00:24Z
2020-02-17T13:00:24Z
2014
2020-02-17T13:00:25Z
We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) and genotyped an additional 10,246 cases and 38,295 controls for follow-up. We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10−20) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10−13). We also showed an association between common variation at 3q28 (TP63, rs13314271, OR = 1.13, P = 7.22 × 10−10) and lung adenocarcinoma that had been previously reported only in Asians. These findings provide further evidence for inherited genetic susceptibility to lung cancer and its biological basis. Additionally, our analysis demonstrates that imputation can identify rare disease-causing variants with substantive effects on cancer risk from preexisting genome-wide association study data.
We acknowledge The Cancer Genome Atlas (TCGA) for their contribution of lung cancer genomic data to this study (TCGA Project Number 3230). We also acknowledge support from the National Institute for Health Research Biomedical Research Centre at the Royal Marsden Hospital. This study was supported by the NIH (U19CA148127, R01CA055769, 5R01CA127219, 5R01CA133996 and 5R01CA121197). The work performed at ICR was supported by Cancer Research UK (C1298/A8780 and C1298/A8362), National Cancer Research Network (NCRN), HEAL, Sanofi-Aventis and National Health Service funding to the Royal Marsden Hospital and Institute of Cancer Research, as well as the National Institute for Health Research Biomedical Research Centre. B.K. was the recipient of a Sir John Fisher Foundation PhD studentship. Work at ICR was also supported by NIH GM103534 and the Institute for Quantitative Biomedical Sciences at Dartmouth to C.I.A. The work performed in Toronto was supported by The Canadian Cancer Society Research Institute (020214), Ontario Institute of Cancer and Cancer Care Ontario Chair Award to R.J.H. and G.L. and the Alan Brown Chair and Lusi Wong Programs at the Princess Margaret Hospital Foundation. The work performed at Heidelberg was supported by Deutsche Krebshilfe (70-2387 and 70-2919) and the German Federal Ministry of Education and Research (EPIC-Heidelberg). The work performed at IARC was supported by the Institut National du Cancer, France, the European Community (LSHG-CT-2005-512113), the Norwegian Cancer Association, the Functional Genomics Programme of Research Council of Norway, the European Regional Development Fund and the State Budget of the Czech Republic (RECAMO, CZ.1.05/2.1.00/03.0101), the NIH (R01-CA111703 and UO1-CA63673), the Fred Hutchinson Cancer Research Center, the US NCI (R01 CA092039), an FP7 grant (REGPOT 245536), the Estonian Government (SF0180142s08), the EU European Regional Development Fund in the frame of Centre of Excellence in Genomics and Estonian Research Infrastructure's Roadmap and the University of Tartu (SP1GVARENG) and an IARC Postdoctoral Fellowship (M.N.T.). Work at the NCI was supported by the Intramural Research Program of the NIH, the NCI, US Public Health Service contracts NCI (N01-CN-45165, N01-RC-45035, N01-RC-37004, NO1-CN-25514, NO1-CN-25515, NO1-CN-25512, NO1-CN-25513, NO1-CN-25516, NO1-CN-25511, NO1-CN-25524, NO1-CN-25518, NO1-CN-75022, NO1-CN-25476 and NO1-CN-25404), the American Cancer Society, the NIH Genes, Environment and Health Initiative in part by HG-06-033-NCI-01 and RO1HL091172-01, genotyping at the Johns Hopkins University Center for Inherited Disease Research (U01HG004438 and NIH HHSN268200782096C) and study coordination at the GENEVA Coordination Center (U01 HG004446). Work was also supported by NIH grants (P50 CA70907, R01CA121197, RO1 CA127219, U19 CA148127 and RO1 CA55769) and a Cancer Prevention Research Institute of Texas grant (RP100443). Genotyping was provided by the Center for Inherited Disease Research (CIDR). Work performed at Harvard was supported by the NIH (CA074386, CA092824 and CA090578). The Icelandic study was supported in part by NIH DA17932.
application/pdf
https://doi.org/10.1038/ng.3002
020889
1061-4036
http://hdl.handle.net/10459.1/68025
eng
Springer Nature
Versió preprint del document publicat a: https://doi.org/10.1038/ng.3002
Nature Genetics, 2014, num. 46, p. 736-741
(c) Wang, Yufei et al., 2014
info:eu-repo/semantics/openAccess
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/37691142-9834-4a85-97dc-bb5f10f7f617/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
SWORD
mets.xml
SWORD deposit package
application/octet-stream
611184
https://repositori.udl.cat/bitstreams/cfbbebea-1b58-4270-ae59-1eb18b7985fd/download
13c7df179744d9138ebe02cb7e584157
MD5
3
ORIGINAL
020889_.pdf
020889_.pdf
Preprint
application/pdf
551564
https://repositori.udl.cat/bitstreams/ce7c40fb-72df-4c7d-9412-7192ca9bcf42/download
8828d4d0d6b5f92e47c2bff6b0ace835
MD5
4
THUMBNAIL
020889_.pdf.jpg
020889_.pdf.jpg
Generated Thumbnail
image/jpeg
2015
https://repositori.udl.cat/bitstreams/f37c6c95-2fca-41d2-887d-73b92860a08c/download
614c148f9086e55ea28d5cf4e68775bb
MD5
5
TEXT
020889_.pdf.txt
020889_.pdf.txt
Extracted Text
text/plain
69360
https://repositori.udl.cat/bitstreams/d05a4527-ca11-49ee-8c48-03459702302a/download
f6601697b3e83b25760a0078059e4618
MD5
6
10459.1/68025
oai:repositori.udl.cat:10459.1/68025
2020-02-18 00:16:18.957
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/574022021-06-28T08:55:43Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_44504
Campoy, Irene
Lanau, Lucia
Altadill, Tatiana
Sequeiros, Tamara
Cabrera, Silvia
Cubo Abert, Montserrat
Pérez Benavente, Assumpción
Garcia, Angel
Borrós i Gómez, Salvador
Santamaria, Anna
Ponce, Jordi
Matias-Guiu, Xavier
Reventós, Jaume
Gil-Moreno, Antonio
Rigau, Marina
Colás, Eva
2016-07-11T07:46:36Z
2016-07-11T07:46:36Z
2016
Background: Uterine aspirates are used in the diagnostic process of endometrial disorders, yet further applications
could emerge if its complex milieu was simplified. Exosome-like vesicles isolated from uterine aspirates could become
an attractive source of biomarkers, but there is a need to standardize isolation protocols. The objective of the study
was to determine whether exosome-like vesicles exist in the fluid fraction of uterine aspirates and to compare protocols
for their isolation, characterization, and analysis.
Methods: We collected uterine aspirates from 39 pre-menopausal women suffering from benign gynecological diseases.
The fluid fraction of 27 of those aspirates were pooled and split into equal volumes to evaluate three differential
centrifugation-based procedures: (1) a standard protocol, (2) a filtration protocol, and (3) a sucrose cushion protocol.
Characterization of isolated vesicles was assessed by electron microscopy, nanoparticle tracking analysis and immunoblot.
Specifically for RNA material, we evaluate the effect of sonication and RNase A treatment at different steps of
the protocol. We finally confirmed the efficiency of the selected methods in non-pooled samples.
Results: All protocols were useful to isolate exosome-like vesicles. However, the Standard procedure was the best
performing protocol to isolate exosome-like vesicles from uterine aspirates: nanoparticle tracking analysis revealed
a higher concentration of vesicles with a mode of 135 ± 5 nm, and immunoblot showed a higher expression of
exosome-related markers (CD9, CD63, and CD81) thus verifying an enrichment in this type of vesicles. RNA contained
in exosome-like vesicles was successfully extracted with no sonication treatment and exogenous nucleic acids digestion
with RNaseA, allowing the analysis of the specific inner cargo by Real-Time qPCR.
Conclusion: We confirmed the existence of exosome-like vesicles in the fluid fraction of uterine aspirates. They were
successfully isolated by differential centrifugation giving sufficient proteomic and transcriptomic material for further
analyses. The Standard protocol was the best performing procedure since the other two tested protocols did not
ameliorate neither yield nor purity of exosome-like vesicles. This study contributes to establishing the basis for future
comparative studies to foster the field of biomarker research in gynecology.
Keywords: Biomarker, Endometrial biopsy, Exosomes, Exosomes isolation protocols, Exosome-like vesicles,
Extracellular vesicles, Gynecological disorders, Microvesicles, RNA, Uterine aspirates
This work was supported by the Spanish Ministry of Health (RD12/0036/0035), the Spanish Ministry of Economy and Competitivity (PI14/02043), the “Fondo Europeo de Desarrollo Regional” FEDER (RTC-2014-3110-1), the AECC (Grupos Estables de Investigacion 2011 - AECC- GCB 110333 REVE), the Fundació La Marató TV3 (2/C/2013), the CIRIT Generalitat de Catalunya (2014 SGR 1330) and the European Commission, 7th Framework Programe, IRSES (PROTBIOFLUID –269285)—Belgium. AGAUR (2014F1_B1 00014) granted Ms. Lanau, the Instituto Carlos III (Spanish Ministry of Economy and Competitivity) supported Dr. Santamaria (CP13/00158) by the Miguel Servet program, and the Spanish Ministry of Economy and Competitiveness (FPDI-2013-18322) granted Dr. Colás.
https://doi.org/10.1186/s12967-016-0935-4
1479-5876
http://hdl.handle.net/10459.1/57402
eng
BioMed Central
Reproducció del document publicat a https://doi.org/10.1186/s12967-016-0935-4
Journal of Translational Medicine, 2016, vol. 14, núm. 180
info:eu-repo/grantAgreement/EC/FP7/269285
cc-by (c) Campoy et al., 2016
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Exosome‑like vesicles in uterine aspirates: a comparison of ultracentrifugation‑based isolation protocols
article
publishedVersion
THUMBNAIL
JTransMed_a2016v14n180.pdf.jpg
JTransMed_a2016v14n180.pdf.jpg
Generated Thumbnail
image/jpeg
4878
https://repositori.udl.cat/bitstreams/0fd12221-2ad6-4407-8084-31285a9bc813/download
4feb73a525af5c5d43b67720a218c7e6
MD5
4
ORIGINAL
JTransMed_a2016v14n180.pdf
JTransMed_a2016v14n180.pdf
application/pdf
3137793
https://repositori.udl.cat/bitstreams/d8161c2a-66b1-4333-8718-e57de7a0c46c/download
73ac73c6988359151828ac552a3f0139
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1370
https://repositori.udl.cat/bitstreams/367b0215-7ed6-4e8b-8a32-8b26b9bbd00b/download
ac86fe33011bda956ed9b032abf4d402
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/267b8735-225b-4239-a5e5-9862757d7831/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
TEXT
JTransMed_a2016v14n180.pdf.txt
JTransMed_a2016v14n180.pdf.txt
Extracted Text
text/plain
53020
https://repositori.udl.cat/bitstreams/0f7e8e6a-5fcd-467c-9aea-bd5acf6d6c10/download
d4fac76992fca43e95c07fad5035d626
MD5
5
10459.1/57402
oai:repositori.udl.cat:10459.1/57402
2021-06-28 08:55:43.459
http://creativecommons.org/licenses/by/3.0/es/
cc-by (c) Campoy et al., 2016
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/591682021-08-30T15:04:34Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Bozić Stanojević, Milica
Guzmán, Carla
Benet, Marta
Sánchez-Campos, Sonia
García-Monzón, Carmelo
Garí Marsol, Eloi
Gatius Calderó, Sònia
Valdivielso Revilla, José Manuel
Jover, Ramiro
2017-01-31T08:01:11Z
2025-01-01
2016
Background & Aims
The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote hepatosteatosis, but the possible role of vitamin D receptor (VDR) in NAFLD has not been investigated.
Methods
The expression of liver VDR was investigated in apolipoprotein E knockout (apoE−/−) mice on a high fat diet, in wild-type mice on methionine and choline deficient diet and in NAFLD patients with hepatosteatosis and non-alcoholic steatohepatitis. The relevance of VDR was assessed in apoE−/− mice by deletion of VDR or paricalcitol treatment and in human HepG2 cells by VDR transfection or silencing. The role of VDR in fibrosis was also determined in VDR knockout mice (VDR−/−) treated with thioacetamide.
Results
Expression of liver VDR was markedly induced in two mouse models of NAFLD, as well as in patients with hepatosteatosis, but decreased in non-alcoholic steatohepatitis. VDR deletion in high fat diet-fed apoE−/− mice protected against fatty liver, dyslipidemia and insulin resistance, and caused a decrease in taurine-conjugated bile acids, but did not influence fibrosis by thioacetamide. apoE−/−VDR−/− mouse livers showed decreased gene expression of CD36, DGAT2, C/EBPα and FGF21, and increased expression of PNPLA2, LIPIN1 and PGC1α. Treatment of apoE−/− mice on high fat diet with paricalcitol had modest opposite effects on steatosis and gene expression. Finally, this set of genes showed concordant responses when VDR was overexpressed or silenced in HepG2 cells.
Conclusions
Induced hepatocyte VDR in NAFLD regulates key hepatic lipid metabolism genes and promotes high fat diet-associated liver steatosis. Therapeutic inhibition of liver VDR may reverse steatosis in early NAFLD.
Lay summary
The amount of vitamin D receptor is induced early in the livers of mice and humans when they develop non-alcoholic fatty liver disease. If the gene for the vitamin D receptor is deleted, hepatic lipid metabolism changes and mice do not accumulate fat in the liver. We conclude that the vitamin D receptor can contribute to the fatty liver disease promoted by a high fat diet.
This work was supported by grants PS12/01770, PI13/01470, PI13/01299 and REDinREN RD12/0021/0026 from the Instituto de Salud Carlos III (ISCIII, Spanish Ministry of Economy and Competitiveness), and FEDER (European Union) funds. MB was supported by the REDinREN (RD12/0021/0026).
https://doi.org/10.1016/j.jhep.2016.05.031
024628
0168-8278
http://hdl.handle.net/10459.1/59168
eng
Elsevier
Reproducció del document publicat a https://doi.org/10.1016/j.jhep.2016.05.031
Journal of Hepatology, 2016, vol. 65, núm. 4, p. 748–757
(c) Elsevier B.V., 2016
info:eu-repo/semantics/restrictedAccess
Vitamin D receptor
Non-alcoholic fatty liver disease
High fat diet
Steatosis
Hepatocytes
Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis
article
publishedVersion
valdivielso@medicina.udl.es
Valdivielso, José Manuel
ORIGINAL
024628.pdf
024628.pdf
application/pdf
1721874
https://repositori.udl.cat/bitstreams/463a5085-2bf8-4d05-b4c4-b2077cf39382/download
8009d1ca092db99781e4200178fd593c
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/a73c0010-859a-4dde-b70d-bfa955a23c68/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
024628.pdf.jpg
024628.pdf.jpg
Generated Thumbnail
image/jpeg
5548
https://repositori.udl.cat/bitstreams/bab191fb-576c-444b-8964-7d95bddfb378/download
8d8ea3989300285ce00f72d3619fa0a9
MD5
3
TEXT
024628.pdf.txt
024628.pdf.txt
Extracted Text
text/plain
60101
https://repositori.udl.cat/bitstreams/2ab610b3-e8cb-4133-8d30-0a54026080dd/download
d37abfc8f2e268fafa08c378121347ad
MD5
4
10459.1/59168
oai:repositori.udl.cat:10459.1/59168
2021-08-30 15:04:34.478
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/594072021-05-25T10:50:31Zcom_10459.1_227com_10459.1_2com_10459.1_59360com_10459.1_47453com_10459.1_241com_10459.1_240col_10459.1_314col_10459.1_59361col_10459.1_59998col_10459.1_30324col_10459.1_333
Betriu i Bars, M. Àngels
Farràs-Sallés, Cristina
Abajo, María
Martínez Alonso, Montserrat
Arroyo, David
Barbé Illa, Ferran
Buti, Miquel
Lecube Torelló, Albert
Portero Otín, Manuel
Purroy Garcia, Francisco
Torres, Gerard
Valdivielso Revilla, José Manuel
Fernández i Giráldez, Elvira
2017-03-29T10:23:36Z
2017-03-29T10:23:36Z
2016
Antecedentes y objetivos: La enfermedad renal crónica (ERC) y la ateromatosis son 2 enfermedades interrelacionadas que aumentan el riesgo de morbimortalidad cardiovascular. Los objetivos del proyecto ILERVAS son: 1) conocer la prevalencia de enfermedad ateromatosa subclínica y de enfermedad renal oculta; 2) valorar el impacto de su diagnóstico precoz sobre la morbimortalidad cardiovascular y la progresión de la ERC; 3) disponer de una plataforma de datos y muestras biológicas. Métodos: Estudio de intervención aleatorizado. Entre 2015 y 2017 se incluirá a 19.800 personas (9.900 en el grupo de intervención y 9.900 en el grupo control) entre 45 y 70 años, sin antecedentes de enfermedad cardiovascular y que presenten al menos un factor de riesgo cardiovascular, seleccionadas aleatoriamente de los centros de atención primaria (AP) de la provincia de Lérida. Un equipo técnico experto se desplazará con una unidad móvil para realizar las exploraciones basales al grupo de intervención: ecografía arterial (carótida, femoral,transcraneal y aorta abdominal), medición del índice tobillo-brazo, espirometría, detección de los productos de glicación avanzada y analítica seca de sangre y orina. Adicionalmente, se recogerán muestras de sangre y orina que serán almacenadas en el biobanco para identificar nuevos biomarcadores con biología de sistemas. Los participantes serán seguidos hasta 2025 para la identificación de eventos cardiovasculares, cambios de tratamiento y modificación de estilos de vida.
Conclusiones: El proyecto ILERVAS permitirá conocer la prevalencia de enfermedad vascular y de enfermedad renal subclínicas, evaluar si su diagnóstico precoz tiene un beneficio en la salud e investigar factores de riesgo emergentes.
Background and objectives: Chronic kidney disease (CKD) and atherosclerosis are 2 interrelated diseases that increase the risk of cardiovascular morbidity and mortality. The objectives of the ILERVAS project are: 1) to determine the prevalence of subclinical arterial disease and hidden kidney disease; 2) to assess the impact of early diagnosis of both diseases on cardiovascular morbidity and mortality and also on the progression of CKD; 3) to have a platform of data and biological samples.
Methods: Randomized intervention study. From 2015 to 2017, 19,800 people (9,900 in the intervention group and 9,900 in the control group) aged between 45 and 70 years without previous history of cardiovascular disease and with at least one cardiovascular risk factor will be randomly selected from the primary health care centres across the province of Lérida. A team of experts will travel around in a mobile unit to carry out the following baseline tests on the intervention group: Artery ultrasound; (carotid, femoral, transcranial and abdominal aorta); ankle-brachial index; spirometry; determination of advanced glycation end products; dried blood spot and urine spot tests. Additionally, blood and urine samples will be collected and stored in the biobank to identify new biomarkers using omics studies. Participants will be followed up until 2025 for identification of cardiovascular events, treatment changes and changes in lifestyle.
Conclusions: The ILERVAS project will reveal the prevalence of subclinical vascular disease and hidden kidney disease, determine whether or not their early diagnosis brings health benefits and will also allow investigation of new risk factors.
https://doi.org/10.1016/j.nefro.2016.02.008
024182
0211-6995
http://hdl.handle.net/10459.1/59407
spa
Sociedad Española de Nefrología
Reproducció del document publicat a https://doi.org/10.1016/j.nefro.2016.02.008
Nefrologia, 2016, vol. 36, núm. 4, p. 389-396
cc-by-nc-nd, (c) Sociedad Española de Nefrología, 2016
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Enfermedad cardiovascular
Placa de ateroma
Enfermedad renal oculta
Diagnóstico precoz
Sistema cardiovascular -- Malalties
Placa ateroscleròtica
Ronyons -- Malalties
Diagnòstic
Estudio de intervención aleatorizado para evaluar la prevalencia de enfermedad ateromatosa y renal ocultas y su impacto en la morbimortalidad: Proyecto ILERVA
Randomised intervention study to assess the prevalence of subclinical vascular disease and hidden kidney disease and its impact on morbidity and mortality: The ILERVAS project
article
publishedVersion
ORIGINAL
024182.pdf
024182.pdf
application/pdf
608784
https://repositori.udl.cat/bitstreams/db503c8e-52ec-4ed1-ad64-8c9cbf949a41/download
fd145adaa6ddc9d26f744a7df99895b4
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1232
https://repositori.udl.cat/bitstreams/9a2ea436-d9d1-46c3-b0ca-2de79978c4bb/download
b51f25f83cca752633b6ec4c418dbcc7
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/584365b4-0a47-4f9d-a013-1ce21925b055/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
TEXT
024182.pdf.txt
024182.pdf.txt
Extracted Text
text/plain
43133
https://repositori.udl.cat/bitstreams/a3412372-3a12-4978-b5e7-3d14b991cc74/download
046cea9d8b3255599ebc624929f19ee0
MD5
5
THUMBNAIL
024182.pdf.jpg
024182.pdf.jpg
Generated Thumbnail
image/jpeg
5034
https://repositori.udl.cat/bitstreams/ce6de5aa-fa0c-40bb-b817-d76c5af77857/download
4c262cc46c8853af5317c80a24ba7b95
MD5
4
10459.1/59407
oai:repositori.udl.cat:10459.1/59407
2021-05-25 10:50:31.852
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
cc-by-nc-nd, (c) Sociedad Española de Nefrología, 2016
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/845252022-12-12T00:06:02Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Belokopytova-Chakh, Alena
Ruiz González, Agustín
Vilardell, Felip
Porcel Pérez, José Manuel
2022-12-11T15:47:45Z
2022-12-11T15:47:45Z
2022
We report a 27-year-old man who presented with cardiac tamponade
and was eventually diagnosed of T-cell lymphoblastic lymphoma
(T-LBL) by the flow cytometric analysis of pericardial fluid. Despite
pericardiocentesis and institution of standard chemotherapy, the
patient developed malignant arrhythmia with hemodynamic instability,
and died soon after admission. Cardiac tamponade is rarely
the first manifestation of a T-LBL.
Describimos el caso de un varón de 27 años que se presentó con un
taponamiento cardiaco y fue diagnosticado de linfoma linfoblástico
de células (T-LBL) mediante citometría de flujo del líquido pericárdico.
A pesar de una pericardiocentesis y de la instauración de
quimioterapia estándar, el paciente desarrolló una arritmia maligna
con inestabilidad hemodinámica y falleció poco después de su
ingreso. El taponamiento cardiaco es rara vez la primera manifestación
de un T-LBL.
https://doi.org/10.22546/65/2775
0304-4866
http://hdl.handle.net/10459.1/84525
eng
Sociedad Gallega de Medicina Interna
Reproducció del document publicat a https://doi.org/10.22546/65/2775
Galicia Clínica, 2022, vol. 83, núm. 2, p. 42-44.
cc-by-nc-nd (c) Alena Belokopytova-Chakh et. al., 2022.
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
T-cell lymphoblastic lymphoma
Pericardial effusion
Cardiac tamponade
Taponamiento cardíaco
Linfoma linfoblástico
Cardiac tamponade as the initial presentation of a T-cell lymphoblastic lymphoma
Taponamiento cardiaco como forma de presentación inicial de un linfoma linfoblástico de células T
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
galcli_a2022vol82num2p42.pdf
galcli_a2022vol82num2p42.pdf
application/pdf
2001632
https://repositori.udl.cat/bitstreams/c245dfc5-ea8a-4b5c-883c-948bfd2957f6/download
5b107b81658fdb5a49ae9e7833c40113
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
805
https://repositori.udl.cat/bitstreams/e9379ffb-f011-4875-a557-92c155cf3ad9/download
4460e5956bc1d1639be9ae6146a50347
MD5
2
TEXT
galcli_a2022vol82num2p42.pdf.txt
galcli_a2022vol82num2p42.pdf.txt
Extracted text
text/plain
13700
https://repositori.udl.cat/bitstreams/d00eb6fc-e95e-414f-906f-15355f8f6f5a/download
df0a32ad831958bcbcc40c65375c918a
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/bd697fc3-ff2e-419f-b637-780dbd98a68c/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
THUMBNAIL
galcli_a2022vol82num2p42.pdf.jpg
galcli_a2022vol82num2p42.pdf.jpg
IM Thumbnail
image/jpeg
6530
https://repositori.udl.cat/bitstreams/e8e9572e-0791-462f-8a93-877b5feacaaa/download
0ec6ad405be447da3719e00e55af0e02
MD5
5
10459.1/84525
oai:repositori.udl.cat:10459.1/84525
2022-12-12 00:06:02.161
http://creativecommons.org/licenses/by-nc-nd/4.0/
cc-by-nc-nd (c) Alena Belokopytova-Chakh et. al., 2022.
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/4642932023-10-28T03:00:22Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
de Gonzalo Calvo, David
Molinero, Marta
Benítez, Iván
Perez-Pons, Manel
García Mateo, Nadia
Ortega, Alicia
Postigo, Tamara
García Hidalgo, María Coronada
Belmonte, Thalía
Rodríguez Muñoz, Carlos
González, Jessica
Torres, Gerard
Gort Paniello, Clara
Moncusí Moix, Anna
Estella, Ángel
Tamayo Lomas, Luis
Martínez de la Gándara, Amalia
Socias, Lorenzo
Peñasco, Yhivian
de la Torre, Maria del Carmen
Bustamante Munguira, Elena
Gallego, Elena
Martínez Varela, Ignacio
Martin Delgado, María Cruz
Vidal Cortés, Pablo
López Messa, Juan
Pérez García, Felipe
Caballero, Jesús
Añón, José M.
Loza Vázquez, Ana
Carbonell, Nieves
Marin Corral, Judith
Jorge García, Ruth Noemí
Barberà, Carme
Ceccato, Adrián
Fernández Barat, Laia
Ferrer, Ricard
García Gasulla, Darío
Lorente-Balanza, Jose Ángel
Menéndez, Rosario
Motos, Anna
Peñuelas, Oscar
Riera, Jordi
Bermejo Martin, Jesús F.
Torres, Antoni
Barbé Illa, Ferran
2023-10-27T11:03:42Z
2023-10-27T11:03:42Z
2023
Background: The identification of critically ill COVID-19 patients at risk of fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in critically ill patients. Second, we constructed a blood miRNA classifier for the early prediction of adverse outcomes in the ICU.
Methods: This was a multicenter, observational and retrospective/prospective study including 503 critically ill patients admitted to the ICU from 19 hospitals. qPCR assays were performed in plasma samples collected within the first 48 h upon admission. A 16-miRNA panel was designed based on recently published data from our group.
Results: Nine miRNAs were validated as biomarkers of all-cause in-ICU mortality in the independent cohort of critically ill patients (FDR < 0.05). Cox regression analysis revealed that low expression levels of eight miRNAs were associated with a higher risk of death (HR from 1.56 to 2.61). LASSO regression for variable selection was used to construct a miRNA classifier. A 4-blood miRNA signature composed of miR-16-5p, miR-192-5p, miR-323a-3p and miR-451a predicts the risk of all-cause in-ICU mortality (HR 2.5). Kaplan‒Meier analysis confirmed these findings. The miRNA signature provides a significant increase in the prognostic capacity of conventional scores, APACHE-II (C-index 0.71, DeLong test p-value 0.055) and SOFA (C-index 0.67, DeLong test p-value 0.001), and a risk model based on clinical predictors (C-index 0.74, DeLong test-p-value 0.035). For 28-day and 90-day mortality, the classifier also improved the prognostic value of APACHE-II, SOFA and the clinical model. The association between the classifier and mortality persisted even after multivariable adjustment. The functional analysis reported biological pathways involved in SARS-CoV infection and inflammatory, fibrotic and transcriptional pathways.
https://doi.org/10.1186/s12931-023-02462-x
2052-4439
https://repositori.udl.cat/handle/10459.1/464293
eng
BMJ
Reproducció del document publicat a: https://doi.org/10.1186/s12931-023-02462-x
Respiratory Research, 2023, vol. 24, núm. 159
cc-by (c)The authors, 2023
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Biomarker
COVID-19
ICU
microRNA
Prognosis
SARS-CoV-2
A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
RespirRes_a2023v24n159.pdf
RespirRes_a2023v24n159.pdf
application/pdf
3301361
https://repositori.udl.cat/bitstreams/8a071e1b-07b4-4209-a74a-e13b0cd9748f/download
cac857208f9a95829709d28e62b78e9c
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1019
https://repositori.udl.cat/bitstreams/2c2ff81a-4fdd-4fbf-bb4d-6c66194d5f39/download
313ea3fe4cd627df823c57a0f12776e5
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
639
https://repositori.udl.cat/bitstreams/c99d1d1e-5684-4f0d-8915-c30a56b2b691/download
15ec217096d63e7cd318d42eb888308c
MD5
3
TEXT
RespirRes_a2023v24n159.pdf.txt
RespirRes_a2023v24n159.pdf.txt
Extracted text
text/plain
49325
https://repositori.udl.cat/bitstreams/a9e67b0f-2de2-40cc-9aec-5750887afb4b/download
02b218e1c59e46e964c03e13d37ba96c
MD5
4
THUMBNAIL
RespirRes_a2023v24n159.pdf.jpg
RespirRes_a2023v24n159.pdf.jpg
Generated Thumbnail
image/jpeg
5407
https://repositori.udl.cat/bitstreams/6d8e2d9e-9515-4b51-b5a5-423c9c2d43b6/download
c31def35325c8a3dcdac7846e5a3e8c8
MD5
5
10459.1/464293
oai:repositori.udl.cat:10459.1/464293
2023-10-28 03:00:22.656
http://creativecommons.org/licenses/by/4.0/
cc-by (c)The authors, 2023
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/484082021-08-30T14:56:39Zcom_10459.1_227com_10459.1_2com_10459.1_59159com_10459.1_47453col_10459.1_314col_10459.1_59160col_10459.1_59998
Herrero Perpiñán, Enrique
Ros Salvador, Joaquim
Bellí i Martínez, Gemma
Cabiscol Català, Elisa
2015-07-07T08:37:01Z
2025-01-01
2008
Protein structure and function can be altered by reactive oxygen species produced either by cell metabolism or by external oxidants. Although
catalases, superoxide dismutases and peroxidases contribute to maintaining non-toxic levels of reactive oxygen species, modification of amino
acid side chains occurs. In particular, oxidative modification of sulphydryl groups in proteins can be a two-faceted process: it could lead to
impairment of protein function or, depending on the redox state of cysteine residues, may activate specific pathways involved in regulating key
cell functions. In yeast cells, the thioredoxin and glutaredoxin systems participate in such redox regulation in different cell compartments, and
interplay exists between both systems. In this context, glutaredoxins with monothiol activity initially characterised in Saccharomyces cerevisiae
may display specific regulatory functions at the mitochondria and nuclei. Furthermore, their structural conservation in other organisms point to a
conserved important role in metal homeostasis also in higher eukaryotes. Control of gene expression in response to oxidative stress is mediated by
several transcription factors, among which Yap1 has a predominant role in S. cerevisiae (Pap1 in Schizosaccharomyces pombe and Cap1 in
Candida albicans). In combination with Gpx3 peroxidase and Ybp1 protein, the activity of Yap1 is itself controlled depending on the redox
state of some of its cysteine residues, which determines the nucleocytoplasmic location of the Yap1 molecules.
https://doi.org/10.1016/j.bbagen.2007.12.004
013101
0006-3002
http://hdl.handle.net/10459.1/48408
eng
Elsevier
Reproducció del document publicat a https://doi.org/10.1016/j.bbagen.2007.12.004
Biochimica et Biophysica Acta, 2008, vol. 1780, núm. 11, p.1217-1235
(c) Elsevier, 2007
info:eu-repo/semantics/restrictedAccess
Catalase
Superoxide dismutase
Peroxidase
Redox control and oxidative stress in yeast cells
article
publishedVersion
enric.herrero@cmb.udl.cat
Enrique Herrero Perpiñán
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/76b78bfc-c130-4a7c-b980-2c2f1a7383fe/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
013101.pdf.jpg
013101.pdf.jpg
Generated Thumbnail
image/jpeg
5029
https://repositori.udl.cat/bitstreams/dea6df11-a122-4ab0-be2c-da91ae4f6ec8/download
aa1b3aaefbab869977f9005950a883eb
MD5
5
TEXT
013101.pdf.txt
013101.pdf.txt
Extracted Text
text/plain
123056
https://repositori.udl.cat/bitstreams/b5889ec0-c697-471c-a0ac-fef16edee6be/download
a1ce1b768f126d1a225da0706c8cde8a
MD5
6
ORIGINAL
013101.pdf
013101.pdf
application/pdf
925877
https://repositori.udl.cat/bitstreams/0d0fd6bb-f3ab-4b23-ac26-2d5cfb44c116/download
4521437be9f734dd6db452829d62f591
MD5
1
10459.1/48408
oai:repositori.udl.cat:10459.1/48408
2021-08-30 14:56:39.352
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/492602021-08-30T15:04:33Zcom_10459.1_227com_10459.1_2com_10459.1_59159com_10459.1_47453col_10459.1_314col_10459.1_59160col_10459.1_59998
Torre Ruiz, M. A. de la
Pujol Carrión, Núria
Sundaram, Venkatraghavan
2015-12-12T09:12:08Z
2025-01-01
2015-01-22
2015-12-12T09:12:11Z
Saccharomyces cerevisiae is an optimal model to study stress responses for various reasons: i) budding yeast genome presents a high degree of homology with the human genome; ii) there are many proteins that show an elevated functional homology with specific human proteins; iii) it is a system whose genetic manipulation is reasonably easy and cheaper than other models; iv) the possibility of working with an haploid state facilitates the study of multiple processes; v) databases are the most complete of all the eukaryotic models. Due to the latest information derived from proteomic and genomic analyses, the genetic, biochemical and molecular information available relative to this biological system is extraordinarily big and complete. In this review, we present an overview of the mechanisms unravelling sensing and transducing oxidative stress. TOR, RAS/PKA, CWI, SNF1, and HOG are the main pathways involved both in the oxidative response and in the correct entry in stationary phase. In general, TOR and RAS/PKA dowregulation and SNF1 and CWI upregulation favour both a correct defence against oxidative damage and the entry in the quiescent state. All of these pathways have counterparts in humans. The actin cytoskeleton plays a dual function as sensor and target of oxidation, in tight connection with the former signalling cascades. In budding yeast, progression through stationary phase and quiescence constitute an accepted current model to study some of the mechanisms that determine life span. Aging is a process associated to oxidative stress and it is in tight relationship with bulk autophagy and mitophagy, both are mechanisms belonging to the oxidative defence and promoters of life extension when correctly regulated by, among other elements, the signalling cascades. - See more at: http://www.eurekaselect.com/125474/article#sthash.AVRLn2Lq.dpuf
application/pdf
https://doi.org/10.2174/1389450115666141020160105
023563
1389-4501
http://hdl.handle.net/10459.1/49260
eng
Bentham Science Publishers
Reproducció del document publicat a: https://doi.org/10.2174/1389450115666141020160105
Current Drug Targets, 2015, vol. 16, num. 1, p. 2-12
(c) Bentham Science Publishers, 2015
info:eu-repo/semantics/restrictedAccess
Aging
Glutaredoxins
MAPK
oxidative stress
signalling
Envelliment
Estrès oxidatiu
Aging
Oxidative stress
Coping with oxidative stress. The yeast model
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
madelatorre@cmb.udl.cat
Torre Ruiz, M. A. de la
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/943ec3aa-c3bf-46e5-85c9-7238210757f8/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
SWORD
mets.xml
SWORD deposit package
application/octet-stream
971412
https://repositori.udl.cat/bitstreams/98240e1c-93f0-49b4-a6fc-e8bd3d49a1ae/download
1b3241fa5b3ab139da3f7f771cb42455
MD5
3
THUMBNAIL
023563.pdf.jpg
023563.pdf.jpg
Generated Thumbnail
image/jpeg
5113
https://repositori.udl.cat/bitstreams/3c92bc72-0e6b-4415-8d2e-98eb52237533/download
73d0a56574d83cd75c1a87d28658223d
MD5
4
ORIGINAL
023563.pdf
application/pdf
1212200
https://repositori.udl.cat/bitstreams/41fa2b08-c9b2-4436-bb34-fd39baf18cb9/download
48eac9b9b938436b2fa1b3276735e4b4
MD5
1
TEXT
023563.pdf.txt
023563.pdf.txt
Extracted Text
text/plain
64897
https://repositori.udl.cat/bitstreams/18f8ea02-92a5-4dfa-be4a-06b66ec830e6/download
2f2f3b6e6056d7eb86ccd242aa477baf
MD5
5
10459.1/49260
oai:repositori.udl.cat:10459.1/49260
2021-08-30 15:04:33.517
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/4632642023-05-03T09:11:18Zcom_10459.1_227com_10459.1_2com_10459.1_236com_10459.1_47453col_10459.1_314col_10459.1_297col_10459.1_59998col_10459.1_49291
Fibla Palazón, Joan
Maceda, Iago
Laplana Lafaja, Marina
Guerrero i Lladós, Montse
Álvarez, Miguel Martín
Burgueño, Jesús
Camps, Agustí
Fàbrega, Jordi
Felisart, Josefina
Grané, Joan
Remón, José Luis
Serra, Jordi
Moral, Pedro
Lao, Oscar
2023-05-02T07:50:52Z
2023-05-02T07:50:52Z
2023
The genetic variation of the European population at a macro-geographic scale follows genetic gradients which reflect main migration events. However, less is known about factors affecting mating patterns at a micro-geographic scale. In this study we have analyzed 726,718 autosomal single nucleotide variants in 435 individuals from the catalan Pyrenees covering around 200 km of a vast and abrupt region in the north of the Iberian Peninsula, for which we have information about the geographic origin of all grand-parents and parents. At a macro-geographic scale, our analyses recapitulate the genetic gradient observed in Spain. However, we also identified the presence of micro-population substructure among the sampled individuals. Such micro-population substructure does not correlate with geographic barriers such as the expected by the orography of the considered region, but by the bishoprics present in the covered geographic area. These results support that, on top of main human migrations, long ongoing socio-cultural factors have also shaped the genetic diversity observed at rural populations.
This work was supported by the Diputació of Lleida grant to JF. OL and IM acknowledge the support from Spanish Ministry of Science and Innovation to the EMBL partnership, the Centro de Excelencia Severo Ochoa, CERCA Program/Generalitat de Catalunya, Spanish Ministry of Science and Innovation through the Instituto de Salud Carlos III, Generalitat de Catalunya through Departament de Salut and Departament d’Empresa i Coneixement, Co-financing with funds from the European Regional Development Fund by the Spanish Ministry of Science and Innovation corresponding to the Programa Operativo FEDER Plurirregional de España (POPE) 2014–2020 and by the Secretaria d’Universitats i Recerca, Departament d’Empresa i Coneixement of the Generalitat de Catalunya corresponding to the Programa Operatiu FEDER de Catalunya 2014–2020. OL gratefully acknowledges the financial support from Ministerio de Economía, Industria y Competitividad BFU 201568759-P and Generalitat de Catalunya (Government of Catalonia)—GRC 2017 SGR 937. IM gratefully acknowledges the financial support from the Government of Catalonia | Agència de Gestió d’Ajuts Universitaris i de Recerca (Agency for Management of University and Research Grants)—GRC 2014 SGR 615. MMA was supported by a FPU15/01251 from Ministerio de Ciencia, innovación y Universidades. MMA acknowledges the financial support from Precipita-FECYT (FBG 309307 project). The samples analyzed in this study are part of a much larger sample whose collection was supported by the project CGL 2011–27866 of the Ministerio de Ciencia y Tecnologia, the Fundació Moret i Marguí to PM.
https://doi.org/10.3389/fgene.2022.1100440
033004
1664-8021
https://repositori.udl.cat/handle/10459.1/463264
eng
Frontiers
info:eu-repo/grantAgreement/MINECO//BFU2015-68759-P/ES/DESARROLLO DE NUEVAS HERRAMIENTAS ESTADISTICAS PARA MEJORAR LA DETECCION DE SUBESTRUCTURA DE POBLACIONES A NIVEL INDIVIDUAL CON APLICACIONES EN HUMANOS/
info:eu-repo/grantAgreement/MECD//FPU15%2F01251/ES/FPU15%2F01251/
Reproducció del document publicat a: https://doi.org/10.3389/fgene.2022.1100440
Frontiers in Genetics, 2023, vol. 13
cc-by (c) Authors, 2023
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/4.0/
Genetic variation
Rural population
Inbreeding
Population differentiation
Bishopric boundaries
Rural catalan Pyrenees
The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
033004.pdf
033004.pdf
application/pdf
4162805
https://repositori.udl.cat/bitstreams/06d2b9f3-273f-41ee-8299-6e99c3ee70ae/download
13124dc94b43528f5438e2dfd5348509
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
639
https://repositori.udl.cat/bitstreams/f4d640e7-f0e8-4df8-b030-13b1dcf91820/download
15ec217096d63e7cd318d42eb888308c
MD5
2
TEXT
033004.pdf.txt
033004.pdf.txt
Extracted text
text/plain
65405
https://repositori.udl.cat/bitstreams/b7c60f47-32c5-4399-9938-c30374a8fd85/download
db965a8a521c00487274397d16870db5
MD5
3
THUMBNAIL
033004.pdf.jpg
033004.pdf.jpg
Generated Thumbnail
image/jpeg
4689
https://repositori.udl.cat/bitstreams/5eab7508-04a8-4d8a-b176-516e5d043610/download
86bcbf9cd4554a05bce5c61eaddf588e
MD5
4
10459.1/463264
oai:repositori.udl.cat:10459.1/463264
2023-05-03 09:11:18.2
https://creativecommons.org/licenses/by/4.0/
cc-by (c) Authors, 2023
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/486642017-03-14T13:29:56Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_49291
Cardona, Maria
López, Juan Antonio
Serafín, Anna
Rongvaux, Anthony
Inserte Igual, Javier
García-Dorado, David
Flavell, Richard
Llovera i Tomàs, Marta
Cañas, Xavier
Vázquez, Jesús
Sanchis, Daniel
2015-08-24T08:35:48Z
2015-08-24T08:35:48Z
2015-06-29
Executioner caspase-3 and -7 are proteases promoting cell death but non-apoptotic roles
are being discovered. The heart expresses caspases only during development, suggesting they contribute to the organ maturation process. Therefore, we aimed at identifying novel functions of caspases in heart development. We induced simultaneous deletion of executioner caspase-3 and -7 in the mouse myocardium and studied its effects. Caspase knockout hearts are hypoplastic at birth, reaching normal weight progressively through myocyte hypertrophy. To identify the molecular pathways involved in these effects, we used microarray-based transcriptomics and multiplexed quantitative proteomics to compare wild type and executioner caspase-deficient myocardium at different developmental stages. Transcriptomics showed reduced expression of genes promoting DNA replication and cell cycle progression in the neonatal caspase-deficient heart suggesting reduced myocyte proliferation, and expression of non-cardiac isoforms of structural proteins in the adult null myocardium. Proteomics showed reduced abundance of proteins involved in oxidative phosphorylation accompanied by increased abundance of glycolytic enzymes underscoring retarded metabolic maturation of the caspase-null myocardium. Correlation between mRNA expression and protein abundance of relevant genes was confirmed, but transcriptomics and proteomics indentified complementary molecular pathways influenced by caspases in the developing heart. Forced expression of wild type or proteolytically inactive caspases in cultured cardiomyocytes induced expression of genes promoting cell division. The results reveal that executioner caspases can modulate heart’s cellularity and maturation during development, contributing novel information about caspase biology and heart development.
This work was partially supported by Ministerio de Economía y Competitividad (MINECO) (Grants SAF2010_19125 and SAF2013_44942 to D.S. and SAF2010-37926 and ProteoRed-PT13/0001/0017 to J.V.); Program Redes Temáticas de Investigación Cooperativa en Salud (RETICS) Grants RD12/0042/0035, RD12/0042/0056 and RD12/0042/0021, Red de Investigación Cardiovascular, RIC to DS, JV and DGD. and FIS-PI121738 to DGD. from Instituto de Salud Carlos III (ISCIII); Grant 2009SGR-346 from the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) to XC and DS. RAF is an investigator of the Howard Hughes Medical Institute.
https://doi.org/10.1371/ journal.pone.0131411
023097
1932-6203
http://hdl.handle.net/10459.1/48664
eng
Public Library of Science
MICINN/PN2008-2011/SAF2010-19125
MINECO/PN2013-2016/SAF2013-44942
MICINN/PN2008-2011/SAF2010-37926
Reproducció del document publicat a https://doi.org/10.1371/ journal.pone.0131411
Plos One, 2015, vol. 10, num. 6, p. 0131411
cc-by, (c) Cardona et al., 2015
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Heart
Gene expression
Muscle cells
Mitochondria
Proteomics
Cell division
Cor
Expressió gènica
Cicle cel·lular
Cèl·lules musculars
Divisió cel·lular
Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart
article
publishedVersion
THUMBNAIL
023097.pdf.jpg
023097.pdf.jpg
Generated Thumbnail
image/jpeg
5581
https://repositori.udl.cat/bitstreams/1a569de0-d00f-4d10-9b6b-ab84d6c7d144/download
2bcbfcf2d2818fd8e8d1ee51158e8978
MD5
6
TEXT
023097.pdf.txt
023097.pdf.txt
Extracted Text
text/plain
71390
https://repositori.udl.cat/bitstreams/0f620f07-10ec-4654-84da-ed4252275d97/download
08cd666f7ac613709859045b680b43fb
MD5
7
ORIGINAL
023097.pdf
023097.pdf
application/pdf
7996762
https://repositori.udl.cat/bitstreams/db40f680-8d16-4874-ac40-c468f5766f09/download
28e4edb05ebe673d86430e9abbde6c89
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1370
https://repositori.udl.cat/bitstreams/d2ece58e-bc53-4e52-a88e-573325d01565/download
ac86fe33011bda956ed9b032abf4d402
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/dd558284-22a3-4d47-b3b1-cf597df5f5e6/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
10459.1/48664
oai:repositori.udl.cat:10459.1/48664
2017-03-14 13:29:56.138
http://creativecommons.org/licenses/by/3.0/es/
cc-by, (c) Cardona et al., 2015
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/590772021-08-30T15:04:27Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_49291
Ferrezuelo, Francisco
Colomina i Gabarrella, Neus
Palmisano, Alida
Garí Marsol, Eloi
Gallego, Carme
Csikász-Nagy, Attila
Aldea, Martí
2017-01-24T09:02:24Z
2025-01-01
2012
Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size control, cell volume at Start displays great individual variability even under constant conditions. Here we show that cell size at Start is robustly set at a single-cell level by the volume growth rate in G1, which explains the observed variability. We find that this growth-rate-dependent sizer is intimately hardwired into the Start network and the Ydj1 chaperone is key for setting cell size as a function of the individual growth rate. Mathematical modelling and experimental data indicate that a growth-rate-dependent sizer is sufficient to ensure size homeostasis and, as a remarkable advantage over a rigid sizer mechanism, it reduces noise in G1 length and provides an immediate solution for size adaptation to external conditions at a population level.
We thank A. Cornadó and S. Rius for technical assistance, J.C. Igual for communicating unpublished results and R. Y. Tsien for the mCherry fusion vector. We also thank A. Aubanell, T. Mazza and J. Sánchez-Matamala for key preliminary contributions, and B. Novak, P. Nurse and J. Torres-Rosell for stimulating discussions. This work was funded by the Ministry of Science and Innovation of Spain (BFU2010-20205), Consolider-Ingenio 2010 (CSD2007-15), the Italian Research Fund FIRB (RBPR0523C3) and the European Union (FEDER). F.F. and N.C. are researchers of the Ramón y Cajal programme.
https://doi.org/10.1038/ncomms2015
018469
2041-1723
http://hdl.handle.net/10459.1/59077
eng
Nature
MICINN/PN2008-2011/BFU2010-20205
Reproducció del document publicat a https://doi.org/10.1038/ncomms2015
Nature Communications, 2012, vol. 3, p. 1-11
(c) Macmillan Publishers Limited, 2012
info:eu-repo/semantics/restrictedAccess
The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation
article
publishedVersion
marti.aldea@cmb.udl.cat
Martí Aldea
ORIGINAL
018469.pdf
018469.pdf
application/pdf
1284599
https://repositori.udl.cat/bitstreams/eea8927b-468a-4b33-a6b1-ca8b409aacf1/download
0f8f29e702a423cef85b86c2c2b240ed
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/48baf2dc-221c-4626-ab6d-ae060bde160a/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
018469.pdf.jpg
018469.pdf.jpg
Generated Thumbnail
image/jpeg
3564
https://repositori.udl.cat/bitstreams/341b43cd-fbaf-49cb-be14-2d36755869a1/download
78b6f6309a2578a813877401a5020e2a
MD5
3
TEXT
018469.pdf.txt
018469.pdf.txt
Extracted Text
text/plain
66317
https://repositori.udl.cat/bitstreams/92bf338c-61d4-4448-a36e-f7a99960fcdd/download
90643e0a3be769ac6685aef7ed2b53ab
MD5
4
10459.1/59077
oai:repositori.udl.cat:10459.1/59077
2021-08-30 15:04:27.31
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/570842021-08-30T15:04:32Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_49291
Ye, Junmei
Cardona, Maria
Llovera i Tomàs, Marta
Comella i Carnicé, Joan Xavier
Sanchis, Daniel
2016-05-23T09:52:39Z
2025-01-01
2012
The Myocyte Enhancer Factor-2 (MEF2) family of transcription factors regulates gene expression during
cardiomyocyte differentiation and adaptation of the myocardium to stress. MEF2 activity is enhanced by increasing
its transcription and by MAPK-dependent phosphorylation, and is reduced by binding to class-II
Histone Deacetylases and by miR-1-mediated degradation of its transcript. Here we show that MEF2 protein
abundance is regulated at the translational level, determining myocyte size, during hypertrophy. In order to
reduce MEF2 protein expression, its silencing through RNA interference required serum deprivation and,
even in this condition, MEF2 protein abundance recovered to basal levels in presence of phenylephrine.
Hypertrophic agonist stimulation of neonatal ventricular cardiomyocytes increased Mef2 expression by enhancing
its translation, without changing its transcription or blocking degradation of the protein. MEF2 abundance
was increased by Calcineurin overexpression in vivo and was reduced by Calcineurin inhibition in
vitro, without affecting Mef2 mRNA levels. Calcineurin activity influenced expression of Polypyrimidine
Tract Protein (PTB), contributing to MEF2 translation. Thus, our results show a previously unrecognized
but relevant level of MEF2 activity regulation through the control of its translation that involves Calcineurin
and PTB.
This work was supported by grant SAF2010_19125 from the Ministerio de Innovación y Ciencia of Spain (MICINN, now Ministerio de Economía y Competitividad) to DS and by the Agencia de Gestió d'Ajuts a Grups de Recerca (AGAUR) from the Generalitat de Catalunya 2009SGR-346 to DS and JXC. JY is a recipient of a fellowship from the Universitat de Lleida (Spain) and MC has a FPU (Formación de profesorado universitario) fellowship from MICINN.
https://doi.org/10.1016/j.yjmcc.2012.07.013
018064
0022-2828
http://hdl.handle.net/10459.1/57084
eng
Elsevier
MICINN/PN2008-2011/SAF2010-19125
Reproducció del document publicat a https://doi.org/10.1016/j.yjmcc.2012.07.013
Journal of Molecular and Cellular Cardiology, 2012, vol. 53, núm. 4, p. 578-587
(c) Elsevier, 2012
info:eu-repo/semantics/restrictedAccess
Cardiomyocyte
Hypertrophy
Myocyte Enhancer Factor-2
Translation of Myocyte Enhancer Factor-2 is induced by hypertrophic stimuli in cardiomyocytes through a Calcineurin-dependent pathway
article
publishedVersion
daniel.sanchis@cmb.udl.cat
Sanchís Almenar, Daniel
ORIGINAL
018064.pdf
018064.pdf
application/pdf
1101678
https://repositori.udl.cat/bitstreams/9029b7eb-ba81-4979-8aaa-636dd4babaa4/download
db4adf248cc0a5f645e609cb4c4b4fbc
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/2096f79c-985c-4e7b-88a0-2ef00c7a0dd0/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
THUMBNAIL
Journal of Molecular and Cellular Cardiology, 2012, vol. 53, núm 4.pdf.jpg
Journal of Molecular and Cellular Cardiology, 2012, vol. 53, núm 4.pdf.jpg
Generated Thumbnail
image/jpeg
5280
https://repositori.udl.cat/bitstreams/6cde064e-0348-45c8-aefa-feca0a34ab01/download
744d37ea286990ceb6d43b7ed5ea3ed2
MD5
4
018064.pdf.jpg
018064.pdf.jpg
Generated Thumbnail
image/jpeg
5280
https://repositori.udl.cat/bitstreams/9ad42b72-7b1b-496d-add5-b51e0c6e32ba/download
744d37ea286990ceb6d43b7ed5ea3ed2
MD5
6
TEXT
Journal of Molecular and Cellular Cardiology, 2012, vol. 53, núm 4.pdf.txt
Journal of Molecular and Cellular Cardiology, 2012, vol. 53, núm 4.pdf.txt
Extracted Text
text/plain
49973
https://repositori.udl.cat/bitstreams/6bbc033f-3e71-47a9-a0c2-2fc95d23bbf9/download
4a23f20a23cbcd79cbd72ffd6d16cb02
MD5
5
018064.pdf.txt
018064.pdf.txt
Extracted Text
text/plain
49973
https://repositori.udl.cat/bitstreams/7e1f2a9b-0f9c-464a-bba7-0c435449c4d6/download
4a23f20a23cbcd79cbd72ffd6d16cb02
MD5
7
10459.1/57084
oai:repositori.udl.cat:10459.1/57084
2021-08-30 15:04:32.239
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/570392021-08-30T15:04:34Zcom_10459.1_227com_10459.1_2col_10459.1_314
Fonseca, Rafael
Blood, Emily
Rué i Monné, Montserrat
Harrington, David
Oken, Martin M.
Kyle, Robert A.
Dewald, Gordon W.
Van Ness, Brian
Van Wier, Scott A.
Henderson, Kimberly J.
Bailey, Richard J.
Greipp, Philip R.
2016-05-18T07:49:03Z
2025-01-01
2003
Nonrandom recurrent chromosomal abnormalities
are ubiquitous in multiple myeloma
(MM) and include, among others,
translocations of the immunoglobulin
heavy chain locus (IgH). IgH translocations
in MM result in the up-regulation of
oncogenes, and include more commonly
t(11;14)(q13;q32), t(4;14)(p16;q32), and
t(14;16)(q32;q23). Based on the recurrent
nature of these translocations and their
finding since the early stages of the
plasma cell (PC) disorders, we hypothesized
that they would confer biologic
and clinical variability. In addition, deletions
of 13q14 and 17p13 have also been
associated with a shortened survival. We
used cytoplasmic Ig–enhanced interphase
fluorescent in situ hybridization to detect
deletions (13q14 and 17p13.1), and translocations
involving IgH in 351 patients
treated with conventional chemotherapy
entered into the Eastern Cooperative Oncology
Group clinical trial E9486/9487.
Translocations were frequently unbalanced
with loss of one of the derivative
chromosomes. The presence of t(4;
14)(p16;q32) (n 42; 26 vs 45 months,
P < .001), t(14;16)(q32;q23) (n 15; 16 vs
41 months, P .003), 17p13 (n 37; 23
vs 44 months, P .005), and 13q14
(n 176; 35 vs 51 months, P .028) were
associated with shorter survival. A strati-
fication of patients into 3 distinct categories
allowed for prognostication: poor
prognosis group (t(4;14)(p16;q32), t(14;
16)(q32;q23), and 17p13), intermediate
prognosis ( 13q14), and good prognosis
group (all others), with median
survivals of 24.7, 42.3, and 50.5 months,
respectively (P < .001). This molecular cytogenetic
classification identifies patients
into poor, intermediate, and good risk
categories. More importantly it provides
further compelling evidence that MM is
composed of subgroups of patients categorized
according to their underlying
genomic aberrations.
https://doi.org/10.1182/blood-2002-10-3017
009171
0006-4971
http://hdl.handle.net/10459.1/57039
eng
American Society of Hematology
Reproducció del document publicat a https://doi.org/10.1182/blood-2002-10-3017
Blood, 2003, vol. 101, núm. 11, p. 4569-4575
(c) The American Society of Hematology, 2003
info:eu-repo/semantics/restrictedAccess
Clinical and biologic implications of recurrent genomic aberrations in myeloma
article
publishedVersion
montse.rue@cmb.udl.cat
Rué i Monné, Montserrat
THUMBNAIL
009171.pdf.jpg
009171.pdf.jpg
Generated Thumbnail
image/jpeg
4612
https://repositori.udl.cat/bitstreams/c8fc5a2c-78a6-47cd-ae3c-4afa84347817/download
11f655805bbc51acde6c39ca7fd03cc1
MD5
3
TEXT
009171.pdf.txt
009171.pdf.txt
Extracted Text
text/plain
44210
https://repositori.udl.cat/bitstreams/8e0737d4-0e57-4670-9552-ee70160eaffc/download
18bc311c7aba99685b1c271f70c5fc7a
MD5
4
ORIGINAL
009171.pdf
009171.pdf
application/pdf
134129
https://repositori.udl.cat/bitstreams/369cb31e-b9e8-4546-b049-64409cdb1828/download
584246a7f97fdbcd691a94d0bfe28e64
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/a0ca7bd4-7765-4e05-9c62-78d9e4b7919d/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
10459.1/57039
oai:repositori.udl.cat:10459.1/57039
2021-08-30 15:04:34.168
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/694662023-03-03T19:09:54Zcom_10459.1_227com_10459.1_2col_10459.1_314
Rahman, M.M.
Franch-Marro, X.
Maestro, J.L.
Martin, D.
Casali, Andreu
2020-09-08T07:44:53Z
2020-09-08T07:44:53Z
2017-09-15
2020-09-08T07:44:53Z
Hormones play essential roles during development and maintaining homeostasis in adult organisms, regulating a plethora of biological processes. Generally, hormones are secreted by glands and perform a systemic action. Here we show that Juvenile Hormones (JHs), insect sesquiterpenoids synthesized by the corpora allata, are also synthesized by the adult Drosophila gut. This local, gut specific JH activity, is synthesized by and acts on the intestinal stem cell and enteroblast populations, regulating their survival and cellular growth through the JH receptors Gce/Met and the coactivator Tai. Furthermore, we show that this local JH activity is important for damage response and is necessary for intestinal tumor growth driven by activating mutations in Wnt and EGFR/Ras pathways. Together, our results identify JHs as key hormonal regulators of gut homeostasis and open the possibility that analogous hormones may play a similar role in maintaining vertebrate adult intestinal stem cell population and sustaining tumor growth.
We are thankful to IRB Barcelona Cell separation Unit and to VDRC and Bloomington stock center for fly stocks. We thank Yolanda Rivera for technical support. We thank Jordi Casanova for comments on the manuscript. We are grateful to members of Jordi Casanova lab for constructive discussion. We thank Idun Dale Rein for FACS analysis. MMR was supported by the Marie Curie Cofund Fellowship under FP7 programme of the ERC. This work was supported by the MICINN (BFU2014-59781P) to AC and MICINN (CGL2014-55786P) and SGR-2014 from Catalan Government to XF-M and D. M. The research has also benefited from FEDER funds.
application/pdf
https://doi.org/10.1038/s41598-017-11199-9
030291
2045-2322
http://hdl.handle.net/10459.1/69466
eng
Nature Publishing Group
info:eu-repo/grantAgreement/MINECO//BFU2014-59781-P/ES/CONTROL HORMONAL DE LA HOMEOSTASIS DE LAS CELULAS MADRE INTESTINALES/
info:eu-repo/grantAgreement/MINECO//CGL2014-55786-P/ES/ORIGEN DE LA METAMORFOSIS: ANALISIS MOLECULAR Y EVOLUTIVO DE LOS GENES DEL
Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-11199-9
Scientific Reports, 2017, vol. 7, núm. 11677
cc-by (c) Rahman, M.M. et al., 2017
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es
Hormones
Local juvenile hormone activity regulates gut homeostasis and tumor growth in adult Drosophila
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
030291.pdf
application/pdf
3526711
https://repositori.udl.cat/bitstreams/865eb678-f12f-4341-8f40-ce420e20970e/download
399e555fe6b7e2cd0a2881b4b2b61ca3
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/1a71c86c-f295-466e-908b-2f6624b90bbc/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
5
THUMBNAIL
030291.pdf.jpg
030291.pdf.jpg
Generated Thumbnail
image/jpeg
5789
https://repositori.udl.cat/bitstreams/fef34519-0588-4cfe-bc04-0183f523d69f/download
07030a1949ed81c3c4141c5a0359c124
MD5
7
CC-LICENSE
license_url
application/octet-stream
43
https://repositori.udl.cat/bitstreams/26dd688a-9d4d-4921-80e5-434729493618/download
5134edb0a80711cbbaa5247c36025151
MD5
2
license_text
text/html
23115
https://repositori.udl.cat/bitstreams/6cfcdd9a-9caf-4fa2-bce4-ebfc09135f4f/download
ec3783401c55aba9b2c045380c0dd4b3
MD5
3
license_rdf
application/octet-stream
20337
https://repositori.udl.cat/bitstreams/2e3049fe-ec25-42cf-928c-51b79f34848d/download
1485691ce20485471fe59ad1ac24bf0f
MD5
4
SWORD
mets.xml
SWORD deposit package
application/octet-stream
3177405
https://repositori.udl.cat/bitstreams/0baec970-72cb-493b-9836-b41687ad756f/download
ea82b8ea14461f512f52853601bc9376
MD5
6
TEXT
030291.pdf.txt
030291.pdf.txt
Extracted Text
text/plain
39492
https://repositori.udl.cat/bitstreams/c5f9b1b4-dcbf-4dcf-8844-bdf557642b54/download
a5db85cd55e316cc1f263c143c9a0aba
MD5
8
10459.1/69466
oai:repositori.udl.cat:10459.1/69466
2023-03-03 19:09:54.14
http://creativecommons.org/licenses/by/3.0/es
cc-by (c) Rahman, M.M. et al., 2017
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/491922023-04-25T12:44:44Zcom_10459.1_227com_10459.1_2com_10459.1_463061com_10459.1_47453col_10459.1_314col_10459.1_463062col_10459.1_59998col_10459.1_49291
Abella i Pons, Francesc
Vilarasau, Assumpció
Cuadrado, Josep
Solsona Tehàs, Francesc
Alves, Rui
Vilaplana Mayoral, Jordi
Serra, Joan
2015-11-30T08:47:13Z
2015-11-30T08:47:13Z
2014
El consumo de tabaco continúa siendo una importante causa de morbilidad y mortalidad. El proceso terapéutico para abandonar el tabaco consiste en la desintoxicación física de la nicotina y en el mantenimiento de la abstinencia de su consumo. Nuestro estudio se
sitúa en este contexto, ofreciendo una estrategia de apoyo por SMS y monitorizando al paciente a lo largo del tratamiento.
Material y método. Este estudio longitudinal compara dos grupos de pacientes: uno con apoyo a través de SMS y otro, de control, que no disfruta de dicho apoyo. Los pacientes recibieron aleatoriamente mensajes de apoyo y refuerzo positivo, así como preguntas
sobre su estado. El resto de la terapia es igual para ambos grupos.
Resultados. El grupo que recibía apoyo por SMS presentó unas tasas de abstinencia mejores que el otro (57,1% frente a 42,9%). Los mismos participantes valoran positivamente la metodología y admiten que les ahorra tiempo y viajes. Conclusión. El uso de las TIC para monitorizar y reforzar el proceso de desintoxicación del consumo de tabaco parece ser efectivo y bien acogido por los pacientes.
El presente trabajo ha sido financiado por
el MICINN-Spain, mediante los contratos
TIN2011-28689-C02-02 y BFU2010-
17704, por la Generalitat de Catalunya
mediante los grupos de investigación
2009SGR809 y 2009SGR145 y por la European Social Fund.
022357
0213-7615
http://hdl.handle.net/10459.1/49192
spa
Asociación Española de Estudios en Drogodependencias
info:eu-repo/grantAgreement/MICINN//TIN2011-28689-C02-02/ES/EJECUCION EFICIENTE DE APLICACIONES MULTIDISCIPLINARES: NUEVOS DESAFIOS EN LA
ERA MULTI%2FMANY CORE/
Reproducció del document publicat a: http://www.aesed.com/revista_red.php
Revista Española de Drogodependencia, 2014, vol. 39, núm. 4, p. 77-87
(c) Asociación Española de Estudios en Drogodependencias, 2014
info:eu-repo/semantics/openAccess
Tabaquisme
Missatges de correu electrònic
Seguimiento y control de pacientes fumadores en proceso de deshabituación mediante SMS. Una experiencia en e-salud
article
publishedVersion
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/8010409f-22c5-4263-9677-c93f92101cbb/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
ORIGINAL
022357.pdf
022357.pdf
application/pdf
345026
https://repositori.udl.cat/bitstreams/161dae9a-32b2-4966-b5f9-b63dbca7f6f5/download
ea3f8df5989998984f633d4b7a393693
MD5
1
THUMBNAIL
022357.pdf.jpg
022357.pdf.jpg
Generated Thumbnail
image/jpeg
4307
https://repositori.udl.cat/bitstreams/13aa059c-ff8c-4a73-b388-9f4b61c7de1e/download
a74a404bc36266fa268f6886cf832390
MD5
3
TEXT
022357.pdf.txt
022357.pdf.txt
Extracted Text
text/plain
24387
https://repositori.udl.cat/bitstreams/f905f245-5cc9-475b-b090-b28e70d66cac/download
ca38f93a6099eccde8d6a5674147db8c
MD5
4
10459.1/49192
oai:repositori.udl.cat:10459.1/49192
2023-04-25 12:44:44.535
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/570872022-02-16T11:00:20Zcom_10459.1_227com_10459.1_2col_10459.1_314col_10459.1_49291
Dolcet Roca, Xavier
Llobet Navàs, David
Pallares, Judit
Rué i Monné, Montserrat
Comella i Carnicé, Joan Xavier
Matias-Guiu, Xavier
2016-05-24T08:02:12Z
2025-01-01
2005
The FLICE-inhibitory protein (FLIP) plays a key role in the regulation of apoptosis triggered by death ligands.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis in some
types of tumor but not in others. To assess the possible role of FLIP in apoptosis resistance in endometrial
carcinoma, we performed an immunohistochemical study on a tissue microarray composed of 95 endometrial
carcinomas. We found positive signals in 43% of the cases, as well as a significant difference in FLIP
expression between stage I and II tumors. Moreover, we observed that endometrial carcinoma cell lines
Ishikawa and KLE did not undergo apoptosis after TRAIL treatment. Cotreatment of these cells with the inhibitor
of transcription actinomycin D resulted in a dramatic decrease in cell viability and induced activation of
caspase-8. These events coincided with downregulation of FLIP mRNA and protein. Inhibitors of caspase-8 or
overexpression of FLIP completely blocked apoptosis induced by actinomycin D plus TRAIL cotreatment. More
importantly, downregulation of endogenous FLIP expression by specific siRNAs sensitized endometrial
carcinoma cells to TRAIL-induced apoptosis in the absence of actinomycin D. Taken together, our results
suggest for the first time a critical role for FLIP in the regulation apoptosis triggered by TRAIL in endometrial
carcinoma cells.
This work was supported by Grants FISS 01/1656, FISS PI020227, SAF 2004-05250 and 2002XT00115. XD holds a postdoctoral fellowship supported by Department d’Universitats, Recerca i Societat de la Informació, Generalitat de Catalunya (2003RED0018). JP holds a research fellowship from the Fondo de Investigaciones Sanitarias, Ministerio de Sanidad y Consumo (BEFI-02/9007). The work was also supported by FIS (PI020051 and Redes de Investigación Cooperativa), Fundació La Caixa 2002 and Suport als Grups de Recerca (Generalitat de Catalunya).
https://doi.org/10.1038/labinvest.3700286
008550
0023-6837
http://hdl.handle.net/10459.1/57087
eng
Nature Publishing Group
MIECI/PN2004-2007/SAF2004-05250
Reproducció del document publicat a https://doi.org/10.1038/labinvest.3700286
Laboratory Investigation, 2005, vol. 85, núm. 7, p. 885-894
(c) USCAP, Inc., 2005
info:eu-repo/semantics/restrictedAccess
Endometrial carcinoma
FLIP
TRAIL
Tissue microarray
FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis
article
publishedVersion
xmatias@bellvitgehospital.cat
Matias-Guiu, Xavier
ORIGINAL
008550.pdf
008550.pdf
application/pdf
432063
https://repositori.udl.cat/bitstreams/fcdafe00-c009-451e-ada1-e18601615090/download
4648b40f885af640c794cbb550b39034
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/6961965c-b500-4a8b-970f-257ec034d236/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
008550.pdf.jpg
008550.pdf.jpg
Generated Thumbnail
image/jpeg
6129
https://repositori.udl.cat/bitstreams/84645fee-0d2a-463d-a013-42b9a74de62d/download
a625e8271fc04ad9eb953888c320b338
MD5
3
TEXT
008550.pdf.txt
008550.pdf.txt
Extracted Text
text/plain
38064
https://repositori.udl.cat/bitstreams/9211a88f-7b77-4981-bde9-8c889e4f871f/download
8d88a296ff2bb72c3a7659090a658151
MD5
4
10459.1/57087
oai:repositori.udl.cat:10459.1/57087
2022-02-16 11:00:20.003
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/570882022-11-28T20:07:24Zcom_10459.1_227com_10459.1_2col_10459.1_314col_10459.1_49291
Pallares, Judit
Bussaglia, Elena
Martínez-Guitarte, Jose Luis
Dolcet Roca, Xavier
Llobet Navàs, David
Rué i Monné, Montserrat
Sanchez-Verde, Lidia
Palacios, José
Prat, Jaime
Matias-Guiu, Xavier
2016-05-24T08:19:03Z
2025-01-01
2005
The tumor suppressor gene PTEN/MMAC1 is located on chromosome 10q23.3. Inactivation of PTEN, either by
mutations, deletions, or promoter hypermethylation, has been identified in a wide variety of tumors. Inactivation
of the two alleles of PTEN is required, because it is a tumor suppressor gene. Immunohistochemical staining
may be an effective screening method to demonstrate the absence of the protein in tumors exhibiting PTEN
inactivation. We studied a tissue microarray, constructed from paraffin-embedded blocks of 95 endometrial
carcinomas, 38 of them previously evaluated for alterations in PTEN. We also studied cell blocks obtained from
one PTEN-defective endometrial cancer cell line, after transfection with either a plasmid encoding wild-type
PTEN or the empty vector. The tumor samples were tested with four different anti-PTEN commercial antibodies:
a polyclonal antibody, the monoclonal antibody 28H6, the monoclonal antibody 10P03, and the monoclonal
antibody 6.H2.1. Results were correlated with the presence of abnormalities in PTEN, as well as with the
immunohistochemical expression of phosphorylated AKT. Antibody 28H6 produced a predominant nuclear
staining, while the other three antibodies produced a predominant cytoplasmic staining. There was no
significant correlation between the results obtained with the four antibodies. The monoclonal antibody 6.H2.1
was the only one that exhibited a correlation with the presence of molecular alterations in PTEN, and a
statistically significant association with immunostaining for phosphorylated AKT (r ¼ 0.249, P ¼ 0.037). The
monoclonal antibody 10P03 exhibited an association with phospho-AKT that did not have statistical
significance. Both 6.H2.1 and 10P03 antibodies stained PTEN-transfected cells, and were negative in the
PTEN-deficient cell line blocks. The polyclonal antibody and the monoclonal antibody 28H6 produced positive
staining in PTEN-deficient cell line blocks, suggesting nonspecific staining. The results indicate that
monoclonal antibody 6.H2.1 may be a suitable alternative for tumors with inactivation of PTEN.
This work was supported by Grants FISS 01/1656, FISS PI020227, SAF 2004-05250, and 2002XT00115. JP holds a research fellowship from the Fondo de Investigaciones Sanitarias, Ministerio de Sanidad y Consumo (BEFI-02/9007)). JLMG and XD hold a postdoctoral fellowship supported by the Department d’Universitats, Recerca i Societat de la Informació, Generalitat de Catalunya (2002RED005 and, 2003RED0018).
https://doi.org/10.1038/modpathol.3800347
002567
0893-3952
http://hdl.handle.net/10459.1/57088
eng
Nature Publishing Group
info:eu-repo/grantAgreement/MEC//SAF2004-05250/ES/
Reproducció del document publicat a https://doi.org/10.1038/modpathol.3800347
Modern Pathology, 2005, vol. 18, núm. 5, p. 719-727
(c) USCAP, Inc., 2005
info:eu-repo/semantics/restrictedAccess
Endometrial carcinoma
PTEN
Tissue microarray
Molecular pathology
Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities
article
publishedVersion
xmatias@bellvitgehospital.cat
Matias-Guiu, Xavier
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/a2118ac2-45b0-43bb-b171-826affe3d5a4/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
002567.pdf.jpg
002567.pdf.jpg
Generated Thumbnail
image/jpeg
6200
https://repositori.udl.cat/bitstreams/66d70306-660f-4d66-b016-fac644316a08/download
efaa03ddba574361e3f9baa8b8a4a125
MD5
3
TEXT
002567.pdf.txt
002567.pdf.txt
Extracted Text
text/plain
33751
https://repositori.udl.cat/bitstreams/a8f437a9-294f-49cf-9a26-8e5190b5cee0/download
7a218a58166c62b6f49d31a44595d6e7
MD5
4
ORIGINAL
002567.pdf
002567.pdf
application/pdf
290344
https://repositori.udl.cat/bitstreams/b8e2e854-5722-4d5e-9a40-b81d3c160f2b/download
1381a74077590e9c6f7428945888f84b
MD5
1
10459.1/57088
oai:repositori.udl.cat:10459.1/57088
2022-11-28 20:07:24.033
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/570322021-08-30T15:04:30Zcom_10459.1_227com_10459.1_2col_10459.1_314col_10459.1_49291
Fernández Hernández, Rita
Rafel i Borrell, Marta
Pérez Fusté, Noel
Aguayo Ortiz, Rafael
Casanova i Seuma, Josep M. (Josep Manel)
Egea Navarro, Joaquim
Ferrezuelo, Francisco
Garí Marsol, Eloi
2016-05-17T09:32:21Z
2025-01-01
2013
The function of Cyclin D1 (CycD1) has been widely studied in the cell nucleus as a regulatory subunit of the cyclindependent
kinases Cdk4/6 involved in the control of proliferation and development in mammals. CycD1 has been also
localized in the cytoplasm, where its function nevertheless is poorly characterized. In this work we have observed that
in normal skin as well as in primary cultures of human keratinocytes, cytoplasmic localization of CycD1 correlated with
the degree of differentiation of the keratinocyte. In these conditions, CycD1 co-localized in cytoplasmic foci with exocyst
components (Sec6) and regulators (RalA), and with β1 integrin, suggesting a role for CycD1 in the regulation of keratinocyte
adhesion during differentiation. Consistent with this hypothesis, CycD1 overexpression increased β1 integrin
recycling and drastically reduced the ability of keratinocytes to adhere to the extracellular matrix. We propose that localization
of CycD1 in the cytoplasm during skin differentiation could be related to the changes in detachment ability of
keratinocytes committed to differentiation.
This work was funded by the Spanish Ministry of Education and Science (BFU2010-20293/BMC), by the Catalan Government (SGR-559), and by Consolider- Ingenio 2010 (CSD2007-00015). Joaquim Egea is a researcher of the Ramon y Cajal program (RYC-2008-03342).
https://doi.org/10.4161/cc.25590
021252
1538-4101
http://hdl.handle.net/10459.1/57032
eng
Taylor & Francis
MICINN/PN2008-2011/BFU2010-20293/BMC
Reproducció del document publicat a https://doi.org/10.4161/cc.25590
Cell Cycle, 2013, vol. 12, núm. 15
(c) Taylor & Francis, 2013
info:eu-repo/semantics/restrictedAccess
Cyclin D1
Cytoplasm
Keratinocytes
Cyclin D1 localizes in the cytoplasm of keratinocytes during skin differentiation and regulates cell–matrix adhesion
article
publishedVersion
eloi.gari@cmb.udl.cat
Garí Marsol, Eloi
ORIGINAL
Cell Cycle, 2013, vol. 12, núm. 15,(1).pdf
Cell Cycle, 2013, vol. 12, núm. 15,(1).pdf
021252.pdf
application/pdf
3732951
https://repositori.udl.cat/bitstreams/23496730-f179-4682-bc36-65b393470c85/download
2611fcdc4d73ef903e977873edb0c3ee
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/fbb589f4-6467-4e4c-b1b9-91e67489a4a8/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
Cell Cycle, 2013, vol. 12, núm. 15,(1).pdf.jpg
Cell Cycle, 2013, vol. 12, núm. 15,(1).pdf.jpg
Generated Thumbnail
image/jpeg
4705
https://repositori.udl.cat/bitstreams/c5a979bb-c190-446c-89d1-0954388e4da7/download
039f95822cd8f765b30ff41ee26bc61b
MD5
3
TEXT
Cell Cycle, 2013, vol. 12, núm. 15,(1).pdf.txt
Cell Cycle, 2013, vol. 12, núm. 15,(1).pdf.txt
Extracted Text
text/plain
8
https://repositori.udl.cat/bitstreams/cd3504fa-5c68-4e53-84c6-ed320d983a00/download
f7623c02d2cd7fc8e87e4eb1187d3b31
MD5
4
10459.1/57032
oai:repositori.udl.cat:10459.1/57032
2021-08-30 15:04:30.827
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/566962021-08-30T15:04:33Zcom_10459.1_227com_10459.1_2col_10459.1_314
Soler González, Jorge
Serna Arnaiz, Catalina
Bosch, Anna
Ruiz-Magaz, Maria Cristina
Huertas, E.
Rué i Monné, Montserrat
2016-03-11T10:50:05Z
2016-03-11T10:50:05Z
2025-01-01
2008
Objectives The incidence and duration of sick leave were studied among immigrants and the native-born
population in Spain.
Methods This observational follow-up study included 1427 immigrants and 2793 Spanish natives treated at five
primary care centers in Lleida in 2005 and followed for 6 months. The sick leave causes were coded according
to the International Classification of Diseases (10th revision). Multivariate Poisson regressions estimated the rate
ratio (RR) for sick leave adjusted for age, and linear regressions evaluated the effect of age, gender, and region
of origin on the total number of sick-leave days.
Results Altogether 19.5% of the natives and 12.7% of the immigrants had at least one sick-leave episode. The
incidence of new episodes per 100 person-years was lower for the immigrants than for the natives (32.5 versus
43.3 for the men and 18.6 versus 35.6 for the women, respectively). The mean duration of sick leave in the 6-
month period was 19.4 (SD 29.4) days for the immigrants and 33.5 (SD 39.2) days for the natives. For the men,
the risk of sick leave was greater for the natives than for the immigrants (adjusted RR 1.70, 95% confidence
interval 1.43–2.02). After adjustment for age, the duration of sick leave for the native workers was 1.5 times
greater than for the immigrants.
Conclusions Even though sick leave was less frequent among the immigrants than among the natives and the
immigrant sick-leave periods were of shorter duration, the two study populations did not show differences in
the causes of disability.
https://doi.org/10.5271/sjweh.1288
013071
0355-3140
http://hdl.handle.net/10459.1/56696
eng
Nordic Association of Occupational Safety and Health
Reproducció del document publicat a https://doi.org/10.5271/sjweh.1288
Scandinavian Journal of Work, Environment and Health, 2008, vol. 34, núm. 6, p. 438-443
(c) Scandinavian Journal of Work, Environment & Health, 2008
info:eu-repo/semantics/restrictedAccess
Absenteeism
Immigration
Job satisfaction
Migrant worker
Sick leave among native and immigrant workers in Spain: a 6-month follow-up study
article
publishedVersion
jorge.soler@medicina.udl.cat
Soler González, Jorge
ORIGINAL
013071.pdf
013071.pdf
application/pdf
176074
https://repositori.udl.cat/bitstreams/597944a5-d844-467c-a1e6-0575e562b31a/download
7ee30d831628b006961467b6c6fad4b7
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/0c2c6427-b485-44e9-ab6a-89dbdb07204d/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
013071.pdf.jpg
013071.pdf.jpg
Generated Thumbnail
image/jpeg
3330
https://repositori.udl.cat/bitstreams/3dba42d1-c324-4520-a5b2-a8484131d20e/download
e8d7a39e1fbe12ca868357cf4beaeb9e
MD5
3
TEXT
013071.pdf.txt
013071.pdf.txt
Extracted Text
text/plain
29151
https://repositori.udl.cat/bitstreams/4b668d01-389c-4133-b798-659e5857bc9e/download
5617e1f75586a4f2e863b8d2e667a9b4
MD5
4
10459.1/56696
oai:repositori.udl.cat:10459.1/56696
2021-08-30 15:04:33.575
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/694692020-09-09T00:19:35Zcom_10459.1_227com_10459.1_2col_10459.1_314
Tarragona Foradada, Jordi
Pallarés, J.
Buetas, P.
Subirats, A.
Matias-Guiu, Xavier
2020-09-08T09:14:14Z
2020-09-08T09:14:14Z
2019-10
2020-09-08T09:14:16Z
application/pdf
030051
2013-5238
http://hdl.handle.net/10459.1/69469
cat
Societat Catalana de Citopatologia
Reproducció del document publicat a: http://webs.academia.cat/societats/citopato/docs/10citopatcat2018.pdf
CITOPAT.CAT , 2019, vol. 10, p. 80-82
(c) Societat Catalana de Citopatologia, 2019
info:eu-repo/semantics/openAccess
Punción-aspiración con aguja fina
Melanoma
Metástasis
Pulmón
Metàstasis de melanoma maligne en nòduls pulmonar múltiples
info:eu-repo/semantics/article
"acceptedVersion"
ORIGINAL
030051.pdf
030051.pdf
application/pdf
1163835
https://repositori.udl.cat/bitstreams/d910e715-1c6d-44ea-90ee-c5eac3753e27/download
7ef05ee627f0020c2c0a592103f4722e
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/1c2ba18d-a9aa-4a99-98eb-140cccb86202/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
SWORD
mets.xml
SWORD deposit package
application/octet-stream
8107291
https://repositori.udl.cat/bitstreams/e9f28a13-b9a7-413a-ac7b-6e4d66d88655/download
64e19b0a1d3c237815f35e87e975d4b0
MD5
3
THUMBNAIL
030051.pdf.jpg
030051.pdf.jpg
Generated Thumbnail
image/jpeg
5224
https://repositori.udl.cat/bitstreams/adbe0666-97ff-4e8e-9f2f-7d66c79cfac7/download
d2d4b57b045102577994f4fe47b3cc58
MD5
5
TEXT
030051.pdf.txt
030051.pdf.txt
Extracted Text
text/plain
5769
https://repositori.udl.cat/bitstreams/d487c321-1276-438f-a610-dfa8221dceb8/download
31b4f8267bec2a7e9fb2e204f481b5a7
MD5
6
10459.1/69469
oai:repositori.udl.cat:10459.1/69469
2020-09-09 00:19:35.254
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/567522021-08-30T15:04:33Zcom_10459.1_227com_10459.1_2col_10459.1_314
Echave Lozano, Pedro
Esparza-Cerón, M. Angel
Cabiscol Català, Elisa
Tamarit Sumalla, Jordi
Ros Salvador, Joaquim
Membrillo-Hernández, Jorge
Lin, Edmund C. C.
2016-03-29T08:54:34Z
2016-03-29T08:54:34Z
2025-01-01
2002
The adhE gene of Escherichia coli encodes a multifunctional ethanol
oxidoreductase (AdhE) that catalyzes successive reductions of
acetyl-CoA to acetaldehyde and then to ethanol reversibly at the
expense of NADH. Mutant JE52, serially selected for acquired and
improved ability to grow aerobically on ethanol, synthesized an
AdhEA267T/E568K with two amino acid substitutions that sequentially
conferred improved catalytic properties and stability. Here
we show that the aerobic growth ability on ethanol depends also
on protection of the mutant AdhE against metal-catalyzed oxidation
by the chaperone DnaK (a member of the Hsp70 family). No
DnaK protection of the enzyme is evident during anaerobic growth
on glucose. Synthesis of DnaK also protected E. coli from H2O2
killing under conditions when functional AdhE is not required. Our
results therefore suggest that, in addition to the known role of
protecting cells against heat stress, DnaK also protects numerous
kinds of proteins from oxidative damage.
https://doi.org/10.1073/pnas.072504199
000008
1091-6490
http://hdl.handle.net/10459.1/56752
eng
National Academy of Sciences
Reproducció del document publicat a http//dx.doi.org/10.1073pnas.072504199
PNAS, 2002, vol. 99, núm. 7, p. 4626-4631
(c) National Academy of Sciences, 2002
info:eu-repo/semantics/restrictedAccess
DnaK dependence of mutant ethanol oxidoreductases evolved for aerobic function and protective role of the chaperone against protein oxidative damage in Escherichia coli
article
publishedVersion
elisa.cabiscol@cmb.udl.cat
Cabiscol Català, Elisa
THUMBNAIL
000008.pdf.jpg
000008.pdf.jpg
Generated Thumbnail
image/jpeg
6125
https://repositori.udl.cat/bitstreams/9edd99c1-e677-4ee5-8f99-98b886d30b28/download
2ead8dc913727068317e1ad91c354d09
MD5
3
TEXT
000008.pdf.txt
000008.pdf.txt
Extracted Text
text/plain
34432
https://repositori.udl.cat/bitstreams/4f967e67-866a-48cd-8818-23efeb3d36b1/download
bd5366e05befc33c9897d9535db5387b
MD5
4
ORIGINAL
000008.pdf
000008.pdf
application/pdf
375211
https://repositori.udl.cat/bitstreams/dac358c7-b0cb-46b4-b384-6a3ca14b35f2/download
b235c6f544b22d685197c9aa8b313ac7
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/59ed1f58-5256-4dd4-8f85-49612eb438ce/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
10459.1/56752
oai:repositori.udl.cat:10459.1/56752
2021-08-30 15:04:33.561
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/4640632023-10-03T03:00:25Zcom_10459.1_227com_10459.1_2com_10459.1_237com_10459.1_47453col_10459.1_314col_10459.1_354col_10459.1_59998
Targa, Adriano
Benítez, Iván
Moncusí Moix, Anna
Dakterzada, Farida
Minguez Roure, Olga
Vaca, Rafaela
Dalmases, Mireia
Sánchez de la Torre, Manuel
Barbé Illa, Ferran
Piñol Ripoll, Gerard
2023-10-02T11:52:47Z
2023-10-02T11:52:47Z
2023
Background Previous studies challenge the impact of obstructive sleep apnea (OSA) once patients are diagnosed with Alzheimer’s disease (AD). Nevertheless, OSA recognizably disrupts sleep, and relevant associations between sleep, AD pathological markers, and cognition have been demonstrated. We aimed to further explore this, evaluating the associations between each breathing cessation event that compose the apnea–hypopnea index (AHI) and the sleep structure to finally investigate whether this was related to increased levels of AD markers and higher cognitive decline.
Methods Observational, prospective study, including consecutive patients diagnosed with mild-moderate AD. The participants were submitted to overnight polysomnography followed by a cerebrospinal fluid collection for AD pathological markers levels determination. Neuropsychological assessment was performed at baseline and after 12 months of follow-up.
Results The cohort was composed of 116 patients (55.2% females) with a median [p25;p75] age of 76.0 [72.0;80.0] years and an AHI of 25.9 [15.1;48.5], which was mainly defined by the presence of hypopneas and obstructive apneas.
These were distinctively associated with the sleep structure, with obstructive apneas being related to arousals and sleep lightening and hypopneas being related to an increased number of arousals only. Despite having a lower
frequency, mixed and central apneas also presented associations with the sleep structure, particularly increasing the time spent in the lighter sleep stages. In relation to AD pathological markers, obstructive and mixed apneas were related to an augment in neurofilament light levels while hypopneas were associated with a higher phosphorylated- tau/amyloid-beta protein ratio. Hypopneas were the most important event for an increased cognitive decline
at the 12-month follow-up.
Conclusions Our findings highlight the importance of a patient-centered approach, with a comprehensive and detailed analysis of the AHI to effectively predict the different outcomes and tailor the appropriate therapeutic strategies.
Generalitat of Catalonia, Department of Health (PERIS 2019 SLT008/18/00050) and “Fundacio La Marato TV3”(464/C/2014) to GPR. Co-financed by FEDER funds from the European Union (‘A way to build Europe’). IRBLleida is a CERCA Programme/Generalitat of Catalonia. FD was supported by Agency for Management of University and Research Grants (FI_B100153). MSdT has received financial support from the “Ramon y Cajal” grant (RYC2019-027831-I) from the “Ministerio de Ciencia e Innovacion—Agencia Estatal de Investigacion” cofunded by the European Social Fund (ESF)/ “Investing in your future.”
https://doi.org/10.1186/s13195-023-01266-x
033426
1758-9193
https://repositori.udl.cat/handle/10459.1/464063
eng
BMC
Reproducció del document publicat a: https://doi.org/10.1186/s13195-023-01266-x
Alzheimer's Research and Therapy, 2023, vol. 15, núm. 1
cc-by (c) Authors, 2023
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Alzheimer’s disease
Obstructive sleep apnea
Apnea–hypopnea index
Hypopneas
Cognitive decline
Breathing cessation events that compose the apnea–hypopnea index are distinctively associated with the adverse outcomes in Alzheimer’s disease
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
033426.pdf
033426.pdf
application/pdf
2745127
https://repositori.udl.cat/bitstreams/4e6b29de-940f-4755-839f-0c12628994b7/download
dcddd4b5adab4cdaaf5a29d80564834c
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1019
https://repositori.udl.cat/bitstreams/a52ff92c-082f-4c76-805b-25cebf89f711/download
313ea3fe4cd627df823c57a0f12776e5
MD5
2
TEXT
033426.pdf.txt
033426.pdf.txt
Extracted text
text/plain
49848
https://repositori.udl.cat/bitstreams/384427c1-be2e-4409-81e0-4b8f77a6bdfb/download
14457622b73cf1fb499a212860a9c734
MD5
4
THUMBNAIL
033426.pdf.jpg
033426.pdf.jpg
Generated Thumbnail
image/jpeg
5634
https://repositori.udl.cat/bitstreams/2d4f52e2-a80a-48ff-a106-e100c85510cc/download
c9c1a30919408b05d103ee743ed5a94a
MD5
5
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
639
https://repositori.udl.cat/bitstreams/99844b18-da06-4dec-a321-d26fdd1ee072/download
15ec217096d63e7cd318d42eb888308c
MD5
3
10459.1/464063
oai:repositori.udl.cat:10459.1/464063
2023-10-03 03:00:25.219
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Authors, 2023
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/707772021-03-18T00:24:59Zcom_10459.1_227com_10459.1_2col_10459.1_314
Bersweiler, Antoine
d’Autréaux, Benoît
Mazon, Hortense
Kriznik, Alexandre
Bellí i Martínez, Gemma
Delaunay-Moisan, Agnès
Toledano, Michel B.
Rahuel-Clermont, Sophie
2021-03-17T12:32:58Z
2021-03-17T12:32:58Z
2017
In Saccharomyces cerevisiae, Yap1 regulates an H2O2-inducible transcriptional response that controls cellular H2O2 homeostasis. H2O2 activates Yap1 by oxidation through the intermediacy of the thiol-peroxidase Orp1. Upon reacting with H2O2, Orp1 catalytic cysteine oxidizes to a sulfenic acid, which then engages either into an intermolecular disulfide with Yap1 that leads to Yap1 activation, or an intramolecular disulfide that commits the enzyme into its peroxidatic cycle. Of these two competing reactions, how the former one, which is kinetically unfavorable, occurs? We show that the Yap1-binding-protein Ybp1 brings together Orp1 and Yap1 into a ternary complex that selectively activates condensation of the Orp1 sulfenylated cysteine with one of the six Yap1 cysteines, while inhibiting Orp1 intramolecular disulfide formation. We propose that Ybp1 operates as a scaffold protein and as a sulfenic acid chaperone to provide specificity into the transfer of oxidizing equivalents by a reactive sulfenic acid species.
We gratefully acknowledge G. Branlant for his essential input to initiate the project. We also thank A. Gruez for assistance with protein stability optimization; S. Boschi-Muller and F. Talfournier for fruitful discussions and help with quench flow experiments; J.M. Alberto for support with the use of the NGERE U954-INSERM chromatographic facility; and J. Charbonnel and G. Palais for excellent technical support. Microcalorimetry and mass spectrometry were performed respectively at the SCBIM (Federation de Recherche 3209 BMCT) and SCMS platforms of Universite de Lorraine. This work was supported by grants from the Ligue contre le Cancer to S.R.-C., and from ANR ERRed, InCA PLBIO INCA_5869 to M.B.T. A.B. was supported by a PhD fellowship from the French research minister.
https://doi.org/10.1038/nchembio.2412
026782
1552-4469
http://hdl.handle.net/10459.1/70777
eng
Nature Reseach
Versió postprint del document publicat a https://doi.org/10.1038/nchembio.2412
Nature Chemical Biology, 2017, vol. 13, núm. 8, p.909-915
(c) Bersweiler et al., 2017
info:eu-repo/semantics/openAccess
A scaffold protein that chaperones a cysteine-sulfenic acid in H2O2 signaling
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
TEXT
026782.pdf.txt
026782.pdf.txt
Extracted Text
text/plain
66883
https://repositori.udl.cat/bitstreams/26b9df55-6141-4d95-8144-196960ab924b/download
8d7e80ad81c7460d43664dd305a93488
MD5
5
ORIGINAL
026782.pdf
026782.pdf
Postprint
application/pdf
5608395
https://repositori.udl.cat/bitstreams/e778e214-387b-4a52-bf93-ac46320338ff/download
a083560993a3f1aa9b64e56fb3773087
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/8542cb79-b6ad-4c5e-8c45-589901707aee/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
026782.pdf.jpg
026782.pdf.jpg
Generated Thumbnail
image/jpeg
2105
https://repositori.udl.cat/bitstreams/8b11d1bc-034f-44dc-87ae-34250dc642d9/download
d9f35b46b2ddb17b213f1de91e41ba56
MD5
4
10459.1/70777
oai:repositori.udl.cat:10459.1/70777
2021-03-18 00:24:59.392
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/603282022-01-12T12:23:37Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Ramírez-Morros, Anna
Granado Casas, Minerva
Alcubierre Calvo, Núria
Martínez Alonso, Montserrat
Real, Jordi
Castelblanco Echavarría, Esmeralda
Esquerda, Aureli
Cao, Gonzalo
Rubinat, Esther
Hernández García, Marta
Alonso, Núria
Fernández i Giráldez, Elvira
Mauricio Puente, Dídac
2017-10-20T09:01:54Z
2017-10-20T09:01:54Z
2017
Aims. To assess whether circulating 25-hydroxyvitamin D3 (25OHD) and mineral metabolism-related factors (serum phosphate, calcium, and parathormone) are associated with subclinical carotid atherosclerosis (SCA), defined as the presence of carotid atherosclerotic plaques (main study outcome), in patients with type 2 diabetes mellitus (T2DM) without kidney disease or previous cardiovascular disease. Methods. We undertook a post hoc analysis of a cross-sectional study in adults with T2DM in whom we evaluated SCA. A total of 303 subjects with T2DM were included. Clinical variables and carotid ultrasound imaging were obtained. Results. We found no association of 25OHD with the presence of SCA. However, calcium phosphate (CaP; mg2/dL2) product was positively associated with the presence of carotid plaques (ORadj = 1.078; 95% CI: 1.017–1.142). An inverse association was observed between higher levels of 25OHD (≥30 ng/mL versus <20 ng/mL concentrations) and common carotid intima-media thickness (cIMT; mm) (βadj ± SE = −0.055 ± 0.024). We conclude that the CaP product is independently associated with the presence of established subclinical carotid atherosclerosis in patients with T2DM.
This study was supported by Grants PS09/01035 and PI15/ 00625 from Instituto de Salud Carlos III, Ministry of Economy and Competitiveness, Spain. CIBERDEM is an initiative from Instituto de Salud Carlos III (Plan Nacional de I+D+I and Fondo Europeo de Desarrollo Regional). Minerva Granado-Casas holds a predoctoral fellowship from Ministerio de Educación, Cultura y Deporte, FPU15/03005.
https://doi.org/10.1155/2017/3498368
026043
2314-6745
http://hdl.handle.net/10459.1/60328
eng
Hindawi Publishing Corporation
Reproducció del document publicat a https://doi.org/10.1155/2017/3498368
Journal of Diabetes Research, 2017, vol. 2017, id. 3498368
cc-by (c) Ramírez-Morros et al., 2017
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Calcium phosphate product is associated with subclinical carotid atherosclerosis in type 2 diabetes
article
publishedVersion
ORIGINAL
026043.pdf
026043.pdf
application/pdf
1403528
https://repositori.udl.cat/bitstreams/d6b4676d-7ae2-4c76-a662-14a890cac818/download
16592785eead0a07fe4a5e9271bfbdd8
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/f961fa5a-c0d2-467e-99d4-f8bb4e8a4916/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://repositori.udl.cat/bitstreams/436e44d4-f03c-4051-9d23-b00c0141a274/download
0175ea4a2d4caec4bbcc37e300941108
MD5
2
THUMBNAIL
026043.pdf.jpg
026043.pdf.jpg
Generated Thumbnail
image/jpeg
4901
https://repositori.udl.cat/bitstreams/63dcd1ce-ee81-4271-895f-686c0c4aff32/download
df1a14ebf5537766960a90c9e84999b7
MD5
4
TEXT
026043.pdf.txt
026043.pdf.txt
Extracted Text
text/plain
41349
https://repositori.udl.cat/bitstreams/3aa2d21d-fc1e-4f88-b924-fb8853915cd9/download
43369864dbad1406dc0c30f367bb4305
MD5
5
10459.1/60328
oai:repositori.udl.cat:10459.1/60328
2022-01-12 12:23:37.32
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Ramírez-Morros et al., 2017
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/679972020-02-13T00:15:28Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Herrero, Rocío
Real, Luis M.
Rivero-Juárez, Antonio
Pineda, Juan Antonio
Camacho, Ángela
Macías, Juan
Laplana Lafaja, Marina
Konieczny, Piotr
Márquez, Francisco J.
Souto, Juan Carlos
Soria, José Manuel
Saulle, Irma
Lo Caputo, Sergio
Biasin, Mara
Rivero, Antonio
Fibla Palazón, Joan
Caruz, Antonio
2020-02-12T07:52:23Z
2020-02-12T07:52:23Z
2015-03
2020-02-12T07:52:23Z
HIV-1 induces activation of complement through the classical and lectin pathways. However, the virus incorporates several membrane-bound or soluble regulators of complement activation (RCA) that inactivate complement. HIV-1 can also use the complement receptors (CRs) for complement-mediated antibody-dependent enhancement of infection (Ć-ADE). We hypothesize that hypofunctional polymorphisms in RCA or CRs may protect from HIV-1 infection. For this purpose, 139 SNPs located in 19 RCA and CRs genes were genotyped in a population of 201 Spanish HIV-1-exposed seronegative individuals (HESN) and 250 HIV-1-infected patients. Two SNPs were associated with infection susceptibility, rs1567190 in CR2 (odds ratio (OR)=2.27, P=1 × 10-4) and rs2842704 in C4BPA (OR=2.11, P=2 × 10-4). To replicate this finding, we analyzed a cohort of Italian, sexually HESN individuals. Although not significant (P=0.25, OR=1.57), similar genotypic proportions were obtained for the CR2 marker rs1567190. The results of the two association analyses were combined through a random effect meta-analysis, with a significant P-value of 2.6x10-5 (OR=2.07). Furthermore, we found that the protective CR2 genotype is correlated with lower levels CR2 mRNA as well as differences in the ratio of the long and short CR2 isoforms.Genes and Immunity advance online publication, 8 January 2015; doi:10.1038/gene.2014.71.
This work was supported by Spanish Health Ministry [PI021476, PI051778 and PI10/01232 to JF, JAP and ACar]; Instituto de Salud Carlos III-RETIC [RD06/006 to JAP]; Fundació Marató TV3 [020730 and 020732 to JF and ACar]; Junta de Andalucía [PI-0335/2009 to ACar]; Fundación Progreso y Salud of the Consejería de Salud de la Junta de Andalucía [AI-0021 to JAP]; and Universidad de Jaen [UJA2013/10/03 to ACar].
application/pdf
https://doi.org/10.1038/gene.2014.71
022124
1466-4879
http://hdl.handle.net/10459.1/67997
eng
Springer Nature
Versió postprint del document publicat a: https://doi.org/10.1038/gene.2014.71
Genes and Immunity, 2015, vol. 16, p. 134-141
(c) Herrero, Rocío et al., 2015
info:eu-repo/semantics/openAccess
HIV infection
genetica asociación
genes complemento
Association of complement receptor 2 polymorphisms withinnate resistance to HIV-1 infection
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
ORIGINAL
022124.pdf
022124.pdf
Postprint
application/pdf
873198
https://repositori.udl.cat/bitstreams/139e0e17-8feb-419d-9ea9-b9674a12c538/download
498366cb9e56f7d8f86da9170f3ad6bc
MD5
4
THUMBNAIL
022124.pdf.jpg
022124.pdf.jpg
Generated Thumbnail
image/jpeg
2029
https://repositori.udl.cat/bitstreams/c1fd9e67-cd06-4bc6-89f3-a9ab6cbdb4cf/download
934d3f92399d20cf54759b1fc5fa5a17
MD5
5
TEXT
022124.pdf.txt
022124.pdf.txt
Extracted Text
text/plain
42722
https://repositori.udl.cat/bitstreams/a6494786-d700-427b-b400-47ac910321c9/download
4a0b31b889bb29ce85f12f2600de21cd
MD5
6
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/77f902d9-028e-4b38-89f7-bf10bbef3983/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
SWORD
mets.xml
SWORD deposit package
application/octet-stream
715881
https://repositori.udl.cat/bitstreams/5a52409a-44b5-4aee-9663-82d23c7618f1/download
c842f1dfdda844535b325b397a1c6b7f
MD5
3
10459.1/67997
oai:repositori.udl.cat:10459.1/67997
2020-02-13 00:15:28.916
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/472172017-08-03T09:27:45Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Barreto Parra, Lina Patricia
Garcera, Ana
Jansson, Kristina
Sunnerhagen, Per
Herrero Perpiñán, Enrique
2014-05-16T16:58:31Z
2014-05-16T16:58:31Z
2006
Saccharomyces cerevisiae cells contain three omega-class glutathione transferases with glutaredoxin activity (Gto1, Gto2, and Gto3), in addition to two glutathione transferases (Gtt1 and Gtt2) not classifiable into standard classes. Gto1 is located at the peroxisomes, where it is targeted through a PTS1-type sequence, whereas Gto2 and Gto3 are in the cytosol. Among the GTO genes, GTO2 shows the strongest induction of expression by agents such as diamide, 1-chloro-2,4-dinitrobenzene, tert-butyl hydroperoxide or cadmium, in a manner that is dependent on transcriptional factors Yap1 and/or Msn2/4. Diamide and 1-chloro-2,4-dinitrobenzene (causing depletion of reduced glutathione) also induce expression of GTO1 over basal levels. Phenotypic analyses with single and multiple mutants in the S. cerevisiae glutathione transferase genes show that, in
the absence of Gto1 and the two Gtt proteins, cells display increased sensitivity to cadmium. A gto1-null mutant also shows growth defects on oleic acid-based medium, which is indicative of abnormal peroxisomal functions, and altered expression of genes related to sulfur amino acid metabolism. As a consequence, growth of the gto1 mutant is delayed in growth medium without lysine, serine, or threonine, and the mutant cells have low levels of reduced glutathione. The role of Gto1 at the S. cerevisiae peroxisomes could be related to the redox regulation
of the Str3 cystathionine -lyase protein. This protein is also located at the peroxisomes in S. cerevisiae, where it is involved in transulfuration of cysteine into homocysteine, and requires a conserved cysteine residue for its biological activity.
https://doi.org/10.1128/EC.00216-06
010456
1535-9778 (versió paper)
1535-9786
http://hdl.handle.net/10459.1/47217
eng
American Society for Microbiology
Reproducció del document publicat a https://doi.org/10.1128/EC.00216-06
Eukaryotic cell, 2006, vol. 5, núm. 10, p. 1748-1759
(c) American Society for Microbiology, 2006
info:eu-repo/semantics/openAccess
Llevat de cervesa
Saccharomyces cerevisiae
Aminoàcids--Metabolisme
A peroxisomal glutathione transferase of Saccharomyces cerevisiae is functionally related to sulfur amino acid metabolism
article
publishedVersion
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/8d90a4ab-3973-49a5-8bd0-e574a0cc178d/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
TEXT
10456.pdf.txt
10456.pdf.txt
Extracted Text
text/plain
66705
https://repositori.udl.cat/bitstreams/eff4b888-7c5d-43a5-a53f-b4899da1b09c/download
994e248919efed30b2b427f2409a5301
MD5
8
ORIGINAL
10456.pdf
10456.pdf
application/pdf
645778
https://repositori.udl.cat/bitstreams/0aeafae3-6b28-4e63-beac-1b1b8c40231c/download
26b28f7e52719c14e14f6e58a16ed7f8
MD5
1
THUMBNAIL
10456.pdf.jpg
10456.pdf.jpg
Generated Thumbnail
image/jpeg
5715
https://repositori.udl.cat/bitstreams/e3844168-6494-47a4-9d3c-6f34c0fa21d7/download
f6ccc639a805725ae2c8ce8e5b73c9d7
MD5
7
10459.1/47217
oai:repositori.udl.cat:10459.1/47217
2017-08-03 09:27:45.016
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/566942021-08-30T15:04:33Zcom_10459.1_227com_10459.1_2col_10459.1_314
Séculi, E.
Fusté Sugrañes, Josep
Brugulat, Pilar
Juncà, S.
Rué i Monné, Montserrat
Guillén, M.
2016-03-11T09:00:12Z
2016-03-11T09:00:12Z
2025-01-01
2001
Objetivo: Analizar las diferencias en la percepción del estado
de salud de los varones y mujeres en las últimas etapas
de la vida y explorar su relación con variables sociodemográficas
y de salud.
Métodos: Datos procedentes de la Encuesta de Salud de
Cataluña de 1994, de 1.459 varones y 1.993 mujeres de 60
y más años. Se realizó un análisis de la autovaloración del
estado de salud según la edad, el sexo, la clase social, la declaración
de enfermedades crónicas y la discapacidades y se
aplicó un modelo de análisis multivariable de regresión logística
teniendo en cuenta el diseño muestral.
Resultados: El 57,3% de las mujeres de 60 y más años declaraba
no tener buena salud, frente al 43,6% de los varones.
También fue superior la proporción de mujeres que padecía
una o más discapacidades (41,2%) respecto a los varones
(28,7%), así como la de enfermedades crónicas, el 92,2% de
las mujeres y el 85,6% de los varones. En el modelo de regresión
logística multivariable continúa manteniéndose una percepción
de mala salud superior en las mujeres y aparecen
como factores explicativos el número de enfermedades cró-
nicas, padecer discapacidades y pertenecer a las clases sociales
más desfavorecidas. La edad en interacción con las enfermedades
crónicas amortigua el efecto de éstas en la
valoración del estado de salud.
Conclusiones: Entre la población anciana, la percepción de
mala salud fue superior en las mujeres incluso ajustando por
otras variables explicativas significativas (clase social, edad,
discapacidades y enfermedades crónicas). Padecer enfermedades
crónicas y/o discapacidades constituyen los factores
explicativos más importantes en la percepción del estado
de salud. El impacto del padecimiento de enfermedades
crónicas en relación con la percepción de mala salud disminuye
a medida que los grupos son de mayor edad.
https://doi.org/10.1016/S0213-9111(01)71550-6
009175
0213-9111
http://hdl.handle.net/10459.1/56694
spa
Elsevier España
Reproducció del document publicat a http:/dx.doi.org/10.1016/S0213-9111(01)71550-6
Gaceta Sanitaria, 2001, vol. 15, núm. 3, p. 217-223
(c) Elsevier España, 2001
info:eu-repo/semantics/restrictedAccess
Género
Estado de salud percibido
Desigualdades en salud
Encuestas de salud
Percepción del estado de salud en varones y mujeres en las últimas etapas de la vida
article
publishedVersion
montse.rue@cmb.udl.cat
Rué i Monné, Montserrat
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1232
https://repositori.udl.cat/bitstreams/ea0aec64-f7da-44d1-be41-f2ed77a8a39c/download
b51f25f83cca752633b6ec4c418dbcc7
MD5
2
THUMBNAIL
009175.pdf.jpg
009175.pdf.jpg
Generated Thumbnail
image/jpeg
4067
https://repositori.udl.cat/bitstreams/6bf5eeb8-8d0e-4146-935d-c2b72112834a/download
35b5610b70ba819cbe518f1d0218f37b
MD5
4
ORIGINAL
009175.pdf
009175.pdf
application/pdf
51732
https://repositori.udl.cat/bitstreams/7f11e0c1-5900-4219-948d-df1628635aa0/download
5997c0e75aaf974b5e3298f535715875
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/abcfbb33-5f23-498d-bc96-cb647d99082f/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
TEXT
009175.pdf.txt
009175.pdf.txt
Extracted Text
text/plain
32851
https://repositori.udl.cat/bitstreams/a2db73a5-63a5-45db-8a8d-264663f51569/download
0553a60faa8b24b30333c2e8915255ea
MD5
5
10459.1/56694
oai:repositori.udl.cat:10459.1/56694
2021-08-30 15:04:33.551
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/570292021-08-30T15:04:34Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Akita, Tenpei
Kumada, Tatsuro
Yoshihara, Sei-ichi
Egea Navarro, Joaquim
Yamagishi, Satoru
2016-05-13T10:29:55Z
2025-01-01
2015
Our sophisticated thoughts and behaviors are based on the miraculous development of our complex nervous network system, in which many different types of proteins and signaling cascades are regulated in a temporally and spatially ordered manner. Here we review our recent attempts to grasp the principles of nervous system development in terms of general cellular phenomena and molecules, such as volume-regulated anion channels, intracellular Ca2+ and cyclic nucleotide signaling, the Npas4 transcription factor and the FLRT family of axon guidance molecules. We also present an example illustrating that the same FLRT family may regulate the development of vascular networks as well. The aim of this review is to open up new vistas for understanding the intricacy of nervous and vascular system development.
https://doi.org/10.1007/s12576-015-0416-1
023960
1880-6546
http://hdl.handle.net/10459.1/57029
eng
Springer
Reproducció del document publicat a https://doi.org/10.1007/s12576-015-0416-1
The Physiological Society of Japan, 2015, vol. 66, núm. 2, p. 175-188
(c) Springer, 2015
info:eu-repo/semantics/restrictedAccess
Nervous system development
Anion channel
Intracellular signaling
Transcription factor
Ion channels, guidance molecules, intracellular signaling and transcription factors regulating nervous and vascular system development
article
publishedVersion
joaquim.egea@cmb.udl.cat
Egea Navarro, Joaquim
THUMBNAIL
023960.pdf.jpg
023960.pdf.jpg
Generated Thumbnail
image/jpeg
5361
https://repositori.udl.cat/bitstreams/8c345334-7905-4879-8373-38fa19e07c0c/download
13c4c52db8a4b26b4434e4953c125fc2
MD5
3
ORIGINAL
023960.pdf
023960.pdf
application/pdf
1922378
https://repositori.udl.cat/bitstreams/6f0f15e7-2eb0-4251-b3a7-79d1b3a0b290/download
cd417806c95529972b4a73eb71c46c0a
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/2ebdb653-6db9-46ad-9dde-7bedd61c9e67/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
TEXT
023960.pdf.txt
023960.pdf.txt
Extracted Text
text/plain
75675
https://repositori.udl.cat/bitstreams/c535e29d-3828-4bbe-8269-c55ba916a8ea/download
0ee7d670a4747fa02f53ed2e4c8433aa
MD5
4
10459.1/57029
oai:repositori.udl.cat:10459.1/57029
2021-08-30 15:04:34.157
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/472002017-08-02T12:22:46Zcom_10459.1_227com_10459.1_2col_10459.1_314
Herrero Perpiñán, Enrique
Jackson, Maria
Bassford, Phillip J.
Sinden, David
Holland, I. Barry
2014-05-14T18:09:20Z
2014-05-14T18:09:20Z
1982
The synthesis of a membrane-bound MalE ,B-galactosidase hybrid protein,
when induced by growth of Escherichia coli on maltose, leads to inhibition of cell
division and eventually a reduced rate of mass increase. In addition, the relative
rate of synthesis of outer membrane proteins, but not that of inner membrane
proteins, was reduced by about 50%o. Kinetic experiments demonstrated that this
reduction coincided with the period of maximum synthesis of the hybrid protein
(and another maltose-inducible protein, LamB). The accumulation of this abnormal
protein in the envelope therefore appeared specifically to inhibit the synthesis,
the assembly of outer membrane proteins, or both, indicating that the hybrid
protein blocks some export site or causes the sequestration of some limiting
factor(s) involved in the export process. Since the MalE protein is normally
located in the periplasm, the results also suggest that the synthesis of periplasmic
and outer membrane proteins may involve some steps in common. The reduced
rate of synthesis of outer membrane proteins was also accompanied by the
accumulation in the envelope of at least one outer membrane protein and at least
two inner membrane proteins as higher-molecular-weight forms, indicating that
processing (removal of the N-terminal signal sequence) was also disrupted by the
presence of the hybrid protein. These results may indicate that the assembly of
these membrane proteins is blocked at a relatively late step rather than at the level
of primary recognition of some site by the signal sequence. In addition, the results
suggest that some step common to the biogenesis of quite different kinds of
envelope protein is blocked by the presence of the hybrid protein.
004171
0021-9193 (versió paper)
1098-5530
http://hdl.handle.net/10459.1/47200
eng
American Society for Microbiology
Reproducció del document publicat a http://jb.asm.org/content/152/1/133.long
Journal of bacteriology, 1982, vol. 152, núm. 1, p. 133-139
(c) American Society for Microbiology, 1982
info:eu-repo/semantics/openAccess
Escheríchia coli
Proteïnes
Escheríchia coli
Insertion of a malE B-Galactosidase fusion protein into the envelope of Escherichia coli disrupts biogenesis of outer membrane proteins and processing of inner membrane proteins
article
publishedVersion
ORIGINAL
4171.pdf
4171.pdf
application/pdf
1451928
https://repositori.udl.cat/bitstreams/be57fc96-cf3e-493c-b2e8-8b23a23083b4/download
a8d04f1d94c0c2ccb8a58e0c3b470178
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/cc62b848-179d-4336-b4f8-e5ddb3ae3105/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
4171.pdf.jpg
4171.pdf.jpg
Generated Thumbnail
image/jpeg
5474
https://repositori.udl.cat/bitstreams/113d48ef-501f-4577-b412-6c127c09bbae/download
c1090651d8bc71ca7b823e6043cd713b
MD5
7
TEXT
4171.pdf.txt
4171.pdf.txt
Extracted Text
text/plain
31813
https://repositori.udl.cat/bitstreams/2f6810c8-2879-4448-8306-4c1e327aedd4/download
d33166d3990b81864a10a496ed75b034
MD5
8
10459.1/47200
oai:repositori.udl.cat:10459.1/47200
2017-08-02 12:22:46.965
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/571042021-08-30T15:04:33Zcom_10459.1_227com_10459.1_2col_10459.1_314
Friedenberg, William R.
Rué i Monné, Montserrat
Blood, Emily
Dalton, William S.
Shustik, Chaim
Larson, Richard A.
Sonneveld, Pieter
Greipp, Philip R.
2016-05-27T07:57:58Z
2025-01-01
2006
BACKGROUND. Preliminary studies have shown valspodar (PSC-833: Novartis Pharmaceuticals,
East Hanover, NJ) to be a potent inhibitor of multidrug resistance
(MDR), one cause of resistance to chemotherapy. An international randomized
control study (Phase III) evaluated the use of vincristine, doxorubicin, and dexamethasone
(VAD) with (n 46) and without (n 48) valspodar in the treatment of
patients with recurring or refractory multiple myeloma.
METHODS. Patients with documented recurrence or refractory myeloma were stratified
based on prior treatment exposure and creatinine and randomized. Because
of interaction of valspodar with vincristine and doxorubicin, the doses of these
drugs were reduced compared with the VAD-alone arm, and the doxorubicin was
further reduced in the last 15 patients when given with valspodar based on
pharmacokinetic and toxicity studies.
RESULTS. There were no complete or near-complete responses. There were 29%
partial responses (PRs) in the VAD-alone arm and 44% with valspodar (P 0.2).
Median progression-free survival was 7 months with VAD alone and 4.9 months
with valspodar (P 0.50). Subjective response was 19% with VAD alone and 17%
with valspodar (P 1.0). Median survival with VAD alone was 18.5 months and
15.3 with the addition of valspodar (P 0.055). Toxicity of Grade 3 or greater
was higher (P 0.0001) in the valspodar arm (89%) compared with the VAD-alone
arm (58%). The reduction of doxorubicin dose reduced toxicity but not significantly
(P 0.11).
CONCLUSION. The addition of the MDR-modulating agent valspodar to VAD did not
improve treatment outcome. Toxicity was increased in the valspodar-treated group
compared with VAD alone.
https://doi.org/10.1002/cncr.21666
009155
0008-543X
http://hdl.handle.net/10459.1/57104
eng
Wiley
Reproducció del document publicat a https://doi.org/10.1002/cncr.21666
Cancer, 2006, vol. 106, núm. 4, p. 830-838
(c) American Cancer Society, 2006
info:eu-repo/semantics/restrictedAccess
Refractory multiple myeloma
VAD
Valspodar
PSC-833
Phase III Study of PSC-833 (Valspodar) in Combination with Vincristine, Doxorubicin, and Dexamethasone (Valspodar/VAD) versus VAD Alone in Patients with Recurring or Refractory Multiple Myeloma (E1A95)
article
publishedVersion
montse.rue@cmb.udl.cat
Rué i Monné, Montserrat
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/062081d6-222f-4403-ae5f-7224b6fbdf2e/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
ORIGINAL
009155.pdf
009155.pdf
application/pdf
152531
https://repositori.udl.cat/bitstreams/f46ae811-64ff-4193-b210-b3cd0c04a519/download
cf17c094faf45f53d90a6d97e57bd2b0
MD5
1
THUMBNAIL
009155.pdf.jpg
009155.pdf.jpg
Generated Thumbnail
image/jpeg
5512
https://repositori.udl.cat/bitstreams/85c2fc8c-4c40-4c76-ac2c-bf34a2de51cc/download
24337336faaed6b4c80bab59f55bc7bd
MD5
3
TEXT
009155.pdf.txt
009155.pdf.txt
Extracted Text
text/plain
40165
https://repositori.udl.cat/bitstreams/9398ad75-c0f5-45fc-8a70-3e60b0a0e86d/download
870fdeb857c5d10fcb895151e15a1c83
MD5
4
10459.1/57104
oai:repositori.udl.cat:10459.1/57104
2021-08-30 15:04:33.361
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/569132022-05-26T13:19:42Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Barceló Bennasar, Antònia
Bauçà, Josep Miquel
Yañez, Aina
Fueyo, Laura
Gomez, Cristina
Peña, Mónica de la
Pierola, Javier
Rodriguez, Alberto
Sánchez de la Torre, Manuel
Abad, Jorge
Mediano, Olga
Amilibia, Jose
Masdeu, María José
Terán, Joaquin
Montserrat i Capdevila, Josep
Mayós Pérez, Mercè
Sánchez de la Torre, Alicia
Barbé Illa, Ferran
2016-04-29T11:03:21Z
2016-04-29T11:03:21Z
2016
Background
Placental growth factor (PlGF) induces angiogenesis and promotes tissue repair, and
plasma PlGF levels change markedly during acute myocardial infarction (AMI). Currently,
the impact of obstructive sleep apnea (OSA) in patients with AMI is a subject of debate. Our
objective was to evaluate the relationships between PlGF levels and both the severity of
acute coronary syndrome (ACS) and short-term outcomes after ACS in patients with and
without OSA.
Methods
A total of 538 consecutive patients (312 OSA patients and 226 controls) admitted for ACS
were included in this study. All patients underwent polygraphy in the first 72 hours after hospital
admission. The severity of disease and short-term prognoses were evaluated during
the hospitalization period. Plasma PlGF levels were measured using an electrochemiluminescence
immunoassay.
Results
Patients with OSA were significantly older and more frequently hypertensive and had higher
BMIs than those without OSA. After adjusting for age, smoking status, BMI and hypertension, PlGF levels were significantly elevated in patients with OSA compared with
patients without OSA (19.9 pg/mL, interquartile range: 16.6–24.5 pg/mL; 18.5 pg/mL, interquartile
range: 14.7–22.7 pg/mL; p<0.001), and a higher apnea-hypopnea index (AHI) was
associated with higher PlGF concentrations (p<0.003). Patients with higher levels of PlGF
had also an increased odds ratio for the presence of 3 or more diseased vessels and for a
Killip score>1, even after adjustment.
Conclusions
The results of this study show that in patients with ACS, elevated plasma levels of PlGF are
associated with the presence of OSA and with adverse outcomes during short-term followup.
Trial Registration
ClinicalTrials.gov NCT01335087
https://doi.org/10.1371/journal.pone.0147686
026715
1932-6203
http://hdl.handle.net/10459.1/56913
eng
Public Library of Science
Reproducció del document publicat a https://doi.org/10.1371/journal.pone.0147686
2016, vol. 11, núm. 3, e0147686
cc-by, (c) Barcelo et al., 2016
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Impact of obstructive sleep apnea on the levels of placental growth factor (PlGF) and their value for predicting short-term adverse outcomes in patients with acute coronary syndrome
article
publishedVersion
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/765649c3-edaa-4484-95fa-15ba5946f450/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
ORIGINAL
026715.PDF
026715.PDF
025555.pdf
application/pdf
243568
https://repositori.udl.cat/bitstreams/5affb3aa-6d44-4a9f-8559-692437992afd/download
6fc9aa94490a5cf63984c4b298e4e206
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1370
https://repositori.udl.cat/bitstreams/50bdab84-8af8-4aaf-8379-05d45c9413b9/download
ac86fe33011bda956ed9b032abf4d402
MD5
2
THUMBNAIL
026715.PDF.jpg
026715.PDF.jpg
Generated Thumbnail
image/jpeg
5721
https://repositori.udl.cat/bitstreams/ff26d9c9-09cc-4fcf-9d47-ea745c65d58a/download
845729005126cd8729ffff2522a80ca2
MD5
4
TEXT
026715.PDF.txt
026715.PDF.txt
Extracted Text
text/plain
45041
https://repositori.udl.cat/bitstreams/3cde9aad-e5f6-4d6a-bfb6-1e0072065efc/download
40439ee383d42b6bc6e4d092fcb8e191
MD5
5
10459.1/56913
oai:repositori.udl.cat:10459.1/56913
2022-05-26 13:19:42.49
http://creativecommons.org/licenses/by/3.0/es/
cc-by, (c) Barcelo et al., 2016
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=
oai:repositori.udl.cat:10459.1/474442017-07-12T15:32:47Zcom_10459.1_227com_10459.1_2com_10459.1_59159com_10459.1_47453col_10459.1_314col_10459.1_59160col_10459.1_59998
Izquierdo Álvarez, Alicia
Casas Herranz, Celia
Herrero Perpiñán, Enrique
2014-07-25T10:52:59Z
2014-07-25T10:52:59Z
2010
Unlike in higher organisms, selenium is not essential for growth in Saccharomyces cerevisiae. In this species, it causes toxic effects at high concentrations. In the present study, we show that when supplied as selenite to yeast cultures growing under fermentative metabolism, its effects can be dissected into two death phases. From the time of initial treatment, it causes loss of membrane integrity and genotoxicity. Both effects occur at higher levels in mutants lacking Grx1p and Grx2p than in wild-type cells, and are reversed by expression of a cytosolic version of the membrane-associated Grx7p glutaredoxin. Grx7p can also rescue the high levels of protein carbonylation damage that occur in selenite-treated cultures of the grx1 grx2 mutant. After longer incubation times, selenite causes abnormal nuclear morphology and the appearance of TUNEL-positive cells, which are considered apoptotic markers in yeast cells. This effect is independent of Grx1p and Grx2p. Therefore, the protective role of the two glutaredoxins is restricted to the initial stages of selenite treatment. Lack of Yca1p metacaspase or of a functional mitochondrial electron transport chain only moderately diminishes apoptotic-like death by selenite. In contrast, selenite-induced apoptosis is dependent on the apoptosis-inducing factor Aif1p. In the absence of the latter, intracellular protein carbonylation is reduced after prolonged selenite treatment, supporting the supposition that part of the oxidative damage is contributed by apoptotic cells.
https://doi.org/10.1099/mic.0.039719-0
16085
2608–2620 (versió paper)
1465-2080
http://hdl.handle.net/10459.1/47444
eng
Society for General Microbiology
Versió preprint del document publicat a: https://doi.org/10.1099/mic.0.039719-0
Microbiology, 2010, vol. 156, núm. 9, p. 2608-2620
(c) Society for General Microbiology
info:eu-repo/semantics/openAccess
Llevat de cervesa
Glutaredoxin
Estrès oxidatiu
Saccharomyces cerevisiae
Estrès oxidatiu
Selenite-induced cell death in Saccharomyces cerevisiae: protective role of glutaredoxins
article
submittedVersion
ORIGINAL
16085.pdf
16085.pdf
application/pdf
508490
https://repositori.udl.cat/bitstreams/8cc6a297-c8db-4a6f-a18a-a3c7b5df6116/download
0c823759378ef916cffa4b20c89949c4
MD5
1
THUMBNAIL
16085.pdf.jpg
16085.pdf.jpg
Generated Thumbnail
image/jpeg
3209
https://repositori.udl.cat/bitstreams/396a1409-8d84-494a-b3d5-92d7ed3cf549/download
6125d8ece46d4c64b521101c36bc58e0
MD5
7
TEXT
16085.pdf.txt
16085.pdf.txt
Extracted Text
text/plain
73128
https://repositori.udl.cat/bitstreams/f545d66f-3766-4533-b8b8-5f47bf2253e1/download
3ba1456da6b8ea9656dae03c77b95a0a
MD5
8
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/94260407-1e67-4a49-a330-91b7507b1b4b/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
10459.1/47444
oai:repositori.udl.cat:10459.1/47444
2017-07-12 15:32:47.215
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=
oai:repositori.udl.cat:10459.1/679992022-11-23T14:51:05Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_49291
Laplana Lafaja, Marina
Sánchez de la Torre, Manuel
Puig, Teresa
Caruz, Antonio
Fibla Palazón, Joan
2020-02-12T09:13:56Z
2020-02-12T09:13:56Z
2014-04-21
2020-02-12T09:14:02Z
Vitamin-D has pleiotropic effects on calcium and bone metabolism, cellular growth control, cell differentiation and modulation of both innate and acquired immune response. Previous studies revealed the association of vitamin-D receptor gene (VDR) polymorphism with infection diseases including HIV-1 infection. To assess for association between polymorphisms of vitamin-D pathway genes CYP27B1, vitamin-D binding protein (VDBP) and VDRwith HIV-1 infection, disease progression to acquired immunodeficiency syndrome (AIDS) was analysed according to CDC93 criteria in a cohort of 185 HIV-1 seroprevalent patients belonging to the injection drug users. Genotype data was obtained from rs10877012, rs3782130 and rs4646536 markers at CYP27B1 locus; rs7041 and rs4588 at VDBP locus; and rs11568820, rs4516035, rs2228570, rs1544410 and rs17878969 at VDR locus. Distribution of genotypes between patients grouped by outcome was compared by contingency table analysis. Marker-marker interaction was assessed by a MDR analysis. Assuming an additive model for VDR markers, a Kaplan-Meier survival analysis was employed to evaluate association with disease progression. Among vitamin-D pathway genes, VDR locus reveals specific 5′UTR and 3′UTR diplotype combinations associated with both, slower and faster progression to AIDS. Marker-marker interaction analysis indicates a strong interaction between VDR markers and a redundant effect for CYP27B1 markers. According to our results, VDR locus association follows an additive model in which increased genetic risk score for the VDR is directly correlated with AIDS progression rates. Our data supports a role of vitamin-D pathway gene variability on HIV-1 disease progression
This work was supported by grants from Fondo de Investigaciones Sanitarias (PI021476 and PI051778 to JF and PI021205 to AC); Fundació Marató TV3 (ref.: 020730 to JF and ref: 020732 to AC) and Ministerio de Ciencia e Innovación (CGL 2007-62875 to J.F.). ML received a fellowship from the University of Lleida.
application/pdf
https://doi.org/10.1016/j.gene.2014.04.035
021488
0378-1119
http://hdl.handle.net/10459.1/67999
eng
Elsevier
info:eu-repo/grantAgreement/MEC//CGL2007-62875/ES/ECOLOGIA MICROBIANA Y GEOMICROBIOLOGIA DE HABITATS LITOBIONTICOS EN AMBIENTES EXTREMOS: DESIERTOS DE ATACAMA Y NEGEV/
Versió postprint del document publicat a: https://doi.org/10.1016/j.gene.2014.04.035
Gene, 2014, vol. 545, num. 1, p. 163-169
cc-by-nc-nd, (c) Elsevier, 2014
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Vitamina D
VDR
Vitamin D Pathaway
Polymorphism
Progression to AIDS
Vitamin-D pathway genes and HIV-1 disease progression in injection drug users
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/dc5423d7-3376-4de7-9cc3-3d8cf3e76343/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
ORIGINAL
021488.pdf
021488.pdf
Postprint
application/pdf
439912
https://repositori.udl.cat/bitstreams/f4b22477-05b8-4dda-9134-a48ce68e1f36/download
0d704a08b086b3b73a74acf6c607f5ba
MD5
4
SWORD
mets.xml
SWORD deposit package
application/octet-stream
322090
https://repositori.udl.cat/bitstreams/1acf682b-5129-46cf-aa6b-8eb533a53879/download
9ee08c588487cc2d945d1de0fbb72f08
MD5
3
THUMBNAIL
021488.pdf.jpg
021488.pdf.jpg
Generated Thumbnail
image/jpeg
2320
https://repositori.udl.cat/bitstreams/78691076-bb4b-4b00-a2f1-69ea4af6e176/download
5662f38ce962fbcfbac5ed85f47abbfa
MD5
5
TEXT
021488.pdf.txt
021488.pdf.txt
Extracted Text
text/plain
41453
https://repositori.udl.cat/bitstreams/1ab15de4-7203-4d61-9dfb-a6d3e7a0559e/download
5fc128a074ca860e8f2f6335f5ffc422
MD5
6
10459.1/67999
oai:repositori.udl.cat:10459.1/67999
2022-11-23 14:51:05.515
http://creativecommons.org/licenses/by-nc-nd/4.0/
cc-by-nc-nd, (c) Elsevier, 2014
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/571062022-09-27T15:13:21Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_49291
Zhang, Jisheng
Bahi i Pla, Núria
Zubiaga, Ana M.
Comella i Carnicé, Joan Xavier
Llovera i Tomàs, Marta
Sanchis, Daniel
2016-05-27T08:30:30Z
2025-01-01
2007
The involvement of caspases in postmitotic cell death
is controversial. Here we report that adult brain and heart are
devoid of many key pro-apoptotic proteins due to a progressive
postnatal silencing event involving a reduction of their transcript
levels. E2F has been shown to control cell cycle progression and
to be transcriptional activator of apoptotic genes. However, our
data demonstrate that apoptotic gene expression in heart, brain
and liver, as well as cardiac and neuronal apoptotic gene silencing
during development, are E2F-independent events. Therefore,
the genes regulating caspase-dependent cell death are expressed
in embryonic organs in an E2F-independent manner and a developmental-related
silencing event represses these genes in postmitotic
adult tissues.
The work was partially supported by a Grant (SAF2005-02197) from the Ministry of Education and Science of Spain (MEC) to D.S., a Grant ‘‘Suport als Grups de Recerca’’ from the Government of Catalonia to JXC/MLL/DS and a Grant (SAF2005-07930-C02-01) to AMZ. DS and MLL are Ramón y Cajal MEC fellows; NB is recipient of a PhD fellowship from the Departament d’Universitats, Recerca i Societat de la Informació (Government of Catalonia). J.Z. is recipient of a PhD fellowship from MEC.
https://doi.org/10.1016/j.febslet.2007.11.046
011262
0014-5793
http://hdl.handle.net/10459.1/57106
eng
Wiley
info:eu-repo/grantAgreement/MEC//SAF2005-02197/ES/
info:eu-repo/grantAgreement/MEC//SAF2005-07930-C02-01/ES/
Reproducció del document publicat a https://doi.org/10.1016/j.febslet.2007.11.046
FEBS Letters, 2007, vol. 581, núm. 30, p. 5781-5786
(c) Federation of European Biochemical Societies, 2007
info:eu-repo/semantics/restrictedAccess
Heart
Brain
Development
Apoptosis
Developmental silencing and independency from E2F of apoptotic gene expression in postmitotic tissues
article
publishedVersion
daniel.sanchis@cmb.udl.cat
Sanchís Almenar, Daniel
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/09575aab-95bd-4c12-8991-e787ac4e5f31/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
ORIGINAL
011262.pdf
011262.pdf
application/pdf
411845
https://repositori.udl.cat/bitstreams/fec32c8f-1c9e-4f44-a20a-3cedacb31b42/download
0842f1cbffe09ff4e40c17ee8f231295
MD5
1
THUMBNAIL
011262.pdf.jpg
011262.pdf.jpg
Generated Thumbnail
image/jpeg
5663
https://repositori.udl.cat/bitstreams/9cc83f47-5e05-4405-9260-a78a7ac19416/download
34a1e86a561aa32ef55eab0e80a72b0b
MD5
3
TEXT
011262.pdf.txt
011262.pdf.txt
Extracted Text
text/plain
33739
https://repositori.udl.cat/bitstreams/5426e1ab-7baf-45f7-82e4-7b7bab553af5/download
aef41dab2080c765844882b18147bd54
MD5
4
10459.1/57106
oai:repositori.udl.cat:10459.1/57106
2022-09-27 15:13:21.432
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/570432021-08-30T15:04:34Zcom_10459.1_227com_10459.1_2col_10459.1_314
Li, Aihong
Zhou, Jianbiao
Zuckerman, David
Dalton, Virginia
Lyons, Cheryl
Silverman, Lewis B.
Sallan, Stephen E.
Gribben, John G.
Rué i Monné, Montserrat
2016-05-18T08:04:51Z
2025-01-01
2003
Immunoglobulin (Ig) and T-cell receptor
(TCR) gene rearrangements provide clonal
markers useful for diagnosis and measurement
of minimal residual disease
(MRD) in acute lymphoblastic leukemia
(ALL). We analyzed the sequences of Ig
and TCR gene rearrangements obtained
at presentation and relapse in 41 children
with ALL to study clonal stability, which
has important implications for monitoring
MRD, during the course of the disease.
In 42%, all original Ig and/or TCR
sequences were conserved. In 24%, one
original sequence was preserved but the
other lost, and in 14% the original sequences
were conserved with new sequences
identified at relapse. In 20% only
new sequences were found at relapse.
Using primers designed from the novel
relapse sequences, the relapse clone
could be identified as subdominant clones
in the diagnostic sample in 8 of 14 patients.
Alteration of these clonal gene
rearrangements is a common feature in
childhood ALL. MRD detection should
include multiple gene targets to minimize
false-negative samples or include also
multicolor flow cytometry. In some cases
the leukemic progenitor cell might arise
earlier in lineage before DHJH recombination
but retain the capacity to further
differentiate into cells capable of altering
the pattern of Ig and/or TCR rearrangements.
https://doi.org/10.1182/blood-2003-05-1455
009166
0006-4971
http://hdl.handle.net/10459.1/57043
eng
American Society of Hematology
Reproducció del document publicat a https://doi.org/10.1182/blood-2003-05-1455
Blood, 2003, vol. 102, núm. 13, p. 4520-4526
(c) The American Society of Hematology, 2003
info:eu-repo/semantics/restrictedAccess
Sequence analysis of clonal immunoglobulin and T-cell receptor gene rearrangements in children with acute lymphoblastic leukemia at diagnosis and at relapse: implications for pathogenesis and for the clinical utility of PCR-based methods of minimal residual disease detection
article
publishedVersion
montse.rue@cmb.udl.cat
Rué i Monné, Montserrat
ORIGINAL
009166.pdf
009166.pdf
application/pdf
195547
https://repositori.udl.cat/bitstreams/6c297b83-bfc8-4088-b14f-6755a2920633/download
eb7dbb6f722ccd685dc4c1250afb8c4d
MD5
1
THUMBNAIL
009166.pdf.jpg
009166.pdf.jpg
Generated Thumbnail
image/jpeg
4743
https://repositori.udl.cat/bitstreams/a7d09f65-cfc9-4a58-b237-d2b845ca416e/download
475cdc4555630e64e7a1a0fea849f25c
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/64eb882b-c31d-4cf3-bb38-cc650a28deaa/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
TEXT
009166.pdf.txt
009166.pdf.txt
Extracted Text
text/plain
46000
https://repositori.udl.cat/bitstreams/f7ee5aa5-8581-476a-af29-caf3dc49a375/download
a64e642fdeb2cf95984e63feadf67672
MD5
4
10459.1/57043
oai:repositori.udl.cat:10459.1/57043
2021-08-30 15:04:34.19
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/659262020-11-06T10:05:09Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Fernández Armenteros, José Manuel
Gómez Arbonés, Javier
Buti, Miquel
Betriu i Bars, M. Àngels
Sanmartín Novell, Verònica
Ortega Bravo, Marta
Martínez Alonso, Montserrat
Garí Marsol, Eloi
Portero Otín, Manuel
Santamaria-Babi, L.
Casanova i Seuma, Josep M. (Josep Manel)
2019-03-11T09:02:29Z
2020-08-28T22:21:57Z
2019
2019-03-11T09:02:29Z
Abstract Background: Psoriasis is a very prevalent systemic chronic inflammatory disease. Major cardiovascular events are the main cause of mortality in these patients which suggests an association between psoriasis and traditional cardiovascular risk factors. Objective: Identify classic cardiovascular risk factors and metabolic syndrome (MS) in patients with psoriasis, their possible association with its severity and compare it with the non-psoriatic population. Methods: This is an observational and cross-sectional population study in Lleida (Spain) from a joint hospital / primary care database. Results: The database comprised 398,701 individuals. There were 6,868 cases registered as psoriasis (1.7%), and 499 of them (7.3%) were classified as moderate-severe psoriasis. Patients with psoriasis had a higher prevalence of traditional cardiovascular risk factors than non-psoriatic population: diabetes mellitus 2 (13.9% vs 7.4%, OR 2.01), dyslipidemia (28.8% vs 17.4%, OR 1.92), arterial hypertension (31.2% vs 19.0%, OR 1.93), obesity (33.7% vs 28.1%, OR 1.30), altered fasting basal glycaemia (21.4% vs 15.1%, OR 1.54), low cholesterol-HDL (38.1% vs 32.3%, OR 1.29), hypertriglyceridemia (45.7% vs 35.2%, OR 1.55) and high waist circumference (75.7% vs 72.3%, OR 1.19). MS was more prevalent in psoriatic patients (28.3% vs 15.1%, OR 2.21) and cardiovascular risk factors were similar between psoriasis severity groups. Psoriatic patients had a higher prevalence of ischemic heart disease (3.3% vs 1.8%, OR 1.87) and vascular-cerebral accidents (1.8% vs 1.2%, OR 1.55). A model for MS showed a significant non-linear relationship with age and sex, and significant differences between patients with and without psoriasis. Conclusion: We found statistically differences in relation to the prevalence of cardiovascular risk factors, MS and major cardiovascular events in psoriatic patients. However, differences were not seen between psoriasis severity groups. Our work reinforces the need for a multidisciplinary approach and close monitoring of cardiovascular risk factors in these patients to prevent a cardiovascular event.
application/pdf
https://doi.org/10.1111/jdv.15159
027663
0926-9959
http://hdl.handle.net/10459.1/65926
eng
Wiley
Versió postprint del document publicat a: https://doi.org/10.1111/jdv.15159
Journal of the European Academy of Dermatology and Venereology, 2019, vol. 33, núm. 1, p. 128-135
(c) European Academy of Dermatology and Venereology, 2018
info:eu-repo/semantics/openAccess
Psoriasis
Epidemiology
Metabolic syndrome
Cardiovascular risk factors
Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.
Psoriasis and cardiovascular risk factors
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
xga@medicina.udl.cat
Xavier Gómez Arbonés
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/b955b328-9d49-4cc6-851a-b2a8ba027f96/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
SWORD
mets.xml
SWORD deposit package
application/octet-stream
128705
https://repositori.udl.cat/bitstreams/67c26651-e201-4b7b-9cad-56f6395ef1de/download
3c3322ebdff0050b70238113e9d89626
MD5
3
THUMBNAIL
027663.pdf.jpg
027663.pdf.jpg
Generated Thumbnail
image/jpeg
2030
https://repositori.udl.cat/bitstreams/e51952d3-ed0b-4c63-be0e-137e9a4b27de/download
0398a000d33b751f601e5959349a5f4e
MD5
5
TEXT
027663.pdf.txt
027663.pdf.txt
Extracted Text
text/plain
27377
https://repositori.udl.cat/bitstreams/b150fb39-2311-4ed6-960b-941dbe3aea97/download
d81ab3f675938fd27aae774ae047300e
MD5
6
ORIGINAL
027663.pdf
027663.pdf
Postprint
application/pdf
247863
https://repositori.udl.cat/bitstreams/571eddfe-af60-4cac-9921-de0402c766d1/download
1fe569180e3c0de7fa393a092fe13e7c
MD5
4
10459.1/65926
oai:repositori.udl.cat:10459.1/65926
2020-11-06 10:05:09.275
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/683202020-03-25T00:20:34Zcom_10459.1_227com_10459.1_2col_10459.1_314col_10459.1_44504
Cárdenas, Pablo D.
Sonawane, Prashant D.
Heinig, Uwe
Jozwiak, Adam
Panda, Sayantan
Abebie, Bekele
Kazachkova, Yana
Pliner, Margarita
Unger, Tamar
Wolf, Dalia
Ofner, Itai
Vilaprinyo Terré, Ester
Meir, Sagit
Davydov, Olga
Gal-on, Amit
Burdman, Saul
Gir, Ashok
Zamir, Dani
Scherf, Tali
Szymanski, Jedrzej
Rogachev, Ilana
Aharoni, Asaph
2020-03-24T10:46:51Z
2020-03-24T10:46:51Z
2019
The genus Solanum comprises three food crops (potato, tomato, and eggplant), which are consumed on daily basis worldwide and also producers of notorious anti-nutritional steroidal glycoalkaloids (SGAs). Hydroxylated SGAs (i.e. leptinines) serve as precursors for leptines that act as defenses against Colorado Potato Beetle (Leptinotarsa decemlineata Say), an important pest of potato worldwide. However, SGA hydroxylating enzymes remain unknown. Here, we discover that 2-OXOGLUTARATE-DEPENDENT-DIOXYGENASE (2-ODD) enzymes catalyze SGA-hydroxylation across various Solanum species. In contrast to cultivated potato, Solanum chacoense, a widespread wild potato species, has evolved a 2-ODD enzyme leading to the formation of leptinines. Furthermore, we find a related 2-ODD in tomato that catalyzes the hydroxylation of the bitter α-tomatine to hydroxytomatine, the first committed step in the chemical shift towards downstream ripening-associated non-bitter SGAs (e.g. esculeoside A). This 2-ODD enzyme prevents bitterness in ripe tomato fruit consumed today which otherwise would remain unpleasant in taste and more toxic.
The work was supported by the Israel Science Foundation (ISF Grant No. 1805/15) and European Research Council (ERC; SAMIT-FP7) personal grants to A.A. The research in the A.A. laboratory was supported by the European Union Seventh Framework Program FP7/2007–2013 under grant agreement no. 613692–TriForC. P.D.C. thanks Becas Chile Program (CONICYT, Chile) for PhD financial support. D.Z. was funded by the European Union’s H2020 Research and Innovation Program grant # 677379 (G2P-SOL).
https://doi.org/10.1038/s41467-019-13211-4
029707
2041-1723
http://hdl.handle.net/10459.1/68320
eng
Springer Nature
Reproducció del document publicat a https://doi.org/10.1038/s41467-019-13211-4
Nature Communications, 2019, vol. 10, núm. 5169
info:eu-repo/grantAgreement/EC/FP7/204575
info:eu-repo/grantAgreement/EC/FP7/613692
info:eu-repo/grantAgreement/EC/H2020/677379/EU/G2P-SOL
cc-by, (c) Cárdenas et al., 2019
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Tomaquera
Alberginiera
Patates
Agricultura
Genètica
Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
THUMBNAIL
029707.pdf.jpg
029707.pdf.jpg
Generated Thumbnail
image/jpeg
4815
https://repositori.udl.cat/bitstreams/ef3edab5-f429-441c-9c68-19a5a8540a02/download
08a473150009745970f9f6dd3e29f633
MD5
4
ORIGINAL
029707.pdf
029707.pdf
application/pdf
1369011
https://repositori.udl.cat/bitstreams/f2d8819f-cda5-49af-8907-4a245bc09d9a/download
847f837edbee6613d2bc38411004f1a2
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://repositori.udl.cat/bitstreams/ee7708c4-1f3a-42df-8a9a-158e07dd900f/download
0175ea4a2d4caec4bbcc37e300941108
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/a1826e3b-557b-4e15-a094-34ed37de9835/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
TEXT
029707.pdf.txt
029707.pdf.txt
Extracted Text
text/plain
82065
https://repositori.udl.cat/bitstreams/1be22900-e0b3-444b-a2f0-f89d4ca75a0c/download
5f6199f9ae9068a0d843766e0226a4ce
MD5
5
10459.1/68320
oai:repositori.udl.cat:10459.1/68320
2020-03-25 00:20:34.358
http://creativecommons.org/licenses/by/4.0/
cc-by, (c) Cárdenas et al., 2019
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/577952022-10-21T17:17:44Zcom_10459.1_227com_10459.1_2com_10459.1_463061com_10459.1_47453com_10459.1_56939col_10459.1_314col_10459.1_463062col_10459.1_59998col_10459.1_56959col_10459.1_49291
Alves, Rui
Piñol, Marc
Vilaplana Mayoral, Jordi
Teixidó Torrelles, Ivan
Cruz, Joaquim
Comas, Jorge
Vilaprinyo Terré, Ester
Sorribas Tello, Albert
Solsona Tehàs, Francesc
2016-09-13T11:42:34Z
2016-09-13T11:42:34Z
2016
Introduction. Most documented rare diseases have genetic origin. Because of their low individual frequency, an initial diagnosis based on phenotypic symptoms is not always easy, as practitioners might never have been exposed to patients suffering from the relevant disease. It is thus important to develop tools that facilitate symptom-based initial diagnosis of rare diseases by clinicians. In this work we aimed at developing a computational approach to aid in that initial diagnosis. We also aimed at implementing this approach in a user friendly web prototype. We call this tool Rare Disease Discovery. Finally, we also aimed at testing the performance of the prototype.
Methods. Rare Disease Discovery uses the publicly available ORPHANET data set of association between rare diseases and their symptoms to automatically predict the most likely rare diseases based on a patient’s symptoms. We apply the method to retrospectively diagnose a cohort of 187 rare disease patients with confirmed diagnosis. Subsequently we test the precision, sensitivity, and global performance of the system under different scenarios by running large scale Monte Carlo simulations. All settings account for situations where absent and/or unrelated symptoms are considered in the diagnosis.
Results. We find that this expert system has high diagnostic precision (≥80%) and sensitivity (≥99%), and is robust to both absent and unrelated symptoms.
Discussion. The Rare Disease Discovery prediction engine appears to provide a fast and robust method for initial assisted differential diagnosis of rare diseases. We coupled this engine with a user-friendly web interface and it can be freely accessed at http://disease-discovery.udl.cat/. The code and most current database for the whole project can be downloaded from https://github.com/Wrrzag/DiseaseDiscovery/tree/no_classifiers.
This work was partially supported by the MEyC under contracts TIN2014-53234-C2- 2-R, TIN2011-28689-C02-02 and BFU2010-17704 and by Universitat de Lleida and Departament de Ciències Mèdiques Bàsiques with bridge grants to RA. The authors are members of the research groups 2014-SGR163 and 2014-SGR243, funded by the Generalitat de Catalunya.
https://doi.org/10.7717/peerj.2211
024564
2167-8359
http://hdl.handle.net/10459.1/57795
eng
PeerJ
info:eu-repo/grantAgreement/MINECO//TIN2014-53234-C2-2-R/ES/PENSAMIENTO COMPUTACIONAL E INGENIERIA DEL RENDIMIENTO PARA APLICACIONES DE CIENCIAS DE LA VIDA Y MEDIOAMBIENTALES - UDL/
info:eu-repo/grantAgreement/MICINN//TIN2011-28689-C02-02/ES/EJECUCION EFICIENTE DE APLICACIONES MULTIDISCIPLINARES: NUEVOS DESAFIOS EN LA
ERA MULTI%2FMANY CORE/
info:eu-repo/grantAgreement/MICINN//BFU2010-17704/ES/METRES (METABOLIC RECONSTRUCTION SERVER DESARROLLO Y APLICACION EN EN ESTUDIO DE PRINCIPIOS DE DISEÑO BIOLOGICO/
Reproducció del document publicat a https://doi.org/10.7717/peerj.2211
PeerJ, 2016, núm. 4, e2211
cc-by, (c) Alves et al., 2016
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Computer assisted diagnosis
Rare diseases
eHealth
Family doctors
User-friendly webserver
Computer-assisted initial diagnosis of rare diseases
article
publishedVersion
THUMBNAIL
024564.pdf.jpg
024564.pdf.jpg
Generated Thumbnail
image/jpeg
4876
https://repositori.udl.cat/bitstreams/15aa3003-5da7-4dfa-8560-c6c20f6b20a1/download
ab8a297a10bf5b6e00540f46804734a8
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/9f16e25b-724e-4528-a2ca-9dc6c6724111/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
TEXT
024564.pdf.txt
024564.pdf.txt
Extracted Text
text/plain
50280
https://repositori.udl.cat/bitstreams/1feacaf7-5e2e-4f69-916d-563f535eae16/download
944598f694ca43e41dcceb26d9818ce9
MD5
5
ORIGINAL
024564.pdf
024564.pdf
application/pdf
703079
https://repositori.udl.cat/bitstreams/ac2a6974-63d7-4274-a6b5-125e247fbf56/download
c95b2f290ab625de0323e8df53c2e950
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1370
https://repositori.udl.cat/bitstreams/7714e2a3-8108-4f3c-bd14-e1b672ff2101/download
ac86fe33011bda956ed9b032abf4d402
MD5
2
10459.1/57795
oai:repositori.udl.cat:10459.1/57795
2022-10-21 17:17:44.442
http://creativecommons.org/licenses/by/3.0/es/
cc-by, (c) Alves et al., 2016
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/571542021-08-30T15:04:33Zcom_10459.1_227com_10459.1_2col_10459.1_314
Ros, Clara
Miret, Marta
Rué i Monné, Montserrat
2016-06-03T09:38:07Z
2025-01-01
2009
Objective: In the last few years, the number of unplanned pregnancies has increased, especially in young
women. Among other measures, emergency contraception (EC) was introduced by the Health Department
to reduce unwanted pregnancies. The aim of this study was to analyze EC use in Catalonia, and to compare
a rural with an urban area (Lleida province and the metropolitan area of Barcelona).
Methods: We performed a descriptive study that included 17,149 women of fertile age who sought access
to the EC pill between October 2004 and August 2007. Data were provided by the Maternal/Infant Health
Program of the Public Health Department.
Results: EC was used primarily by women between 16 and 24 years of age, usually on the weekends. Most
of these women (78.5%) had used EC twice and only 1.8% had used this medication once. Consumption was
higher in Lleida, with a comparative utilization figure and 95% confidence interval of 1.42 (1.35–1.50) with
respect to Barcelona.
Conclusions: The finding that EC use was higher in younger women coincides with the goal of distributing
this medication. EC seems not to be associated with a decrease in voluntary pregnancy terminations. More
reproductive information is required from all the actors involved in policies and health interventions,
encouraging healthier sexual behavior.
https://doi.org/10.1016/j.gaceta.2009.05.010
013930
0213-9111
http://hdl.handle.net/10459.1/57154
spa
Elsevier
Reproducció del document publicat a https://doi.org/10.1016/j.gaceta.2009.05.010
Gaceta Sanitaria, 2009, vol. 23, núm.6, p. 496-500
(c) Elsevier, 2009
info:eu-repo/semantics/restrictedAccess
Emergency contraception
Estudio descriptivo sobre el uso de la anticoncepción de emergencia en Cataluña. Comparación entre una zona rural y una urbana
article
publishedVersion
montse.rue@cmb.udl.cat
Rué i Monné, Montserrat
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/a5db9f42-8643-4f00-9c97-13bae6288333/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
TEXT
013930.pdf.txt
013930.pdf.txt
Extracted Text
text/plain
29823
https://repositori.udl.cat/bitstreams/58c747a5-1d99-4e41-8502-abd549ebce4e/download
b9e53195325522ca79e9eea1c0269be7
MD5
4
ORIGINAL
013930.pdf
013930.pdf
application/pdf
96261
https://repositori.udl.cat/bitstreams/2144fe9c-23f1-4241-815e-e8024f760516/download
bbb0b0d9e43927a64387d94c61e32bec
MD5
1
THUMBNAIL
013930.pdf.jpg
013930.pdf.jpg
Generated Thumbnail
image/jpeg
5280
https://repositori.udl.cat/bitstreams/400326ec-fae1-4b63-af93-e58d5d0a3aab/download
7588b576a8f288211845de11e4bc60ee
MD5
3
10459.1/57154
oai:repositori.udl.cat:10459.1/57154
2021-08-30 15:04:33.363
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/570642021-08-30T15:04:33Zcom_10459.1_227com_10459.1_2col_10459.1_314
Egea Navarro, Joaquim
Vig Nissen, Ulla
Dufour, Audrey
Sahin, Mustafa
Greer, Paul
Kullander, Klas
Mrsic-Flogel, Thomas D.
Greenberg, Michael E.
Kiehn, Ole
Vanderhaeghen, Pierre
Klein, Rüdiger
2016-05-20T07:58:24Z
2025-01-01
2005
Signaling by receptor tyrosine kinases (RTKs) is mediated by their intrinsic kinase activity. Typically, kinase-activating mutations result in ligand-independent signaling and gain-of-function phenotypes. Like other RTKs, Ephs require kinase activity to signal, but signaling by Ephs in vitro also requires clustering by their membrane bound ephrin ligands. The relative importance of Eph kinase activity and clustering for in vivo functions is unknown. We find that knockin mice expressing a mutant form of EphA4 (EphA4EE), whose kinase is constitutively activated in the absence of ephrinB ligands, are deficient in the development of thalamocortical projections and some aspects of central pattern generator rhythmicity. Surprisingly, other functions of EphA4 were regulated normally by EphA4EE, including midline axon guidance, hindlimb locomotion, in vitro growth cone collapse, and phosphorylation of ephexin1. These results suggest that signaling of Eph RTKs follows a multistep process of induced kinase activity and higher-order clustering different from RTKs responding to soluble ligands.
https://doi.org/10.1016/j.neuron.2005.06.029
017843
0896-6273
http://hdl.handle.net/10459.1/57064
eng
Elsevier
Reproducció del document publicat a https://doi.org/10.1016/j.neuron.2005.06.029
Neuron, 2005, vol, 47, núm 4, p. 515-528
(c) Elsevier Inc., 2005
info:eu-repo/semantics/restrictedAccess
Regulation of EphA4 Kinase Activity Is Required for a Subset of Axon Guidance Decisions Suggesting a Key Role for Receptor Clustering in Eph Function
article
publishedVersion
joaquim.egea@cmb.udl.cat
Egea Navarro, Joaquim
THUMBNAIL
017843.pdf.jpg
017843.pdf.jpg
Generated Thumbnail
image/jpeg
5646
https://repositori.udl.cat/bitstreams/4c0b2e2a-9300-4a13-b8af-b051b1361273/download
d6b65ac774e415899fa084188f50a8ad
MD5
3
TEXT
017843.pdf.txt
017843.pdf.txt
Extracted Text
text/plain
70943
https://repositori.udl.cat/bitstreams/8f36319b-6a4a-4e7f-8003-3cdb376a7c65/download
a7ccb75fbb7c569d0aaf3ce6362d4c6a
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/7a2e87d6-70b2-4813-b6ed-ddd4de7d3f4d/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
ORIGINAL
017843.pdf
017843.pdf
application/pdf
835300
https://repositori.udl.cat/bitstreams/b710c76b-5a93-4ce5-b6cd-0ad753b0ac18/download
2ed578b08b98d65e56a5a1af1c13916f
MD5
1
10459.1/57064
oai:repositori.udl.cat:10459.1/57064
2021-08-30 15:04:33.905
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/657502019-02-20T00:32:21Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Murali, Rajmohan
Davidson, Ben
Fadare, Oluwole
Carlson, Joseph A.
Crum, Christopher
Gilks, C. Blake
Irving, Julie A.
Malpica, Anais
Matias-Guiu, Xavier
McCluggage, W. Glenn
Mittal, Khush
Oliva, Esther
Parkash, Vinita
Rutgers, Joanne
Staats, Paul
Stewart, Colin
Tornos, Carmen
Soslow, Robert A.
2019-02-19T08:51:27Z
2019-02-19T08:51:27Z
2019
This review of challenging diagnostic issues concerning high-grade endometrial carcinomasisderivedfromtheauthors’ reviewoftheliteraturefollowedbydiscussionsatthe Endometrial Cancer Workshop sponsored by the International Society of Gynecological Pathologists in 2016. Recommendations presented are evidence-based, insofar as this is possible,giventhatthelevelsofevidenceareweakormoderateduetosmallsamplesizesand nonuniform diagnostic criteria used in many studies. High-grade endometrioid carcinomas include FIGO grade 3 endometrioid carcinomas, serous carcinomas, clear cell carcinomas, undifferentiated carcinomas, and carcinosarcomas. FIGO grade 3 endometrioid carcinoma is diagnosed when an endometrioid carcinoma exhibits >50% solid architecture (excluding squamousareas), orwhenan architecturallyFIGOgrade2endometrioid carcinomaexhibits marked cytologic atypia, provided that a glandular variant of serous carcinoma has been excluded. The most useful immunohistochemical studies to make the distinction between these 2 histotypes are p53, p16, DNA mismatch repair proteins, PTEN, and ARID1A. Endometrial clear cell carcinomas must display prototypical architectural and cytologic features for diagnosis. Immunohistochemical stains, including, Napsin A and p504s can be used as ancillary diagnostic tools; p53 expression is aberrant in a minority of clear cell carcinomas. Of note, clear cells are found in all types of high-grade endometrial carcinomas, leading to a tendency to overdiagnose clear cell carcinoma. Undifferentiated carcinoma (which when associated with a component of low-grade endometrioid carcinoma is termed “dedifferentiated carcinoma”) is composed of sheets of monotonous, typically dyscohesive cells, which can have a rhabdoid appearance; they often exhibit limited expression of cytokeratins and epithelial membrane antigen, are usually negative for PAX8 and hormone receptors, lack membranous e-cadherin and commonly demonstrate loss of expression of DNA mismatch repair proteins and SWI-SNF chromatin remodeling proteins. Carcinosarcomas must show unequivocal morphologic evidence of malignant epithelial and mesenchymal differentiation.
This work was funded in part through the NIH/NCI Cancer Center Support Grant P30 CA008748.
https://doi.org/10.1097/PGP.0000000000000491
0277-1691
http://hdl.handle.net/10459.1/65750
eng
Lippincott, Williams & Wilkins
Reproducció del document publicat a https://doi.org/10.1097/PGP.0000000000000491
International Journal of Gynecological Pathology, 2019, vol. 38, p. S40–S63
cc-by (c) Rajmohan Murali et al., 2019
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Carcinosarcoma
Clear cell carcinoma
Dedifferentiated carcinoma
Endometrioid carcinoma
High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
THUMBNAIL
Insogynpat_a2019v38pS40.pdf.jpg
Insogynpat_a2019v38pS40.pdf.jpg
Generated Thumbnail
image/jpeg
5211
https://repositori.udl.cat/bitstreams/d9c5f859-b90a-4604-93a5-dc369c3bfd41/download
69605c28d6ac5f0a03359b0ffcfefc29
MD5
4
TEXT
Insogynpat_a2019v38pS40.pdf.txt
Insogynpat_a2019v38pS40.pdf.txt
Extracted Text
text/plain
100619
https://repositori.udl.cat/bitstreams/198edb9f-de27-48e4-b6a7-f44a8513695d/download
3a75d625f30910b29cbb3285c46c627e
MD5
5
ORIGINAL
Insogynpat_a2019v38pS40.pdf
Insogynpat_a2019v38pS40.pdf
application/pdf
1854146
https://repositori.udl.cat/bitstreams/0487fd89-b479-4f3a-bf91-13d5d2605dfe/download
760e1300b024c80843f5ddf80d61829d
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://repositori.udl.cat/bitstreams/d3b57d5b-14b6-46b6-a4a0-bd290a64e8a6/download
0175ea4a2d4caec4bbcc37e300941108
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/69dbd9ed-5dc9-4cba-807a-01c69871e1e5/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
10459.1/65750
oai:repositori.udl.cat:10459.1/65750
2019-02-20 00:32:21.633
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Rajmohan Murali et al., 2019
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/651752018-11-27T12:43:27Zcom_10459.1_227com_10459.1_2col_10459.1_314
Argilés, Josep M.
Llovera i Tomàs, Marta
López-Soriano, Francisco J.
2018-11-23T08:56:32Z
2018-11-23T08:56:32Z
1993
2018-11-23T08:56:33Z
L'etiologia del càncer es basa fonamentalment en l'aparició d'un dany genètic en una cèl·lula que ocasiona una expressió anormal de determinats gens, els productes dels quals canvien dramàticament el fenotip cel·lular. Com a conseqüència d 'aquest fet, les cèl·lules transformades adquireixen tota una sèrie de característiques bioquímiques que els donen un gran avantatge en la seva competició per substrats i factors tròfics amb les cèl·lules normals. El creixement tumoral indueix en l'hoste tot un seguit de canvis metabòlics que es tradueix en un profund desequilibri energètic com a conseqüència de l'elevat grau d'ineficiència metabòlica generat per la massa tumoral en creixement. El conjunt d 'alteracions porta al pacient a una profunda caquèxia caracteritzada per una massiva pèrdua de pes i desgast muscular que sovint acaba amb la mort abans que el tumor hagi arribat a adquirir el màxim grau de malignitat. En els darrers anys s'ha pogut comprovar que gran part de les adaptacions metabòliques generades en resposta a l'estímul invasiu són conseqüència de l'acció de compostos alliberats per les pròpies cèl·lules del sistema immunitari de l 'animal o individu portador del tumor. Per tot això, la futura recerca en el tractament del càncer ha d'ésser dirigida, d 'una banda, a un millor coneixement del sistema bioquímic hoste-tumor i, d'una altra, al desenvolupament de nous fàrmacs antitumorals que tinguin en compte no només l'anihilació del tumor, sinó també la resposta metabòlica de l'hoste, responsable, en molts casos, de l'aparició del síndrome caquèctic i, conseqüentment, de la mort del pacient.
application/pdf
008543
http://hdl.handle.net/10459.1/65175
cat
Institut d'Estudis Catalans
Reproducció del document publicat a: https://www.raco.cat/index.php/TreballsSCBiologia/article/view/238149/320409
Treballs de la Societat Catalana de Biologia. Biologia del Desenvolupament, 1993, vol. 43, p. 51-80
cc-by-nc-nd (c) Josep M. Argilés et al., 1993
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.ca.
Creixement tumoral
Hoste
Metabolisme
Citocines
Caquèxia
Creixement tumoral i metabolisme de l'hoste: dues cares d'una mateixa moneda
info:eu-repo/semantics/article
publishedVersion
ORIGINAL
008543.pdf
application/pdf
11379121
https://repositori.udl.cat/bitstreams/2ba7b6ce-8057-4b32-9d0e-17caaac28961/download
3a21e10bbcef9b02434b168d8a8dea08
MD5
1
SWORD
mets.xml
SWORD deposit package
application/octet-stream
10151441
https://repositori.udl.cat/bitstreams/1ec582b8-978e-440c-886f-7e88ad8300df/download
2188dfe9be6474884a24077e3e71d49d
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/972f30f6-9aad-4561-af45-31edfec27a80/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
008543.pdf.jpg
008543.pdf.jpg
Generated Thumbnail
image/jpeg
3340
https://repositori.udl.cat/bitstreams/2ab11281-3888-4659-a3af-819ca267c6c8/download
402b4e357fe12c1dcd646aad836ddaa4
MD5
4
TEXT
008543.pdf.txt
008543.pdf.txt
Extracted Text
text/plain
93550
https://repositori.udl.cat/bitstreams/d69fd240-0604-4e6a-90b8-85e952b93db7/download
f09da11b158586c914ffb68b5260509f
MD5
5
10459.1/65175
oai:repositori.udl.cat:10459.1/65175
2018-11-27 12:43:27.317
http://creativecommons.org/licenses/by-nc-nd/3.0/es/deed.ca.
cc-by-nc-nd (c) Josep M. Argilés et al., 1993
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=
oai:repositori.udl.cat:10459.1/725302023-02-09T08:27:18Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_49291
Pérez Fusté, Noel
Ferrezuelo, Francisco
Garí Marsol, Eloi
2021-12-13T09:18:32Z
2021-12-13T09:18:32Z
2016-06-27
2021-12-13T09:18:32Z
Amplification of cyclin D1 is a frequent alteration in many cancers of different type and origin. We recently described a novel regulatory axis involving cyclin D1 in the regulation of tumor invasion and metastasis. Membrane-associated cyclin D1-CDK4 complexes promote activation of the small GTPase RAC1 through phosphorylation of the regulatory protein paxillin.
This work has been supported by research grants from Spanish Ministry of Education and Science (BFU2013-42895), Catalan Government (SGR-559), and Fundació Alicia Cuello de Merigó.
application/pdf
https://doi.org/10.1080/23723556.2016.1203471
024629
2372-3556
http://hdl.handle.net/10459.1/72530
eng
Taylor & Francis
info:eu-repo/grantAgreement/MINECO//BFU2013-42895-P/ES/ESTUDIO DE LOS MECANISMOS QUE REGULAN LA ACTIVIDAD CITOPLASMATICA DEL COMPLEJO CYCD1-CDK4. CARACTERIZACION DE SU RELEVANCIA FUNCIONAL EN MAMIFEROS/
Versió postprint del document publicat a: https://doi.org/10.1080/23723556.2016.1203471
Molecular & Cellular Oncology, 2016, vol. 3, núm. 5, p. e1203471
(c) Taylor & Francis, 2016
info:eu-repo/semantics/openAccess
Cyclin D1
Cell invasion
Metastasis
Cyclin D1 promotes tumor cell invasion and metastasis by cytoplasmic mechanisms
info:eu-repo/semantics/article
acceptedVersion
ORIGINAL
molecular_2016v3n5.pdf
molecular_2016v3n5.pdf
postprint
application/pdf
408103
https://repositori.udl.cat/bitstreams/53ca816d-330d-45d5-a9f8-9a7661f49c57/download
31c04419999445df60cb3bdd9b2f1609
MD5
4
THUMBNAIL
molecular_2016v3n5.pdf.jpg
molecular_2016v3n5.pdf.jpg
Generated Thumbnail
image/jpeg
2122
https://repositori.udl.cat/bitstreams/96a3f936-e682-42c5-9646-4d9016c55c89/download
250e599f036b2178642dc7d2ff69efc8
MD5
5
TEXT
molecular_2016v3n5.pdf.txt
molecular_2016v3n5.pdf.txt
Extracted Text
text/plain
10146
https://repositori.udl.cat/bitstreams/56d7dcc7-8e71-480c-95d7-26f92bc053d0/download
82b0f23bd802aa549a482aa6b0962b82
MD5
6
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/3649a774-8a67-479b-a31a-94472e87d9f9/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
SWORD
mets.xml
SWORD deposit package
application/octet-stream
354532
https://repositori.udl.cat/bitstreams/00188055-644e-4d36-9e38-258c85831f8d/download
31f8657f3a02c2cfd88670c8cc4e9d40
MD5
3
10459.1/72530
oai:repositori.udl.cat:10459.1/72530
2023-02-09 08:27:18.356
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/675982020-07-13T10:33:47Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_241col_10459.1_314col_10459.1_59998col_10459.1_30324
Bhardwaj, Deepshikha
Nàger Grifo, Mireia
Visa Pretel, Anna
Crespí Sallán, Marta
Coopman, PJ
Cantí Nicolás, Carles
Herreros Danés, Judit
2019-11-25T09:23:25Z
2019-11-25T09:23:25Z
2018-04-01
2019-11-25T09:23:26Z
β-catenin is a central component of adherent junctions and a key effector of canonical Wnt signalling, in which dephosphorylated Ser/Thr β-catenin regulates gene transcription. β-catenin phosphorylation at Tyr142 (PTyr142 β-catenin), which is induced by receptor and Src family Tyr kinases, represents a previously described β- catenin switch from adhesive to migratory roles. In addition to classical β-catenin roles, phosphorylated Ser/Thr β-catenin and total β-catenin were involved in centrosomal functions, including mitotic spindle formation and centrosome separation. Here we find that PTyr142 β-catenin is present in centrosomes in non-transformed and glioblastoma cells and that, in contrast to the Ser/Thr phosphorylated β-catenin, PTyr142 β-catenin centrosomal levels drop in mitosis. Furthermore, we show that the inhibitor of Spleen Tyrosine Kinase (Syk) piceatannol decreases centrosomal PTyr142 β-catenin levels, indicating that Syk regulates centrosome PTyr142 β-catenin. Our findings suggest that PTyr142 β-catenin negatively regulates mitotic progression and highlight the contribution of different phosphorylated β-catenin forms in the coordination of the cell and centrosome cycles.
This work was funded by grants from Instituto de Salud Carlos III/ Feder/“Una manera de hacer Europa” (PI08/0790 and PI13/01980 to JH). DB was a recipient of FI‐Agaur fellowship. MN, MCS, and AV were UdL predoctoral fellows. MN held an IRBLleida/Diputació de Lleida fellowship.
application/pdf
https://doi.org/10.1002/jcb.26571
026372
0730-2312
http://hdl.handle.net/10459.1/67598
eng
Willey
Versió preprint del document publicat a: https://doi.org/10.1002/jcb.26571
Journal of Cellular Biochemistry, 2018, vol. 119, núm. 4, p. 3632-3640
(c) Wiley Periodicals, Inc., 2017
info:eu-repo/semantics/openAccess
Catenines
Glioblastoma multiforme
Phosphorylated Tyr142 β-catenin localizes to centrosomes and is regulated by Syk
info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
TEXT
026372.pdf.txt
026372.pdf.txt
Extracted Text
text/plain
33947
https://repositori.udl.cat/bitstreams/c7b041d9-50b6-4d07-bd4b-c122f0f05496/download
8e4c8bf027b201bed7b8a5204488cdcc
MD5
5
ORIGINAL
026372.pdf
026372.pdf
application/pdf
41829713
https://repositori.udl.cat/bitstreams/93660064-871b-4518-8137-593af768e20c/download
28be1864161aa8ba5f46cec97d6175ee
MD5
6
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/78c65ed0-99d9-46c4-8acf-71eae0520ff9/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
SWORD
mets.xml
SWORD deposit package
application/octet-stream
41286145
https://repositori.udl.cat/bitstreams/b4c6f558-b4eb-4a0a-9222-19caaffa0c7d/download
e725f00064b9aea124680ad55d794d71
MD5
3
THUMBNAIL
026372.pdf.jpg
026372.pdf.jpg
Generated Thumbnail
image/jpeg
4040
https://repositori.udl.cat/bitstreams/97d6114b-0434-4951-bb53-9af881cdd864/download
1ba58c167af7d881f9f67954fcb464f2
MD5
4
10459.1/67598
oai:repositori.udl.cat:10459.1/67598
2020-07-13 10:33:47.473
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/733182022-12-02T09:37:43Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Solache Berrocal, Guillermo
Rolle Sóñora, Valeria
Martín Fernández, Noelia
Cambray Carner, Serafí
Valdivielso Revilla, José Manuel
Rodríguez, Isabel
2022-03-18T08:51:13Z
2022-03-18T08:51:13Z
2020
Background: Novel ways of determining cardiovascular risk are needed as a consequence of population ageing and the increased prevalence of chronic kidney disease (CKD), both of which favour vascular calcification. Since the formation of arterial calcium deposits has a genetic component, single nucleotide polymorphisms (SNPs) could predict cardiovascular events.
Methods: A selection of 1927 CKD patients and controls recruited by the NEFRONA study were genotyped for 60 SNPs from 22 candidate genes. A calcium score was calculated from the echogenicity of arterial atherosclerotic plaques and the presence of cardiovascular events during a 4-year period was recorded. Association of SNPs with the calcium score was identified by multiple linear regression models and their capacity to predict events was assessed by means of Cox proportional hazards regression and receiver operating characteristics curves.
Results: Two variants, rs2296241 of CYP24A1 and rs495392 of KL, were associated with the calcium score. Despite this, only heterozygotes for rs495392 had a lower risk of suffering an event compared with homozygotes for the major allele {hazard ratio (HR) 0.67 [95% confidence interval (CI) 0.48-0.93]}. Of note, the calcium score was associated with an increased risk of cardiovascular events [HR 1.71 (95% CI 1.35-2.17)]. The addition of the rs495392 genotype to classical cardiovascular risk factors did not increase the predictive power [area under the curve (AUC) 71.3 (95% CI 61.1-85.5) versus 71.4 (61.5-81.4)].
Conclusions: Polymorphisms of CYP24A1 and KL are associated with the extent of calcification but do not predict cardiovascular events. However, the echogenic determination of the extent of calcium deposits seems a promising non-irradiating method for the scoring of calcification in high-risk populations.
This work was financed by the Spanish National Plan for Scientific and Technical Research and Innovation 2013–2016, co-founded by European Union FEDER/ERDF funds ISCIIFEDER/ERDF (PI10/00173, PI18/00610, PI18/00694) and Thematic Network for Collaborative Research in Health (RETICS) REDinREN from ISCIII (RD16/0009/0005, RD16/0009/0011). G.S.-B. received a graduate fellowship from the Gobierno del Principado de Asturias (“Severo Ochoa” Program). I.R. is financially supported by FINBA. Funders had no role in the design, execution, interpretation or writing of the study.
https://doi.org/10.1093/ndt/gfaa240
032813
0931-0509
1460-2385
http://hdl.handle.net/10459.1/73318
eng
Oxford University Press
European Renal Association - European Dialysis and Transplant Association
Reproducció del document publicat a: https://doi.org/10.1093/ndt/gfaa240
Nephrology Dialysis Transplantation, 2021, vol. 36, núm. 11, p. 2076–2083
cc-by-nc (c)Authors, 2020
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/4.0/
Calcium score
Cardiovascular risk
Klotho
Single nucleotide polymorphism
Vitamin D 24-hydroxylase
CYP24A1 and KL polymorphisms are associated with the extent of vascular calcification but do not improve prediction of cardiovascular events
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
032813.pdf
032813.pdf
application/pdf
331654
https://repositori.udl.cat/bitstreams/1089965c-cc35-44ed-af29-41e0fc74598e/download
3b058ec6407b4d87565887bbbb9348c6
MD5
1
THUMBNAIL
032813.pdf.jpg
032813.pdf.jpg
Generated Thumbnail
image/jpeg
5914
https://repositori.udl.cat/bitstreams/c379c196-1f77-4dbc-87af-37f13d480156/download
dfbffd074c736ee89e9d6910c74303ab
MD5
4
TEXT
032813.pdf.txt
032813.pdf.txt
Extracted Text
text/plain
40132
https://repositori.udl.cat/bitstreams/7a1511b3-915f-40fc-9c10-294f98b1d712/download
f153e5a85443650769cdcb70e9fc3031
MD5
5
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/f76fc9ea-5c6d-4bd9-9022-de301aeed8ce/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
914
https://repositori.udl.cat/bitstreams/005e2dfe-aa7e-4b05-a09b-c7e02947718f/download
24013099e9e6abb1575dc6ce0855efd5
MD5
2
10459.1/73318
oai:repositori.udl.cat:10459.1/73318
2022-12-02 09:37:43.257
http://creativecommons.org/licenses/by-nc/4.0/
cc-by-nc (c)Authors, 2020
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/4646672024-03-12T14:12:38Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_49291
Ruiz Mitjana, Anna
Vidal Sabanés, Maria
Navaridas Fernández de Bobadilla, Raúl
Perramon Güell, Aida
Yeramian Hakim, Andree
Nicholson Sabaté, Nathan
Egea Navarro, Joaquim
Encinas Martín, Mario
Matias-Guiu, Xavier
Dolcet Roca, Xavier
2023-12-05T09:20:53Z
2023-12-05T09:20:53Z
2023
Metformin is a widespread antidiabetic agent that is commonly used as a treatment against type 2 diabetes mellitus patients. Regarding its therapeutic potential, multiple studies have concluded that Metformin exhibits antineoplastic activity on several types of cancer, including endometrial carcinoma. Although Metformin’s antineoplastic activity is well documented, its cellular and molecular anticancer mechanisms are still a matter of controversy because a plethora of anticancer mechanisms have been proposed for different cancer cell types. In this study, we addressed the cellular and molecular mechanisms of Metformin’s antineoplastic activity by using both in vitro and in vivo studies of Pten-loss driven carcinoma mouse models. In vivo, Metformin reduced endometrial neoplasia initiated by Pten-deficiency. Our in vitro studies using Pten-deficient endometrial organoids focused on both cellular and molecular levels in Metformin’s tumor suppressive action. At cellular level, we showed that Metformin is involved in not only the proliferation of endometrial epithelial cells but also their regulation via a variety of mechanisms of epithelial-to-mesenchymal transition (EMT) as well as TGF-β-induced apoptosis. At the molecular level, Metformin was shown to affect the TGF-β signalling., a widely known signal that plays a pivotal role in endometrial carcinogenesis. In this respect, Metformin restored TGF-β-induced apoptosis of Pten-deficient endometrial organoids through a p38-dependent mechanism and inhibited TGF-β-induced EMT on no-polarized endometrial epithelial cells by inhibiting ERK/MAPK signalling. These results provide new insights into the link between the cellular and molecular mechanism for Metformin’s antineoplastic activity in Pten-deficient endometrial cancers.
This research was supported by grants and PID2019-104734RB-I00 and PID2022-141220OB-I00 from the Spanish Ministerio de Ciencia, Innovacion ´ y Universidades.
https://doi.org/10.1016/j.biopha.2023.115817
033971
0753-3322
https://repositori.udl.cat/handle/10459.1/464667
eng
Elsevier
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104734RB-I00/ES/DESCIFRANDO REDES DE SEÑALIZACION EN EL CANCER DE ENDOMETRIO: PAPEL DEL MICRORNA-424(322)%2F503 NEOPLASIAS ENDOMETRIALES Y SU REGULACION POR LAS VIAS PI3K%2FAKT Y TGF-BETA%2FSMAD/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/PID2022-141220OB-I00/ES/
Reproducció del document publicat a https://doi.org/10.1016/j.biopha.2023.115817
Biomedicine & Pharmacotherapy, 2023, vol. 168, 115817
cc-by-nc-nd (c) Anna Ruiz-Mitjana et al., 2023
Attribution-NonCommercial-NoDerivatives 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Metformin
Endometrial cancer
Pten
Mouse model of cancer
Drug repurposing
Metformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
899
https://repositori.udl.cat/bitstreams/0feda53f-752c-4f87-bf5c-20d03335f8ae/download
3b6ce8e9e36c89875e8cf39962fe8920
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
639
https://repositori.udl.cat/bitstreams/60b375b8-63b5-43fd-83ef-8ced1d77eaeb/download
15ec217096d63e7cd318d42eb888308c
MD5
3
TEXT
033971.pdf.txt
033971.pdf.txt
Extracted text
text/plain
75272
https://repositori.udl.cat/bitstreams/69012af8-4b62-4c8b-b369-bf5b931b811c/download
70cb3e8be3b0330434891d8e640301f8
MD5
4
THUMBNAIL
033971.pdf.jpg
033971.pdf.jpg
Generated Thumbnail
image/jpeg
5831
https://repositori.udl.cat/bitstreams/4ca50300-a43f-4c71-9690-628d186af85f/download
4cf3902442ed19a69b2e6e2ea3b7ae45
MD5
5
ORIGINAL
033971.pdf
033971.pdf
application/pdf
13887791
https://repositori.udl.cat/bitstreams/2c593ed9-9de0-4b03-a228-fe0150a1a2da/download
a85ebbc7c32232d323774d66191bc456
MD5
1
10459.1/464667
oai:repositori.udl.cat:10459.1/464667
2024-03-12 14:12:38.897
http://creativecommons.org/licenses/by-nc-nd/4.0/
cc-by-nc-nd (c) Anna Ruiz-Mitjana et al., 2023
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/628442018-03-21T00:48:10Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Alcubierre Calvo, Núria
Castelblanco Echavarría, Esmeralda
Martínez Alonso, Montserrat
Granado Casas, Minerva
Esquerda, Aureli
Traveset Maeso, Alicia
Martínez González, María Dolores
Franch-Nadal, Josep
Mauricio Puente, Dídac
2018-03-20T09:56:37Z
2018-03-20T09:56:37Z
2018-03-12
2018-03-20T09:56:39Z
Background: In this cross-sectional study, we assessed the possible association of vitamin D deficiency with self-reported treatment satisfaction and health-related quality of life in patients with type 2 diabetes. Methods: We performed a sub-analysis of a previous study and included a total of 292 type 2 diabetic patients. We evaluated treatment satisfaction and health-related quality of life through specific tools: the Diabetes Treatment Satisfaction Questionnaire and the Audit of Diabetes-Dependent Quality of Life. Vitamin D deficiency was defined as 25 (OH) D serum levels < 15 ng/mL. Results: Multivariable linear regression models were used to estimate the relationship of vitamin D deficiency with both outcomes once adjusted for self-reported patient characteristics. Vitamin D deficiency was significantly associated with the final score of the Diabetes Treatment Satisfaction Questionnaire and the single "diabetes-specific quality of life" dimension of the Audit of Diabetes-Dependent Quality of Life (p = 0.0198 and p = 0.0070, respectively). However, lower concentrations of 25-OH vitamin D were not associated with the overall quality of life score or the perceived frequency of hyperglycaemia and hypoglycaemia. Conclusions: Our study shows the association between vitamin D deficiency and both the self-reported diabetes treatment satisfaction and the diabetes-specific quality of life in patients with type 2 diabetes.
This study was supported by the Spanish Ministry of Health, Instituto de Salud Carlos III (ISCIII) (PS09/01035 and PI15/00625) and European Regional Development Fund (ERDF). N. A holds a pre-doctoral fellowship from ISCIII, FI11/0008. Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases is an initiative of ISCIII, Spain. The Health Sciences Research Institute Germans Trias i Pujol is part of the CERCA Programme/Generalitat de Catalunya.
application/pdf
https://doi.org/10.1186/s12955-018-0873-3
026784
1477-7525
http://hdl.handle.net/10459.1/62844
eng
BioMed Central
Reproducció del document publicat a: https://doi.org/10.1186/s12955-018-0873-3
Health And Quality of Life Outcomes, 2018, vol. 16, num. 44, p. 1-8
cc-by (c) Alcubierre Calvo, Núria et al., 2018
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es
Diabetis
Vitamina D
Retinopatia diabètica
Diabetes
Vitamin D
Diabetic retinopathy
Vitamin D deficiency is associated with poorer satisfaction with diabetes-related treatment and quality of life in patients with type 2 diabetes: a cross-sectional study
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
CC-LICENSE
license_url
application/octet-stream
43
https://repositori.udl.cat/bitstreams/a2c5558e-2de6-4bae-af5c-4739ba93fd97/download
5134edb0a80711cbbaa5247c36025151
MD5
2
license_text
text/html
23115
https://repositori.udl.cat/bitstreams/8484631b-be16-4657-a9c8-2b0a01273f48/download
ec3783401c55aba9b2c045380c0dd4b3
MD5
3
license_rdf
application/octet-stream
20337
https://repositori.udl.cat/bitstreams/14b724b7-ecb9-4559-aa44-7bc81bfee652/download
1485691ce20485471fe59ad1ac24bf0f
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/8a90998b-6a20-4611-8c5d-65a45ca0afaa/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
5
SWORD
mets.xml
SWORD deposit package
application/octet-stream
331641
https://repositori.udl.cat/bitstreams/3ae23d75-4bac-444d-b1bf-6b4c623b4abb/download
17661a7468a24b2ddd2189922aa5e86d
MD5
6
ORIGINAL
026784.pdf
application/pdf
391351
https://repositori.udl.cat/bitstreams/960efe1f-f51d-4c21-931a-c85e5518cd2e/download
d327fdcaa703846cc3d43721692b9fca
MD5
1
THUMBNAIL
026784.pdf.jpg
026784.pdf.jpg
Generated Thumbnail
image/jpeg
5284
https://repositori.udl.cat/bitstreams/3877b701-f391-475e-abaf-6e4df70c6a8f/download
4c608c524f68fcef7610b650e18f8985
MD5
7
TEXT
026784.pdf.txt
026784.pdf.txt
Extracted Text
text/plain
40209
https://repositori.udl.cat/bitstreams/4de5eecb-61ed-4573-b40f-e10a6d274024/download
8ee86ef847921e3859cc92bacba05f23
MD5
8
10459.1/62844
oai:repositori.udl.cat:10459.1/62844
2018-03-21 00:48:10.052
http://creativecommons.org/licenses/by/3.0/es
cc-by (c) Alcubierre Calvo, Núria et al., 2018
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/570032021-08-30T15:04:33Zcom_10459.1_227com_10459.1_2col_10459.1_314
Ammarguellat, Fatima
Llovera i Tomàs, Marta
Kelly, Paul A.
Goffin, Vincent
2016-05-10T07:50:34Z
2025-01-01
2001
Previous reports have shown a direct effect of erythropoietin
(Epo) on vascular smooth muscle cells
(VSMCs). Our aim was to assess expression of the Epo
receptor (EpoR) on VSMCs and to study the activation
of two major signaling cascades activated by Epo,
namely JAK2/STAT5 and MAPK pathways. All experiments
were performed in parallel using the Eporesponsive
UT7 cell line. From semiquantitative RTPCR
experiments, VSMCs were estimated to express
;30-fold less EpoR mRNA than UT7 cells. Epo-induced
phosphorylation of proteins involved in the EpoR/
JAK2/STAT5 cascade could not be detected in VSMCs,
even using pharmacological doses of Epo (250 IU/ml).
In contrast, a strong activation of MAP kinase pathway
was detected with as low as 10 IU/ml Epo. We
suggest that MAPK activation reflects a physiologically
relevant effect of Epo on VSMCs that may be
correlated to cell proliferation.
https://doi.org/10.1006/bbrc.2001.5085
008512
0006-291X
http://hdl.handle.net/10459.1/57003
eng
Elsevier
Reproducció del document publicat a https://doi.org/10.1006/bbrc.2001.5085
Biochemical and Biophysical Research Communications, 2001, vol. 284, núm. 4, p. 1031-1038
(c) Academic Press, 2001
info:eu-repo/semantics/restrictedAccess
Epo
Epo receptor
MAP kinase
VSMC
Low Doses of EPO Activate MAP Kinases but Not JAK2–STAT5 in Rat Vascular Smooth Muscle Cells
article
publishedVersion
marta.llovera@cmb.udl.cat
Llovera i Tomàs, Marta
ORIGINAL
008512.pdf
008512.pdf
application/pdf
392134
https://repositori.udl.cat/bitstreams/1366d386-b24c-42b7-889d-a3d30e2c0161/download
6754e710ee65abbafaba4dae11d207d6
MD5
1
TEXT
008512.pdf.txt
008512.pdf.txt
Extracted Text
text/plain
33607
https://repositori.udl.cat/bitstreams/bc44597f-90ae-4193-b5dd-10d9d550d04c/download
5bfa9054146411a8e1a201627bfe36ec
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/6bd33c50-faf4-4625-9972-943d3e8f2dd0/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
008512.pdf.jpg
008512.pdf.jpg
Generated Thumbnail
image/jpeg
4965
https://repositori.udl.cat/bitstreams/6b4644a6-1924-4f79-a12c-5b910cb0041b/download
a80d1a4057e812827f476f16a6a7f9b9
MD5
3
10459.1/57003
oai:repositori.udl.cat:10459.1/57003
2021-08-30 15:04:33.814
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/570532021-08-30T15:04:34Zcom_10459.1_227com_10459.1_2col_10459.1_314
Torres-Arzayus, Maria I.
Font de Mora, Jaime
Yuan, Jing
Vazquez, Francisca
Bronson, Roderick
Rué i Monné, Montserrat
Sellers, William R.
Brown, Myles
2016-05-19T08:53:52Z
2025-01-01
2004
The gene encoding AIB1, an estrogen receptor coactivator, is amplified in a subset of human breast cancers. Here we
show that overexpression of AIB1 in transgenic mice (AIB1-tg) leads to mammary hypertrophy, hyperplasia, abnormal
postweaning involution, and the development of malignant mammary tumors. Tumors are also increased in other organs,
including the pituitary and uterus. AIB1 overexpression increases mammary IGF-I mRNA and serum IGF-I protein levels.
In addition, IGF-I receptor and downstream signaling molecules are activated in primary mammary epithelial cells and
mammary tumor cells derived from AIB1-tg mice. Knockdown of AIB1 expression in cultured AIB1-tg mammary tumor
cells leads to reduced IGF-I mRNA levels and increased apoptosis, suggesting that an autocrine IGF-I loop underlies the
mechanism of AIB1-induced oncogenesis.
https://doi.org/10.1016/j.ccr.2004.06.027
009164
1535-6108
http://hdl.handle.net/10459.1/57053
eng
Elsevier
Reproducció del document publicat a https://doi.org/10.1016/j.ccr.2004.06.027
Cancer Cell, 2004, vol. 6, núm. 3, p. 263-274
(c) Cell Press, 2004
info:eu-repo/semantics/restrictedAccess
High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene
article
publishedVersion
montse.rue@cmb.udl.cat
Rué i Monné, Montserrat
TEXT
009164.pdf.txt
009164.pdf.txt
Extracted Text
text/plain
60969
https://repositori.udl.cat/bitstreams/8247763c-cf72-4b9b-be53-be243b7c2b54/download
4017af4df0894d95792cb6715c28e9fd
MD5
4
ORIGINAL
009164.pdf
009164.pdf
application/pdf
810830
https://repositori.udl.cat/bitstreams/fff80666-d598-4c73-a65e-efaf8b0a25a1/download
6a0c510f4f03d6e6e55fdace6e73b245
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/c158891c-d061-4207-a5a9-47009a835fe5/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
THUMBNAIL
009164.pdf.jpg
009164.pdf.jpg
Generated Thumbnail
image/jpeg
6112
https://repositori.udl.cat/bitstreams/266733da-fd98-4cf7-9852-b856527eec85/download
a35a187f12723473969b1648d5e4aa5d
MD5
3
10459.1/57053
oai:repositori.udl.cat:10459.1/57053
2021-08-30 15:04:34.062
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/4650782024-02-14T03:00:30Zcom_10459.1_227com_10459.1_2col_10459.1_314col_10459.1_49291col_10459.1_44504
Bayona, Clara
Alza, Lía
Ranđelović, Teodora
Sallán, Marta C.
Visa Pretel, Anna
Cantí Nicolás, Carles
Ochoa, Ignacio
Oliván, Sara
Herreros Danés, Judit
2024-02-13T09:23:49Z
2024-02-13T09:23:49Z
2024-02-12
2024-02-13T09:23:49Z
Glioblastoma (GBM) is a highly malignant brain tumour characterised by limited treatment options and poor prognosis. The tumour microenvironment, particularly the central hypoxic region of the tumour, is known to play a pivotal role in GBM progression. Cells within this region adapt to hypoxia by stabilising transcription factor HIF1-α, which promotes cell proliferation, dedifferentiation and chemoresistance. In this study we sought to examine the effects of NNC-55-0396, a tetralol compound which overactivates the unfolded protein response inducing apoptosis, using the organ-on-chip technology. We identified an increased sensitivity of the hypoxic core of the chip to NNC, which correlates with decreasing levels of HIF1-α in vitro. Moreover, NNC blocks the macroautophagic process that is unleashed by hypoxia as revealed by increased levels of autophagosomal constituent LC3-II and autophagy chaperone p62/SQSTM1. The specific effects of NNC in the hypoxic microenvironment unveil additional anti-cancer abilities of this compound and further support investigations on its use in combined therapies against GBM.
This work was supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 829010 (PRIME H2020-FETOPEN-2018-2019-2020-01). We also acknowledge the financial support from the Spanish Ministry of Economy and Competitiveness (MINECO fellowship, DIN 2020-011544); Ministry of Science and Innovation, the European Regional Development Fund (Proyect PID2021-126051OB-C41 funded by MCIN/AEI/10.13039/501100011033/FEDER, UE); MINECO Retos Program RTI2018-094739-B-I00 to CC and JH) and Fundació La Marató de TV3 (201909-30 to CC). CB would like to thank the Government of Aragon (DGA) for the predoctoral funding. AV is funded by Asociación Española Contra el Cáncer and LA is a recipient of an FI-AGAUR fellowship. We are grateful to Maria Casals and David Argilés for technical assistance. Cell culture experiments were performed in the Cell Culture Technical Scientific Service, Universitat de Lleida (Lleida, Catalonia, Spain). Authors would like to acknowledge the use of Servicio General de Apoyo a la Investigación-SAI, Universidad de Zaragoza.
application/pdf
https://doi.org/10.1038/s41419-024-06492-1
034008
2041-4889
https://repositori.udl.cat/handle/10459.1/465078
eng
Springer Nature
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094739-B-I00/ES/NUEVOS MECANISMOS DE DESREGULACION DE LA SEÑALIZACION POR CALCIO CONTRA EL GLIOBLASTOMA/
Reproducció del document publicat a: https://doi.org/10.1038/s41419-024-06492-1
Cell Death & Disease, 2024, vol. 15, num. 127
info:eu-repo/grantAgreement/EC/H2020/829010/EU/FETOPEN
cc-by (c) Authors, 2024
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-sa/4.0
Cancer microenvironment
Cancer models
Microfluidics
Tetralol derivative NNC-55-0396 targets hypoxic cells in the glioblastoma microenvironment: an organ-on-chip approach
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
034008.pdf
application/pdf
6206384
https://repositori.udl.cat/bitstreams/be2932c4-f983-4b46-86b9-28a1cf6f39ff/download
d4e1041c6aa2c024bfd0c0fb705d5fca
MD5
1
CC-LICENSE
license_url
application/octet-stream
49
https://repositori.udl.cat/bitstreams/a7564750-afd8-4b73-b35d-c57c9546643f/download
c0b3e2a72fe5e4b72fa5798bb22cd3a3
MD5
2
license_text
text/html
23768
https://repositori.udl.cat/bitstreams/66d7482e-3eac-488f-b436-b93ae8c3483e/download
f6497521076c327a81992858a2154bff
MD5
3
license_rdf
application/octet-stream
24325
https://repositori.udl.cat/bitstreams/3d0e0227-65ca-4b7e-b571-a0601f95d9c8/download
6391b802d6a1a215f0b85a700194d772
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
639
https://repositori.udl.cat/bitstreams/4ee666a9-ebec-461a-9218-c9caded35e42/download
15ec217096d63e7cd318d42eb888308c
MD5
5
bundle.name
mets.xml
SWORD deposit package
application/octet-stream
5805060
https://repositori.udl.cat/bitstreams/e52cdc44-4431-42d5-9bd4-accb442a3d8a/download
0026c69719d6ff9b26de4963d0cff4d8
MD5
6
TEXT
034008.pdf.txt
034008.pdf.txt
Extracted text
text/plain
48421
https://repositori.udl.cat/bitstreams/d138b99e-f184-47da-bed4-12b7824dc86f/download
372ec0fcf800768129bb481ed52b7426
MD5
7
THUMBNAIL
034008.pdf.jpg
034008.pdf.jpg
Generated Thumbnail
image/jpeg
6701
https://repositori.udl.cat/bitstreams/7a44710c-54a8-45b5-ab14-96635e36b34a/download
d0e7293323e8f65f0f6b2f478ebf6b57
MD5
8
10459.1/465078
oai:repositori.udl.cat:10459.1/465078
2024-02-14 03:00:30.593
https://creativecommons.org/licenses/by-sa/4.0
cc-by (c) Authors, 2024
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
Q29uY2VkZWl4byBsYSBsbGljw6huY2lhIGkgZXN0aWMgbGVnaXRpbWF0IHBlciBlbnZpYXIgYXF1ZXN0IGZvcm11bGFyaSBpIGFjY2VwdGFyIGxlcyBjb25kaWNpb25zIGRlIGRpcMOyc2l0IGkgZGlmdXNpw7MgYWwgUmVwb3NpdG9yaSBPYmVydCBkZSBsYSBVZEwgZGUgbGVzIGRhZGVzIHF1ZSBzJ2hpIGRlc2NyaXVlbiAocGVycXXDqCBzw7NjIHRpdHVsYXIgZGVscyBkcmV0cyBzb2JyZSBsZXMgZGFkZXMgbyBiw6kgcGVycXXDqCBkaXNwb3NvIGRlIGxhIGNvbXBldMOobmNpYSBvIGRlbHMgcGVybWlzb3MgcGVyIGZlci1obykuIERlY2xhcm8gcXVlIGVsIGRpcMOyc2l0IGkgZGlmdXNpw7MgZGUgbGVzIGRhZGVzIG5vIHZ1bG5lcmEgZHJldHMgZGUgdGVyY2VycyAobmkgZGUgcHJvcGlldGF0IGludGVsZWN0dWFsLCBuaSBpbmR1c3RyaWFsLCBuaSBkZSBwcml2YWNpdGF0LCBuaSBkZSBjYXAgbWVuYSkgZGUgbWFuZXJhIHF1ZSBleG9uZXJvIGEgbGEgVWRMIGRlIHF1YWxzZXZvbCBvYmxpZ2FjacOzIG8gcmVzcG9uc2FiaWxpdGF0IGRhdmFudCBxdWFsc2V2b2wgYWNjacOzIGxlZ2FsIHF1ZSBlcyBwdWd1aSBzdXNjaXRhciBkZXJpdmFkYSBkZWwgY29udGluZ3V0LCBkaXDDsnNpdCBvIGRpZnVzacOzIGRlIGxlcyBkYWRlcy4K
oai:repositori.udl.cat:10459.1/3172020-07-14T08:39:35Zcom_10459.1_227com_10459.1_2col_10459.1_314
Alves, Rui
Sorribas Tello, Albert
2010-04-14T10:42:19Z
2010-04-14T10:42:19Z
2007
Background: Current advances in genomics, proteomics and other areas of molecular biology make the identification and reconstruction of novel pathways an emerging area of great interest. One such class of pathways is involved in the biogenesis of Iron-Sulfur Clusters (ISC).
Results: Our goal is the development of a new approach based on the use and combination of mathematical, theoretical and computational methods to identify the topology of a target network. In this approach, mathematical models play a central role for the evaluation of the alternative
network structures that arise from literature data-mining, phylogenetic profiling, structural methods, and human curation. As a test case, we reconstruct the topology of the reaction and regulatory network for the mitochondrial ISC biogenesis pathway in S. cerevisiae. Predictions
regarding how proteins act in ISC biogenesis are validated by comparison with published
experimental results. For example, the predicted role of Arh1 and Yah1 and some of the interactions we predict for Grx5 both matches experimental evidence. A putative role for frataxin in directly regulating mitochondrial iron import is discarded from our analysis, which agrees with also published experimental results. Additionally, we propose a number of experiments for testing other predictions and further improve the identification of the network structure.
Conclusion: We propose and apply an iterative in silico procedure for predictive reconstruction of the network topology of metabolic pathways. The procedure combines structural bioinformatics tools and mathematical modeling techniques that allow the reconstruction of biochemical networks. Using the Iron Sulfur cluster biogenesis in S. cerevisiae as a test case we indicate how this procedure can be used to analyze and validate the network model against experimental results. Critical evaluation of the obtained results through this procedure allows devising new wet lab experiments to confirm its predictions or provide alternative explanations for further improving the models.
https://doi.org/10.1186%2F1752-0509-1-10
010678
1752-0509
http://hdl.handle.net/10459.1/317
eng
BioMed Central
Reproducció del document publicat a https://doi.org/10.1186%2F1752-0509-1-10
BMC Systems Biology, 2007, vol. 1, núm.10, p. 1-19
cc-by, (c) Alves and Sorribas, 2007
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.0/es/deed.ca
Saccharomyces cerevisiae -- Metabolisme
In silico pathway reconstruction: Iron-sulfur cluster biogenesis in Saccharomyces cerevisiae
article
publishedVersion
TEXT
1752-0509-1-10.pdf.txt
1752-0509-1-10.pdf.txt
Extracted Text
text/plain
90975
https://repositori.udl.cat/bitstreams/4d806ac8-31f1-466a-972f-3a425ae65748/download
7c97cb00aeee1104b0976902ae3019e6
MD5
17
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1846
https://repositori.udl.cat/bitstreams/29ae82ed-8053-4ca3-ae19-7f0ac86e690f/download
86668a794ba62cb544c3c99afb384146
MD5
5
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
24637
https://repositori.udl.cat/bitstreams/e8c5cc63-9173-4b7d-a6c8-f1ab701d94ea/download
0efe8f1eca8ecb2ed203a894608d7c09
MD5
7
license_text
license_text
text/html; charset=utf-8
20901
https://repositori.udl.cat/bitstreams/f9af6136-80c1-4fea-ba06-dd103791ed5c/download
1f2747d4709567dd87bd8f89348c86d4
MD5
8
license_url
license_url
text/plain; charset=utf-8
46
https://repositori.udl.cat/bitstreams/43d2551d-948c-4a04-a750-78d69931389a/download
9f2020a497eacc3c6092de175e4836a8
MD5
9
ORIGINAL
1752-0509-1-10.pdf
1752-0509-1-10.pdf
application/pdf
1274397
https://repositori.udl.cat/bitstreams/9d181c0a-402f-4bdc-aac6-1deb9eb36523/download
9ee5d1697811c7ebebdbd1b66a4b7a15
MD5
1
THUMBNAIL
1752-0509-1-10.pdf.jpg
1752-0509-1-10.pdf.jpg
Generated Thumbnail
image/jpeg
5294
https://repositori.udl.cat/bitstreams/14b6b1bf-2233-4480-97e3-3ab994e0cf10/download
edea04091af1fa5b5aeb405e967e2b32
MD5
16
10459.1/317
oai:repositori.udl.cat:10459.1/317
2020-07-14 08:39:35.194
http://creativecommons.org/licenses/by/2.0/es/deed.ca
cc-by, (c) Alves and Sorribas, 2007
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/591122021-08-30T15:04:34Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Aldea, Martí
Garí Marsol, Eloi
Colomina i Gabarrella, Neus
2017-01-25T10:22:26Z
2025-01-01
2007
Cells adapt their size to both intrinsic and extrinsic demands and, among them, those that stem from growth and proliferation rates are crucial for cell size homeostasis. Here we revisit mechanisms that regulate cell cycle and cell growth in budding yeast. Cyclin Cln3, the most upstream activator of Start, is retained at the endoplasmic reticulum in early G1 and released by specific chaperones in late G1 to initiate the cell cycle. On one hand, these chaperones are rate-limiting for release of Cln3 and cell cycle entry and, on the other hand, they are required for key biosynthetic processes. We propose a model whereby the competition for specialized chaperones between growth and cycle machineries could gauge biosynthetic rates and set a critical size threshold at Start.
We thank Francisco Ferrezuelo, Jordi Torres, Carme Gallego and Paul Nurse for helpful discussions. This work was funded by the Ministry of Education and Science of Spain, Fundació La Caixa and the European Union (FEDER). N.C. is a researcher of the Ramon y Cajal programme.
https://doi.org/10.4161/cc.6.21.4920
012041
1538-4101
http://hdl.handle.net/10459.1/59112
eng
Taylor & Francis
Reproducció del document publicat a https://doi.org/10.4161/cc.6.21.4920
Cell Cycle, 2007, vol. 6, núm. 21, p. 2599-2603
(c) Landes Bioscience, 2007
info:eu-repo/semantics/restrictedAccess
Cell cycle
Start
Critical cell size
Growth rate
Chaperones
Cln3
Ydj1
Control of cell cycle and cell growth by molecular chaperones
article
publishedVersion
marti.aaldea@cmb.udl.cat
Aldea, Martí
THUMBNAIL
012041.pdf.jpg
012041.pdf.jpg
Generated Thumbnail
image/jpeg
3217
https://repositori.udl.cat/bitstreams/0e33246f-1ac6-413e-918a-0e0cc094c272/download
293d2ff835ac5a6b3a8fdf6386541344
MD5
3
TEXT
012041.pdf.txt
012041.pdf.txt
Extracted Text
text/plain
30176
https://repositori.udl.cat/bitstreams/52b0ba8b-ab23-4537-98a4-2ec293dc156d/download
9bf8a44c0e246ed43863c6df903d306a
MD5
4
ORIGINAL
012041.pdf
012041.pdf
application/pdf
492249
https://repositori.udl.cat/bitstreams/b7378fd7-354d-427c-8581-b9c162fb136f/download
b0e6cbc04f58b1358ecceb143c433bf1
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/ed890764-6845-4bbf-9cdd-96dde27b7701/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
10459.1/59112
oai:repositori.udl.cat:10459.1/59112
2021-08-30 15:04:34.359
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/697082023-01-24T15:59:11Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_49291
Romero, Antonia María
Ramos-Alonso, Lucía
Montellá-Manuel, Sandra
García-Martínez, José
Torre Ruiz, M. A. de la
Pérez-Ortín, José E.
Martínez-Pastor, María Teresa
Puig, Sergi
2020-10-26T13:36:35Z
2020-10-26T13:36:35Z
2019-09
2020-10-26T13:36:35Z
Iron is an essential micronutrient that participates as a cofactor in a broad range of metabolic processes including mitochondrial respiration, DNA replication, protein translation and lipid biosynthesis. Adaptation to iron deficiency requires the global reorganization of cellular metabolism directed to optimize iron utilization. The budding yeast Saccharomyces cerevisiae has been widely used to characterize the responses of eukaryotic microorganisms to iron depletion. In this report, we used a genomic approach to investigate the contribution of transcription rates to the modulation of mRNA levels during adaptation of yeast cells to iron starvation. We reveal that a decrease in the activity of all RNA polymerases contributes to the down-regulation of many mRNAs, tRNAs and rRNAs. Opposite to the general expression pattern, many genes including components of the iron deficiency response, the mitochondrial retrograde pathway and the general stress response display a remarkable increase in both transcription rates and mRNA levels upon iron limitation, whereas genes encoding ribosomal proteins or implicated in ribosome biogenesis exhibit a pronounced fall. This expression profile is consistent with an activation of the environmental stress response. The phosphorylation stage of multiple regulatory factors strongly suggests that the conserved nutrient signaling pathway TORC1 is inhibited during the progress of iron deficiency. These results suggest an intricate crosstalk between iron metabolism and the TORC1 pathway that should be considered in many disorders.
This work was supported by predoctoral contracts from the Spanish Ministry of Science, Innovation and Universities (MICINN) to AMR and LRA; a fellowship from the “Generalitat de Catalunya” (Spain) to SMM; European Union Funds (FEDER) and MICINN grants BIO2017-87828-C2-1-P to SP, BIO2017-87828-C2-2-P to MATR, BFU2016-77728-C3-3-P to JEPO, and BFU2015-71978-REDT to SP and JEPO; and Regional Government of Valencia PROMETEOII 2015/006 grant to JEPO.
application/pdf
https://doi.org/10.1016/j.bbagrm.2019.194414
029476
1874-9399
http://hdl.handle.net/10459.1/69708
eng
Elsevier
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2017-87828-C2-1-P/ES/REGULACION TRANSCRIPCIONAL Y POSTRANSCRIPCIONAL DE PROCESOS METABOLICOS DEPENDIENTES DE LA DISPONIBILIDAD DE HIERRO Y COBRE EN LEVADURAS Y PLANTAS/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2017-87828-C2-2-P/ES/INFLUENCIA DE LA DISPONIBILIDAD Y HORMESIS DEL HIERRO EN LA RESPUESTA AUTOFAGICA Y OXIDATIVA Y EN LA EXTENSION CRONOLOGICA DE LA VIDA EN LEVADURAS/
MINECO/PN2013-2016/BFU2016-77728-C3-3-P
info:eu-repo/grantAgreement/MINECO//BFU2015-71978-REDT/ES/LA VIDA DEL MRNA DESDE LA TRANSCRIPCION A LA DEGRADACION/
Versió postprint del document publicat a: https://doi.org/10.1016/j.bbagrm.2019.194414
Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 2019, vol. 1862, num. 9, p. 194414
cc-by-nc-nd (c) Elsevier, 2019
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/3.0/es
A genome-wide transcriptional study reveals that iron deficiency inhibits the yeast TORC1 pathway
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
THUMBNAIL
029476.pdf.jpg
029476.pdf.jpg
Generated Thumbnail
image/jpeg
2476
https://repositori.udl.cat/bitstreams/0b317df8-25a0-4f30-b60a-ad524eef5976/download
da6e4f9710a82d1e43fde71dbd11770e
MD5
8
ORIGINAL
029476.pdf
029476.pdf
Postprint
application/pdf
4603036
https://repositori.udl.cat/bitstreams/e8bee49f-e70d-4882-8e96-8b2926647785/download
db4182f0ff9938a3e612bae71b89a27f
MD5
7
CC-LICENSE
license_url
application/octet-stream
49
https://repositori.udl.cat/bitstreams/1b547cca-c2f9-4857-931e-bf3965edf8fe/download
fd26723f8d7edacdb29e3f03465c3b03
MD5
2
license_text
text/html
23276
https://repositori.udl.cat/bitstreams/c0e9ab24-019a-4507-97aa-c97e113c542c/download
dee46d6d9b23aac7b2f1bf36a82cece7
MD5
3
license_rdf
application/octet-stream
23594
https://repositori.udl.cat/bitstreams/f55bf537-aa25-404f-96d5-c7a3e950e327/download
f8dc1202367987bad3050a5dac12c346
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/c3524ce5-f857-43c1-b9a4-a472e1fe2dc8/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
5
SWORD
mets.xml
SWORD deposit package
application/octet-stream
1976480
https://repositori.udl.cat/bitstreams/5d4c41fd-e8fc-4fb7-b32f-ee29864ab3a9/download
c5d7c90b0571d2e46606e6721aa0a644
MD5
6
TEXT
029476.pdf.txt
029476.pdf.txt
Extracted Text
text/plain
78879
https://repositori.udl.cat/bitstreams/91972de8-d6db-443c-81ea-21ba2a9ebfbf/download
065926772b673bd4cabe2fe52dc6d85b
MD5
9
10459.1/69708
oai:repositori.udl.cat:10459.1/69708
2023-01-24 15:59:11.582
http://creativecommons.org/licenses/by-nc-nd/3.0/es
cc-by-nc-nd (c) Elsevier, 2019
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/629712018-04-06T09:59:06Zcom_10459.1_242com_10459.1_2com_10459.1_227com_10459.1_47453col_10459.1_10990col_10459.1_314col_10459.1_59998
Royo Sánchez-Palencia, José Luis
Valls Marsal, Joan
Acemel, Rafael D.
Gómez-Marin, Carlos
Pascual Pons, Mariona
Lupiañez, Arantxa
Gomez-Skarmeta, Jose Luis
Fibla Palazón, Joan
2018-04-04T08:47:06Z
2018-04-04T08:47:06Z
2018
Previous reports have proposed that personality may have played a role on human Out-Of-
Africa migration, pinpointing some genetic variants that were positively selected in the migrating
populations. In this work, we discuss the role of a common copy-number variant within
the SIRPB1 gene, recently associated with impulsive behavior, in the human Out-Of-Africa
migration. With the analysis of the variant distribution across forty-two different populations,
we found that the SIRPB1 haplotype containing duplicated allele significantly correlated with
human migratory distance, being one of the few examples of positively selected loci found
across the human world colonization. Circular Chromosome Conformation Capture (4C-seq)
experiments from the SIRPB1 promoter revealed important 3D modifications in the locus
depending on the presence or absence of the duplication variant. In addition, a 3' enhancer
showed neural activity in transgenic models, suggesting that the presence of the CNV may
compromise the expression of SIRPB1 in the central nervous system, paving the way to construct
a molecular explanation of the SIRPB1 variants role in human migration.
https://doi.org/10.1371/journal.pone.0193614
026796
1932-6203
http://hdl.handle.net/10459.1/62971
eng
Public Library of Science
Reproducció del document publicat a https://doi.org/10.1371/journal.pone.0193614
Plos One, 2018, vol. 13, núm. 3
cc-by (c) Royo et al., 2018
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
A common copy-number variant within SIRPB1 correlates with human Out-of-Africa migration after genetic drift correction
article
publishedVersion
ORIGINAL
026796.pdf
026796.pdf
application/pdf
10306016
https://repositori.udl.cat/bitstreams/e6ce5090-6ae3-41b0-bc2a-cfcaa68b63f8/download
09d1752c93b46e50d9551b8205f4d10d
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
805
https://repositori.udl.cat/bitstreams/31411706-ffe6-45b1-9681-1c22934cb1ae/download
4460e5956bc1d1639be9ae6146a50347
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/49c82c18-060d-432a-b9f4-4259dda56631/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
THUMBNAIL
026796.pdf.jpg
026796.pdf.jpg
Generated Thumbnail
image/jpeg
4935
https://repositori.udl.cat/bitstreams/7837d317-4058-4927-9e30-2caaa54b97f6/download
dbf4d1af5d09998c168e8f42c19080c3
MD5
4
TEXT
026796.pdf.txt
026796.pdf.txt
Extracted Text
text/plain
50720
https://repositori.udl.cat/bitstreams/1ac18a5c-bc4f-4c7b-82fb-215b2d4ab21c/download
0b2899ec1f4be70e56b22db96371fd31
MD5
5
10459.1/62971
oai:repositori.udl.cat:10459.1/62971
2018-04-06 09:59:06.319
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Royo et al., 2018
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/677792022-01-12T12:24:53Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Granado Casas, Minerva
Martín, Mariona
Martínez Alonso, Montserrat
Alcubierre Calvo, Núria
Hernández García, Marta
Alonso, Núria
Castelblanco Echavarría, Esmeralda
Mauricio Puente, Dídac
2020-01-09T08:27:58Z
2020-01-09T08:27:58Z
2020-01-02
2020-01-09T08:27:58Z
This study aimed to assess the potential association between dietary patterns (i.e., the Mediterranean Diet (MedDiet) and healthy eating) and patient-reported quality of life (QoL) and treatment satisfaction (TS) in adults with type 1 diabetes (T1D). A food frequency questionnaire, the Audit of Diabetes-Dependent Quality of Life (ADDQoL-19), and the Diabetes Treatment Satisfaction Questionnaire-status version (DTSQ-s) were administered via personal interviews to 258 participants with T1D. Multivariable analysis showed that a moderate or high adherence to the MedDiet was associated with greater diabetes-specific QoL (β = 0.32, 95% CI = 0.03; 0.61; p = 0.029). None of the dietary quality indexes (i.e., the alternate Mediterranean Diet Score (aMED) and the alternate Healthy Eating Index (aHEI)) were associated with the overall TS. However, the aHEI was positively associated with the specific items of TS "convenience" and "flexibility" (β = 0.03, 95% CI = 0.00; 0.06; p = 0.042 and β = 0.04; 95% CI = 0.01; 0.06; p = 0.011, respectively). On the other hand, the aHEI was negatively associated with the dimension "recommend to others" (β = −0.5, 95% CI = −0.99; −0.02; p = 0.042). In conclusion, a moderate and high adherence to the MedDiet was associated with greater QoL. Although neither aMED nor aHEI were associated with the overall TS, some specific items were positively (i.e., "convenience", "flexibility") or negatively ("recommend to others") related to the aHEI. Further research is needed to assess how to improve medical nutrition therapy and its impact on patient-reported outcomes in people with T1D.
This research was funded by grants from the Catalan Diabetes Association (Beca d’Educació
Terapèutica 2015), Instituto de Salud Carlos III, ISCIII (Ministry of Economy and Competitiveness) (PI12/0183
and PI15/0625) with co-funding from the European Regional Development Fund (ERDF). CIBER for Diabetes
and Associated Metabolic Diseases (CIBERDEM) is an initiative of ISCIII, Spain. M.G.-C. holds a predoctoral
fellowship from Ministerio de Educación, Cultura y Deporte, FPU15/03005.
application/pdf
https://doi.org/10.3390/nu12010131
029408
2072-6643
http://hdl.handle.net/10459.1/67779
eng
MDPI
Reproducció del document publicat a: https://doi.org/10.3390/nu12010131
Nutrients, 2020, vol. 12, num. 1, 131 (10 pp.)
cc-by (c) Granado Casas, Minerva et al., 2020
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
The Mediterranean Diet is Associated with an Improved Quality of Life in Adults with Type 1 Diabetes
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
029408.pdf
application/pdf
286038
https://repositori.udl.cat/bitstreams/4a4091d6-5e93-4065-a6fb-2ec808a3f2d7/download
6b2943cd9236ef3e55e1df88c560fccd
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/8c55a8d6-a81b-4733-b17e-41660a4c654a/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
5
SWORD
mets.xml
SWORD deposit package
application/octet-stream
283049
https://repositori.udl.cat/bitstreams/aa869e20-1231-45e4-970e-542e50c28c2c/download
1b805205ccb349b7f9df9c58436e0e03
MD5
6
THUMBNAIL
029408.pdf.jpg
029408.pdf.jpg
Generated Thumbnail
image/jpeg
4524
https://repositori.udl.cat/bitstreams/a061905b-e142-483e-b23a-bcee32bdfbdf/download
9c365bc2bed5dd5fdf80817c90e74713
MD5
7
CC-LICENSE
license_url
application/octet-stream
43
https://repositori.udl.cat/bitstreams/bdf9fdf0-204d-4bf8-8c9f-82388a2c7787/download
5134edb0a80711cbbaa5247c36025151
MD5
2
license_text
text/html
23115
https://repositori.udl.cat/bitstreams/dd92d93d-00fb-40d2-914e-2541e59d396b/download
ec3783401c55aba9b2c045380c0dd4b3
MD5
3
license_rdf
application/octet-stream
20337
https://repositori.udl.cat/bitstreams/04d60313-0ee1-4652-8216-fff5198ee434/download
1485691ce20485471fe59ad1ac24bf0f
MD5
4
TEXT
029408.pdf.txt
029408.pdf.txt
Extracted Text
text/plain
41266
https://repositori.udl.cat/bitstreams/74ee86c6-bf77-4eb9-837b-f49e6e0872c8/download
9bb1f262653004ea27a64d44ba1a6851
MD5
8
10459.1/67779
oai:repositori.udl.cat:10459.1/67779
2022-01-12 12:24:53.459
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Granado Casas, Minerva et al., 2020
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/844612022-12-04T00:06:41Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Forné Izquierdo, Carles
Yuguero Torres, Oriol
2022-12-03T11:32:29Z
2022-12-03T11:32:29Z
2022
Background: The Maslach Burnout Inventory (MBI) is an instrument commonly used to evaluate burnout syndrome.
The goal of the present study was to assess the internal reliability and the performance of the items and the subscales
of the MBI-HSS (the version for professionals working in human services) by validating its factorial structure in Spanish
urgency healthcare personnel.
Methods: Cross-sectional study including 259 healthcare emergency professionals (physicians and nurses) in the
Spanish health region of Lleida and the Pyrenees. Burnout was measured using the Spanish validated version of the
MBI-HSS. Internal reliability was estimated using Cronbach’s alpha coefcient. The sampling adequacy was assessed
using the Kaiser-Meyer-Olkin measure along with the Bartlett’s test of sphericity. A principal axis exploratory factor
analysis with an oblique transformation of the solution and a confrmatory factor analysis with maximum likelihood
estimation were performed. Goodness-of-ft was assessed by means of the chi-square ratio by the degrees of free dom, the standardized root mean square residual (SRMR), the root mean square error of approximation (RMSEA), the
Tucker-Lewis Index (TLI) and the comparative ft index (CFI).
Results: The three subscales showed good internal reliability with Cronbach’s alpha coefcients exceeding the
critical value of 0.7. Exploratory factor analysis revealed fve factors with eigenvalues greater than 1. Nevertheless,
confrmatory factor analysis showed a relatively satisfactory ft of the three-factor structure (χ2
/df=2.6, SRMR=0.07,
RMSEA=0.08, TLI=0.87, CFI=0.89), which was improved when several items were removed (χ2
/df=1.7, SRMR=0.04,
RMSEA=0.05, TLI=0.97, CFI=0.98).
Conclusions: Although it is necessary exploring new samples to get to more consistent conclusions, the MBI-HSS
is a reliable and factorially valid instrument to evaluate burnout syndrome in health professionals from the Spanish
emergency services.
https://doi.org/10.1186/s12909-022-03666-3
1472-6920
http://hdl.handle.net/10459.1/84461
eng
Springer Nature
Reproducció del document publicat a https://doi.org/10.1186/s12909-022-03666-3
BMC Medical Education, 2022, vol. 22, art. 615.
cc-by (c) Carles Forné Izquierdo et. al., 2022.
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Burnout
Psychological
Factor Analysis
Statistical
Maslach Burnout Inventory - Human Services Survey
Emergencies
Factor structure of the Maslach Burnout Inventory Human Services Survey in Spanish urgency healthcare personnel: a cross-sectional study
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://repositori.udl.cat/bitstreams/bda9b9cc-715a-473a-94cd-9d98f6ebb86b/download
0175ea4a2d4caec4bbcc37e300941108
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/9683f97a-419d-480e-b07c-2d7d4fa15adf/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
TEXT
bmcme_a2022vol22p615.pdf.txt
bmcme_a2022vol22p615.pdf.txt
Extracted text
text/plain
40056
https://repositori.udl.cat/bitstreams/94a09666-7a0b-41e7-85ab-48cca7ce6a18/download
276cd410aac0350a0b651f4bf5ebbab9
MD5
4
ORIGINAL
bmcme_a2022vol22p615.pdf
bmcme_a2022vol22p615.pdf
application/pdf
875164
https://repositori.udl.cat/bitstreams/0f6a7ea0-1161-4bc2-8d96-3642788ab39e/download
ef86a66061a7c58808bddbe7a97c12bd
MD5
1
THUMBNAIL
bmcme_a2022vol22p615.pdf.jpg
bmcme_a2022vol22p615.pdf.jpg
IM Thumbnail
image/jpeg
6008
https://repositori.udl.cat/bitstreams/3f64b43b-242a-458d-8da4-28cddeea7a6b/download
372a578cd92993e43bb3d1729fce8ab0
MD5
5
10459.1/84461
oai:repositori.udl.cat:10459.1/84461
2022-12-04 00:06:41.398
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Carles Forné Izquierdo et. al., 2022.
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/716312021-07-15T00:09:59Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Porcel Pérez, José Manuel
Esquerda, Aureli
Martínez Alonso, Montserrat
Bielsa Martín, Silvia
Salud Salvia, Maria Antonieta
2021-07-14T12:14:08Z
2021-07-14T12:14:08Z
2016-03-01
2021-07-14T12:14:08Z
The diagnosis of malignant pleural effusions may be challenging when cytological examination of aspirated pleural fluid is equivocal or noncontributory. The purpose of this study was to identify protein candidate biomarkers differentially expressed in the pleural fluid of patients with mesothelioma, lung adenocarcinoma, lymphoma, and tuberculosis (TB).A multiplex protein biochip comprising 120 biomarkers was used to determine the pleural fluid protein profile of 29 mesotheliomas, 29 lung adenocarcinomas, 12 lymphomas, and 35 tuberculosis. The relative abundance of these predetermined biomarkers among groups served to establish the differential diagnosis of: malignant versus benign (TB) effusions, lung adenocarcinoma versus mesothelioma, and lymphoma versus TB. The selected putative markers were validated using widely available commercial techniques in an independent sample of 102 patients.Significant differences were found in the protein expressions of metalloproteinase-9 (MMP-9), cathepsin-B, C-reactive protein, and chondroitin sulfate between malignant and TB effusions. When integrated into a scoring model, these proteins yielded 85% sensitivity, 100% specificity, and an area under the curve (AUC) of 0.98 for labeling malignancy in the verification sample. For lung adenocarcinoma-mesothelioma discrimination, combining CA19-9, CA15-3, and kallikrein-12 had maximal discriminatory capacity (65% sensitivity, 100% specificity, AUC 0.94); figures which also refer to the validation set. Last, cathepsin-B in isolation was only moderately useful (sensitivity 89%, specificity 62%, AUC 0.75) in separating lymphomatous and TB effusions. However, this last differentiation improved significantly when cathepsin-B was used with respect to the patient's age (sensitivity 72%, specificity 100%, AUC 0.94).In conclusion, panels of 4 (i.e., MMP-9, cathepsin-B, C-reactive protein, chondroitin sulfate), or 3 (i.e., CA19-9, CA15-3, kallikrein-12) different protein biomarkers on pleural fluid samples are highly discriminative for signaling a malignant versus tuberculous effusion, or lung adenocarcinoma versus mesothelioma, respectively. Cathepsin-B could also be helpful in establishing the presence of a lymphomatous effusion versus that of TB, if the patient's age is simultaneously taken into consideration.
This manuscript was supported by a research grant from the Instituto de
Salud Carlos III (FIS 09/00199).
application/pdf
https://doi.org/10.1097/MD.0000000000003044
024149
0025-7974
http://hdl.handle.net/10459.1/71631
eng
Wolters Kluwer Health
Reproducció del document publicat a: https://doi.org/10.1097/MD.0000000000003044
Medicine, 2016, vol. 95, num. 10, p. e3044
cc-by (c) Wolters Kluwer Health, 2016
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Identifying thoracic malignancies through pleural fluid biomarkers: a predictive multivariate model
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
CC-LICENSE
license_url
application/octet-stream
43
https://repositori.udl.cat/bitstreams/9ea366e8-abb0-47aa-9cce-816d6c198495/download
5134edb0a80711cbbaa5247c36025151
MD5
2
license_text
text/html
23115
https://repositori.udl.cat/bitstreams/bb858514-3f19-4255-9040-4297e02e2867/download
ec3783401c55aba9b2c045380c0dd4b3
MD5
3
license_rdf
application/octet-stream
20337
https://repositori.udl.cat/bitstreams/ce03c62b-b3f1-4e49-8014-3b2bdb7bf951/download
1485691ce20485471fe59ad1ac24bf0f
MD5
4
ORIGINAL
024149.pdf
application/pdf
399287
https://repositori.udl.cat/bitstreams/618ecdf7-9deb-4aaf-99f5-568c0ea3a363/download
f1998bca86cb1a2596662c2d26e1402c
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/a82f78b4-5fa2-4280-9075-cdab63470149/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
5
SWORD
mets.xml
SWORD deposit package
application/octet-stream
297921
https://repositori.udl.cat/bitstreams/fb19e235-1730-47ee-898c-0994b66a8578/download
bc6ed36a72563d6ca3621c98fef0156b
MD5
6
THUMBNAIL
024149.pdf.jpg
024149.pdf.jpg
Generated Thumbnail
image/jpeg
5464
https://repositori.udl.cat/bitstreams/537d91fb-6019-4522-b174-c8f557ee8e54/download
497d7e702bc924643e724234a6f31edb
MD5
7
TEXT
024149.pdf.txt
024149.pdf.txt
Extracted Text
text/plain
41194
https://repositori.udl.cat/bitstreams/9fa5dc38-f690-4375-bc81-170cba510713/download
0b6202bd644da869b9a560941c76ae47
MD5
8
10459.1/71631
oai:repositori.udl.cat:10459.1/71631
2021-07-15 00:09:59.369
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Wolters Kluwer Health, 2016
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/4642782023-10-27T03:00:33Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_241col_10459.1_314col_10459.1_59998col_10459.1_30324col_10459.1_49291
Navaridas Fernández de Bobadilla, Raúl
Vidal Sabanés, Maria
Ruiz Mitjana, Anna
Perramon Güell, Aida
Megino-Luque, Cristina
Llobet Navàs, David
Matias-Guiu, Xavier
Egea Navarro, Joaquim
Encinas Martín, Mario
Bardia, Lídia
Colombelli, Julien
Dolcet Roca, Xavier
2023-10-26T11:38:31Z
2023-10-26T11:38:31Z
2023
Letter to the editor
This work was supported by the Spanish Ministry of Science, Innovation and Universities (grant code PID2019-104734RB-I00) and the Spanish Association Against Cancer (grant code LABAE19004LLOB). This work was also funded by the Institute of Health Carlos III (MS17/00063) (co-founded by the European Social Fund [ESF] “investing in your future”).
https://doi.org/10.1002/cac2.12409
033221
2523-3548
2523-3548
https://repositori.udl.cat/handle/10459.1/464278
eng
Wiley
104734R
Reproducció del document publicat a: https://doi.org/10.1002/cac2.12409
Cancer Communications, 2023, vol. 43, p. 620–624
cc-by-nc-nd (c) TheAuthors, 2023
Attribution-NonCommercial-NoDerivatives 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Transient and DNA-free in vivo CRISPR/Cas9 genome editing for flexible modeling of endometrial carcinogenesis
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
033221.pdf
033221.pdf
application/pdf
5921808
https://repositori.udl.cat/bitstreams/ac4442da-4c09-459b-9d5b-77f7106c500b/download
d173443ec0c58d1fe93b9906714fbe7e
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
899
https://repositori.udl.cat/bitstreams/fc18017d-3b4c-4a6f-a3a4-0d2821b7470f/download
3b6ce8e9e36c89875e8cf39962fe8920
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
639
https://repositori.udl.cat/bitstreams/3d68ff3b-9085-44f9-b876-1cd95e3eb850/download
15ec217096d63e7cd318d42eb888308c
MD5
3
TEXT
033221.pdf.txt
033221.pdf.txt
Extracted text
text/plain
23609
https://repositori.udl.cat/bitstreams/61e167d7-0f5c-40a9-af1a-00a49a52d165/download
bd6e063bb2f5cc7078000153c4812be1
MD5
4
THUMBNAIL
033221.pdf.jpg
033221.pdf.jpg
Generated Thumbnail
image/jpeg
6707
https://repositori.udl.cat/bitstreams/c751e7d9-3d58-4923-ba13-2085ba061dd6/download
239707ae1e0f32a33c27785ac91dab0f
MD5
5
10459.1/464278
oai:repositori.udl.cat:10459.1/464278
2023-10-27 03:00:33.226
http://creativecommons.org/licenses/by-nc-nd/4.0/
cc-by-nc-nd (c) TheAuthors, 2023
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/482842023-01-02T14:36:23Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_49291
Arrospide, Arantzazu
Forné Izquierdo, Carles
Rué i Monné, Montserrat
Torà, Núria
Mar, Javier
Baré, Marisa
2015-06-02T10:58:30Z
2015-06-02T10:58:30Z
2013
Background: The aim of this study was to evaluate the calibration and discriminatory power of three predictive
models of breast cancer risk.
Methods: We included 13,760 women who were first-time participants in the Sabadell-Cerdanyola Breast Cancer
Screening Program, in Catalonia, Spain. Projections of risk were obtained at three and five years for invasive cancer
using the Gail, Chen and Barlow models. Incidence and mortality data were obtained from the Catalan registries.
The calibration and discrimination of the models were assessed using the Hosmer-Lemeshow C statistic, the area
under the receiver operating characteristic curve (AUC) and the Harrell’s C statistic.
Results: The Gail and Chen models showed good calibration while the Barlow model overestimated the number of
cases: the ratio between estimated and observed values at 5 years ranged from 0.86 to 1.55 for the first two models
and from 1.82 to 3.44 for the Barlow model. The 5-year projection for the Chen and Barlow models had the highest
discrimination, with an AUC around 0.58. The Harrell’s C statistic showed very similar values in the 5-year projection
for each of the models. Although they passed the calibration test, the Gail and Chen models overestimated the
number of cases in some breast density categories.
Conclusions: These models cannot be used as a measure of individual risk in early detection programs to
customize screening strategies. The inclusion of longitudinal measures of breast density or other risk factors in joint
models of survival and longitudinal data may be a step towards personalized early detection of BC.
This study was funded by grant PS09/01340 and The Spanish Network on Chronic Diseases REDISSEC (RD12/0001/0007) from the Health Research Fund (Fondo de Investigación Sanitaria) of the Spanish Ministry of Health.
https://doi.org/10.1186/1471-2407-13-587
020551
1471-2407
http://hdl.handle.net/10459.1/48284
eng
BioMed Central
info:eu-repo/grantAgreement/MICINN//PS09%2F01340/ES/OPTIMIZACION DE LOS PROGRAMAS DE CRIBADO POBLACIONAL MEDIANTE MODELOS MATEMATICOS: APLICACION AL CRIBADO DEL CANCER DE MAMA EN ESPAÑA/
Reproducció del document publicat a https://doi.org/10.1186/1471-2407-13-587
BMC Cancer, 2013, núm. 13, vol. 587, p. 1-9
cc-by, (c) Arrospide et al., 2013
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Breast cancer
Screening
Risk models
An assessment of existing models for individualized breast cancer risk estimation in a screening program in Spain
article
publishedVersion
ORIGINAL
020551.pdf
020551.pdf
application/pdf
194043
https://repositori.udl.cat/bitstreams/5a5d92f2-e2f5-4557-a944-45b7e995acd3/download
250badf988da8d7e29b1cd92204e2f6c
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1232
https://repositori.udl.cat/bitstreams/bd88097d-b98c-4199-b25a-9acec89b1e01/download
b51f25f83cca752633b6ec4c418dbcc7
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/790ab388-d5aa-4569-8655-625ae916dd96/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
THUMBNAIL
020551.pdf.jpg
020551.pdf.jpg
Generated Thumbnail
image/jpeg
5223
https://repositori.udl.cat/bitstreams/56c4d67a-64f6-4c2a-9fe6-0a11bebcd160/download
d4b857bca7cd7cf75da5c287a5d4a1dd
MD5
6
TEXT
020551.pdf.txt
020551.pdf.txt
Extracted Text
text/plain
43308
https://repositori.udl.cat/bitstreams/f4bc3ba1-19e5-4aac-8bde-64d78f1fd67e/download
fb237fc50a1f138bc317b801d6f43bc4
MD5
7
10459.1/48284
oai:repositori.udl.cat:10459.1/48284
2023-01-02 14:36:23.273
http://creativecommons.org/licenses/by/3.0/es/
cc-by, (c) Arrospide et al., 2013
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/600182020-06-25T09:36:45Zcom_10459.1_227com_10459.1_2col_10459.1_314
Hidalgo, Manuel
Galan, Jose J.
Sáez, Carmen
Ferrero, Eduardo
Castilla, Carolina
Ramirez Lorca, Reposo
Pelaez, Pablo
Ruiz, Agustín
Japón, Miguel A.
Royo Sánchez-Palencia, José Luis
2017-07-10T08:50:40Z
2017-07-10T08:50:40Z
2008
Background: On its physiological cellular context, PTTG1 controls sister chromatid segregation
during mitosis. Within its crosstalk to the cellular arrest machinery, relies a checkpoint of integrity
for which gained the over name of securin. PTTG1 was found to promote malignant transformation
in 3T3 fibroblasts, and further found to be overexpressed in different tumor types. More recently,
PTTG1 has been also related to different processes such as DNA repair and found to trans-activate
different cellular pathways involving c-myc, bax or p53, among others. PTTG1 over-expression has
been correlated to a worse prognosis in thyroid, lung, colorectal cancer patients, and it can not be
excluded that this effect may also occur in other tumor types. Despite the clinical relevance and
the increasing molecular characterization of PTTG1, the reason for its up-regulation remains
unclear.
Method: We analysed PTTG1 differential expression in PC-3, DU-145 and LNCaP tumor cell
lines, cultured in the presence of the methyl-transferase inhibitor 5-Aza-2'-deoxycytidine. We also
tested whether the CpG island mapping PTTG1 proximal promoter evidenced a differential
methylation pattern in differentiated thyroid cancer biopsies concordant to their PTTG1
immunohistochemistry status. Finally, we performed whole-genome LOH studies using Affymetix
50 K microarray technology and FRET analysis to search for allelic imbalances comprising the
PTTG1 locus.
Conclusion: Our data suggest that neither methylation alterations nor LOH are involved in
PTTG1 over-expression. These data, together with those previously reported, point towards a
post-transcriptional level of missregulation associated to PTTG1 over-expression.
This project was funded by The Fundación de Investigación Biomédica Mutua Madrileña Automovilista. Neocodex have been partially funded by the Ministerio de Educación y Ciencia of Spain (FIT-010000-2004-69, PTQ04-1-0006, PTQ2003-0549, PTQ2003-0546 and PTQ2003-0783). MAJ was also supported by SAF2005- 07713-C03-03 and CS by FIS 06/757.
https://doi.org/10.1186/1471-2407-8-110
019954
1471-2458
http://hdl.handle.net/10459.1/60018
eng
BioMed Central
Reproducció del document publicat a https://doi.org/10.1186/1471-2407-8-110
BMC Cancer, 2008, vol. 8, núm. 110, p. 1-9
cc-by (c) Hidalgo et al., 2008
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Methylation alterations are not a major cause of PTTG1 missregulation
article
publishedVersion
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://repositori.udl.cat/bitstreams/d8a55dc5-5448-4539-906b-64a5ff6efcf5/download
0175ea4a2d4caec4bbcc37e300941108
MD5
2
ORIGINAL
019954.pdf
019954.pdf
application/pdf
852954
https://repositori.udl.cat/bitstreams/f953d37f-fd5d-4c9c-bb17-3296e5d5b86b/download
714303619fb4c439f69d343337358d24
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/d60c76db-5b3d-400f-aabe-101ac9a4b0bf/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
THUMBNAIL
019954.pdf.jpg
019954.pdf.jpg
Generated Thumbnail
image/jpeg
5204
https://repositori.udl.cat/bitstreams/c21d3297-5bee-4c84-92da-dffe1e1210eb/download
56fb1944a9029d5379dfad6122957b49
MD5
4
TEXT
019954.pdf.txt
019954.pdf.txt
Extracted Text
text/plain
38113
https://repositori.udl.cat/bitstreams/a0cecf62-9c53-49b6-97c4-83794b9ba9a9/download
75a6805877bbea05dab15eaae39c7b69
MD5
5
10459.1/60018
oai:repositori.udl.cat:10459.1/60018
2020-06-25 09:36:45.259
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Hidalgo et al., 2008
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/588422020-01-20T12:22:08Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Lecube Torelló, Albert
Valladares, Silvia
López Cano, Carolina
Gutiérrez Carrasquilla, Liliana
Ciudin, Andreea
Fort, José Manuel
Reñé Espinet, Josep Maria
Matias-Guiu, Xavier
Torres, Inés de
Bueno Díez, Marta
Pallares, Judit
Baena-Fustegueras, Juan A
2016-12-16T09:58:40Z
2016-12-16T09:58:40Z
2016
Helicobacter pylory (HP) infection has been associated to an increased rate of type 2 diabetes
(T2D) and liver disease through its effect on insulin resistance and systemic inflammation.
However, results are inconstant and no studies exist in morbidly obese patients, in
which both insulin resistance and inflammation coexist.
https://doi.org/10.1371/journal.pone.0166741
024913
1932-6203
http://hdl.handle.net/10459.1/58842
eng
Public Library of Science
Reproducció del document publicat a https://doi.org/10.1371/journal. pone.0166741
Plos One, 2016, vol. 11, p. 1-9
cc-by (c) Lecube et al., 2016
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
The role of morbid obesity in the promotion of metabolic disruptions and non-alcoholic steatohepatitis by Helicobacter Pylori
article
publishedVersion
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1370
https://repositori.udl.cat/bitstreams/d976425e-ff77-4d74-a291-b7162d55bd89/download
ac86fe33011bda956ed9b032abf4d402
MD5
2
THUMBNAIL
024913.pdf.jpg
024913.pdf.jpg
Generated Thumbnail
image/jpeg
4958
https://repositori.udl.cat/bitstreams/633f6624-a6c3-465c-940d-9961803b4f2c/download
7dfd0788781e9d5acba25b22039b0943
MD5
4
ORIGINAL
024913.pdf
024913.pdf
application/pdf
689101
https://repositori.udl.cat/bitstreams/218166ec-8426-4260-b679-24cd0977dbc6/download
7e629b7205adf3299fbb5f32413a2092
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/7130562d-0e4a-4ff3-896a-4330ab748d49/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
TEXT
024913.pdf.txt
024913.pdf.txt
Extracted Text
text/plain
34221
https://repositori.udl.cat/bitstreams/4317e4fb-f2d4-483f-aa41-e7cfdb6ef89d/download
0d3543dd4cfd19476d411b6a1942400a
MD5
5
10459.1/58842
oai:repositori.udl.cat:10459.1/58842
2020-01-20 12:22:08.678
http://creativecommons.org/licenses/by/3.0/es/
cc-by (c) Lecube et al., 2016
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/657492019-02-20T00:32:16Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Cho, Kathleen R.
Cooper, Kumarasen
Croce, Sabrina
Djordevic, Bojana
Herrington, Simon
Howitt, Brooke
Ip, Philip
Koebel, Martin
Lax, Sigurd
Quade, Bradley
Shaw, Patricia
Vidal, August
Yemelyanova, Anna
Clarke, Blaise
Hedrick Ellenson, Lora
Longacre, Teri A
Shih, Ie-Ming
McCluggage, W. Glenn
Malpica, Anais
Oliva, Esther
Parkash, Vinita
Matias-Guiu, Xavier
2019-02-19T08:32:51Z
2019-02-19T08:32:51Z
2019
The aim of this article is to propose guidelines and recommendations in problematic areas in pathologic reporting of endometrial carcinoma (EC) regarding special techniques and ancillary studies. An organizing committee designed a comprehensive survey with different questions related to pathologic features, diagnosis, and prognosis of EC that was sent to all members of the International Society of Gynecological Pathologists. The special techniques/ancillary studies group received 4 different questions to be addressed. Five members of the group reviewed the literature and came up with recommendations and an accompanying text which were discussed and agreed upon by all members of the group. Twelve different recommendations are made. They address the value of immunohistochemistry, ploidy, and molecular analysis for assessing prognosis in EC, the value of steroid hormone receptor analysis to predict response to hormone therapy, and parameters regarding applying immunohistochemistry and molecular tests for assessing mismatch deficiency in EC.
https://doi.org/10.1097/PGP.0000000000000496
0277-1691
http://hdl.handle.net/10459.1/65749
eng
Lippincott, Williams & Wilkins
Reproducció del document publicat a https://doi.org/10.1097/PGP.0000000000000496
International Journal of Gynecological Pathology, 2019, vol. 38, p. S114–S122
cc-by (c) Kathleen R. Cho et al., 2019
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Endometrial carcinoma
Guidelines
ISGyP
Molecular pathology
International Society of Gynecological Pathologists (ISGyP) Endometrial Cancer Project: Guidelines From the Special Techniques and Ancillary Studies Group
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
Insogynpat_a2019v38pS114.pdf
Insogynpat_a2019v38pS114.pdf
application/pdf
149068
https://repositori.udl.cat/bitstreams/c03c7191-07ae-4361-8a7f-a11371be3824/download
25415645c52bcf40080e95d71bb5476d
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/3c69e274-be65-4de2-8d35-f95573602c2f/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
TEXT
Insogynpat_a2019v38pS114.pdf.txt
Insogynpat_a2019v38pS114.pdf.txt
Extracted Text
text/plain
42630
https://repositori.udl.cat/bitstreams/e492e646-21b2-44f2-b4ff-1738840e4d10/download
542f88c6dcfa7affef34ed3ebca28c0a
MD5
5
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://repositori.udl.cat/bitstreams/bc8d2d4e-43a6-4ad9-8b55-eb04078c92f8/download
0175ea4a2d4caec4bbcc37e300941108
MD5
2
THUMBNAIL
Insogynpat_a2019v38pS114.pdf.jpg
Insogynpat_a2019v38pS114.pdf.jpg
Generated Thumbnail
image/jpeg
5219
https://repositori.udl.cat/bitstreams/33010e0a-93e6-4224-8709-b3971e2f17da/download
47d326e48626c1852471c8663cea787f
MD5
4
10459.1/65749
oai:repositori.udl.cat:10459.1/65749
2019-02-20 00:32:16.699
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Kathleen R. Cho et al., 2019
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/843602023-05-02T13:47:02Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_44504
Lucido, Abel
Basallo, Oriol
Sorribas Tello, Albert
Marin-Sanguino, Alberto
Vilaprinyo Terré, Ester
Alves, Rui
2022-11-26T12:23:40Z
2022-11-26T12:23:40Z
2022
Strigolactones mediate plant development, trigger symbiosis with arbuscular
mycorrhizal fungi, are abundant in 80% of the plant kingdom and help plants
gain resistance to environmental stressors. They also induce germination
of parasitic plant seeds that are endemic to various continents, such as
Orobanche in Europe or Asia and Striga in Africa. The genes involved in the
early stages of strigolactones biosynthesis are known in several plants. The
regulatory structure and the latter parts of the pathway, where flux branching
occurs to produce alternative strigolactones, are less well-understood. Here
we present a computational study that collects the available experimental
evidence and proposes alternative biosynthetic pathways that are consistent
with that evidence. Then, we test the alternative pathways through in silico
simulation experiments and compare those experiments to experimental
information. Our results predict the differences in dynamic behavior between
alternative pathway designs. Independent of design, the analysis suggests
that feedback regulation is unlikely to exist in strigolactone biosynthesis. In
addition, our experiments suggest that engineering the pathway to modulate
the production of strigolactones could be most easily achieved by increasing
the flux of b-carotenes going into the biosynthetic pathway. Finally, we find
that changing the ratio of alternative strigolactones produced by the pathway
can be done by changing the activity of the enzymes after the flux branching
points.
This work was partially funded by PROSTRIG, an ERANET project from FACEJPI (PCI2019-103382, MICIUN) and project PI20/00377 (FIS). AL received funding from the European Union’s H2020 research and innovation programme under Marie Skłodowska-Curie grant agreement No. 801586.
https://doi.org/10.3389/fpls.2022.979162
033199
2296-6463
http://hdl.handle.net/10459.1/84360
eng
Frontiers Media
Reproducció del document publicat a https://doi.org/10.3389/fpls.2022.979162
Frontiers in Plant Science, 2022, vol. 13, art. 979162.
info:eu-repo/grantAgreement/EC/H2020/801586/EU/IberusTalent
cc-by (c) Abel Lucido et. al., 2022.
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Strigolactones
Arbuscular mycorrhizal fungi
Mathematical modeling
Computational biology
Feedback regulation
Biosynthetic pathway
A mathematical model for strigolactone biosynthesis in plants
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
TEXT
033199.pdf.txt
033199.pdf.txt
Extracted text
text/plain
56891
https://repositori.udl.cat/bitstreams/11d9a0e6-8968-479e-94d8-1bc4f162351c/download
16dff8e7f020671cb83685fc6d66fd2d
MD5
4
ORIGINAL
033199.pdf
033199.pdf
application/pdf
3914225
https://repositori.udl.cat/bitstreams/e3b45a09-4ca1-48bb-ae39-56858fd34e15/download
3f9389379b43a11de6052584114e0b5f
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://repositori.udl.cat/bitstreams/a76aa2b3-655c-4c69-a625-12bd09e9d592/download
0175ea4a2d4caec4bbcc37e300941108
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/0c3469bb-8ded-4522-a027-458b92201313/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
THUMBNAIL
033199.pdf.jpg
033199.pdf.jpg
IM Thumbnail
image/jpeg
7152
https://repositori.udl.cat/bitstreams/36d392cf-e43c-43f0-9634-a5ba590a998d/download
d7ef8457afee6ad8865837dd02f93d81
MD5
5
10459.1/84360
oai:repositori.udl.cat:10459.1/84360
2023-05-02 13:47:02.186
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Abel Lucido et. al., 2022.
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/732452022-03-11T00:14:46Zcom_10459.1_227com_10459.1_2com_10459.1_237com_10459.1_47453col_10459.1_314col_10459.1_354col_10459.1_59998col_10459.1_44504
Laza-Vásquez, Celmira
Hernández-Leal, María José
Carles Lavila, Misericordia
Pérez Lacasta, María José
Cruz Esteve, María Inés
Rué i Monné, Montserrat
2022-03-10T10:54:06Z
2022-03-10T10:54:06Z
2022
Abstract:This study explored the barriers and facilitators to the implementation of a risk-basedbreast cancer screening program from the point of view of Spanish health professionals. A cross-sectional study with 220 Spanish health professionals was designed. Data were collected in 2020 viaa web-based survey and included the advantages and disadvantages of risk-based screening andbarriers and facilitators for the implementation of the program. Descriptive statistics and Likert scaleresponses analyzed as category-ordered data were obtained. The risk-based screening was consideredimportant or very important to reduce breast cancer mortality and promote a more proactive role forwomen in breast cancer prevention, to increase coverage for women under 50 years, to promote abreast cancer prevention strategy for women at high risk, and to increase efficiency and effectiveness.Switching to a risk-based program from an age-based program was rated as important or veryimportant by 85% of participants. As barriers for implementation, risk communication, the workloadof health professionals, and limited human and financial resources were mentioned. Despite thebarriers, there is good acceptance, and it seems feasible, from the perspective of health professionals,to implement a risk-based breast cancer screening program in Spain. However, this poses a numberof organizational and resource challenges.
This research was funded by Instituto de Salud Carlos III and co-funded by Fondo Europeode Desarrollo Regional (FEDER) ‘Una manera de hacer Europa’, grant numbers PI17/00834 andPI18/00773. C.L.-V. received a grant from Santander Program scholarship 2020 as a predoctoral fellowat the University of Lleida and M.J.H.-L. was supported by the European Regional Development Fund,European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curiegrant agreement No. 713679 from the Rovira i Virgili University. The funders did not participate inthe study design; collection, management, analysis, and interpretation of data; writing of the report;and the decision to submit the report for publication
https://doi.org/10.3390/ijerph19031406
032032
1660-4601
http://hdl.handle.net/10459.1/73245
eng
MDPI
Reproducció del document publicat a: https://doi.org/10.3390/ijerph19031406
International Journal Of Environmental Research And Public Health, 2022, vol. 19
info:eu-repo/grantAgreement/EC/H2020/713679/EU/MFP
cc-by (c)Authors, 2022
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Breast cancer
Personalized screening
Barriers
Facilitators
Health professionals
Barriers and facilitators to the implementation of a personalized breast cancer screening program: Views of Spanish health professionals
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
THUMBNAIL
032032.pdf.jpg
032032.pdf.jpg
Generated Thumbnail
image/jpeg
4210
https://repositori.udl.cat/bitstreams/6609aa3b-fa58-47d7-9e57-eb7f7f31931b/download
cfd7def5fdf4352fa86f38f5b1e0a034
MD5
4
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://repositori.udl.cat/bitstreams/e79290d2-69e4-4907-9f18-4b7249f0f542/download
0175ea4a2d4caec4bbcc37e300941108
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/e020516f-9649-4b04-ad82-1e920c5b2da2/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
TEXT
032032.pdf.txt
032032.pdf.txt
Extracted Text
text/plain
16
https://repositori.udl.cat/bitstreams/a3956f03-97ad-4d48-9a7c-79c26843edb7/download
b7522a194a0baeec15b5f475a85e2a75
MD5
5
ORIGINAL
032032.pdf
032032.pdf
application/pdf
8485036
https://repositori.udl.cat/bitstreams/d28c7271-12be-44ed-a731-7ea9afbcb7ac/download
f69c9a8dd7f4e02633899169b5b585a0
MD5
1
10459.1/73245
oai:repositori.udl.cat:10459.1/73245
2022-03-11 00:14:46.326
http://creativecommons.org/licenses/by/4.0/
cc-by (c)Authors, 2022
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/482712017-07-26T09:23:00Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Landa, Iñigo
Ruiz-Llorente, Sergio
Montero-Conde, Cristina
Inglada-Pérez, Lucía
Schiavi, Francesca
Leskelä, Susanna
Pita, Guillermo
Milne, Roger
Maravall Royo, Javier
Ramos, Ignacio
Andía, Víctor
Rodríguez-Poyo, Paloma
Jara-Albarrán, Antonino
Meoro, Amparo
Peso, Cristina del
Arribas, Luis
Iglesias, Pedro
Caballero, Javier
Serrano, Joaquín
Picó, Antonio
Pomares, Francisco
Giménez, Gabriel
López-Mondéjar, Pedro
Castello, Roberto
Merante-Boschin, Isabella
Pelizzo, Maria-Rosa
Mauricio Puente, Dídac
Opocher, Giuseppe
Rodríguez-Antona, Cristina
González- Neira, Anna
Matias-Guiu, Xavier
Santisteban, Pilar
Robledo, Mercedes
2015-05-28T08:20:42Z
2015-05-28T08:20:42Z
2009
In order to identify genetic factors related to thyroid cancer susceptibility, we adopted a candidate gene approach. We studied
tag- and putative functional SNPs in genes involved in thyroid cell differentiation and proliferation, and in genes found to be
differentially expressed in thyroid carcinoma. A total of 768 SNPs in 97 genes were genotyped in a Spanish series of 615 cases
and 525 controls, the former comprising the largest collection of patients with this pathology froma single population studied
to date. SNPs in an LD block spanning the entire FOXE1 gene showed the strongest evidence of association with papillary
thyroid carcinoma susceptibility. This association was validated in a second stage of the study that included an independent
Italian series of 482 patients and 532 controls. The strongest association results were observed for rs1867277 (OR[perallele]
= 1.49; 95%CI = 1.30–1.70; P = 5.961029). Functional assays of rs1867277 (NM_004473.3:c.2283G.A) within the FOXE1
59 UTR suggested that this variant affects FOXE1 transcription. DNA-binding assays demonstrated that, exclusively, the
sequence containing the A allele recruited the USF1/USF2 transcription factors, while both alleles formed a complex in which
DREAM/CREB/aCREM participated. Transfection studies showed an allele-dependent transcriptional regulation of FOXE1. We
propose a FOXE1 regulation model dependent on the rs1867277 genotype, indicating that this SNP is a causal variant in
thyroid cancer susceptibility. Our results constitute the first functional explanation for an association identified by a GWAS and
thereby elucidate a mechanism of thyroid cancer susceptibility. They also attest to the efficacy of candidate gene approaches
in the GWAS era.
https://doi.org/10.1371/journal.pgen.1000637
015925
1553-7390
http://hdl.handle.net/10459.1/48271
eng
Public Library of Science
Reproducció del document publicat a https://doi.org/10.1371/journal.pgen.1000637
PLoS Genetics, 2009, vol. 5, núm. 9, e1000637
cc-by, (c) Landa et al., 2009
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors
article
publishedVersion
THUMBNAIL
015925.pdf.jpg
015925.pdf.jpg
Generated Thumbnail
image/jpeg
6429
https://repositori.udl.cat/bitstreams/e0a58955-fac6-4dfe-aedf-9129c992b05e/download
63c4ba06c0c3c56765ad5bed2585d88e
MD5
6
ORIGINAL
015925.pdf
015925.pdf
application/pdf
530361
https://repositori.udl.cat/bitstreams/5e6d4036-d1bb-4c0f-8a87-723660524f47/download
3ada0c3a158d931c6f3dd01060af9017
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1232
https://repositori.udl.cat/bitstreams/fe3af172-0812-4912-8f0d-1033f06cd285/download
b51f25f83cca752633b6ec4c418dbcc7
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/6ab38a1b-874f-4251-8439-a10a9b821d98/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
TEXT
015925.pdf.txt
015925.pdf.txt
Extracted Text
text/plain
66553
https://repositori.udl.cat/bitstreams/b8d07b78-6db5-4b26-93c9-cecf0709bbff/download
b1d988bf8f2cad907409e5f34d91d870
MD5
7
10459.1/48271
oai:repositori.udl.cat:10459.1/48271
2017-07-26 09:23:00.742
http://creativecommons.org/licenses/by/3.0/es/
cc-by, (c) Landa et al., 2009
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/484182021-08-30T14:56:39Zcom_10459.1_227com_10459.1_2com_10459.1_59159com_10459.1_47453col_10459.1_314col_10459.1_59160col_10459.1_59998
Matias, Ana C.
Marinho, H. Susana
Cyrne, Luísa
Herrero Perpiñán, Enrique
Antunes, Fernando
2015-07-07T10:39:31Z
2025-01-01
2011
Taking into account published contradictory results concerning the regulation of fatty acid synthase (Fas)
by H2O2, we carried out a systematic study where two methods of H2O2 delivery (steady-state and bolus
addition) and the effect of a wide range of H2O2 concentrations were investigated. A decrease in Fas activity
was observed for cells exposed to 100 and 150 lMH2O2 in a steady-state, while a bolus addition of the
same H2O2 concentrations did not alter Fas activity. Similar results were observed for the mRNA levels of
FAS1, the gene that encodes Fas subunit b. However, the exposure to a steady-state 50 lMH2O2 dose lead
to an increase in FAS1 mRNA levels, showing a biphasic modulation of Fas by H2O2. The results obtained
emphasize that cellular effects of H2O2 can vary over a narrow range of concentrations. Therefore, a tight
control of H2O2 exposure, which can be achieved by exposing H2O2 in a steady-state, is important for cellular
studies of H2O2-dependent redox regulation.
https://doi.org/10.1016/j.abb.2011.08.009
017835
0003-9861
http://hdl.handle.net/10459.1/48418
eng
Elsevier
Reproducció del document publicat a https://doi.org/10.1016/j.abb.2011.08.009
Archives of Biochemistry and Biophysics, 2011, vol. 515, núm. 1-2, p. 107-111
(c) Elsevier, 2011
info:eu-repo/semantics/restrictedAccess
H2O2
Adaptation
Fatty acid synthase
Biphasic modulation of fatty acid synthase by hydrogen peroxide in Saccharomyces cerevisiae
article
publishedVersion
enric.herrero@cmb.udl.cat
Enrique Herrero Perpiñán
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/3c80ef10-1efb-4b8a-98f2-b643dd048805/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
TEXT
017835.pdf.txt
017835.pdf.txt
Extracted Text
text/plain
24931
https://repositori.udl.cat/bitstreams/3cc86d6c-1db2-4051-8dc3-26c2a2f3261b/download
018e31f69bb463ac1560c3c1dc373982
MD5
6
ORIGINAL
017835.pdf
017835.pdf
application/pdf
410586
https://repositori.udl.cat/bitstreams/797b8e3c-7ea1-42cf-8540-fedd2ecef9fd/download
69b2bfba6e2b605a85f103b98e21d049
MD5
1
THUMBNAIL
017835.pdf.jpg
017835.pdf.jpg
Generated Thumbnail
image/jpeg
5588
https://repositori.udl.cat/bitstreams/89e2bd32-8aa0-466a-86c9-21bd76f4885c/download
7b18a1308cf69b5100a9b693812372b0
MD5
5
10459.1/48418
oai:repositori.udl.cat:10459.1/48418
2021-08-30 14:56:39.417
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/463672023-01-27T20:01:54Zcom_10459.1_227com_10459.1_2com_10459.1_59159com_10459.1_47453col_10459.1_314col_10459.1_59160col_10459.1_59998col_10459.1_49291
Díaz de la Loza, María del Carmen
Gallardo, Mercedes
García-Rubio, María Luisa
Izquierdo, Alicia
Herrero Perpiñán, Enrique
Aguilera, Andrés
Wellinger, Ralf Erik
2012-12-10T13:36:20Z
2012-12-10T13:36:20Z
2011
Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron–sulfur cluster biosynthesis is important for the maintenance of nuclear genome stability in Saccharomyces cerevisiae. Cells lacking the mitochondrial chaperone Zim17 (Tim15/Hep1), a component of the iron–sulfur biosynthesis machinery, have limited respiration activity, mimic the metabolic response to iron starvation and suffer a dramatic increase in nuclear genome recombination. Increased oxidative damage or deficient DNA repair do not account for the observed genomic hyperrecombination. Impaired cell-cycle progression and genetic interactions of ZIM17 with components of the RFC-like complex involved in mitotic checkpoints indicate that replicative stress causes hyperrecombination in zim17Δ mutants. Furthermore, nuclear accumulation of pre-ribosomal particles in zim17Δ mutants reinforces the importance of iron–sulfur clusters in normal ribosome biosynthesis. We propose that compromised ribosome biosynthesis and cell-cycle progression are interconnected, together contributing to replicative stress and nuclear genome instability in zim17Δ mutants.
European Union (EUROFAN II to A.A.); Spanish Ministry of Science and Innovation (BIO2003-07172 and BIO2006-08051 to R.E.W. and Consolider Ingenio 2010, CSD2007-0015); Junta de Andalucía (P08-CTS-04297 to R.E.W.); Pre-doctoral FPI fellowship from the Spanish Ministry of Science and Innovation (to M.D.L.). Funding for open access charge: Proyecto de investigación de excelencia (P08-CTS-04297) of the Junta de Andalucía.
https://doi.org/10.1093/nar/gkr193
016913
0305-1048
http://hdl.handle.net/10459.1/46367
eng
Oxford University Press
info:eu-repo/grantAgreement/MICYT//BIO2003-07172/ES/
info:eu-repo/grantAgreement/MEC//BIO2006-08051/ES/CARACTERIZACION DE PROTEINAS Y SUSTANCIAS SUPRESORAS DE LOS DAÑOS EN EL ADN DEBIDAS A LA ACCION DE LA TOPOISOMERASA I/
info:eu-repo/grantAgreement/MEC//CSD2007-0015/ES/
Reproducció del document publicat a: https://doi.org/10.1093/nar/gkr193
Nucleic Acids Research, 2011, vol. 39, núm. 14, p. 6002-6015
cc-by-nc, (c) Díaz de la Loza et al., 2011
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/2.5/es/deed.ca
Iron-Sulfur Proteins
Mitochondrial proteins
Saccharomyces cerevisiae proteins
Zim 17 protein
Llevat de cervesa
Expressió gènica
Ferro
Zim17/Tim15 links mitochondrial iron–sulfur cluster biosynthesis to nuclear genome stability
article
publishedVersion
ORIGINAL
NAR_2011.pdf
NAR_2011.pdf
application/pdf
6970151
https://repositori.udl.cat/bitstreams/fbfb1910-c34a-45f0-8baf-7544f5fac84c/download
993efbe793bc056035821d1efa97cdd2
MD5
2
TEXT
NAR_2011.pdf.txt
NAR_2011.pdf.txt
Extracted Text
text/plain
59584
https://repositori.udl.cat/bitstreams/be615c39-0930-4460-b1a3-ab033df778ee/download
dbf61f2cdb615f1863beffaefd526bef
MD5
7
THUMBNAIL
NAR_2011.pdf.jpg
NAR_2011.pdf.jpg
Generated Thumbnail
image/jpeg
6145
https://repositori.udl.cat/bitstreams/56e434cb-0455-4c01-bcdd-781ccbf60f1f/download
e06b5d56d6ca41d43fc93a009fa41aab
MD5
6
10459.1/46367
oai:repositori.udl.cat:10459.1/46367
2023-01-27 20:01:54.775
http://creativecommons.org/licenses/by-nc/2.5/es/deed.ca
cc-by-nc, (c) Díaz de la Loza et al., 2011
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
oai:repositori.udl.cat:10459.1/492862016-09-06T13:03:57Zcom_10459.1_227com_10459.1_2com_10459.1_240col_10459.1_314col_10459.1_333
Cardús i Figueras, Anna
Gallego, Carme
Muray, S.
Marco, M. P.
Parisi Capdevila, Eva
Aldea, Martí
Fernández i Giráldez, Elvira
2016-01-11T09:21:53Z
2016-01-11T09:21:53Z
2003
Existen datos experimentales contradictorios respecto al comportamiento de
las células de músculo liso vascular (CMLV) expuestas al calcitriol. Determinar
el efecto del calcitriol y de sus análogos a nivel vascular tiene una considerable
trascendencia clínica ya que la proliferación de las CMLV está implicada
en el mecanismo patogénico de la arteriosclerosis y de la resistencia tras angioplastia.
En este trabajo demostramos mediante incorporación de BrdU que el calcitriol
estimula la proliferación en las CMLV. La proliferación es menor al añadir
al medio de cultivo Paracalcitol o EB1089 a dosis equimolar. En concordancia
con estos hechos, también observamos que el calcitriol induce la expresión del
mRNA VDR mientras que no existe este efecto con ninguno de los análogos estudiados.
En conclusión, el calcitriol tiene un efecto directo estimulador de la proliferación
de las CMLV que no se observa con el Paracalcitol y EB1089 a concentración
equimolar.
0211-6995
http://hdl.handle.net/10459.1/49286
spa
Sociedad Espanola de Nefrologia
Reproducció del document publicat a http://www.revistanefrologia.com/es-publicacion-nefrologia-articulo-efecto-diferencial-los-analogos-vitamina-d-proliferacion-celulas-musculo-liso-X0211699503028771#
Nefrologia, 2003, vol. 23, p. 117-121
cc-by-nc-nd (c) Cardús Figueras et al., 2003
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Células músculo liso vascular
Proliferación
Calcitriol
Efecto diferencial de los análogos de la vitamina D en la proliferación de células de músculo liso vascular
article
publishedVersion
THUMBNAIL
Nefrologia, 2003, vol. 23, supl. 2, p. 117-121.pdf.jpg
Nefrologia, 2003, vol. 23, supl. 2, p. 117-121.pdf.jpg
Generated Thumbnail
image/jpeg
4448
https://repositori.udl.cat/bitstreams/e8ebcbf3-1124-430c-b2ce-b32be7f091b3/download
a8089159a9fce6906b20a061fbec4a8f
MD5
4
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1232
https://repositori.udl.cat/bitstreams/ac9fd4c5-41b7-45d4-822c-012d500d8491/download
b51f25f83cca752633b6ec4c418dbcc7
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/46193516-22e7-4bbe-8779-f93f4ae39503/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
ORIGINAL
Nefrologia, 2003, vol. 23, supl. 2, p. 117-121.pdf
Nefrologia, 2003, vol. 23, supl. 2, p. 117-121.pdf
Nefrol_a2003v23s2p117
application/pdf
63410
https://repositori.udl.cat/bitstreams/5cef819c-f8f9-4ba9-ba38-5bbc7c9dfffc/download
735ad41ac617d27ba8355784c3270950
MD5
1
TEXT
Nefrologia, 2003, vol. 23, supl. 2, p. 117-121.pdf.txt
Nefrologia, 2003, vol. 23, supl. 2, p. 117-121.pdf.txt
Extracted Text
text/plain
18379
https://repositori.udl.cat/bitstreams/02b83307-0049-4869-9112-b8b5accc7bec/download
8c5551806ba776fe7f8687a8334e6876
MD5
5
10459.1/49286
oai:repositori.udl.cat:10459.1/49286
2016-09-06 13:03:57.163
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
cc-by-nc-nd (c) Cardús Figueras et al., 2003
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/571222021-08-30T15:04:29Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998col_10459.1_49291
Reverter Branchat, Gemma
Cabiscol Català, Elisa
Tamarit Sumalla, Jordi
Sorolla Bardají, Maria Alba
Torre Ruiz, M. A. de la
Ros Salvador, Joaquim
2016-05-31T07:58:41Z
2025-01-01
2007
Alcohol dehydrogenase 1 (Adh1)p catalyses the conversion of acetaldehyde to ethanol,
regenerating NAD+. In Saccharomyces cerevisiae, Adh1p is oxidatively modified during ageing
and, consequently, its activity becomes reduced. To analyse whether maintaining this activity is
advantageous for the cell, a yeast strain with an extra copy of the ADH1 gene (2 ADH1) was
constructed, and the effects on chronological and replicative ageing were analysed. The strain
showed increased survival in stationary phase (chronological ageing) due to induction of
antioxidant enzymes such as catalase and superoxide dismutases. In addition, 2 ADH1 cells
displayed an increased activity of silent information regulator 2 (Sir2)p, an NAD+-dependent
histone deacetylase, due to a higher NAD+/NADH ratio. As a consequence, a 30 % extension in
replicative life span was observed. Taken together, these results suggest that the maintenance of
enzymes that participate in NAD+/NADH balancing is important to chronological and
replicative life-span parameters.
This work has been supported by grants BFU2004-00593/BMC from the Ministerio de Educación y Ciencia (Spain) and SGR2005-00677 from the Generalitat de Catalunya. G. R.-B. and M. A. S. are recipients of PhD fellowships from the Ministerio de Educación y Ciencia (Spain).
https://doi.org/10.1099/mic.0.2007/009340-0
011503
1350-0872
http://hdl.handle.net/10459.1/57122
eng
Microbiology Society
MIECI/PN2004-2007/BFU2004-00593/BMC
Reproducció del document publicat a https://doi.org/10.1099/mic.0.2007/009340-0
Microbiology, 2007, vol. 153, núm. 11, p. 3667-3676
(c) SGM, 2007
info:eu-repo/semantics/restrictedAccess
Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1
article
publishedVersion
joaquim.ros@cmb.udl.es
Ros Salvador, Joaquim
ORIGINAL
011503.pdf
011503.pdf
application/pdf
305045
https://repositori.udl.cat/bitstreams/6220caa1-1ed2-4b6d-b3f1-c720e8f94281/download
62867bc190d5cba60988d196732a2577
MD5
1
THUMBNAIL
011503.pdf.jpg
011503.pdf.jpg
Generated Thumbnail
image/jpeg
5911
https://repositori.udl.cat/bitstreams/0e8ef2cf-152d-4068-bfc8-cf44e29e55e7/download
129f661ba3ee89eace3cceef800ee1cb
MD5
3
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/67ca9017-aa5e-4ff9-a133-90e6f9703ebd/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
TEXT
011503.pdf.txt
011503.pdf.txt
Extracted Text
text/plain
48928
https://repositori.udl.cat/bitstreams/f2a224b5-7285-489c-947a-51ec05a712cf/download
1a5962bb701923a6611ff412cb401450
MD5
4
10459.1/57122
oai:repositori.udl.cat:10459.1/57122
2021-08-30 15:04:29.656
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/676812023-11-15T10:29:55Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_241col_10459.1_314col_10459.1_59998col_10459.1_30324col_10459.1_49291
Vaquero, Marta
Cuesta, Sara
Anerillas Aljama, Carlos
Altés Bargalló, Gisela
Ribera i Calvet, Joan
Basson, M. Albert
Licht, Jonathan D.
Egea Navarro, Joaquim
Encinas Martín, Mario
2019-12-09T12:07:37Z
2019-12-09T12:07:37Z
2019-08-01
2019-12-09T12:07:38Z
Background: Congenital anomalies of the kidney and urinary tract (CAKUT) is a group of diseases that include a broad spectrum of developmental defects of the genitourinary system. Mouse models indicate that perturbations of the GDNF-Ret signaling pathway are a major genetic cause of CAKUT. Sprouty1 is an intracellular Ret inhibitor whose mutation results in supernumerary kidneys, megaureters, and hydronephrosis in mice. Both the molecular mechanisms and the structural domains critical for Sprouty function are a matter of controversy, partly because studies pursuing this objective rely on ectopic overexpression in cell lines. A conserved N-terminal tyrosine has been frequently, but not always, identified as critical for their function in vitro. Methods: We have generated Sprouty1 knockin mice bearing a tyrosine-to-alanine substitution in position 53, corresponding to the conserved N-terminal tyrosine of Sprouty1. We have characterized development of the genitourinary systems of these mice via different methods, including the use of reporter mice expressing EGFP form the Ret locus, and whole mount cytokeratin staining. Results: Mice lacking this tyrosine grow ectopic ureteric buds that ultimately will form supernumerary kidneys, a phenotype indistinguishable to that of Sprouty1 knockout mice. Sprouty1 knockin mice also present megaureters and vesicoureteral reflux, caused by failure of ureters to separate from Wolffian ducts and migrate to their definitive position. Conclusions: Tyrosine 53 is absolutely necessary to convey Sprouty1 function during genitourinary development.
This work was supported by grants BFU2010-47175-P and BFU2017-83646-P (AEI/FEDER, UE) from MINECO to ME. MV was supported by a predoctoral fellowship from AGAUR. CA was supported by a predoctoral fellowship from Universitat de Lleida. SC was supported by a Cofund action from the Marie Curie program of the EU. We are grateful to Dr. Sanjay Jain (Washington University, St Louis) for sharing RetEGFP mice, and to Dr. Tung-Tien Sun (New York University) for Uroplakin antibody. We thank Anna Macià (IRB Lleida) for her contribution to the initial development of this manuscript, as well as Marta Hereu, Maria Santacana, Mónica Domingo and Maria Carrele for their excellent technical assistance.
application/pdf
https://doi.org/10.1681/ASN.2018111085
028598
1046-6673
http://hdl.handle.net/10459.1/67681
eng
American Society of Nephrology
info:eu-repo/grantAgreement/MINECO//BFU2010-47175-P/ES/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-83646-P/ES/DEFINIENDO EL PAPEL DE LAS PROTEINAS SPROUTY EN LA SENESCENCIA CELULAR/
Versió postprint del document publicat a: https://doi.org/10.1681/ASN.2018111085
Journal of the American Society of Nephrology, 2019, vol. 30, núm. 8, p. 1398-1411
info:eu-repo/semantics/openAccess
Sprouty
Ret
Genitourinary Development
Wolffian Duct
Ureteric bud
Sprouty1 controls genitourinary development via its N-terminal tyrosine
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/05b6f2d0-e128-4e7e-aafb-2d85a622ae16/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
SWORD
mets.xml
SWORD deposit package
application/octet-stream
2760280
https://repositori.udl.cat/bitstreams/44b779f2-85e4-4d2a-b4e9-0c585cb8c82d/download
d5d1f7431321b407cfd492cbf1a5c40d
MD5
3
TEXT
028598.pdf.txt
028598.pdf.txt
Extracted Text
text/plain
49325
https://repositori.udl.cat/bitstreams/3455bf63-b051-47fc-9953-b88d41748ae0/download
1e4c43bd5744f197c7d1bdb4de3ccff9
MD5
5
ORIGINAL
028598.pdf
028598.pdf
application/pdf
3334128
https://repositori.udl.cat/bitstreams/7eef30fc-4b39-4ca8-9cfd-00e4f1279202/download
d2363eae836a9c37d3c641288c947974
MD5
6
THUMBNAIL
028598.pdf.jpg
028598.pdf.jpg
Generated Thumbnail
image/jpeg
2973
https://repositori.udl.cat/bitstreams/a357e7fa-d040-480a-85d7-419be3518e9a/download
58b50e3816dd84ead38a29b5bd9576ee
MD5
4
10459.1/67681
oai:repositori.udl.cat:10459.1/67681
2023-11-15 10:29:55.436
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/416622020-07-14T08:39:35Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Martínez Alonso, Montserrat
Llecha Cano, Núria
Mayorga Mayorga, Maritza Elfride
Sorolla Bardají, Anabel
Dolcet Roca, Xavier
Sanmartín Novell, Verònica
Abal Diaz, Leandro
Casanova i Seuma, Josep M. (Josep Manel)
Baradad Brusau, Manuel
Yeramian Hakim, Andree
Egido Garcia, Ramon Maria
Puig, Susana
Vilella, Ramón
Matias-Guiu, Xavier
Martí Laborda, Rosa Ma.
2011-10-27T09:28:53Z
2011-10-27T09:28:53Z
2009
Somatostatin analogues (SAs) are potential anticancer agents. This study was designed to investigate the expression of somatostatin receptors (SSTRs) in melanoma cells and the effect of two SAs on cell proliferation and viability. Eighteen primary and metastatic human cutaneous melanoma cell lines were treated with octreotide and SOM230. Expression of SSTR1, SSTR2, SSTR3 and SSTR5 was assessed by real-time polymerase chain reaction. Proliferation, viability and cell death were assessed using standard assays. Inhibition was modelled by mixed-effect regression. Melanoma cells expressed one or more SSTR. Both SAs inhibited proliferation of most melanoma cell lines, but inhibition was less than 50%. Neither SA affected cell viability or induced cell death. The results suggest that melanoma cell lines express SSTRs. The SAs investigated, under the conditions used in this study, did not, however, significantly inhibit melanoma growth or induce cell death. Novel SAs, combination therapy with SAs and their anti-angiogenic properties should be further investigated.
014917
0300-0605
http://hdl.handle.net/10459.1/41662
eng
Field House Publishing
Reproducció del document publicat a http://www.jimronline.net/content/fullpdf.asp?ArticleID=1303
The Journal of International Medical Research, 2009, vol. 37, núm. 6, p. 1813-1822
(c) Field House Publishing, 2009
info:eu-repo/semantics/openAccess
Malignant melanoma
Somatostatin analogues
Octreotide
SOM230
Pell -- Càncer
Octreotida
Somatostatina
Medicaments antineoplàstics
Melanoma
Apoptosi
Expression of somatostatin receptors in human melanoma cell lines: effect of two different somatostatin analogues, octreotide and SOM230, on cell proliferation
article
publishedVersion
THUMBNAIL
1303.pdf.jpg
1303.pdf.jpg
Generated Thumbnail
image/jpeg
5297
https://repositori.udl.cat/bitstreams/b0797592-65af-4570-b373-75d6dfbe2fa6/download
3db7623414f93d54f103fb1a268ce621
MD5
9
TEXT
1303.pdf.txt
1303.pdf.txt
Extracted Text
text/plain
28803
https://repositori.udl.cat/bitstreams/24782c71-cd52-427c-9a0f-7d834557a44e/download
18952f7d5d49979ea26fcd64fb9043a8
MD5
10
ORIGINAL
1303.pdf
1303.pdf
application/pdf
146362
https://repositori.udl.cat/bitstreams/773dd5d9-127c-4584-a210-89837b9b7f46/download
a9a9d55083edb654801731103cd27ce8
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1846
https://repositori.udl.cat/bitstreams/30ed8395-410e-4a56-9632-66d6d1d7ca42/download
91b447e44beb1f31e7de19c8baece60a
MD5
2
10459.1/41662
oai:repositori.udl.cat:10459.1/41662
2020-07-14 08:39:35.331
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/303302020-07-14T08:39:35Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Rué i Monné, Montserrat
Serna Arnaiz, Catalina
Soler González, Jorge
Bosch, Anna
Ruiz-Magaz, Maria Cristina
Galván, Leonardo
2011-02-07T13:11:34Z
2011-02-07T13:11:34Z
2008
Background: There are few studies comparing pharmaceutical costs and the use of medications between immigrants and the autochthonous population in Spain. The objective of this study is to evaluate whether there are differences in pharmaceutical consumption and expenses between immigrant and Spanish-born populations.
Methods: Prospective observational study in 1,630 immigrants and 4,154 Spanish-born individuals visited by fifteen primary care physicians at five public Primary Care Clinics (PCC) during 2005 in the city of Lleida, Catalonia (Spain). Data on pharmaceutical consumption and expenses was
obtained from a comprehensive computerized data-collection system. Multinomial regression models were used to estimate relative risks and confidence intervals of pharmaceutical expenditure, adjusting for age and sex.
Results: The percentage of individuals that purchased medications during a six-month period was 53.7% in the immigrant group and 79.2% in the autochthonous group. Pharmaceutical expenses and consumption were lower in immigrants than in autochthonous patients in all age groups and both genders. The relative risks of being in the highest quartile of expenditure, for Spanish-born versus immigrants, were 6.9, 95% CI = (4.2, 11.5) in men and 5.3, 95% CI = (3.5, 8.0) in women, with the reference category being not having any pharmaceutical expenditure.
Conclusion: Pharmaceutical expenses are much lower for immigrants with respect to
autochthonous patients, both in the percentage of prescriptions filled at pharmacies and the number of containers of medication obtained, as well as the prices of the medications used. Future studies should explore which factors explain the observed differences in pharmaceutical expenses and if these disparities produce health inequalities.
https://doi.org/10.1186/1472-6963-8-35
011824
1472-6963
http://hdl.handle.net/10459.1/30330
eng
BioMed Central
Reproducció del document publicat a https://doi.org/10.1186/1472-6963-8-35
BMC Health Services Research, 2008, vol. 8, núm. 35, p. 1-10
cc-by, (c) Rué et al., 2008
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.0/es/deed.ca
Indústria farmacèutica
Emigració i immigració -- Ús de medicaments
Medicaments -- Ús
Differences in pharmaceutical consumption and expenses between immigrant and Spanish-born populations in Lleida, (Spain): a 6-months prospective observational study
article
publishedVersion
ORIGINAL
1472-6963-8-35.pdf
1472-6963-8-35.pdf
application/pdf
287875
https://repositori.udl.cat/bitstreams/56bf8e9e-8514-4eed-b478-d00c58cb252d/download
f15e6e054cea3b6b7b1ee326b7e5ea75
MD5
1
CC-LICENSE
license_url
license_url
text/plain; charset=utf-8
46
https://repositori.udl.cat/bitstreams/13a1ab88-5f53-4e84-ad3e-42f55de855bb/download
9f2020a497eacc3c6092de175e4836a8
MD5
2
license_text
license_text
text/html; charset=utf-8
20984
https://repositori.udl.cat/bitstreams/c9386857-4109-473f-a17e-356ca36b0dad/download
519f1ac8c4ec2ad4035e18f03366c46c
MD5
3
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
19583
https://repositori.udl.cat/bitstreams/8253ca3d-d51b-4d67-b997-3ff19b7896ab/download
eb39846f5da34470227704690b96025c
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1846
https://repositori.udl.cat/bitstreams/83dc56c8-8a03-49f5-9960-c640c012131b/download
0e38e5e6ac8a424e39de8df479dd75a3
MD5
5
THUMBNAIL
1472-6963-8-35.pdf.jpg
1472-6963-8-35.pdf.jpg
Generated Thumbnail
image/jpeg
5540
https://repositori.udl.cat/bitstreams/9bd68b11-1236-42cd-af9f-06026ce88a58/download
b79462edc957872ede5ef705198264e6
MD5
12
TEXT
1472-6963-8-35.pdf.txt
1472-6963-8-35.pdf.txt
Extracted Text
text/plain
45123
https://repositori.udl.cat/bitstreams/f24394b5-2b63-44d5-b5f3-3034e9eaff07/download
e6b8112ba9fc27d8a95a72e829e13979
MD5
13
10459.1/30330
oai:repositori.udl.cat:10459.1/30330
2020-07-14 08:39:35.319
http://creativecommons.org/licenses/by/2.0/es/deed.ca
cc-by, (c) Rué et al., 2008
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/710182022-03-16T12:23:19Zcom_10459.1_227com_10459.1_2com_10459.1_241col_10459.1_314col_10459.1_30324
Klionsky, Daniel J.
Cantí Nicolás, Carles
Garcera, Ana
Herreros Danés, Judit
Soler i Tatché, Rosa Ma.
others
2021-04-14T06:57:44Z
2022-02-08T23:21:46Z
2021-02-08
2021-04-14T06:57:44Z
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
application/pdf
https://doi.org/10.1080/15548627.2020.1797280
031126
1554-8627
http://hdl.handle.net/10459.1/71018
eng
Taylor & Francis
Versió postprint del document publicat a: https://doi.org/10.1080/15548627.2020.1797280
Autophagy, 2021, vol. 17, núm. 1, p. 1-382
(c) Taylor & Francis, 2021
info:eu-repo/semantics/openAccess
Autophagosome
LC3
Cancer
Macroautophagy
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
rosa.soler@udl.cat
Rosa Ma. Soler i Tatché
ORIGINAL
031126.pdf
031126.pdf
Postprint
application/pdf
8606922
https://repositori.udl.cat/bitstreams/48905329-9847-4c08-8bff-58203c77ba23/download
3e07a8bc389d7cea50666408a52e32f7
MD5
4
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/3c750051-3441-48c0-92f0-439308b4a929/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
SWORD
mets.xml
SWORD deposit package
application/octet-stream
6098124
https://repositori.udl.cat/bitstreams/73dae8c0-7228-46da-8e5f-2e0a01666af0/download
2290b18088a6d275964e4fd0af577730
MD5
3
TEXT
031126.pdf.txt
031126.pdf.txt
Extracted Text
text/plain
2374269
https://repositori.udl.cat/bitstreams/3ffbc307-4c7d-4e5e-b24a-aa6d3b0331ce/download
0b65968ce04ee2968052b35b5fa0a673
MD5
6
THUMBNAIL
031126.pdf.jpg
031126.pdf.jpg
Generated Thumbnail
image/jpeg
2190
https://repositori.udl.cat/bitstreams/b670024d-8344-44fc-9924-b61598215b33/download
7c3cd38e867bd2bc0e856ae717c41019
MD5
5
10459.1/71018
oai:repositori.udl.cat:10459.1/71018
2022-03-16 12:23:19.113
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=
oai:repositori.udl.cat:10459.1/691382022-09-27T14:59:10Zcom_10459.1_242com_10459.1_2com_10459.1_227com_10459.1_47453col_10459.1_10990col_10459.1_314col_10459.1_59998col_10459.1_49291
Laplana Lafaja, Marina
Bravo, M. J.
Fernández-Fuertes, M.
Ruiz-García, C.
Alarcón-Martin, E.
Colmenero, J. D.
Caruz, Antonio
Fibla Palazón, Joan
Real, Luis M.
Royo Sánchez-Palencia, José Luis
2020-06-29T09:35:36Z
2021-06-09T22:32:43Z
2020-06-09
2020-06-29T09:35:36Z
TLR2 plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter Insertion/Deletion polymorphism with contradictory data about its role in HIV-1 infection. We analyzed rs111200466 in HIV-1 disease progression and showed a correlation with a faster progression to the CD4+<200cells/μL outcome for Deletion allele carriers (Cox regression analysis: Hazard Ratio=2.4; 95%CI:1.4-4, P=0.001). When naïve patients with CD4+<200cells/μL start antiretroviral treatment, rs111200466-Deletion carriers showed a trend towards a slower, recovery rate (time required to reach CD4+>350cells/μL, Cox P=0.36). Our data suggests rs111200466 as a prognosis factor for HIV-1 disease progression.
This work was supported by grant SAF2016-80125-R (Ministerio de Economía, Industria y Competitividad, Spain) to AC., grant PI-0001-2017 (Consejería de salud, Spain) to L.M. Real and by grant SAS111229 supported by the Junta de Andalucía to M.J. Bravo.
application/pdf
https://doi.org/10.1093/infdis/jiaa327
030102
0022-1899
http://hdl.handle.net/10459.1/69138
eng
Infectious Diseases Society of America
Oxford University Press
info:eu-repo/grantAgreement/MINECO//SAF2016-80125-R/ES/
Versió postprint del document publicat a: https://doi.org/10.1093/infdis/jiaa327
The Journal of Infectious Diseases, 2020, vol. 222, núm. 12, p. 2007–2011
(c) Laplana Lafaja, Marina et al., 2020
info:eu-repo/semantics/openAccess
Polymorphism
HIV infection
HIV progression
Toll Like Receptor 2 promoter -196 to -174 deletion affects CD4 levels along HIV infection progression
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
joan.fibla@udl.cat
Fibla Palazón, Joan
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/9c839992-815e-4a04-b3de-f77fb025ee7e/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
SWORD
mets.xml
SWORD deposit package
application/octet-stream
791024
https://repositori.udl.cat/bitstreams/31a243cb-f12c-48cb-9510-fe5a644f8d51/download
7dd6ba1f9764e6664fa3096f550d15b2
MD5
3
ORIGINAL
030102.pdf
030102.pdf
Postprint
application/pdf
594233
https://repositori.udl.cat/bitstreams/44422a3d-de96-40c3-b25d-ed1c19a3efd5/download
d54eaa48c08b41adad08439302fcf12e
MD5
4
THUMBNAIL
030102.pdf.jpg
030102.pdf.jpg
Generated Thumbnail
image/jpeg
2050
https://repositori.udl.cat/bitstreams/49d01f80-9321-4a15-ace7-2caeba9024e5/download
db7edfb6f100c0d112ab5b75d6fbad50
MD5
5
TEXT
030102.pdf.txt
030102.pdf.txt
Extracted Text
text/plain
22768
https://repositori.udl.cat/bitstreams/099650b3-138e-4ecc-8d0e-46e96bd87267/download
5a38b8aa3d49b711fb357fcd011f4c5f
MD5
6
10459.1/69138
oai:repositori.udl.cat:10459.1/69138
2022-09-27 14:59:10.315
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/486182021-08-30T15:04:33Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Molina Navarro, Maria Micaela
Casas Herranz, Celia
Piedrafita Llorens, Lídia
Bellí i Martínez, Gemma
Herrero Perpiñán, Enrique
2015-07-17T11:57:09Z
2025-01-01
2003
The Saccharomyces cerevisiae monothiol glutare-
doxin Grx5 participates in the mitochondrial biogenesis of
iron–sulfur clusters. Grx5 homologues exist in organisms from
bacteria to humans. Chicken (cGRX5) and human (hGRX5)
homologues contain a mitochondrial targeting sequence, suggest-
ing a mitochondrial localization for these two proteins. We have
compartmentalized the Escherichia coli and Synechocystis sp.
homologues, and also cGRX5 and hGRX5, in the mitochondrial
matrix of a yeast grx5 mutant. All four heterologous proteins
rescue the defects of the mutant. The chicken cGRX5 gene was
significantly expressed throughout the embryo stages in different
tissues. These results underline the functional conservation of
Grx5 homologues throughout evolution.
https://doi.org/10.1016/j.febslet.2006.03.037
009696
0014-5793
http://hdl.handle.net/10459.1/48618
eng
Elsevier
Reproducció del document publicat a https://doi.org/10.1016/j.febslet.2006.03.037
FEBS Letters, 2006, vol. 580, p. 2273-2280
(c) Federation of European Biochemical Societies, 2006
(c) Elsevier, 2006
info:eu-repo/semantics/restrictedAccess
Glutaredoxin
Iron–sulfur cluster
Mitochondria
Redox regulation
Glutathione
Prokaryotic and eukaryotic monothiol glutaredoxins are able to perform the functions of Grx5 in the biogenesis of Fe/S clusters in yeast mitochondria
article
publishedVersion
enric.herrero@cmb.udl.cat
Herrero Perpiñán, Enrique
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/d8d3e6bf-7e2d-417a-9dea-6cf75035ce5c/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
2
ORIGINAL
009696.pdf
009696.pdf
application/pdf
602990
https://repositori.udl.cat/bitstreams/4e0fae75-a5cd-48e7-ab55-60cf4d19ee37/download
cb7d502c39348571c164fb10ebaeb5d8
MD5
1
THUMBNAIL
009696.pdf.jpg
009696.pdf.jpg
Generated Thumbnail
image/jpeg
5713
https://repositori.udl.cat/bitstreams/0a38a819-2ef7-49a1-a874-766270210f1b/download
f352fabebace5a9fc2d9886afef8076b
MD5
5
TEXT
009696.pdf.txt
009696.pdf.txt
Extracted Text
text/plain
35649
https://repositori.udl.cat/bitstreams/9fea9292-1d45-4252-be91-0d86f92a6205/download
4fa36c4dce898875ed3ead0e0c019279
MD5
6
10459.1/48618
oai:repositori.udl.cat:10459.1/48618
2021-08-30 15:04:33.492
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/4638632023-10-27T08:57:05Zcom_10459.1_56965com_10459.1_2com_10459.1_243com_10459.1_227com_10459.1_47453col_10459.1_57707col_10459.1_3332col_10459.1_314col_10459.1_59998col_10459.1_49291col_10459.1_44504
Basallo, Oriol
Pérez, Lucía
Lucido, Abel
Sorribas Tello, Albert
Marin-Saguino, Alberto
Vilaprinyo Terré, Ester
Perez‑Fons, Laura
Albacete, Alfonso
Martínez-Andújar, Cristina
Fraser, Paul D.
Christou, Paul
Capell Capell, Teresa
Alves, Rui
2023-08-01T07:54:36Z
2023-08-01T07:54:36Z
2023
Many highly valued chemicals in the pharmaceutical, biotechnological, cosmetic, and biomedical industries belong to the terpenoid family. Biosynthesis of these chemicals relies on polymerization of Isopentenyl di-phosphate (IPP) and/or dimethylallyl diphosphate (DMAPP) monomers, which plants synthesize using two alternative pathways: a cytosolic mevalonic acid (MVA) pathway and a plastidic methyleritritol-4-phosphate (MEP) pathway. As such, developing plants for use as a platform to use IPP/DMAPP and produce high value terpenoids is an important biotechnological goal. Still, IPP/DMAPP are the precursors to many plant developmental hormones. This creates severe challenges in redirecting IPP/DMAPP towards production of non-cognate plant metabolites. A potential solution to this problem is increasing the IPP/DMAPP production flux in planta. Here, we aimed at discovering, understanding, and predicting the effects of increasing IPP/DMAPP production in plants through modelling. We used synthetic biology to create rice lines containing an additional ectopic MVA biosynthetic pathway for producing IPP/DMAPP. The rice lines express three alternative versions of the additional MVA pathway in the plastid, in addition to the normal endogenous pathways. We collected data for changes in macroscopic and molecular phenotypes, gene expression, isoprenoid content, and hormone abundance in those lines. To integrate the molecular and macroscopic data and develop a more in depth understanding of the effects of engineering the exogenous pathway in the mutant rice lines, we developed and analyzed data-centric, line-specific, multilevel mathematical models. These models connect the effects of variations in hormones and gene expression to changes in macroscopic plant phenotype and metabolite concentrations within the MVA and MEP pathways of WT and mutant rice lines. Our models allow us to predict how an exogenous IPP/DMAPP biosynthetic pathway affects the flux of terpenoid precursors. We also quantify the long-term effect of plant hormones on the dynamic behavior of IPP/DMAPP biosynthetic pathways in seeds, and predict plant characteristics, such as plant height, leaf size, and chlorophyll content from molecular data. In addition, our models are a tool that can be used in the future to help in prioritizing re-engineering strategies for the exogenous pathway in order to achieve specific metabolic goals
PROSTRIG, an ERANET project from FACEJPI (PCI2019-103382, MICIUN), partially funded this project. AL received funding from the European Union’s H2020 research and innovation programme under Marie Skłodowska-Curie grant agreement No. 801586. OB received a Ph. D. fellowship from AGAUR (2022FI_B 00395). LP received a Ph. D. fellowship from MINECO. This work was also partially supported by The Spanish Ministry of Economy and Competitiveness (MINECO, project BIO2014-54426-P) and the European Union Framework Program DISCO (from DISCOvery to products: a next-generation pipeline for the sustainable generation of high-value plant products, project 613513) also partially funded this work.
https://doi.org/10.3389/fpls.2023.1133299
033497
1664-462X
https://repositori.udl.cat/handle/10459.1/463863
eng
Frontiers Media SA
info:eu-repo/grantAgreement/MINECO//BIO2014-54426-P/ES/UNA CELULA DE ARROZ MODERNIZADA PARA INVESTIGACIONES EN BIOLOGIA SINTETICA Y SUS APLICACIONES/
Reproducció del document publicat a https://doi.org/10.3389/fpls.2023.1133299
Frontiers in Plant Science, vol. 14, núm. 1133299, p. 1-17
info:eu-repo/grantAgreement/EC/H2020/801586/EU/IberusTalent
info:eu-repo/grantAgreement/EC/FP7/613513
cc-by (c) Basallo et al., 2023
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
MEP pathway
Metabolic engineering
Multi level modelling
Terpenoid synthetic biology
MVA (mevalonic acid) pathway
Models matemàtics
Fosfomicina
Gens
Changing biosynthesis of terpenoid percursors in rice through synthetic biology
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
033497.pdf
033497.pdf
application/pdf
3337562
https://repositori.udl.cat/bitstreams/322c3ed2-8c61-4a2c-b193-7c223aec76c8/download
d74f79eafe24f682a3143171b8903f4c
MD5
1
TEXT
033497.pdf.txt
033497.pdf.txt
Extracted text
text/plain
100386
https://repositori.udl.cat/bitstreams/f38f8bcd-dbb2-4c9b-8347-13c1bda08d5f/download
b4fb495b18e7a960c28a31a2c7ab3420
MD5
4
THUMBNAIL
033497.pdf.jpg
033497.pdf.jpg
Generated Thumbnail
image/jpeg
4752
https://repositori.udl.cat/bitstreams/8c37624d-abff-461b-8624-7c55eaf2fee8/download
66ac8ca89dc4a744061556ba64f17c4b
MD5
5
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1019
https://repositori.udl.cat/bitstreams/5972e2f0-475c-4b2f-9d3b-89db4406466f/download
313ea3fe4cd627df823c57a0f12776e5
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
639
https://repositori.udl.cat/bitstreams/a49c70c2-84be-4f7b-b2db-f891cee16c87/download
15ec217096d63e7cd318d42eb888308c
MD5
3
10459.1/463863
oai:repositori.udl.cat:10459.1/463863
2023-10-27 08:57:05.181
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Basallo et al., 2023
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/4642602024-03-12T23:01:09Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Parisi, Eva
Hidalgo, Iván
Montal Roura, Robert
Pallisé, Ona
Tarragona Foradada, Jordi
Sorolla Bardají, Anabel
Novell, Anna
Campbell, Kyra
Sorolla Bardají, Maria Alba
Casali, Andreu
Salud Salvia, Maria Antonieta
2023-10-26T06:46:36Z
2023-10-26T06:46:36Z
2023
Metastasis is the leading cause of colorectal cancer (CRC)-related deaths. Therefore, the identification of accurate biomarkers predictive of metastasis is needed to better stratify high-risk patients to provide preferred management and reduce mortality. In this study, we identified 13 new genes that modified circulating tumor cell numbers using a genome-wide genetic screen in a whole animal CRC model. Candidate genes were subsequently evaluated at the gene expression level in both an internal human CRC cohort of 153 patients and an independent cohort from the TCGA including 592 patients. Interestingly, the expression of one candidate, PLA2G12A, significantly correlated with both the time to recurrence and overall survival in our CRC cohort, with its low expression being an indicator of a poor clinical outcome. By examining the TCGA cohort, we also found that low expression of PLA2G12A was significantly enriched in epithelial–mesenchymal transition signatures. Finally, the candidate functionality was validated in vitro using three different colon cancer cell lines, revealing that PLA2G12A deficiency increases cell proliferation, migration, and invasion. Overall, our study identifies PLA2G12A as a prognostic biomarker of early-stage CRC, providing evidence that its deficiency promotes tumor growth and dissemination.
This research was funded by the Merck Salud Foundation Project Award (2019), the University and Research Grants Management Agency (AGAUR) of the Catalonia Government grants 2017SRG1620 and 2021FIB00025, Instituto de Salud Carlos III grants PI21/01619 and JR21/00039, Spanish Ministry of Science and Innovation grant PID2019-1946GB-100, The National Centre for the Replacement, Refinement and Reduction of Animals in Research grant NC/W001136/1 and Wellcome Trust grant 204615/Z/16/Z. This research was also supported by the CERCA Program of the Generalitat de Catalunya and the IRBLleida (Fundació Pifarré).
https://doi.org/10.3390/ijms241310889
034039
1422-0067
https://repositori.udl.cat/handle/10459.1/464260
eng
MDPI
Reproducció del document publicat a https://doi.org/10.3390/ijms241310889
International Journal of Molecular Sciences, 2023, vol. 24, núm. 13, 10889
cc-by (c) Eva Parisi et al., 2023
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
PLA2G12A
Colorectal cancer
Prognosis
Drosophila
PLA2G12A as a Novel Biomarker for Colorectal Cancer with Prognostic Relevance
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
034039.pdf
034039.pdf
application/pdf
3614832
https://repositori.udl.cat/bitstreams/adf30331-ab69-4ae5-bdc7-61267fa3cd68/download
4f6e3987e3291f108c026ec6c169ffaf
MD5
1
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
1019
https://repositori.udl.cat/bitstreams/07d65398-3898-4493-9891-48f21a1d5d76/download
313ea3fe4cd627df823c57a0f12776e5
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
639
https://repositori.udl.cat/bitstreams/aef7be44-e7c8-4ccc-9d40-1ec19181b345/download
15ec217096d63e7cd318d42eb888308c
MD5
3
TEXT
034039.pdf.txt
034039.pdf.txt
Extracted text
text/plain
64259
https://repositori.udl.cat/bitstreams/2dae9a74-0998-4492-8007-8a8d97c866d3/download
bd37c7affde588b31ff84544915e5792
MD5
4
THUMBNAIL
034039.pdf.jpg
034039.pdf.jpg
Generated Thumbnail
image/jpeg
5758
https://repositori.udl.cat/bitstreams/88024d94-8255-49b5-9894-ba9052c92de2/download
751d1637d1498f3a334fb918ba201fcd
MD5
5
10459.1/464260
oai:repositori.udl.cat:10459.1/464260
2024-03-12 23:01:09.937
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Eva Parisi et al., 2023
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
Q29uY2VkZWl4byBsYSBsbGljw6huY2lhIGkgZXN0aWMgbGVnaXRpbWF0IHBlciBlbnZpYXIgYXF1ZXN0IGZvcm11bGFyaSBpIGFjY2VwdGFyIGxlcyBjb25kaWNpb25zIGRlIGRpcMOyc2l0IGkgZGlmdXNpw7MgYWwgUmVwb3NpdG9yaSBPYmVydCBkZSBsYSBVZEwgZGUgbGVzIGRhZGVzIHF1ZSBzJ2hpIGRlc2NyaXVlbiAocGVycXXDqCBzw7NjIHRpdHVsYXIgZGVscyBkcmV0cyBzb2JyZSBsZXMgZGFkZXMgbyBiw6kgcGVycXXDqCBkaXNwb3NvIGRlIGxhIGNvbXBldMOobmNpYSBvIGRlbHMgcGVybWlzb3MgcGVyIGZlci1obykuIERlY2xhcm8gcXVlIGVsIGRpcMOyc2l0IGkgZGlmdXNpw7MgZGUgbGVzIGRhZGVzIG5vIHZ1bG5lcmEgZHJldHMgZGUgdGVyY2VycyAobmkgZGUgcHJvcGlldGF0IGludGVsZWN0dWFsLCBuaSBpbmR1c3RyaWFsLCBuaSBkZSBwcml2YWNpdGF0LCBuaSBkZSBjYXAgbWVuYSkgZGUgbWFuZXJhIHF1ZSBleG9uZXJvIGEgbGEgVWRMIGRlIHF1YWxzZXZvbCBvYmxpZ2FjacOzIG8gcmVzcG9uc2FiaWxpdGF0IGRhdmFudCBxdWFsc2V2b2wgYWNjacOzIGxlZ2FsIHF1ZSBlcyBwdWd1aSBzdXNjaXRhciBkZXJpdmFkYSBkZWwgY29udGluZ3V0LCBkaXDDsnNpdCBvIGRpZnVzacOzIGRlIGxlcyBkYWRlcy4K
oai:repositori.udl.cat:10459.1/603462023-05-02T11:05:24Zcom_10459.1_227com_10459.1_2com_10459.1_47453com_10459.1_240col_10459.1_314col_10459.1_59998col_10459.1_333
Carles Lavila, Misericòrdia
Martínez Alonso, Montserrat
Pons Rodríguez, Anna
Pérez Lacasta, María José
Perestelo Pérez, Lilisbeth
Sala, Maria Rosa
Vidal, Carmen
Garcia, Montse
Toledo Chávarri, Ana
Codern-Bové, Núria
Feijoo Cid, Maria
Romero, Anabel
Pla, Roger
Soler González, Jorge
Castells, Xavier
Rué i Monné, Montserrat
2017-10-24T08:18:25Z
2017-10-24T08:18:25Z
2017
The decision to participate or not in breast cancer screening is complex due to the trade-off between the expected benefit of breast cancer mortality reduction and the major harm of overdiagnosis. It seems ethically necessary to inform women so that they can actively participate in decision-making and make an informed choice based on their values and preferences.
The objective of this study is to assess the effects of receiving information about the benefits and harms of screening on decision-making, in women approaching the age of invitation to mammography screening.
This work is supported by the research grant “Women participation in decisions and strategies on early detection of breast cancer” (PI14/00113) from the Instituto de Salud Carlos III and cofunded by Fondo Europeo de Desarrollo Regional (FEDER) “Una manera de hacer Europa.” Anna Pons received a grant for PhD students from the Lleida Biomedical Research Institute (IRBLLEIDA).
https://doi.org/10.1186/s13063-017-2161-7
025931
1745-6215
http://hdl.handle.net/10459.1/60346
eng
BioMed Central
Reproducció del document publicat a https://doi.org/10.1186/s13063-017-2161-7
Trials, 2017, vol. 18, núm. 913541, p.2161-2167
cc-by (c) Carles et al., 2017
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Screening
Breast cancer
Informed choice
Early detection
The effect of information about the benefits and harms of mammography on women’s decision-making: study protocol for a randomized controlled trial
article
publishedVersion
ORIGINAL
025931.pdf
025931.pdf
application/pdf
517799
https://repositori.udl.cat/bitstreams/5a035323-7b17-4ef2-a598-1b19373a7fb2/download
e7ac45bbd68c92903447f78031ac8cce
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/4e5cf5a9-ba5d-4993-96c2-b91702959c14/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
908
https://repositori.udl.cat/bitstreams/4c71e623-6b49-44d9-b6a1-8078bf70c003/download
0175ea4a2d4caec4bbcc37e300941108
MD5
2
THUMBNAIL
025931.pdf.jpg
025931.pdf.jpg
Generated Thumbnail
image/jpeg
4820
https://repositori.udl.cat/bitstreams/d2c10c5b-48ca-463e-9973-9a0cb519e82a/download
db20fd715699988aa0c46326426cd596
MD5
4
TEXT
025931.pdf.txt
025931.pdf.txt
Extracted Text
text/plain
40948
https://repositori.udl.cat/bitstreams/5b5aa3db-9b2a-4601-8c42-c46dbd38b133/download
32ef1c3032bd7a56720004b14e66e97b
MD5
5
10459.1/60346
oai:repositori.udl.cat:10459.1/60346
2023-05-02 11:05:24.887
http://creativecommons.org/licenses/by/4.0/
cc-by (c) Carles et al., 2017
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/600102021-04-29T09:27:09Zcom_10459.1_227com_10459.1_2com_10459.1_59360com_10459.1_47453com_10459.1_241col_10459.1_314col_10459.1_59361col_10459.1_59998col_10459.1_30324
Cabré Cucó, Rosanna
Naudí i Farré, Alba
Dominguez Gonzalez, Mayelin
Ayala Jové, Ma. Victoria (Maria Victoria)
Jové Font, Mariona
Mota Martorell, Natàlia
Piñol Ripoll, Gerard
Gil Villar, M. Pilar
Rué i Monné, Montserrat
Portero Otín, Manuel
Ferrer, Isidre
Pamplona Gras, Reinald
2017-07-06T11:54:01Z
2017-12-31T23:27:49Z
2017
Human brain aging is the physiological process which underlies as cause of cognitive decline in the elderly and the main risk factor for neurodegenerative diseases such as Alzheimer's disease. Human neurons are functional throughout a healthy adult lifespan, yet the mechanisms that maintain function and protect against neurodegenerative processes during aging are unknown. Here we show that protein oxidative and glycoxidative damage significantly increases during human brain aging, with a breakpoint at 60 years old. This trajectory is coincident with a decrease in the content of the mitochondrial respiratory chain complex I–IV. We suggest that the deterioration in oxidative stress homeostasis during aging induces an adaptive response of stress resistance mechanisms based on the sustained expression of REST, and increased or decreased expression of Akt and mTOR, respectively, over the adult lifespan in order to preserve cell neural survival and function.
R.C. received predoctoral fellowships from the Autonomous Government of Catalonia. We thank T. Yohannan for editorial help. Research reported in this publication was supported by the Spanish Ministry of Economy and Competitiveness, Institute of Health Carlos III (FIS Grants PI14/00757 and PI14/00328), and the Autonomous Government of Catalonia (2014SGR69 and 2014SGR168) to I.F. and R.P. This study was co-financed by FEDER funds from the European Union (‘a way to build Europe’).
https://doi.org/10.1016/j.freeradbiomed.2016.12.010
025637
0891-5849
http://hdl.handle.net/10459.1/60010
eng
Elsevier
Versió postprint del document publicat a https://doi.org/10.1016/j.freeradbiomed.2016.12.010
Free Radical Biology and Medicine, 2017, vol. 103, p. 14–22
cc-by-nc-nd (c) Elsevier, 2016
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Cell survival pathways
Mechanistic target of rapamycin (mTOR)
Mitochondria respiratory chain
Mitochondrial stress
Protein oxidation
Repressor element 1-silencing transcription factor (REST)
Sixty years old is the breakpoint of human frontal cortex aging
article
acceptedVersion
reinald.pamplona@mex.udl.cat
Reinald Pamplona
TEXT
025637.pdf.txt
025637.pdf.txt
Extracted Text
text/plain
52771
https://repositori.udl.cat/bitstreams/31ed4947-005b-4431-b57c-5280d11f14a1/download
a86fabdf77f8fabf321dc327eb0dc56e
MD5
6
ORIGINAL
025637.pdf
025637.pdf
Postprint
application/pdf
787165
https://repositori.udl.cat/bitstreams/e622c5bf-c72b-44b1-9043-c13937e911bd/download
508db926b3401439718266c06beab3da
MD5
4
CC-LICENSE
license_rdf
license_rdf
application/rdf+xml; charset=utf-8
805
https://repositori.udl.cat/bitstreams/85398c08-5e7b-4d2b-9515-0dacf8d9be1d/download
4460e5956bc1d1639be9ae6146a50347
MD5
2
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/d50ff139-33b5-49c5-9da6-c9afbc86beaf/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
3
THUMBNAIL
025637.pdf.jpg
025637.pdf.jpg
Generated Thumbnail
image/jpeg
2488
https://repositori.udl.cat/bitstreams/b9c2a9ee-5fa7-4358-a543-284f2b1c76b6/download
26bb1bdc5de4da930d07addc73d2ba1b
MD5
5
10459.1/60010
oai:repositori.udl.cat:10459.1/60010
2021-04-29 09:27:09.652
http://creativecommons.org/licenses/by-nc-nd/4.0/
cc-by-nc-nd (c) Elsevier, 2016
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
oai:repositori.udl.cat:10459.1/661612022-06-14T12:58:49Zcom_10459.1_227com_10459.1_2com_10459.1_47453col_10459.1_314col_10459.1_59998
Pérez Lacasta, María José
Martínez Alonso, Montserrat
Garcia, Montse
Sala, Maria
Perestelo Pérez, Lilisbeth
Vidal, Carmen
Codern-Bové, Núria
Feijoo Cid, Maria
Toledo Chávarri, Ana
Cardona, Àngels
Pons Rodríguez, Anna
Carles Lavila, Misericordia
Rué i Monné, Montserrat
2019-04-09T11:38:58Z
2019-04-09T11:38:58Z
2019-03-26
2019-04-09T11:38:58Z
BACKGROUND:
In Spain, women invited to breast screening are not usually informed about potential harms of screening. The objective of the InforMa study is to assess the effect of receiving information about the benefits and harms of breast screening on informed choice and other decision-making outcomes, in women approaching the age of invitation to mammography screening.
METHODS:
Two-stage randomised controlled trial. In the first stage, 40 elementary territorial units of the public healthcare system were selected and randomised to intervention or control. In the second stage, women aged 49-50 years were randomly selected. The target sample size was 400 women. Women in the intervention arm received a decision aid (DA) with detailed information on the benefits and harms of screening. Women in the control arm received a standard leaflet that did not mention harms and recommended accepting the invitation to participate in the Breast Cancer Screening Program (BCSP). The primary outcome was informed choice, defined as adequate knowledge and intentions consistent with attitudes. Secondary outcomes included decisional conflict, worry about breast cancer, time perspective, opinions about the DA or the leaflet, and participation in the BCSP.
RESULTS:
In the intervention group, 23.2% of 203 women made an informed choice compared to only 0.5% of 197 women in the control group (p < 0.001). Attitudes and intentions were similar in both study groups with a high frequency of women intending to be screened, 82.8% vs 82.2% (p = 0.893). Decisional conflict was significantly lower in the intervention group. No differences were observed in confidence in the decision, anxiety, and participation in BCSP.
CONCLUSIONS:
Women in Spain lack knowledge on the benefits and harms of breast screening. Providing quantitative information on benefits and harms has produced a considerable increase in knowledge and informed choice, with a high acceptance of the informative materials.
TRIAL REGISTRATION:
Trial identifier NCT03046004 at ClinicalTrials.gov registry. Registered on February 4 2017. Trial name: InforMa study.
This study was supported by the research grant “Women participation in decisions and strategies on early detection of breast cancer” (PI14/00113) from the Instituto de Salud Carlos III and cofunded by Fondo Europeo de Desarrollo Regional (FEDER) “Una manera de hacer Europa.” Anna Pons received a grant for PhD students from the Lleida Biomedical Research Institute (IRBLleida). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
application/pdf
https://doi.org/10.1371/journal.pone.0214057
028527
1932-6203
http://hdl.handle.net/10459.1/66161
eng
Public Library of Science
Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0214057
Plos One, 2019, vol. 14, núm. 3, p. e0214057
cc-by (c) Pérez Lacasta, María José et al., 2019
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es
Mama -- Radiografia
Mama -- Càncer
Effect of information about the benefits and harms of mammography on women's decision making: The InforMa randomised controlled trial
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ORIGINAL
028527.pdf
application/pdf
954972
https://repositori.udl.cat/bitstreams/327c0634-13c1-4b93-9da9-911cf774ed09/download
f980e1cccb6202fe886bebf4b295ed9e
MD5
1
LICENSE
license.txt
license.txt
text/plain; charset=utf-8
1748
https://repositori.udl.cat/bitstreams/fcbc6d03-2ae1-43b7-923b-794bc2baf301/download
8a4605be74aa9ea9d79846c1fba20a33
MD5
5
SWORD
mets.xml
SWORD deposit package
application/octet-stream
752337
https://repositori.udl.cat/bitstreams/71510be0-cf71-4db0-9d20-54e14d6302ed/download
edc62482ab3c1647888b3ca3f610466d
MD5
6
THUMBNAIL
028527.pdf.jpg
028527.pdf.jpg
Generated Thumbnail
image/jpeg
4936
https://repositori.udl.cat/bitstreams/2956fdc5-155a-44ed-805f-618c464cf469/download
fde3618e91f4f38c0e5ab3872d861c58
MD5
7
CC-LICENSE
license_url
application/octet-stream
43
https://repositori.udl.cat/bitstreams/9c26a42e-0343-4beb-a0a5-e398b3e04a9d/download
5134edb0a80711cbbaa5247c36025151
MD5
2
license_text
text/html
23115
https://repositori.udl.cat/bitstreams/d3d0092d-6b18-47af-b027-6202aec5e6b9/download
ec3783401c55aba9b2c045380c0dd4b3
MD5
3
license_rdf
application/octet-stream
20337
https://repositori.udl.cat/bitstreams/dfc5ce31-7ada-4da6-a579-3da998645a6d/download
1485691ce20485471fe59ad1ac24bf0f
MD5
4
TEXT
028527.pdf.txt
028527.pdf.txt
Extracted Text
text/plain
70936
https://repositori.udl.cat/bitstreams/b3368d90-56f4-47fc-80f9-49ca88dc6eca/download
49c34d04ce4679ac3da003f79c88beda
MD5
8
10459.1/66161
oai:repositori.udl.cat:10459.1/66161
2022-06-14 12:58:49.404
http://creativecommons.org/licenses/by/3.0/es
cc-by (c) Pérez Lacasta, María José et al., 2019
https://repositori.udl.cat
Repositori Obert UdL
repositori@udl.cat
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
xoai///col_10459.1_314/100