L'IRBLleida és un centre de recerca conjunt entre la Universitat i el Departament de Salut de la Generalitat de Catalunya. Té com a funció potenciar les sinergies de recerca biomèdica entre ambdós institucions i està compromès en avançar en la recerca biomèdica com a mitja per millorar la salut de la població i facilitar una activitat assistencial òptima en situacions de malaltia. [Més informació].

Recent Submissions

  • The dimensional assessment of personality psychopathology basic questionnaire: shortened versions item analysis 

    Aluja Fabregat, Antón; Blanch Plana, Angel; Blanco Calvo, Eduardo; Marti Guiu, Maite; Balada, Ferran (Universidad Complutense de Madrid and Colegio Oficial de Psicólogos de Madrid, 2014)
    This study has been designed to evaluate and replicate the psychometric properties of the Dimensional Assessment of Personality Psychopathology-Basic Questionnaire (DAPP-BQ) and the DAPP-BQ short form (DAPP-SF) in a large ...
  • Catalan and Hungarian Validation of the Zuckerman- Kuhlman-Aluja Personality Questionnaire (ZKA-PQ) 

    Surányi, Zsuzsanna; Aluja Fabregat, Antón (Universidad Complutense de Madrid and Colegio Oficial de Psicólogos de MadridCambridge University Press, 2014)
    The goal of this study was to examine the cross-cultural validity and reliability of the Zuckerman-Kuhlman- Aluja Personality Questionnaire (ZKA-PQ) – a recently published instrument for assessing the Zuckerman’s ...
  • Observational multicenter study to evaluate the prevalence and prognosis of subclinical atheromatosis in a Spanish chronic kidney disease cohort: baseline data from the NEFRONA study 

    Arroyo, David; Betriu i Bars, M. Àngels; Martínez Alonso, Montserrat; Vidal Amat, Teresa; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (BioMed Central, 2014)
    Background: Cardiovascular events (CVE) are more prevalent in chronic kidney disease (CKD) than in general population, being the main cause of morbimortality. Specific risk factors related to CKD have been suggested, because ...
  • Sixty years old is the breakpoint of human frontal cortex aging 

    Cabré Cucó, Rosanna; Naudí i Farré, Alba; Dominguez Gonzalez, Mayelin; Ayala Jové, Ma. Victoria (Maria Victoria); Jové Font, Mariona; Mota Martorell, Natalia; Piñol Ripoll, Gerard; Gil Villar, Maria P.; Rué i Monné, Montserrat; Portero Otín, Manuel; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2017)
    Human brain aging is the physiological process which underlies as cause of cognitive decline in the elderly and the main risk factor for neurodegenerative diseases such as Alzheimer's disease. Human neurons are functional ...
  • Genetic structure of the Spanish population 

    Gayán, Javier; Galan, José J.; González-Pérez, Antonio; Sáez, María Eugenia; Martínez-Larrad, María Teresa; Zabena, Carina; Rivero, M. Carmen; Salinas, Ana; Ramírez-Lorca, Reposo; Morón, Francisco J.; Royo Sánchez-Palencia, José Luis; Moreno-Rey, Concha; Velasco, Juan; Carrasco, José M.; Molero, Eva; Ochoa, Carolina; Ochoa, María Dolores; Gutiérrez, Marta; Reina, Mercedes; Pascual, Rocío; Romo-Astorga, Alejandro; Susillo-González, Juan Luis; Vázquez, Enrique; Real, Luis M.; Ruiz, Agustín; Serrano-Ríos, Manuel (BioMed Central, 2010-05-25)
    Background Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. ...
  • Central sleep apnoea is related to the severity and short-term prognosis of acute coronary syndrome 

    Florés, Marina; Batlle Garcia, Jordi de; Sánchez de la Torre, Alicia; Sánchez de la Torre, Manuel; Aldomá, Albina; Worner, Fernando; Galera, Estefanía; Seminario, Asunción; Torres, Gerard; Dalmases, Mireia; Montserrat i Capdevila, Josep; Garmendia, Onintza; Barbé Illa, Ferran (Public Library of Science, 2016)
    Objective To evaluate the relation of central sleep apnoea (CSA) to the severity and short-term prognosis of patients who experience acute coronary syndrome (ACS). Methods Observational study with cross-sectional and ...
  • Síndrome de Ross: una causa infrecuente neurológica de trastorno de la sudoración 

    Balcells Terés, Anna; Sanahuja Montesinos, Jordi; Guitard Sein-Echaluce, Ma. Luisa; Albertí, Antonia; Ortiz, Ariadna; Barcenilla Gaite, Fernando (Viguera Editores, 2014-10-01)
    El síndrome de Ross es una rara entidad de disfunción degenerativa del sistema nervioso autónomo, que se caracteriza por la tríada de pupila tónica de Adie, arreflexia osteotendinosa y hipohidrosis/anhidrosis segmentaria. ...
  • Comparative effect of three neurotoxic insecticides with different modes of action on adult males and females of three tortricid moth pests 

    Navarro Roldán, Miguel Ángel; Avilla Hernández, Jesús; Bosch Serra, Dolors; Valls Marsal, Joan; Gemeno Marín, César (Oxford University Press, 2017)
    Insecticides are the dominant pest management method in fruit and vegetable crops worldwide owing to their quick effect, low cost, and relatively easy application, but they bear negative effects on human health and the ...
  • High levels of hemoglobin promote carotid adventitial vasa vasorum neoangiogenesis in chronic kidney disease 

    Arcidiacono, Maria V.; Martínez Alonso, Montserrat; Belart, Montserrat; Vilar, Ana; Martín, Marisa; Craver Hospital, Lourdes; Betriu i Bars, M. Àngels; Mauricio Puente, Dídac; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira; Borràs, Mercè (Hindawi, 2017-01-04)
    Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa ...
  • Evaluating multi-locus phylogenies for species boundaries determination in the genus Diaporthe 

    Santos, Liliana; Alves, Artur; Alves, Rui (Peerj, 2017-03-28)
    Background. Species identification is essential for controlling disease, understanding epidemiology, and to guide the implementation of phytosanitary measures against fungi from the genus Diaporthe. Accurate Diaporthe ...
  • GESAP trial rationale and methodology: management of patients with suspected obstructive sleep apnea in primary care units compared to sleep units 

    Tarraubella Balanya, Núria; Batlle Garcia, Jordi de; Nadal Braque, Núria; Castro-Grattoni, Anabel L.; Gómez Falguera, Silvia; Sánchez de la Torre, Manuel; Barbé Illa, Ferran (Nature Publishing Group, 2016-12)
    BACKGROUND Obstructive sleep apnea syndrome (OSA) is a chronic sleep disorder characterized by repeated episodes of upper airway collapse during sleep. This leads to arterial hypoxemia and sleep disruption and causes daytime ...
  • A review on the use of NEO-PI-R validity scales in normative, job selection, and clinical samples 

    Blanch Plana, Angel; Aluja Fabregat, Antón; Gallart Masia, Salvador; Dolcet, Joan Marc (Universidad de Zaragoza, 2009)
    Background and Objectives: In this study we review the use of the Positive Presentation Management (PPM) and Negative Presentation Management (NPM) scales, two NEO-PI-R derived measures originally devised to control for ...
  • Vascular calcification induced by chronic kidney disease is mediated by an increase of 1α-hydroxylase expression in vascular smooth muscle cells 

    Torremadé Pascual, Noèlia; Bozić Stanojević, Milica; Panizo García, Sara; Barrio Vazquez, Sara; Fernandez Martín, José L.; Encinas Martín, Mario; Goltzman, David; Arcidiacono, Maria V.; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (Wiley, 2016-04-01)
    Vascular calcification (VC) is a complication of chronic kidney disease that predicts morbidity and mortality. Uremic serum promotes VC, but the mechanism involved is unknown. A role for 1,25(OH)2 D3 in VC has been proposed, ...
  • Multilayer OMIC data in medullary thyroid carcinoma identifies the STAT3 pathway as a potential therapeutic target in RETM918T tumors 

    Mancikova, Veronica; Montero Conde, Cristina; Perales Paton, Javier; Fernandez, Agustin F; Santacana Espasa, Maria; Jodkowska, Karolina; Inglada-Pérez, Lucía; Castelblanco Echavarría, Esmeralda; Borrego, Salud; Encinas Martín, Mario; Matias-Guiu, Xavier; Fraga, Mario; Robledo, Mercedes (American Association for Cancer Research., 2016-09-12)
    Purpose: Medullary thyroid carcinoma (MTC) is a rare disease with few genetic drivers, and the etiology specific to each known susceptibility mutation remains unknown. Exploiting multilayer genomic data, we focused our ...
  • Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice 

    Vaquero, Marta; Macià Armengol, Anna; Anerillas Aljama, Diego; Velasco Sánchez, Ana; Matias-Guiu, Xavier; Ribera i Calvet, Joan; Encinas Martín, Mario (Society for Endocrinology, 2016-02-01)
    Pheochromocytomas (PCCs) are rare catecholamine-secreting tumors arising from the chromaffin cells in the adrenal medulla. Closely related paragangliomas share developmental origin but arise extra-adrenally, in the paraganglia ...
  • Utilización de los recursos web para el intercambio de conocimientos en la poblacion enfermera 

    Martínez Soldevila, Jordi; Barallat Gimeno, Eva; Gea Sánchez, Montserrat; Blanco Blanco, Joan; Martínez Barriuso, Josep Maria; Ballesté Torralba, Jordi (Fundación Índex, 2015)
    En el transcurso de los estudios universitarios los alumnos del grado de enfermería constituyen su identidad profesional. Este proceso está influenciado por varios factores tales como: la dinámica del sistema de salud, las ...
  • Chronic treatment with the AMPA agonist AICAR prevents skeletal muscle pathology but fails to improve clinical outcome in a mouse model of severe spinal muscular atrophy 

    Cerveró Cebrià, Clàudia; Montull, Neus; Tarabal Mostazo, Olga; Piedrafita, Lidia; Esquerda Colell, Josep; Calderó i Pardo, Jordi (Springer Verlag, 2016)
    Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder characterized by spinal and brainstem motor neuron (MN) loss and skeletal muscle paralysis. Currently there is no effective treatment other than supportive ...
  • Productos finales de glicación avanzada en la obesidad mórbida y tras la cirugía bariátrica: cuando la memoria glucémica empieza a fallar 

    Sánchez Peña, Enric; Baena-Fustegueras, Juan A; Fuente Juárez, Mari Cruz de la; Gutiérrez Carrasquilla, Liliana; Bueno Díez, Marta; Ros López, Susana; Lecube Torelló, Albert (Elsevier España, 2017-01-18)
    Antecedentes y objetivo: Los productos finales de glicación avanzada (AGE) son un indicador de memoria metabólica. Su concentración se incrementa cuando existe estrés oxidativo, inflamación o hiperglucemia crónica. Se ...
  • Estudio de intervención aleatorizado para evaluar la prevalencia de enfermedad ateromatosa y renal ocultas y su impacto en la morbimortalidad: Proyecto ILERVA 

    Betriu i Bars, M. Àngels; Farràs, Cristina; Abajo, María; Martínez Alonso, Montserrat; Arroyo, David; Barbé Illa, Ferran; Buti, Miquel; Lecube Torelló, Albert; Portero Otín, Manuel; Purroy Garcia, Francisco; Torres, Gerard; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (Sociedad Española de Nefrología, 2016)
    Antecedentes y objetivos: La enfermedad renal crónica (ERC) y la ateromatosis son 2 enfermedades interrelacionadas que aumentan el riesgo de morbimortalidad cardiovascular. Los objetivos del proyecto ILERVAS son: 1) conocer ...
  • Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease 

    Gomez Pastor, Rocio; Burchfiel, Eileen T.; Neef, Daniel W.; Jaeger, Alex M.; Cabiscol Català, Elisa; McKinstry, Spencer U.; Doss, Argenia; Aballay, Alejandro; Lo, Donald C.; Akimov, Sergey S.; Ross, Christopher A.; Eroglu, Cagla; Thiele, Dennis J. (Nature, 2017)
    Huntington’s Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death. Expression of the cellular protein folding and pro-survival machinery ...

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