Recent Submissions

  • Estudio de intervención aleatorizado para evaluar la prevalencia de enfermedad ateromatosa y renal ocultas y su impacto en la morbimortalidad: Proyecto ILERVA 

    Betriu i Bars, M. Àngels; Farràs, Cristina; Abajo, María; Martínez Alonso, Montserrat; Arroyo, David; Barbé Illa, Ferran; Buti, Miquel; Lecube Torelló, Albert; Portero Otín, Manuel; Purroy Garcia, Francisco; Torres, Gerard; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (Sociedad Española de Nefrología, 2016)
    Antecedentes y objetivos: La enfermedad renal crónica (ERC) y la ateromatosis son 2 enfermedades interrelacionadas que aumentan el riesgo de morbimortalidad cardiovascular. Los objetivos del proyecto ILERVAS son: 1) conocer ...
  • Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model 

    Gou Fabregas, Myriam; Ramírez-Núñez, Omar; Cacabelos Barral, Daniel; Bahi i Pla, Núria; Portero Otín, Manuel; Garcera, Ana; Soler i Tatché, Rosa M. (Elsevier, 2014)
    Amyotrophic Lateral Sclerosis (ALS), a severe neurodegenerative disease, affects the upper and lower motor neurons in the brain and spinal cord. In some studies, ALS disease progression has been associatedwith an increase ...
  • Biofortification of crops with nutrients: factors affecting utilization and storage 

    Díaz-Gómez, J.; Twyman, Richard M.; Zhu, Changfu; Farré Martinez, Gemma; Serrano Casasola, José Carlos Enrique; Portero Otín, Manuel; Muñoz Odina, Mª Pilar; Sandmann, Gerhard; Capell Capell, Teresa; Christou, Paul (Elsevier, 2017-01-06)
    Biofortification is an effective and economical method to improve the micronutrient content of crops, particularly staples that sustain human populations in developing countries. Whereas conventional fortification requires ...
  • Metabolomics predicts neuroimaging characteristics of transient ischemic attack patients 

    Purroy Garcia, Francisco; Cambray Carner, Serafí; Mauri-Capdevila, Gerard; Jové Font, Mariona; Sanahuja Montesinos, Jordi; Farré, Joan; Benabdelhak Abbou, Ikram; Molina Seguin, Jessica; Colàs Campàs, Laura; Begué Gómez, Robert; Gil, M. Isabel; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2016)
    Background: Neuroimaging is essential for the diagnosis and prognosis of transient ischemic attack (TIA). The discovery of a plasmatic biomarker related to neuroimaging findings is of enormous interest because, despite ...
  • Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex 

    Cabré Cucó, Rosanna; Jové Font, Mariona; Naudí i Farré, Alba; Ayala Jové, Ma. Victoria (Maria Victoria); Piñol Ripoll, Gerard; Gil Villar, Maria P.; Dominguez Gonzalez, Mayelin; Obis Monné, Èlia; Berdun, Rebeca; Mota Martorell, Natalia; Portero Otín, Manuel; Ferrer, Isidre; Pamplona Gras, Reinald (Frontiers in Molecular Neurosciencie, 2016)
    Brain neurons offer diverse responses to stresses and detrimental factors during development and aging, and as a result of both neurodegenerative and neuropsychiatric disorders. This multiplicity of responses can be ascribed ...
  • Voltage-gated calcium channel blockers deregulate macroautophagy in cardiomyocytes 

    Pushparaj, Charumathi; Das, Arindam; Purroy, Rosa; Nàger, Mireia; Herreros Danes, Judit; Pamplona Gras, Reinald; Cantí Nicolás, Carles (Elsevier, 2015)
    Voltage-gated calcium channel blockers are widely used for the management of cardiovascular diseases, however little is known about their effects on cardiac cells in vitro. We challenged neonatal ventricular cardiomyocytes ...
  • Mitochondrial ATP-Synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer's disease pathology 

    Terni, Beatrice; Boada Pallàs, Jordi; Portero Otín, Manuel; Pamplona Gras, Reinald; Ferrer, Isidre (Wiley, 2010)
    Oxidative stress has been implicated in the pathogenesis of several neurodegenerative diseases including Alzheimer's disease (AD). Several proteins have been identified as targets of oxidative damage in AD dementia (usually ...
  • Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates 

    Martínez, Anna; Portero Otín, Manuel; Pamplona Gras, Reinald; Ferrer, Isidre (Wiley, 2010)
    Human neurodegenerative diseases with abnormal protein aggregates are associated with aberrant post-translational modifications, solubility, aggregation and fibril formation of selected proteins which cannot be degraded ...
  • Biomarkers of aging in Drosophila 

    Jacobson, Jake; Lambert, Adrian J.; Portero Otín, Manuel; Pamplona Gras, Reinald; Magwere, Tapiwanashe; Miwa, Satomi; Driege, Yasmine; Brand, Martin D.; Partridge, Linda (Wiley, 2010)
    Low environmental temperature and dietary restriction (DR) extend lifespan in diverse organisms. In the fruit fly Drosophila, switching flies between temperatures alters the rate at which mortality subsequently increases ...
  • Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy 

    Fourcade, Stéphane; Ruiz, Montserrat; Guilera, Cristina; Hahnen, Eric; Brichta, Lars; Naudí i Farré, Alba; Portero Otín, Manuel; Dacremont, Georges; Cartier, Nathalie; Wanders, Ronald; Kemp, Stephan; Mandel, Jean Louis; Wirth, Brunhilde; Pamplona Gras, Reinald; Aubourg, Patrick; Pujol, Aurora (Oxford University Press, 2010)
    X-linked adrenoleukodystrophy (X-ALD) is a fatal, axonal demyelinating, neurometabolic disease. It results from the functional loss of a member of the peroxisomal ATP-binding cassette transporter subfamily D (ABCD1), ...
  • Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease 

    Ilieva, Ekaterina V.; Naudí i Farré, Alba; Kichev, Anton Vladimirov; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Elsevier, 2010)
    Both oxidative and endoplasmic reticulum (ER) stress is associated with multiple neurodegenerative, age-related diseases. The rare disorder Pick disease (PiD) shares some pathological hallmarks of other neurodegenerative ...
  • Mitochondrial Dysfunction and Oxidative and Endoplasmic Reticulum Stress in Argyrophilic Grain Disease 

    Ilieva, Ekaterina V.; Kichev, Anton Vladimirov; Naudí i Farré, Alba; Ferrer, Isidre; Pamplona Gras, Reinald; Portero Otín, Manuel (Oxford University Press, 2011)
    Argyrophilic grain disease (AGD) is characterized by the accumulation of hyperphosphorylated 4R tau in dendritic varicosities (i.e."grains") in neurons and pretangles in certain areas of the cerebral cortex and other brain ...
  • Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-Adrenoleukodystrophy 

    Fourcade, Stéphane; Schlüter, Agatha; López Erauskin, Jone; Guilera, Cristina; Jové Font, Mariona; Naudí i Farré, Alba; García Arumí, Elena; Andreu, Antoni L.; Starkov, Anatoly A.; Pamplona Gras, Reinald; Ferrer, Isidre; Portero Otín, Manuel; Pujol, Aurora (Mary Ann Liebert, Inc., 2011)
    Aims: Chronic metabolic impairment and oxidative stress are associated with the pathogenesis of axonal dysfunction in a growing number of neurodegenerative conditions. To investigate the intertwining of both noxious factors, ...
  • Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: a paradigm for multifactorial neurodegenerative diseases? 

    Galea, Elena; Launay, Nathalie; Portero Otín, Manuel; Ruiz, Montserrat; Pamplona Gras, Reinald; Aubourg, Patrick; Ferrer, Isidre; Pujol, Aurora (Elsevier, 2012)
    X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative disorder expressed as four disease variants characterized by adrenal insufficiency and graded damage in the nervous system. X-ALD is caused by a loss ...
  • Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism 

    Gonzalo Benito, Hugo; Brieva, Luis; Tatzber, Franz; Jové Font, Mariona; Cacabelos Barral, Daniel; Cassanyé, Anna; Lanau, Lucia; Boada Pallàs, Jordi; Serrano Casasola, José Carlos Enrique; González Mingot, Cristina; Hernández, Lourdes; Peralta, Sílvia; Pamplona Gras, Reinald; Portero Otín, Manuel (Wiley, 2012)
    Metabolomic and lipidomic analyses have been used for the profiling of neurodegenerative processes, both in targeted and untargeted approaches. In this work we have applied these techniques to the study of CSF samples of ...
  • Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system 

    Keipert, Susanne; Ost, M.; Chadt, A.; Voigt, A.; Ayala Jové, Ma. Victoria (Maria Victoria); Portero Otín, Manuel; Pamplona Gras, Reinald; Al-Hasani, H.; Klaus, Susanne (American Physiological Society, 2013)
    Ectopic expression of uncoupling protein 1 (UCP1) in skeletal muscle (SM) mitochondria increases lifespan considerably in high-fat diet-fed UCP1 Tg mice compared with wild types (WT). To clarify the underlying mechanisms, ...
  • Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters 

    Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Ramírez-Núñez, Omar; Serrano Casasola, José Carlos Enrique; Cassanyé, Anna; Arola i Ferrer, Lluís; Caimari, Antoni; Bas, Josep M. del; Crescenti, Anna; Pamplona Gras, Reinald; Portero Otín, Manuel (Oxford Journals, 2013)
    Aims Atherosclerosis is the main pathological process contributing to cardiovascular disease, with diet being the most important factor involved. Although the lipidome of atheromatous plaque has been studied previously, ...
  • Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy 

    Morató, Laia; Galino, Jorge; Ruiz, Montserrat; Calingasan, Noel Ylagan; Starkov, Anatoly A.; Dumont, Magali; Naudí i Farré, Alba; Martínez, Juan José; Aubourg, Patrick; Portero Otín, Manuel; Pamplona Gras, Reinald; Galea, Elena; Flint Beal, M.; Ferrer, Isidre; Fourcade, Stéphane; Pujol, Aurora (Oxford Journals, 2013)
    X-linked adrenoleukodystrophy is a neurometabolic disorder caused by inactivation of the peroxisomal ABCD1 transporter of very long-chain fatty acids. In mice, ABCD1 loss causes late onset axonal degeneration in the spinal ...
  • Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy 

    López Erauskin, Jone; Galino, Jorge; Ruiz, M.; Cuezva, J. M.; Fabregat, I.; Cacabelos Barral, Daniel; Boada Pallàs, Jordi; Martínez, Juan José; Ferrer, Isidre; Pamplona Gras, Reinald; Villarroya, F.; Portero Otín, Manuel; Fourcade, Stéphane; Pujol, A. (Oxford Journals, 2013)
    X-linked adrenoleukodystrophy (X-ALD) is an inherited metabolic disorder of the nervous system characterized by axonopathy in spinal cords and/or cerebral demyelination, adrenal insufficiency and accumulation of very ...
  • The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage 

    Moreno Martínez, José Antonio; Díaz-Gómez, J.; Nogareda, Carmina; Angulo Asensio, Eduardo; Sandmann, Gerhard; Portero Otín, Manuel; Serrano Casasola, José Carlos Enrique; Twyman, Richard M.; Capell Capell, Teresa; Zhu, Changfu; Christou, Paul (Nature, 2016)
    Carotenoids are important dietary nutrients with health-promoting effects. The biofortification of staple foods with carotenoids provides an efficient delivery strategy but little is known about the fate and distribution ...

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