Les línies de recerca del grup són les següents: a) estudi dels factors neurotròfics i les vies de senyalització intracel·lular activades per aquests factors en relació a la seva funció sobre la supervivència i mort neuronal, i b) estudi dels processos que regulen la mort cel·lular en el teixit cardíac. El coneixement dels mecanismes implicats en aquests processos és essencial per abordar el tractament de malalties del sistema nerviós i les malalties del sistema cardiovascular. [Més informació].

Recent Submissions

  • Neuroprotection by neurotrophic factors and membrane depolarization is regulated by calmodulin kinase IV 

    Pérez García, María José; Gou Fàbregas, Myriam; Pablo Llavall, Yolanda de; Llovera i Tomàs, Marta; Comella i Carnicé, Joan Xavier; Soler i Tatché, Rosa Ma (American Society for Biochemistry and Molecular Biology, 2008)
    Neurotrophic factors promote motoneuron (MN) survival through increased intracellular calcium (Ca(2+)) and regulation of the phosphatidylinositol (PI) 3-kinase/protein kinase B (PKB) pathway by calmodulin (CaM). Activation ...
  • The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins 

    Moubarak, Rana S.; Solé Serra, Carme; Pascual, Marta; Gutierrez, Humberto; Llovera i Tomàs, Marta; Pérez García, María José; Gozzelino, Raffaella; Segura Ginard, Miguel Francisco; Iglesias Guimarais, Victoria; Reix, Stéphanie; Soler i Tatché, Rosa Ma; Davies, Alun M.; Soriano, Eduardo; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Society for Neuroscience, 2010)
    FLICE-inhibitory protein (FLIP) is an endogenous inhibitor of the signaling pathway triggered by the activation of death receptors. Here, we reveal a novel biological function for the long form of FLIP (FLIP-L) in neuronal ...
  • Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function 

    McDermott Roe, Chris; Ye, Junmei; Ahmed, Rizwan; Sun, Xi-Ming; Serafín, Anna; Ware, James; Bottolo, Leonardo; Muckett, Phil; Cañas, Xavier; Zhang, Jisheng; Rowe, Glenn C.; Buchan, Rachel; Lu, Han; Braithwaite, Adam; Mancini, Massimiliano; Hauton, David; Martí, Ramon; García Arumí, Elena; Hubner, Norbert; Jacob, Howard; Serikawa, Tadao; Zidek, Vaclav; Papousek, Frantisek; Kolar, Frantisek; Cardona Colom, Maria; Ruiz Meana, Marisol; García Dorado, David; Comella i Carnicé, Joan Xavier; Felkin, Leanne E.; Barton, Paul J. R.; Zoltan Arany; Pravenec, Michal; Petretto, Enrico; Sanchis, Daniel; Cook, Stuart A. (Macmillan Publishers Limited, 2011)
    Left ventricular mass (LVM) is a highly heritable trait1 and an independent risk factor for all-cause mortality2. So far, genome-wide association studies have not identified the genetic factors that underlie LVM variation3, ...
  • FAIM-L Is an IAP-Binding Protein That Inhibits XIAP Ubiquitinylation and Protects from Fas-Induced Apoptosis 

    Moubarak, Rana S.; Planells Ferrer, Laura; Urresti, Jorge; Reix, Stéphanie; Segura, Miguel F.; Carriba, Paulina; Marqués Fernàndez, Fernando; Solé Serra, Carme; Llecha Cano, Núria; López Soriano, Joaquin; Sanchis, Daniel; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Society for Neuroscience, 2013)
    The neuronal long isoform of Fas Apoptotic Inhibitory Molecule (FAIM-L) protects from death receptor (DR)-induced apoptosis, yet its mechanism of protection remains unknown. Here, we show that FAIM-L protects rat neuronal ...
  • Polypyrimidine tract binding proteins (PTB) regulate the expression of apoptotic genes and susceptibility to caspase-dependent apoptosis in differentiating cardiomyocytes 

    Zhang, Jisheng; Bahi i Pla, Núria; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Nature Publishing Group, 2009)
    Cardiac morphologic abnormalities in mice deficient for key regulators of the caspase-dependent signaling underscored its role in heart development. However, the mechanisms regulating apoptotic gene expression in the ...
  • Ubiquitination of TrkA by Nedd4-2 regulates receptor lysosomal targeting and mediates receptor signaling 

    Georgieva, Maya V.; Pablo Llavall, Yolanda de; Sanchis, Daniel; Comella i Carnicé, Joan Xavier; Llovera i Tomàs, Marta (Wiley, 2011)
    The nerve growth factor receptor TrkA (tropomyosin-related kinase receptor) participates in the survival and differentiation of several neuronal populations. The C-terminal tail of TrkA contains a PPXY motif, the binding ...
  • Developmental silencing and independency from E2F of apoptotic gene expression in postmitotic tissues 

    Zhang, Jisheng; Bahi i Pla, Núria; Zubiaga, Ana M.; Comella i Carnicé, Joan Xavier; Llovera i Tomàs, Marta; Sanchis, Daniel (Wiley, 2007)
    The involvement of caspases in postmitotic cell death is controversial. Here we report that adult brain and heart are devoid of many key pro-apoptotic proteins due to a progressive postnatal silencing event involving a ...
  • Translation of Myocyte Enhancer Factor-2 is induced by hypertrophic stimuli in cardiomyocytes through a Calcineurin-dependent pathway 

    Ye, Junmei; Cardona, Maria; Llovera i Tomàs, Marta; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Elsevier, 2012)
    The Myocyte Enhancer Factor-2 (MEF2) family of transcription factors regulates gene expression during cardiomyocyte differentiation and adaptation of the myocardium to stress. MEF2 activity is enhanced by increasing its ...
  • Frataxin deficiency in neonatal rat ventricular myocytes targets mitochondria and lipid metabolism 

    Obis Monné, Èlia; Irazusta, Verónica Patricia; Sanchis, Daniel; Ros Salvador, Joaquim; Tamarit Sumalla, Jordi (Elsevier, 2014)
    Friedreich ataxia (FRDA) is a hereditary disease caused by deficient frataxin expression. This mitochondrial protein has been related to iron homeostasis, energy metabolism, and oxidative stress. Patients with FRDA experience ...
  • A TrkB/EphrinA Interaction Controls Retinal Axon Branching and Synaptogenesis 

    Marler, Katharine J. M.; Becker-Barroso, Elena; Martínez, Albert; Llovera i Tomàs, Marta; Wentzel, Corinna; Poopalasundaram, Subathra; Hindges, Robert; Soriano, Eduardo; Comella i Carnicé, Joan Xavier; Drescher, Uwe (Society for Neuroscience, 2008)
    Toward understanding topographically specific branching of retinal axons in their target area, we have studied the interaction between neurotrophin receptors and members of the Eph family. TrkB and its ligand BDNF are ...
  • A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart 

    Ye, Junmei; Llorian, Miriam; Cardona, Maria; Rongvaux, Anthony; Moubarak, Rana S.; Comella i Carnicé, Joan Xavier; Bassel-Duby, Rhonda; Flavell, Richard A.; Olson, Eric N.; Smith, Christopher W. J.; Sanchis, Daniel (Company of Biologists Ltd., 2013)
    Polypyrimidine tract binding protein (PTB) regulates pre-mRNA splicing, having special relevance for determining gene expression in the differentiating muscle. We have previously shown that PTB protein abundance is ...
  • Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe 

    Cornago Protomártir, Marta; Garcia-Alberich, C.; Blasco Angulo, Natividad; Vall-llaura Espinosa, Núria; Nager Grifo, Mireia; Herreros Danes, Judit; Comella i Carnicé, Joan Xavier; Sanchis, Daniel; Llovera i Tomàs, Marta (Nature Publishing Group, 2014-10-02)
    Glioblastoma multiforme is resistant to conventional anti-tumoral treatments due to its infiltrative nature and capability of relapse; therefore, research efforts focus on characterizing gliomagenesis and identifying ...
  • Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart 

    Cardona, Maria; López, Juan Antonio; Serafín, Anna; Rongvaux, Anthony; Inserte Igual, Javier; García-Dorado, David; Flavell, Richard; Llovera i Tomàs, Marta; Cañas, Xavier; Vázquez, Jesús; Sanchis, Daniel (Public Library of Science, 2015-06-29)
    Executioner caspase-3 and -7 are proteases promoting cell death but non-apoptotic roles are being discovered. The heart expresses caspases only during development, suggesting they contribute to the organ maturation process. ...
  • Signalling by neurotrophins and hepatocyte growth factor regulates axon morphogenesis by differential β-catenin phosphorylation 

    David, Mónica Delia; Yeramian Hakim, Andree; Duñach, Mireia; Llovera i Tomàs, Marta; Cantí Nicolás, Carles; Garcia de Herreros, Antonio; Comella i Carnicé, Joan Xavier; Herreros Danes, Judit (Company of Biologist, 2008)
    Tyrosine phosphorylation of ß-catenin, a component of adhesion complexes and the Wnt pathway, affects cell adhesion, migration and gene transcription. By reducing ßcatenin availability using shRNA-mediated gene silencing ...
  • EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes 

    Zhang, Jisheng; Ye, Junmei; Altafaj, Albert; Cardona Colom, Maria; Bahi i Pla, Núria; Llovera i Tomàs, Marta; Cañas, Xavier; Cook, Stuart A.; Comella i Carnicé, Joan Xavier; Sanchis, Daniel (Public Library of Science (PLoS), 2011)
    Mitochondrial dysfunction, caspase activation and caspase-dependent DNA fragmentation are involved in cell damage in many tissues. However, differentiated cardiomyocytes repress the expression of the canonical apoptotic ...