El Grup estudia les alteracions moleculars dels càncers d'endometri, tiroide i la pell, en correlació amb les característiques clíniques i patològiques: 1) Estudi de gens involucrats en l'apòptosi en el càncer d'endometri i de pell (NFkB, survivina, PTEN, BAX, receptors de mort i els seus lligands, Flip); 2) Perfils d'expressió en càncers d'endometri, tiroides i melanoma; 3) Resposta de fàrmacs inhibidors de tirosin cinases i anàlogs de somatostatina en línies cel·lulars de melanoma. [Més informació].

Recent Submissions

  • Reproducibility of measurement of myometrial invasion in endometrial carcinoma 

    van der Putten, Louis J. M.; van de Vijver, Koen; Bartosch, Carla; Davidson, Ben; Gatius, Sònia; Matias-Guiu, Xavier; McCluggage, W. Glenn; Toledo, Gemma; van der Wurff, Anneke A. M.; Pijnenborg, Johanna M. A.; Massuger, Leon F. A. G.; Bulten, Johan (Springer Berlin Heidelberg, 2016)
    Myometrial invasion (MI) as a percentage (%MI), categorized into <50 or ≥50 %, is an important predictor of prognosis in endometrial carcinoma. Recent studies suggest that tumor-free distance (TFD) to serosa and the absolute ...
  • Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: discovery and validation studies 

    Hellner, Karin; Miranda, Fabrizio; Fotso Chedom, Donatien; Herrero Gonzalez, Sandra; Hayden, Daniel M.; Tearle, Rick; Artibani, Mara; KaramiNejadRanjbar, Mohammad; Williams, Ruth; Gaitskell, Kezia; Elorbany, Samar; Xu, Ruoyan; Laios, Alex; Buiga, Petronela; Ahmed, Karim; Dhar, Sunanda; Yu Zhang, Rebecca; Campo, Leticia; Myers, Kevin A.; Lozano, María; Ruiz Miró, Maria; Gatius, Sònia; Mota, Alba; Moreno Bueno, Gema; Matias-Guiu, Xavier; Benítez, Javier; Witty, Lorna; McVean, Gil; Leedham, Simon; Tomlinson, Ian; Drmanac, Radoje; Cazier, Jean Baptiste; Klein, Robert; Dunne, Kevin; Bast Jr, Robert C.; Kennedy, Stephen H.; Hassan, Bassim; Lise, Stefano; Garcia, María José; Peters, Brock A.; Yau, Christopher; Sauka-Spengler, Tatjana; Ashour Ahmed, Ahmed (Elsevier, 2016)
    Current screening methods for ovarian cancer can only detect advanced disease. Earlier detection has proved difficult because the molecular precursors involved in the natural history of the disease are unknown. To identify ...
  • TGF-β-Induced transcription sustains amoeboid melanoma migration and dissemination 

    Cantelli, Gaia; Orgaz, Jose L.; Rodríguez Hernández, Irene; Karagiannis, Panagiotis; Maiques, Oscar; Matias-Guiu, Xavier; Nestle, Frank O.; Martí Laborda, Rosa Ma.; Karagiannis, Sophia N.; Sanz Moreno, Victoria (Elsevier, 2015)
    Cell migration underlies metastatic dissemination of cancer cells, and fast “amoeboid” migration in the invasive fronts of tumors is controlled by high levels of actomyosin contractility. How amoeboid migration is regulated ...
  • Optimal protocol for PTEN immunostaining; role of analytical and preanalytical variables in PTEN staining in normal and neoplastic endometrial, breast, and prostatic tissues 

    Maiques, Oscar; Santacana Espasa, Maria; Valls Marsal, Joan; Pallares, Judit; Mirantes Barbeito, Cristina; Gatius, Sònia; García Dios, Diego Andrés; Amant, Frederic; Pedersen, Hans Christian; Dolcet Roca, Xavier; Matias-Guiu, Xavier (Elsevier, 2014)
    In some tumors, phosphatase and tensin homolog (PTEN) inactivation may have prognostic importance and predictive value for targeted therapies. Immunohistochemistry (IHC) may be an effective method to demonstrate PTEN loss. ...
  • Development of a sequential workflow based on LC-PRM for the verification of endometrial cancer protein biomarkers in uterine aspirate samples 

    Martínez García, Elena; Lesur, Antoine; Devis, Laura; Rosa Campos, Alexandre; Cabrera, Silvia; Oostrum, Jan van; Matias-Guiu, Xavier; Gil Moreno, Antonio; Reventós, Jaume; Colas, Eva; Domon, Bruno (Impact Journals, 2016)
    About 30% of endometrial cancer (EC) patients are diagnosed at an advanced stage of the disease, which is associated with a drastic decrease in the 5-year survival rate. The identification of biomarkers in uterine aspirate ...
  • Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism 

    Jové Font, Mariona; Gatius, Sònia; Yeramian Hakim, Andree; Portero Otín, Manuel; Eritja Sánchez, Núria; Santacana Espasa, Maria; Colas, Eva; Ruiz, Maria; Pamplona Gras, Reinald; Matias-Guiu, Xavier (Impact Journals, 2016)
    Metabolomics, an essential technique in precision medicine, contributes to the molecular fingerprinting of tumours, further helping to understand their pathogenesis. In this work, using a LC-ESI-QTOF-MS/MS platform, we ...
  • Exosome‑like vesicles in uterine aspirates: a comparison of ultracentrifugation‑based isolation protocols 

    Campoy, Irene; Lanau, Lucia; Altadill, Tatiana; Sequeiros, Tamara; Cabrera, Silvia; Cubo Abert, Montserrat; Pérez Benavente, Assumpción; Garcia, Angel; Borrós, Salvador; Santamaria, Anna; Ponce, Jordi; Matias-Guiu, Xavier; Reventós, Jaume; Gil Moreno, Antonio; Rigau, Marina; Colas, Eva (BioMed Central, 2016)
    Background: Uterine aspirates are used in the diagnostic process of endometrial disorders, yet further applications could emerge if its complex milieu was simplified. Exosome-like vesicles isolated from uterine aspirates ...
  • Quantification of Unmethylated Alu (QUAlu): a tool to assess global hypomethylation in routine clinical samples 

    Buj, Raquel; Mallona, Izaskun; Díez Villanueva, Anna; Barrera, Víctor; Mauricio Puente, Dídac; Puig Domingo, Manuel; Reverter, Jordi L.; Matias-Guiu, Xavier; Azuara, Daniel; Ramírez, Jose L.; Alonso, Sergio; Rosell, Rafael; Capellà, Gabriel; Perucho, Manuel; Robledo, Mercedes; Peinado, Miguel A.; Jordà, Mireia (Impact Journals, 2016)
    Hypomethylation of DNA is a hallmark of cancer and its analysis as tumor biomarker has been proposed, but its determination in clinical settings is hampered by lack of standardized methodologies. Here, we present QUAlu ...
  • Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin 

    Fusté, Noel P.; Fernández Hernández, Rita; Cemeli, Tània; Mirantes Barbeito, Cristina; Pedraza González, Neus; Rafel i Borrell, Marta; Torres Rosell, Jordi; Colomina i Gabarrella, Neus; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Garí Marsol, Eloi (Nature Publishing Group, 2016)
    Cyclin D1 (Ccnd1) together with its binding partner Cdk4 act as a transcriptional regulator to control cell proliferation and migration, and abnormal Ccnd1 Cdk4 expression promotes tumour growth and metastasis. While ...
  • GATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1 

    Zhong, Yi; Wang, Zheng; Fu, Baojin; Pan, Fan; Yachida, Shinichi; Dhara, Mousumi; Albesiano, Emilia; Li, Li; Naito, Yoshiki; Vilardell, Felip; Cummings, Christopher; Martinelli, Paola; Li, Ang; Yonescu, Raluca; Ma, Qingyong; Griffin, Constance A.; Real, Francisco X.; Iacobuzio-Donahue, Christine A. (Public Library of Science, 2011)
    Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease characterized by late diagnosis and treatment resistance. Recurrent genetic alterations in defined genes in association with perturbations of developmental ...
  • Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats 

    Arjó Pont, Gemma; Portero Otín, Manuel; Piñol Felis, Carme; Viñas Salas, Joan; Matias-Guiu, Xavier; Capell Capell, Teresa; Bartholomaeus, Andrew; Parrot, Wayne; Christou, Paul (Springer Verlag, 2013)
    A recent paper published in the journal Food and Chemical Toxicology presents the results of a long-term toxicity study related to a widely-used commercial herbicide (RoundupTM) and a Rounduptolerant genetically modified ...
  • Abdominal tuberculosis mimicking Crohn’s disease’s exacerbation: a clinical, diagnostic and surgical dilemma. A case report 

    Papis, Davide; Branchi, Vittorio; Gómez Quiles, Luis; Herrerias, Fernando; Vilardell, Felip; Gonzalez, Marta; Olsina Kissler, Jorge Juan (Elsevier, 2015)
    INTRODUCTION: Tuberculosis in Europe is a health public problem, which has increased constantly over the last few decades. The most common clinical manifestation of tuberculosis is pulmonary. The diagnosis of extrapulmonary ...
  • ER alpha-mediated repression of pro-inflammatory cytokine expression by glucocorticoids reveals a crucial role for TNF alpha and IL1 alpha in lumen formation and maintenance 

    Eritja Sánchez, Núria; Mirantes Barbeito, Cristina; Llobet Navàs, David; Masip, Gemma; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Company of Biologists Ltd., 2013)
    Most glandular tissues comprise polarized epithelial cells organized around a single central lumen. Although there is active research investigating the molecular networks involved in the regulation of lumenogenesis, little ...
  • Impaired Vitamin D Signaling in Endothelial Cell Leads to an Enhanced Leukocyte-Endothelium Interplay: Implications for Atherosclerosis Development 

    Dolcet Roca, Xavier; Encinas Martín, Mario; Bozić Stanojević, Milica; Álvarez, Ángeles; Pablo, Carmen de; Sanchez-Niño, Maria-Dolores; Ortiz, Alberto; Fernández i Giráldez, Elvira; Valdivielso Revilla, José Manuel (Public Library of Science, 2015)
    Endothelial cell activation leading to leukocyte recruitment and adhesion plays an essential role in the initiation and progression of atherosclerosis. Vitamin D has cardioprotective actions, while its deficiency is a risk ...
  • Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer 

    Alonso-Alconada, Lorena; Muinelo-Romay, Laura; Madissoo, Kadri; Díaz-López, Antonio; Krakstad, Camilla; Trovik, Jone; Wik, Elisabeth; Hapangama, Dharani; Coenegrachts, Lieve; Cano, Amparo; Gil-Moreno, Antonio; Chiva, Luís; Cueva, Juan; Vieito, María; Ortega Izquierdo, Maria Eugenia; Mariscal, Javier; Colas, Eva; Castellví, Josep; Cusido, Maite; Dolcet Roca, Xavier; Nijman, Hans W.; Bosse, Tjalling; Green, John A.; Romano, Andrea; Reventós, Jaume; López-López, Rafael; Salvesen, Helga B.; Amant, Frederic; Matias-Guiu, Xavier; Moreno-Bueno, Gema; Abal, Miguel (Biomed Central, 2014)
    Background: About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk with unfavorable prognosis. In the framework of the European Network for Individualized Treatment in EC (ENITEC), we ...
  • An inducible knockout mouse to model the cellautonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias 

    Mirantes Barbeito, Cristina; Eritja Sánchez, Núria; Dosil, Maria Alba; Santacana Espasa, Maria; Pallares, Judit; Gatius, Sònia; Bergadà Bertran, Laura; Maiques, Oscar; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Company of Biologists, 2013)
    PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. The role of PTEN in carcinogenesis has been validated by knockout mouse models. PTEN heterozygous mice develop neoplasms in multiple ...
  • Antioxidants impair anti-tumoral effects of Vorinostat, but not anti-neoplastic effects of Vorinostat and caspase-8 downregulation 

    Bergadà Bertran, Laura; Yeramian Hakim, Andree; Sorolla Bardají, Anabel; Matias-Guiu, Xavier; Dolcet Roca, Xavier (Public Library of Science, 2014)
    We have recently demonstrated that histone deacetylase inhibitor, Vorinostat, applied as a single therapy or in combination with caspase-8 downregulation exhibits high anti-tumoral activity on endometrial carcinoma cell ...
  • Pathway-based analysis of a melanoma genome-wide association study: analysis of genes related to tumour-immunosuppression 

    Schoof, Nils; Iles, Mark M.; Bishop, D. Timothy; Newton-Bishop, Julia A.; Barrett, Jennifer H.; GenoMEL consortium (Public Library of Science, 2011)
    Systemic immunosuppression is a risk factor for melanoma, and sunburn-induced immunosuppression is thought to be causal. Genes in immunosuppression pathways are therefore candidate melanoma-susceptibility genes. If variants ...
  • The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors 

    Landa, Iñigo; Ruiz-Llorente, Sergio; Montero-Conde, Cristina; Inglada-Pérez, Lucía; Schiavi, Francesca; Leskelä, Susanna; Pita, Guillermo; Milne, Roger; Maravall Royo, Javier; Ramos, Ignacio; Andía, Víctor; Rodríguez-Poyo, Paloma; Jara-Albarrán, Antonino; Meoro, Amparo; Peso, Cristina del; Arribas, Luis; Iglesias, Pedro; Caballero, Javier; Serrano, Joaquín; Picó, Antonio; Pomares, Francisco; Giménez, Gabriel; López-Mondéjar, Pedro; Castello, Roberto; Merante-Boschin, Isabella; Pelizzo, Maria-Rosa; Mauricio Puente, Dídac; Opocher, Giuseppe; Rodríguez-Antona, Cristina; González- Neira, Anna; Matias-Guiu, Xavier; Santisteban, Pilar; Robledo, Mercedes (Public Library of Science, 2009)
    In order to identify genetic factors related to thyroid cancer susceptibility, we adopted a candidate gene approach. We studied tag- and putative functional SNPs in genes involved in thyroid cell differentiation and ...
  • Expression of somatostatin receptors in human melanoma cell lines: effect of two different somatostatin analogues, octreotide and SOM230, on cell proliferation 

    Martínez Alonso, Montserrat; Llecha Cano, Núria; Mayorga Mayorga, Maritza Elfride; Sorolla Bardají, Anabel; Dolcet Roca, Xavier; Sanmartín Novell, Verònica; Abal Diaz, Leandro; Casanova i Seuma, Josep M. (Josep Manel); Baradad Brusau, Manuel; Yeramian Hakim, Andree; Egido Garcia, Ramon Maria; Puig, S.; Vilella, R.; Matias-Guiu, Xavier; Martí Laborda, Rosa Ma. (Field House Publishing, 2009)
    Somatostatin analogues (SAs) are potential anticancer agents. This study was designed to investigate the expression of somatostatin receptors (SSTRs) in melanoma cells and the effect of two SAs on cell proliferation and ...