El Grup estudia les alteracions moleculars dels càncers d'endometri, tiroide i la pell, en correlació amb les característiques clíniques i patològiques: 1) Estudi de gens involucrats en l'apòptosi en el càncer d'endometri i de pell (NFkB, survivina, PTEN, BAX, receptors de mort i els seus lligands, Flip); 2) Perfils d'expressió en càncers d'endometri, tiroides i melanoma; 3) Resposta de fàrmacs inhibidors de tirosin cinases i anàlogs de somatostatina en línies cel·lulars de melanoma. [Més informació].

Recent Submissions

  • Tenosynovitis with rice body formation presenting as a cutaneous abscess 

    Moreno, Sara; Forcada Calvet, Pau; Soria, Xavier; Altemir, Victoria; Gatius, Sònia; Gil, Mabel; Matias-Guiu, Xavier; Casanova i Seuma, Josep M. (Josep Manel); Martí Laborda, Rosa Ma. (John Wiley & Sons, 2014)
    A 62-year-old woman with a past medical history of rheumatoid arthritis was referred to the Department of Dermatology because of an enlarging cutaneous lesion on the right thumb which resembled a soft tissue infection. ...
  • Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis 

    Bozić Stanojević, Milica; Guzmán, Carla; Benet, Marta; Sánchez-Campos, Sonia; García-Monzón, Carmelo; Garí Marsol, Eloi; Gatius, Sònia; Valdivielso Revilla, José Manuel; Jover, Ramiro (Elsevier, 2016)
    Background & Aims The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote ...
  • Unilateral milia-type intradermal tophi associated with underlying urate subcutaneous deposition: an uncommon cutaneous presentation of gout 

    Aguayo Ortiz, Rafael; Baradad Brusau, Manuel; Soria, Xavier; Abal Diaz, Leandro; Sanmartín Novell, Verònica; Egido Garcia, Ramon Maria; Gallel Vicente, María del Pilar; Casanova i Seuma, Josep M. (Josep Manel); Martí Laborda, Rosa Ma. (Wiley online library, 2013)
    Tophi develop during the most advanced clinical stage of gout, and are usually located on or around the joints. However, unusual skin features caused by intradermal and/or subcutaneous deposition of tophaceous material ...
  • Erk1/2 activation in stromal fibroblasts from sporadic basal cell carcinomas 

    Aguayo Ortiz, Rafael; Rafel i Borrell, Marta; Santacana Espasa, Maria; Pérez Fusté, Noel; Garí Marsol, Eloi (American Society for Dermatologic Surgery, 2015)
    BACKGROUND Constitutive activation of the Erk pathway can lead to oncogenic transformation. However, the Erk pathway is not activated in human basal cell carcinomas (BCCs); although in animal models, this seems to be ...
  • Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility 

    Fernández, Rosa M. H.; Ruiz Miró, Maria; Dolcet Roca, Xavier; Aldea, Martí; Garí Marsol, Eloi (Nature, 2011)
    Alterations in the levels of adhesion and motility of cells are critical events in the development of metastasis. Cyclin D1 (CycD1) is one of the most frequently amplified oncogenes in many types of cancers and it is ...
  • Utilidad de la siascopia en el diagnóstico de lesiones melanocíticas 

    Veà Jódar, Àlvar; Barrera, Josefa; Velasco Sánchez, Ana; Casanova i Seuma, Josep M. (Josep Manel); Matias-Guiu, Xavier; Martí Laborda, Rosa Ma. (Elsevier, 2014)
    El melanoma cutáneo es una de las neoplasias malignas cuya tasa de incidencia está aumentando más rápidamente en todo el mundo. Se ha incrementado de forma sostenida un 3-8% anual desde los años 60, duplicándose cada ...
  • Concordance study between one-step nucleic acid amplification and morphologic techniques to detect lymph node metastasis in papillary carcinoma of the thyroid 

    del Carmen, Sofía; Gatius, Sònia; Franch Arcas, Guzmán; Baena-Fustegueras, Juan A; Gonzalez, Oscar; Zafon, Carles; Cuevas, Dolors; Valls Marsal, Joan; Pérez, Angustias; Martinez, Mercedes; Ros López, Susana; García Macías, Carmen; Iglesias, Carmela; Matias-Guiu, Xavier; de Álava, Enrique (Elsevier, 2016)
    Tumor resection in papillary thyroid carcinoma (PTC) is often accompanied by lymph node (LN) removal of the central and lateral cervical compartments. One-step nucleic acid amplification (OSNA) is a polymerase chain ...
  • The role of morbid obesity in the promotion of metabolic disruptions and non-alcoholic steatohepatitis by Helicobacter Pylori 

    Lecube Torelló, Albert; Valladares, Silvia; López Cano, Carolina; Gutiérrez Carrasquilla, Liliana; Ciudin, Andreea; Fort, José Manuel; Reñé Espinet, Josep M.; Matias-Guiu, Xavier; Torres, Inés de; Bueno Díez, Marta; Pallarés, Judit; Baena-Fustegueras, Juan A (Public Library of Science, 2016)
    Helicobacter pylory (HP) infection has been associated to an increased rate of type 2 diabetes (T2D) and liver disease through its effect on insulin resistance and systemic inflammation. However, results are inconstant ...
  • Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis 

    Moran, Sebastian; Martínez Cardús, Anna; Sayols, Sergi; Musulén, Eva; Balañá, Carme; Estival Gonzalez, Anna; Moutinho, Cátia; Heyn, Holger; Diaz Lagares, Angel; Castro de Moura, Manuel; Stella, Giulia M.; Comoglio, Paolo M.; Ruiz Miró, Maria; Pazo Cid, Roberto; Antón, Antonio; Lopez Lopez, Rafael; Soler, Gemma; Longo, Federico; Guerra, Isabel; Fernandez, Sara; Assenov, Yassen; Plass, Christoph; Morales, Rafael; Carles, Joan; Bowtell, David; Mileshkin, Linda; Sia, Daniela; Tothill, Richard; Tabernero, Josep; Llovet, Josep M.; Esteller, Manel; Matias-Guiu, Xavier (Elsevier, 2016)
    Cancer of unknown primary ranks in the top ten cancer presentations and has an extremely poor prognosis. Identification of the primary tumour and development of a tailored site-specific therapy could improve the survival ...
  • Reproducibility of measurement of myometrial invasion in endometrial carcinoma 

    van der Putten, Louis J. M.; van de Vijver, Koen; Bartosch, Carla; Davidson, Ben; Gatius, Sònia; Matias-Guiu, Xavier; McCluggage, W. Glenn; Toledo, Gemma; van der Wurff, Anneke A. M.; Pijnenborg, Johanna M. A.; Massuger, Leon F. A. G.; Bulten, Johan (Springer Berlin Heidelberg, 2016)
    Myometrial invasion (MI) as a percentage (%MI), categorized into <50 or ≥50 %, is an important predictor of prognosis in endometrial carcinoma. Recent studies suggest that tumor-free distance (TFD) to serosa and the absolute ...
  • Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: discovery and validation studies 

    Hellner, Karin; Miranda, Fabrizio; Fotso Chedom, Donatien; Herrero Gonzalez, Sandra; Hayden, Daniel M.; Tearle, Rick; Artibani, Mara; KaramiNejadRanjbar, Mohammad; Williams, Ruth; Gaitskell, Kezia; Elorbany, Samar; Xu, Ruoyan; Laios, Alex; Buiga, Petronela; Ahmed, Karim; Dhar, Sunanda; Yu Zhang, Rebecca; Campo, Leticia; Myers, Kevin A.; Lozano, María; Ruiz Miró, Maria; Gatius, Sònia; Mota, Alba; Moreno Bueno, Gema; Matias-Guiu, Xavier; Benítez, Javier; Witty, Lorna; McVean, Gil; Leedham, Simon; Tomlinson, Ian; Drmanac, Radoje; Cazier, Jean Baptiste; Klein, Robert; Dunne, Kevin; Bast Jr, Robert C.; Kennedy, Stephen H.; Hassan, Bassim; Lise, Stefano; Garcia, María José; Peters, Brock A.; Yau, Christopher; Sauka-Spengler, Tatjana; Ashour Ahmed, Ahmed (Elsevier, 2016)
    Current screening methods for ovarian cancer can only detect advanced disease. Earlier detection has proved difficult because the molecular precursors involved in the natural history of the disease are unknown. To identify ...
  • TGF-β-Induced transcription sustains amoeboid melanoma migration and dissemination 

    Cantelli, Gaia; Orgaz, Jose L.; Rodríguez Hernández, Irene; Karagiannis, Panagiotis; Maiques, Oscar; Matias-Guiu, Xavier; Nestle, Frank O.; Martí Laborda, Rosa Ma.; Karagiannis, Sophia N.; Sanz Moreno, Victoria (Elsevier, 2015)
    Cell migration underlies metastatic dissemination of cancer cells, and fast “amoeboid” migration in the invasive fronts of tumors is controlled by high levels of actomyosin contractility. How amoeboid migration is regulated ...
  • Optimal protocol for PTEN immunostaining; role of analytical and preanalytical variables in PTEN staining in normal and neoplastic endometrial, breast, and prostatic tissues 

    Maiques, Oscar; Santacana Espasa, Maria; Valls Marsal, Joan; Pallares, Judit; Mirantes Barbeito, Cristina; Gatius, Sònia; García Dios, Diego Andrés; Amant, Frederic; Pedersen, Hans Christian; Dolcet Roca, Xavier; Matias-Guiu, Xavier (Elsevier, 2014)
    In some tumors, phosphatase and tensin homolog (PTEN) inactivation may have prognostic importance and predictive value for targeted therapies. Immunohistochemistry (IHC) may be an effective method to demonstrate PTEN loss. ...
  • Development of a sequential workflow based on LC-PRM for the verification of endometrial cancer protein biomarkers in uterine aspirate samples 

    Martínez García, Elena; Lesur, Antoine; Devis, Laura; Rosa Campos, Alexandre; Cabrera, Silvia; Oostrum, Jan van; Matias-Guiu, Xavier; Gil Moreno, Antonio; Reventós, Jaume; Colas, Eva; Domon, Bruno (Impact Journals, 2016)
    About 30% of endometrial cancer (EC) patients are diagnosed at an advanced stage of the disease, which is associated with a drastic decrease in the 5-year survival rate. The identification of biomarkers in uterine aspirate ...
  • Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism 

    Jové Font, Mariona; Gatius, Sònia; Yeramian Hakim, Andree; Portero Otín, Manuel; Eritja Sánchez, Núria; Santacana Espasa, Maria; Colas, Eva; Ruiz, Maria; Pamplona Gras, Reinald; Matias-Guiu, Xavier (Impact Journals, 2016)
    Metabolomics, an essential technique in precision medicine, contributes to the molecular fingerprinting of tumours, further helping to understand their pathogenesis. In this work, using a LC-ESI-QTOF-MS/MS platform, we ...
  • Exosome‑like vesicles in uterine aspirates: a comparison of ultracentrifugation‑based isolation protocols 

    Campoy, Irene; Lanau, Lucia; Altadill, Tatiana; Sequeiros, Tamara; Cabrera, Silvia; Cubo Abert, Montserrat; Pérez Benavente, Assumpción; Garcia, Angel; Borrós, Salvador; Santamaria, Anna; Ponce, Jordi; Matias-Guiu, Xavier; Reventós, Jaume; Gil Moreno, Antonio; Rigau, Marina; Colas, Eva (BioMed Central, 2016)
    Background: Uterine aspirates are used in the diagnostic process of endometrial disorders, yet further applications could emerge if its complex milieu was simplified. Exosome-like vesicles isolated from uterine aspirates ...
  • Quantification of Unmethylated Alu (QUAlu): a tool to assess global hypomethylation in routine clinical samples 

    Buj, Raquel; Mallona, Izaskun; Díez Villanueva, Anna; Barrera, Víctor; Mauricio Puente, Dídac; Puig Domingo, Manuel; Reverter, Jordi L.; Matias-Guiu, Xavier; Azuara, Daniel; Ramírez, Jose L.; Alonso, Sergio; Rosell, Rafael; Capellà, Gabriel; Perucho, Manuel; Robledo, Mercedes; Peinado, Miguel A.; Jordà, Mireia (Impact Journals, 2016)
    Hypomethylation of DNA is a hallmark of cancer and its analysis as tumor biomarker has been proposed, but its determination in clinical settings is hampered by lack of standardized methodologies. Here, we present QUAlu ...
  • Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin 

    Pérez Fusté, Noel; Fernández Hernández, Rita; Cemeli, Tània; Mirantes Barbeito, Cristina; Pedraza González, Neus; Rafel i Borrell, Marta; Torres Rosell, Jordi; Colomina i Gabarrella, Neus; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Garí Marsol, Eloi (Nature Publishing Group, 2016)
    Cyclin D1 (Ccnd1) together with its binding partner Cdk4 act as a transcriptional regulator to control cell proliferation and migration, and abnormal Ccnd1 Cdk4 expression promotes tumour growth and metastasis. While ...
  • GATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1 

    Zhong, Yi; Wang, Zheng; Fu, Baojin; Pan, Fan; Yachida, Shinichi; Dhara, Mousumi; Albesiano, Emilia; Li, Li; Naito, Yoshiki; Vilardell, Felip; Cummings, Christopher; Martinelli, Paola; Li, Ang; Yonescu, Raluca; Ma, Qingyong; Griffin, Constance A.; Real, Francisco X.; Iacobuzio-Donahue, Christine A. (Public Library of Science, 2011)
    Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease characterized by late diagnosis and treatment resistance. Recurrent genetic alterations in defined genes in association with perturbations of developmental ...
  • Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats 

    Arjó Pont, Gemma; Portero Otín, Manuel; Piñol Felis, Carme; Viñas Salas, Joan; Matias-Guiu, Xavier; Capell Capell, Teresa; Bartholomaeus, Andrew; Parrot, Wayne; Christou, Paul (Springer Verlag, 2013)
    A recent paper published in the journal Food and Chemical Toxicology presents the results of a long-term toxicity study related to a widely-used commercial herbicide (RoundupTM) and a Rounduptolerant genetically modified ...

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