El grup de Cicle Cel·lular estudia els mecanismes interns que regulen la divisió de les cèl·lules eucariotes. En concret s'analitzen: (a) els mecanismes depenents de complexos SMC i SUMO que garanteixen l'estabilitat del genoma durant el cicle i en resposta a dany en el DNA. (b) els mecansimes implicats en el control de l'entrada en cicle i la seva relació amb polaritat, migració i adhesió cel·lular. Com a models de polaritat i adhesió cel·lular s'utilitzen fibroblastes embrionaris de ratolí, línies cel·lulars i cultius primaris de queratinòcits humans. Com a model en estudis de replicació, cohesió i segregació de cromosomes emprem el llevat Saccharomyces cerevisiae i línies cel·lulars humanes. L'objectiu general d'aquests treballs és contribuir a un millor coneixement dels processos que es troben alterats durant la pèrdua de la integritat del genoma i en patologies com el càncer. [Més informació].

Recent Submissions

  • Tenosynovitis with rice body formation presenting as a cutaneous abscess 

    Moreno, Sara; Forcada Calvet, Pau; Soria, Xavier; Altemir, Victoria; Gatius, Sònia; Gil, Mabel; Matias-Guiu, Xavier; Casanova i Seuma, Josep M. (Josep Manel); Martí Laborda, Rosa Ma. (John Wiley & Sons, 2014)
    A 62-year-old woman with a past medical history of rheumatoid arthritis was referred to the Department of Dermatology because of an enlarging cutaneous lesion on the right thumb which resembled a soft tissue infection. ...
  • Sgs1’s roles in DNA end resection, HJ dissolution, and crossover suppression require a two-step SUMO regulation dependent on Smc5/6 

    Bermúdez López, Marcelino; Villoria, María Teresa; Esteras, Miguel; Jarmuz, Adam; Torres Rosell, Jordi; Clemente Blanco, Andrés; Aragón, Luis (Cold Spring Harbor Laboratory Press, 2016)
    The RecQ helicase Sgs1 plays critical roles during DNA repair by homologous recombination, fromend resection to Holliday junction (HJ) dissolution. Sgs1 has both pro- and anti-recombinogenic roles, and therefore its ...
  • Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis 

    Bozić Stanojević, Milica; Guzmán, Carla; Benet, Marta; Sánchez-Campos, Sonia; García-Monzón, Carmelo; Garí Marsol, Eloi; Gatius, Sònia; Valdivielso Revilla, José Manuel; Jover, Ramiro (Elsevier, 2016)
    Background & Aims The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote ...
  • Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination 

    De Piccoli, Giacomo; Cortes Ledesma, Felipe; Ira, Gregory; Torres Rosell, Jordi; Uhle, Stefan; Farmer, Sarah; Hwang, Ji-Young; Machin, Felix; Ceschia, Audrey; McAleenan, Alexandra; Cordon Preciado, Violeta; Clemente Blanco, Andrés; Vilella Mitjana, Felipe; Ullal, Pranav; Jarmuz, Adam; Leitao, Beatriz; Bressan, Debra; Dotiwala, Farokh; Papusha, Alma; Zhao, Xiaolan; Myung, Kyungjae; Haber, James E.; Aguilera, Andrés; Aragón, Luis (Nature, 2006)
    DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that the ...
  • Bck2 is a phase-independent activator of cell cycle-regulated genes in yeast 

    Ferrezuelo, Francisco; Aldea, Martí; Futcher, Bruce (Landes Bioscience, 2009)
    During the cell division cycle of the yeast Saccharomyces cerevisiae, the G1-to-S transition depends upon the activation of two transcription factors (SBF and MBF), which are responsible for the cell cycle-regulated ...
  • Cyclin Cln3 is retained at the ER and released by the J chaperone Ydj1 in late G1 to trigger cell cycle entry 

    Vergés, Emili; Colomina i Gabarrella, Neus; Garí Marsol, Eloi; Gallego, Carme; Aldea, Martí (Elsevier, 2007)
    G1 cyclin Cln3 plays a key role in linking cell growth and proliferation in budding yeast. It is generally assumed that Cln3, which is present throughout G1, accumulates passively in the nucleus until a threshold is reached ...
  • 1,25-Dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter 

    Cardús i Figueras, Anna; Panizo García, Sara; Encinas Martín, Mario; Dolcet Roca, Xavier; Gallego, Carme; Aldea, Martí; Fernandez, Elvira; Valdivielso Revilla, José Manuel (Elsevier, 2009)
    In previous studies we have demonstrated that the active form of vitamin D (1,25(OH)2D3) increases vascular endothelial growth factor (VEGF) expression and release in vascular smooth muscle cells (VSMC) in vitro. However, ...
  • Unilateral milia-type intradermal tophi associated with underlying urate subcutaneous deposition: an uncommon cutaneous presentation of gout 

    Aguayo Ortiz, Rafael; Baradad Brusau, Manuel; Soria, Xavier; Abal Diaz, Leandro; Sanmartín Novell, Verònica; Egido Garcia, Ramon Maria; Gallel Vicente, María del Pilar; Casanova i Seuma, Josep M. (Josep Manel); Martí Laborda, Rosa Ma. (Wiley online library, 2013)
    Tophi develop during the most advanced clinical stage of gout, and are usually located on or around the joints. However, unusual skin features caused by intradermal and/or subcutaneous deposition of tophaceous material ...
  • Dermatofibrosarcoma protuberans sobre cicatriz de apendicectomía 

    Veà Jódar, Àlvar; Aguayo Ortiz, Rafael; Soria, Xavier; Sanmartín Novell, Verònica; Casanova i Seuma, Josep M. (Josep Manel) (Elsevier, 2015)
    El dermatofibrosarcoma protuberans (DFSP) es un tumor cutáneo relativamente raro, con una incidencia aproximada de 4 casos por cada millón de habitantes y año1,2. Ahora bien, es el sarcoma cutáneo más frecuente, ...
  • Control of cell cycle and cell growth by molecular chaperones 

    Aldea, Martí; Garí Marsol, Eloi; Colomina i Gabarrella, Neus (Taylor & Francis, 2007)
    Cells adapt their size to both intrinsic and extrinsic demands and, among them, those that stem from growth and proliferation rates are crucial for cell size homeostasis. Here we revisit mechanisms that regulate cell cycle ...
  • Whi3 regulates morphogenesis in budding yeast by enhancing Cdk functions in apical growth 

    Colomina i Gabarrella, Neus; Ferrezuelo, Francisco; Vergés, Emili; Aldea, Martí; Garí Marsol, Eloi (Landes Bioscience, 2009)
    The Whi3 protein is associated with the endoplasmic reticulum, interacts with Cdc28, the budding-yeast Cdk, binds the mRNA of cyclin CLN3 and prevents accumulation of the Cdc28-Cln3 in the nucleus until late G1. Besides ...
  • Erk1/2 activation in stromal fibroblasts from sporadic basal cell carcinomas 

    Aguayo Ortiz, Rafael; Rafel i Borrell, Marta; Santacana Espasa, Maria; Pérez Fusté, Noel; Garí Marsol, Eloi (American Society for Dermatologic Surgery, 2015)
    BACKGROUND Constitutive activation of the Erk pathway can lead to oncogenic transformation. However, the Erk pathway is not activated in human basal cell carcinomas (BCCs); although in animal models, this seems to be ...
  • Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility 

    Fernández, Rosa M. H.; Ruiz Miró, Maria; Dolcet Roca, Xavier; Aldea, Martí; Garí Marsol, Eloi (Nature, 2011)
    Alterations in the levels of adhesion and motility of cells are critical events in the development of metastasis. Cyclin D1 (CycD1) is one of the most frequently amplified oncogenes in many types of cancers and it is ...
  • Utilidad de la siascopia en el diagnóstico de lesiones melanocíticas 

    Veà Jódar, Àlvar; Barrera, Josefa; Velasco Sánchez, Ana; Casanova i Seuma, Josep M. (Josep Manel); Matias-Guiu, Xavier; Martí Laborda, Rosa Ma. (Elsevier, 2014)
    El melanoma cutáneo es una de las neoplasias malignas cuya tasa de incidencia está aumentando más rápidamente en todo el mundo. Se ha incrementado de forma sostenida un 3-8% anual desde los años 60, duplicándose cada ...
  • Perfiles psicológicos de los pacientes con psicodermatosis 

    Fernández Armenteros, José Manuel; Molinero Ponce, Isabel; Castan Campanera, Ester; Casanova i Seuma, Josep M. (Josep Manel) (Elsevier, 2016)
    La psicodermatología es una rama común a la dermatología y la psiquiatría. Se centra en el estudio de las manifestaciones cuta´neas producidas por alteraciones psiquiátricas. Es una disciplina situada en áreas comunes ...
  • Alopecias cicatriciales 

    Abal Diaz, Leandro; Soria, Xavier; Casanova i Seuma, Josep M. (Josep Manel) (Elsevier, 2012)
    Las alopecias cicatriciales constituyen un grupo de trastornos que dan lugar a una pérdida permanente de cabello como consecuencia de diversos procesos. En este artículo nos centraremos en las alopecias cicatriciales ...
  • The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation 

    Ferrezuelo, Francisco; Colomina i Gabarrella, Neus; Palmisano, Alida; Garí Marsol, Eloi; Gallego, Carme; Csikász-Nagy, Attila; Aldea, Martí (Nature, 2012)
    Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size control, cell volume ...
  • Evaluación de las prácticas clínicas de Dermatología en el grado de Medicina 

    Casanova i Seuma, Josep M. (Josep Manel); Sanmartín Novell, Verònica; Martí Laborda, Rosa Ma.; Morales, J.L.; Soler, J.; Purroy Garcia, Francisco; Pujol, R. (Elsevier, 2014)
    La adquisición de competencias (conjunto de conocimientos, habilidades y actitudesque conforman la actuación profesional) se considera un requisito necesario para la acreditacióndel grado de Medicina. Las competencias en ...
  • The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress 

    Amaral, Nuno; Vendrell, Alexandre; Maier, Michael; Kumar, Arun; Mendoza, Manuel; Funaya, Charlotta; Geli, María Isabel; Idrissi, Fatima-Zahra; Colomina i Gabarrella, Neus; Torres Rosell, Jordi (Nature, 2016)
    Anaphase chromatin bridges can lead to chromosome breakage if not properly resolved before completion of cytokinesis. The NoCut checkpoint, which depends on Aurora B at the spindle midzone, delays abscission in response ...
  • Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity 

    Clotet Bellmunt, Josep; Escoté, Xavier; Àngel Adrover, Miquel; Yaakov, Gilad; Garí Marsol, Eloi; Aldea, Martí; de Nadal, Eulàlia; Posas, Francesc (EMBOPress, 2006)
    Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. Exposure of yeast to osmostress leads to activation of the Hog1 SAPK, which controls ...

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