El grup de Cicle Cel·lular estudia els mecanismes interns que regulen la divisió de les cèl·lules eucariotes. En concret s'analitzen: (a) els mecanismes depenents de complexos SMC i SUMO que garanteixen l'estabilitat del genoma durant el cicle i en resposta a dany en el DNA. (b) els mecansimes implicats en el control de l'entrada en cicle i la seva relació amb polaritat, migració i adhesió cel·lular. Com a models de polaritat i adhesió cel·lular s'utilitzen fibroblastes embrionaris de ratolí, línies cel·lulars i cultius primaris de queratinòcits humans. Com a model en estudis de replicació, cohesió i segregació de cromosomes emprem el llevat Saccharomyces cerevisiae i línies cel·lulars humanes. L'objectiu general d'aquests treballs és contribuir a un millor coneixement dels processos que es troben alterats durant la pèrdua de la integritat del genoma i en patologies com el càncer. [Més informació].

Recent Submissions

  • Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer 

    Fusté, Noel P.; Castelblanco Echavarría, Esmeralda; Felip, Isidre; Santacana Espasa, Maria; Fernández-Hernández, Rita; Gatius, Sònia; Pedraza González, Neus; Pallares, Judit; Cemeli, Tània; Valls Marsal, Joan; Tarres, Marc; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Matias-Guiu, Xavier; Garí Marsol, Eloi (Impact Journals, 2016)
    Cyclin D1 (Ccnd1) is a proto-oncogen amplified in many different cancers and nuclear accumulation of Ccnd1 is a characteristic of tumor cells. Ccnd1 activates the transcription of a large set of genes involved in cell ...
  • Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin 

    Fusté, Noel P.; Fernández Hernández, Rita; Cemeli, Tània; Mirantes Barbeito, Cristina; Pedraza González, Neus; Rafel i Borrell, Marta; Torres Rosell, Jordi; Colomina i Gabarrella, Neus; Ferrezuelo, Francisco; Dolcet Roca, Xavier; Garí Marsol, Eloi (Nature Publishing Group, 2016)
    Cyclin D1 (Ccnd1) together with its binding partner Cdk4 act as a transcriptional regulator to control cell proliferation and migration, and abnormal Ccnd1 Cdk4 expression promotes tumour growth and metastasis. While ...
  • Cth2 protein mediates early adaptation of yeast cells to oxidative stress conditions 

    Castells i Roca, Laia; Pijuan, Jordi; Ferrezuelo, Francisco; Bellí i Martínez, Gemma; Herrero Perpiñán, Enrique (Public Library of Science, 2016)
    Cth2 is an mRNA-binding protein that participates in remodeling yeast cell metabolism in iron starvation conditions by promoting decay of the targeted molecules, in order to avoid excess iron consumption. This study shows ...
  • ATPase-dependent control of the Mms21 SUMO ligase during DNA repair 

    Bermúdez López, Marcelino; Pociño Merino, Irene; Sánchez, Humberto; Bueno, Andrés; Guasch, Clàudia; Almedawar, Seba; Brú i Virgili, Sergi; Garí Marsol, Eloi; Wyman, Claire; Reverter Cendrós, David; Colomina i Gabarrella, Neus; Torres Rosell, Jordi (Plos Biology, 2015-03-12)
    Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus ...
  • Protein Kinase KIS Localizes to RNA Granules and Enhances Local Translation 

    Cambray Carner, Serafí; Pedraza González, Neus; Rafel i Borrell, Marta; Garí Marsol, Eloi; Aldea, Martí; Gallego, Carme (American Society for Microbiology, 2009)
    The regulation of mRNA transport is a fundamental process for cytoplasmic sorting of transcripts and spatially controlled translational derepression once properly localized. There is growing evidence that translation is ...
  • Can eukaryotic cells monitor the presence of unreplicated DNA? 

    Torres Rosell, Jordi; Piccoli, Giacomo De; Aragón, Luis (BioMed Central, 2007)
    Completion of DNA replication before mitosis is essential for genome stability and cell viability. Cellular controls called checkpoints act as surveillance mechanisms capable of detecting errors and blocking cell cycle ...
  • Spindle-independent condensation-mediated segregation of yeast ribosomal DNA in late anaphase 

    Machín, Felix; Torres Rosell, Jordi; Jarmuz, Adam; Aragón, Luis (The Rockefeller University Press, 2005)
    Mitotic cell division involves the equal segregation of all chromosomes during anaphase. The presence of ribosomal DNA (rDNA) repeats on the right arm of chromosome XII makes it the longest in the budding yeast genome. ...
  • Transcription of ribosomal genes can cause nondisjunction 

    Machín, Felix; Torres Rosell, Jordi; Piccoli, Giacomo De; Carballo, Jesús A.; Cha, Rita S.; Jarmuz, Adam; Aragón, Luis (The Rockefeller University Press, 2006)
    Mitotic disjunction of the repetitive ribosomal DNA (rDNA) involves specialized segregation mechanisms dependent on the conserved phosphatase Cdc14. The reason behind this requirement is unknown. We show that rDNA ...
  • The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages 

    Bermúdez López, Marcelino; Ceschia, Audrey; Piccoli, Giacomo de; Colomina i Gabarrella, Neus; Pasero, Philippe; Aragón, Luis; Torres Rosell, Jordi (Oxford University Press, 2010)
    Mitotic chromosome segregation requires the removal of physical connections between sister chromatids. In addition to cohesin and topological entrapments, sister chromatid separation can be prevented by the presence of ...
  • The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle 

    Ferrezuelo, Francisco; Colomina i Gabarrella, Neus; Futcher, Bruce; Aldea, Martí (BioMed Central, 2010)
    Background: The G1-to-S transition of the cell cycle in the yeast Saccharomyces cerevisiae involves an extensive transcriptional program driven by transcription factors SBF (Swi4-Swi6) and MBF (Mbp1-Swi6). Activation of ...
  • The cell cycle–regulated genes of schizosaccharomyces pombe 

    Oliva, Anna; Rosebrock, Adam; Ferrezuelo, Francisco; Pyne, Saumyadipta; Chen, Haiying; kiena, Steve; Futcher, Bruce; Leatherwood, Janet (Public Library of Science (PLoS), 2005)
    Many genes are regulated as an innate part of the eukaryotic cell cycle, and a complex transcriptional network helps enable the cyclic behavior of dividing cells. This transcriptional network has been studied in Saccharomyces ...