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  • Methylation alterations are not a major cause of PTTG1 missregulation 

    Hidalgo, Manuel; Galan, Jose J.; Sáez, Carmen; Ferrero, Eduardo; Castilla, Carolina; Ramirez Lorca, Reposo; Pelaez, Pablo; Ruiz, Agustin; Japón, Miguel A.; Royo Sánchez-Palencia, José Luis (BioMed Central, 2008)
    Background: On its physiological cellular context, PTTG1 controls sister chromatid segregation during mitosis. Within its crosstalk to the cellular arrest machinery, relies a checkpoint of integrity for which gained the ...
  • A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis 

    Gayán, Javier; González-Pérez, Antonio; Bermudo, Fernando; Eugenia Sáez, María; Royo Sánchez-Palencia, Jose Luis; Quintas, Antonio; Galan, José J.; Morón, Francisco J.; Ramirez Lorca, Reposo; Real, Luis M; Ruiz González, Agustín (BioMed Central, 2008)
    Background: The difficulty in elucidating the genetic basis of complex diseases roots in the many factors that can affect the development of a disease. Some of these genetic effects may interact in complex ways, proving ...
  • AKT2 Blocks Nucleus Translocation of Apoptosis-Inducing Factor (AIF) and Endonuclease G (EndoG) While Promoting Caspase Activation during Cardiac Ischemia 

    Yang, Shuai; Zhao, Xinmei; Xu, Hui; Chen, Fan; Xu, Yitao; Li, Zhe; Sanchis, Daniel; Jin, Liang; Zhang, Yubin; Ye, Junmei (MDPI, 2017)
    The AKT (protein kinase B, PKB) family has been shown to participate in diverse cellular processes, including apoptosis. Previous studies demonstrated that protein kinase B2 (AKT2 − / − ) mice heart was sensitized to ...
  • Sixty years old is the breakpoint of human frontal cortex aging 

    Cabré Cucó, Rosanna; Naudí i Farré, Alba; Dominguez Gonzalez, Mayelin; Ayala Jové, Ma. Victoria (Maria Victoria); Jové Font, Mariona; Mota Martorell, Natalia; Piñol Ripoll, Gerard; Gil Villar, Maria P.; Rué i Monné, Montserrat; Portero Otín, Manuel; Ferrer, Isidre; Pamplona Gras, Reinald (Elsevier, 2017)
    Human brain aging is the physiological process which underlies as cause of cognitive decline in the elderly and the main risk factor for neurodegenerative diseases such as Alzheimer's disease. Human neurons are functional ...
  • Genetic structure of the Spanish population 

    Gayán, Javier; Galan, José J.; González-Pérez, Antonio; Sáez, María Eugenia; Martínez-Larrad, María Teresa; Zabena, Carina; Rivero, M. Carmen; Salinas, Ana; Ramírez-Lorca, Reposo; Morón, Francisco J.; Royo Sánchez-Palencia, José Luis; Moreno-Rey, Concha; Velasco, Juan; Carrasco, José M.; Molero, Eva; Ochoa, Carolina; Ochoa, María Dolores; Gutiérrez, Marta; Reina, Mercedes; Pascual, Rocío; Romo-Astorga, Alejandro; Susillo-González, Juan Luis; Vázquez, Enrique; Real, Luis M.; Ruiz, Agustín; Serrano-Ríos, Manuel (BioMed Central, 2010-05-25)
    Background Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. ...
  • Central sleep apnoea is related to the severity and short-term prognosis of acute coronary syndrome 

    Florés, Marina; Batlle Garcia, Jordi de; Sánchez de la Torre, Alicia; Sánchez de la Torre, Manuel; Aldomá, Albina; Worner, Fernando; Galera, Estefanía; Seminario, Asunción; Torres, Gerard; Dalmases, Mireia; Montserrat i Capdevila, Josep; Garmendia, Onintza; Barbé Illa, Ferran (Public Library of Science, 2016)
    Objective To evaluate the relation of central sleep apnoea (CSA) to the severity and short-term prognosis of patients who experience acute coronary syndrome (ACS). Methods Observational study with cross-sectional and ...
  • High levels of hemoglobin promote carotid adventitial vasa vasorum neoangiogenesis in chronic kidney disease 

    Arcidiacono, Maria V.; Martínez Alonso, Montserrat; Belart, Montserrat; Vilar, Ana; Martín, Marisa; Craver Hospital, Lourdes; Betriu i Bars, M. Àngels; Mauricio Puente, Dídac; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira; Borràs, Mercè (Hindawi, 2017-01-04)
    Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa ...
  • Evaluating multi-locus phylogenies for species boundaries determination in the genus Diaporthe 

    Santos, Liliana; Alves, Artur; Alves, Rui (Peerj, 2017-03-28)
    Background. Species identification is essential for controlling disease, understanding epidemiology, and to guide the implementation of phytosanitary measures against fungi from the genus Diaporthe. Accurate Diaporthe ...
  • GESAP trial rationale and methodology: management of patients with suspected obstructive sleep apnea in primary care units compared to sleep units 

    Tarraubella Balanya, Núria; Batlle Garcia, Jordi de; Nadal Braque, Núria; Castro-Grattoni, Anabel L.; Gómez Falguera, Silvia; Sánchez de la Torre, Manuel; Barbé Illa, Ferran (Nature Publishing Group, 2016-12)
    BACKGROUND Obstructive sleep apnea syndrome (OSA) is a chronic sleep disorder characterized by repeated episodes of upper airway collapse during sleep. This leads to arterial hypoxemia and sleep disruption and causes daytime ...
  • Sleep Apnea and Hypertension: Are there gender differences? The Vitoria Sleep Cohort 

    Cano-Pumarega, Irene; Barbé Illa, Ferran; Esteban, Andrés; Martínez-Alonso, Montserrat; Egea, Carlos; Durán-Cantolla, Joaquín; Spanish Sleep Network (American College of Chest Physicians, 2017-03-11)
    Background Evidence from longitudinal studies has reported contradictory results regarding the association between obstructive sleep apnea (OSA) and hypertension. In a previous analysis of the Vitoria Sleep Cohort, we ...
  • Aplicación de las redes neuronales artificiales para la estratificación de riesgo de mortalidad hospitalaria 

    Trujillano Cabello, Javier; March Llanes, Jaume; Badia Castello, Mariona; Rodríguez, A.; Sorribas Tello, Albert (Elsevier, 2003)
    Objetivo: Comparar la capacidad de predicción de mortalidad hospitalaria de una red neuronal artificial (RNA) con el Acute Physiology and Chronic Health Evaluation II (APACHE II) y la regresión logística (RL), y comparar ...
  • Multilayer OMIC data in medullary thyroid carcinoma identifies the STAT3 pathway as a potential therapeutic target in RETM918T tumors 

    Mancikova, Veronica; Montero Conde, Cristina; Perales Paton, Javier; Fernandez, Agustin F; Santacana Espasa, Maria; Jodkowska, Karolina; Inglada-Pérez, Lucía; Castelblanco Echavarría, Esmeralda; Borrego, Salud; Encinas Martín, Mario; Matias-Guiu, Xavier; Fraga, Mario; Robledo, Mercedes (American Association for Cancer Research., 2016-09-12)
    Purpose: Medullary thyroid carcinoma (MTC) is a rare disease with few genetic drivers, and the etiology specific to each known susceptibility mutation remains unknown. Exploiting multilayer genomic data, we focused our ...
  • Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice 

    Vaquero, Marta; Macià Armengol, Anna; Anerillas Aljama, Diego; Velasco Sánchez, Ana; Matias-Guiu, Xavier; Ribera i Calvet, Joan; Encinas Martín, Mario (Society for Endocrinology, 2016-02-01)
    Pheochromocytomas (PCCs) are rare catecholamine-secreting tumors arising from the chromaffin cells in the adrenal medulla. Closely related paragangliomas share developmental origin but arise extra-adrenally, in the paraganglia ...
  • Estudio de intervención aleatorizado para evaluar la prevalencia de enfermedad ateromatosa y renal ocultas y su impacto en la morbimortalidad: Proyecto ILERVA 

    Betriu i Bars, M. Àngels; Farràs, Cristina; Abajo, María; Martínez Alonso, Montserrat; Arroyo, David; Barbé Illa, Ferran; Buti, Miquel; Lecube Torelló, Albert; Portero Otín, Manuel; Purroy Garcia, Francisco; Torres, Gerard; Valdivielso Revilla, José Manuel; Fernández i Giráldez, Elvira (Sociedad Española de Nefrología, 2016)
    Antecedentes y objetivos: La enfermedad renal crónica (ERC) y la ateromatosis son 2 enfermedades interrelacionadas que aumentan el riesgo de morbimortalidad cardiovascular. Los objetivos del proyecto ILERVAS son: 1) conocer ...
  • Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease 

    Gomez Pastor, Rocio; Burchfiel, Eileen T.; Neef, Daniel W.; Jaeger, Alex M.; Cabiscol Català, Elisa; McKinstry, Spencer U.; Doss, Argenia; Aballay, Alejandro; Lo, Donald C.; Akimov, Sergey S.; Ross, Christopher A.; Eroglu, Cagla; Thiele, Dennis J. (Nature, 2017)
    Huntington’s Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death. Expression of the cellular protein folding and pro-survival machinery ...
  • Neuroprotection by neurotrophic factors and membrane depolarization is regulated by calmodulin kinase IV 

    Pérez García, María José; Gou Fàbregas, Myriam; Pablo Llavall, Yolanda de; Llovera i Tomàs, Marta; Comella i Carnicé, Joan Xavier; Soler i Tatché, Rosa Ma (American Society for Biochemistry and Molecular Biology, 2008)
    Neurotrophic factors promote motoneuron (MN) survival through increased intracellular calcium (Ca(2+)) and regulation of the phosphatidylinositol (PI) 3-kinase/protein kinase B (PKB) pathway by calmodulin (CaM). Activation ...
  • Mtl1 is required to activate general stress response through Tor1 and Ras2 inhibition under conditions of glucose starvation and oxidative stress 

    Petkova, Mima Ivanova; Pujol Carrión, Núria; Arroyo, J.; Garcia-Cantalejo, J.; Torre Ruiz, M. A. de la (American Society for Biochemistry and Molecular Biology, 2010)
    Mtl1 is a member of the cell wall integrity (CWI) pathway of Saccharomyces cerevisiae, which functions as a cell wall sensor for oxidative stress. Genome-wide transcriptional analysis revealed a cluster of genes that were ...
  • Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer 

    Eritja Sánchez, Núria; Chen, Bo-Juen; Rodríguez Barrueco, Ruth; Santacana Espasa, Maria; Gatius, Sònia; Vidal, August; Martí, Maria Dolores; Ponce, Jordi; Bergadà Bertran, Laura; Yeramian Hakim, Andree; Encinas, Mario; Ribera i Calvet, Joan; Reventós, Jaume; Boyd, Jeff; Villanueva, Alberto; Matias-Guiu, Xavier; Dolcet Roca, Xavier; Llobet Navàs, David (Taylor & Francis, 2017)
    Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in complete tumor remission and are frequently challenged by the appearance of refractory cell clones, eventually resulting in disease ...
  • Glutaredoxins Grx4 and Grx3 of Saccharomyces cerevisiae Play a Role in Actin Dynamics through Their Trx Domains, Which Contributes to Oxidative Stress Resistance 

    Pujol Carrión, Núria; Torre Ruiz, M. A. de la (American Society for Microbiology, 2010)
    Grx3 and Grx4 are two monothiol glutaredoxins of Saccharomyces cerevisiae that have previously been characterized as regulators of Aft1 localization and therefore of iron homeostasis. In this study, we present data showing ...
  • The MAP Kinase Slt2 Is Involved in Vacuolar Function and Actin Remodeling in Saccharomyces cerevisiae Mutants Affected by Endogenous Oxidative Stress 

    Pujol Carrión, Núria; Petkova, Mima Ivanova; Serrano Endolz, Luis; Torre Ruiz, M. A. de la (American Society for Microbiology, 2013)
    Oxidative stress causes transient actin cytoskeleton depolarization and also provokes vacuole fragmentation in wild-type cells. Under conditions of oxidative stress induced by hydrogen peroxide, the Slt2 protein is required ...

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