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  • HBPF: a Home Blood Pressure Framework with SLA guarantees to follow up hypertensive patients 

    Cuadrado, Josep; Vilaplana, Jordi; Mateo, Jordi; Solsona Tehàs, Francesc; Solsona, Sara; Rius, Josep; Alves, Rui; Camafort, Miguel (PeerJ Computer Science, 2016)
    Hypertension or high blood pressure is a condition on the rise. Not only does it affect the elderly but is also increasingly spreading to younger sectors of the population. Treating it involves exhaustive monitoring of ...
  • BCL-XL regulates TNF-α-mediated cell death independently of NF-κB, FLIP and IAPs 

    Gozzelino, Raffaella; Sole, Carme; Llecha Cano, Nuria; Segura Ginard, Miguel Francisco; Moubarak, Rana S.; Iglesias Guimarais, Victoria; Perez Garcia, M Jose; Reix, Stephanie; Zhang, Jisheng; Badiola, Nahuai; Sanchis, Daniel; Rodriguez Alvarez, Jose; Trullas, Ramon; Yuste, Victor J.; Comella i Carnicé, Joan Xavier (Springer Nature, 2008)
    Upon activation, tumor necrosis factor alpha (TNF-α) receptor can engage apoptotic or survival pathways. Inhibition of macromolecular synthesis is known to sensitize cells to TNF-α-induced cell death. It is believed that ...
  • Whi3, a Developmental Regulator of Budding Yeast, Binds a Large Set of mRNAs Functionally Related to the Endoplasmic Reticulum 

    Colomina i Gabarrella, Neus; Ferrezuelo, Francisco; Wang, Hongyin; Aldea, Martí; Garí Marsol, Eloi (The journal of biological chemistry, 2008)
    Whi3 is an RNA-binding protein associated with the endoplasmic reticulum (ER) that binds the CLN3 mRNA and plays a key role in the efficient retention of cyclin Cln3 at the ER. In the present work, we have identified new ...
  • Bayesian joint ordinal and survival modeling for breast cancer risk assessment 

    Armero, C.; Forné, Carles; Rué i Monné, Montserrat; Forte, A.; Perpiñán, H.; Gómez, G.; Baré, M. (Wiley online library, 2016)
    We propose a joint model to analyze the structure and intensity of the association between longitudinal measurements of an ordinal marker and time to a relevant event. The longitudinal process is defined in terms of a ...
  • The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins 

    Moubarak, Rana S.; Solé, Carme; Pascual, Marta; Gutierrez, Humberto; Llovera i Tomàs, Marta; Pérez García, Maria José; Gozzelino, Raffaella; Segura Ginard, Miguel Francisco; Iglesias Guimarais, Victoria; Reix, Stéphanie; Soler i Tatché, Rosa Ma; Davies, Alun M.; Soriano, Eduardo; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Society for Neuroscience, 2010)
    FLICE-inhibitory protein (FLIP) is an endogenous inhibitor of the signaling pathway triggered by the activation of death receptors. Here, we reveal a novel biological function for the long form of FLIP (FLIP-L) in neuronal ...
  • Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function 

    McDermott Roe, Chris; Ye, Junmei; Ahmed, Rizwan; Sun, Xi-Ming; Serafín, Anna; Ware, James; Bottolo, Leonardo; Muckett, Phil; Cañas, Xavier; Zhang, Jisheng; Rowe, Glenn C.; Buchan, Rachel; Lu, Han; Braithwaite, Adam; Mancini, Massimiliano; Hauton, David; Martí, Ramon; García Arumí, Elena; Hubner, Norbert; Jacob, Howard; Serikawa, Tadao; Zidek, Vaclav; Papousek, Frantisek; Kolar, Frantisek; Cardona Colom, Maria; Ruiz Meana, Marisol; García Dorado, David; Comella, Joan X.; Felkin, Leanne E.; Barton, Paul J. R.; Zoltan Arany; Pravenec, Michal; Petretto, Enrico; Sanchis, Daniel; Cook, Stuart A. (Macmillan Publishers Limited, 2011)
    Left ventricular mass (LVM) is a highly heritable trait1 and an independent risk factor for all-cause mortality2. So far, genome-wide association studies have not identified the genetic factors that underlie LVM variation3, ...
  • Reproducibility of measurement of myometrial invasion in endometrial carcinoma 

    van der Putten, Louis J. M.; van de Vijver, Koen; Bartosch, Carla; Davidson, Ben; Gatius, Sònia; Matias-Guiu, Xavier; McCluggage, W. Glenn; Toledo, Gemma; van der Wurff, Anneke A. M.; Pijnenborg, Johanna M. A.; Massuger, Leon F. A. G.; Bulten, Johan (Springer Berlin Heidelberg, 2016)
    Myometrial invasion (MI) as a percentage (%MI), categorized into <50 or ≥50 %, is an important predictor of prognosis in endometrial carcinoma. Recent studies suggest that tumor-free distance (TFD) to serosa and the absolute ...
  • FAIM-L Is an IAP-Binding Protein That Inhibits XIAP Ubiquitinylation and Protects from Fas-Induced Apoptosis 

    Moubarak, Rana S.; Planells Ferrer, Laura; Urresti, Jorge; Reix, Stéphanie; Segura, Miguel F.; Carriba, Paulina; Marqués Fernàndez, Fernando; Solé Serra, Carme; Llecha Cano, Núria; López Soriano, Joaquin; Sanchis, Daniel; Yuste Mateos, Víctor J. (Víctor José); Comella i Carnicé, Joan Xavier (Society for Neuroscience, 2013)
    The neuronal long isoform of Fas Apoptotic Inhibitory Molecule (FAIM-L) protects from death receptor (DR)-induced apoptosis, yet its mechanism of protection remains unknown. Here, we show that FAIM-L protects rat neuronal ...
  • The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug 

    Mesa-Arango, Ana Cecilia; Trevijano Contador, Nuria; Román, Elvira; Sánchez Fresneda, Ruth; Casas Herranz, Celia; Herrero Perpiñán, Enrique; Argüelles, Juan Carlos; Pla, Jesús; Cuenca Estrella, Manuel; Zaragoza, Oscar (American Society for Microbiology, 2014)
    Amphotericin B (AMB) is an antifungal drug that binds to ergosterol and forms pores at the cell membrane, causing the loss of ions. In addition, AMB induces the accumulation of reactive oxygen species (ROS), and although ...
  • Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: discovery and validation studies 

    Hellner, Karin; Miranda, Fabrizio; Fotso Chedom, Donatien; Herrero Gonzalez, Sandra; Hayden, Daniel M.; Tearle, Rick; Artibani, Mara; KaramiNejadRanjbar, Mohammad; Williams, Ruth; Gaitskell, Kezia; Elorbany, Samar; Xu, Ruoyan; Laios, Alex; Buiga, Petronela; Ahmed, Karim; Dhar, Sunanda; Yu Zhang, Rebecca; Campo, Leticia; Myers, Kevin A.; Lozano, María; Ruiz Miró, Maria; Gatius, Sònia; Mota, Alba; Moreno Bueno, Gema; Matias-Guiu, Xavier; Benítez, Javier; Witty, Lorna; McVean, Gil; Leedham, Simon; Tomlinson, Ian; Drmanac, Radoje; Cazier, Jean Baptiste; Klein, Robert; Dunne, Kevin; Bast Jr, Robert C.; Kennedy, Stephen H.; Hassan, Bassim; Lise, Stefano; Garcia, María José; Peters, Brock A.; Yau, Christopher; Sauka-Spengler, Tatjana; Ashour Ahmed, Ahmed (Elsevier, 2016)
    Current screening methods for ovarian cancer can only detect advanced disease. Earlier detection has proved difficult because the molecular precursors involved in the natural history of the disease are unknown. To identify ...
  • An in vitro system for the rapid functional characterization of genes involved in carotenoid biosynthesis and accumulation 

    Bai, Chao; Rivera Vélez, Sol Maiam; Medina, Vicente; Alves, Rui; Vilaprinyo Terré, Ester; Sorribas Tello, Albert; Canela i Garayoa, Ramon; Capell Capell, Teresa; Sandmann, Gerhard; Christou, Paul; Zhu, Changfu (Wiley, 2014)
    We have developed an assay based on rice embryogenic callus for rapid functional characterization of metabolic genes. We validated the assay using a selection of well-characterized genes with known functions in the carotenoid ...
  • TGF-β-Induced transcription sustains amoeboid melanoma migration and dissemination 

    Cantelli, Gaia; Orgaz, Jose L.; Rodríguez Hernández, Irene; Karagiannis, Panagiotis; Maiques, Oscar; Matias-Guiu, Xavier; Nestle, Frank O.; Martí Laborda, Rosa Ma.; Karagiannis, Sophia N.; Sanz Moreno, Victoria (Elsevier, 2015)
    Cell migration underlies metastatic dissemination of cancer cells, and fast “amoeboid” migration in the invasive fronts of tumors is controlled by high levels of actomyosin contractility. How amoeboid migration is regulated ...
  • Optimal protocol for PTEN immunostaining; role of analytical and preanalytical variables in PTEN staining in normal and neoplastic endometrial, breast, and prostatic tissues 

    Maiques, Oscar; Santacana Espasa, Maria; Valls Marsal, Joan; Pallares, Judit; Mirantes Barbeito, Cristina; Gatius, Sònia; García Dios, Diego Andrés; Amant, Frederic; Pedersen, Hans Christian; Dolcet Roca, Xavier; Matias-Guiu, Xavier (Elsevier, 2014)
    In some tumors, phosphatase and tensin homolog (PTEN) inactivation may have prognostic importance and predictive value for targeted therapies. Immunohistochemistry (IHC) may be an effective method to demonstrate PTEN loss. ...
  • Fracaso renal agudo secundario a crisis de hipercalcemia muy severa por hiperparatiroidismo primario 

    Chacón, Andrea; Vilar, Ana; Arroyo, David; Sarró, Felipe; Craver Hospital, Lourdes; Ros, Susana; López, Carolina; Castillo, Alex; Matias-Guiu, Xavier; Fernández i Giráldez, Elvira (Elsevier, 2015)
    La crisis hipercalcémica es una forma de presentación poco frecuente del hiperparatiroidismo primario. Solo existen pequeñas series de casos reportadas en la literatura1 and 2. Se caracteriza por hipercalcemia severa, ...
  • Physical Activity Behavior, Aerobic Fitness and Quality of Life in School-Age Children 

    Serra Payà, Noemí; Ensenyat Solé, Assumpta; Serra Paya, Pau; Blanco Nespereira, Alfonso (Elsevier, 2015)
    The aim of this article is to assess the differences in sedentary and physical activity behavior, physical fitness and quality of lifein school-age children according to their adiposity state (BMI-SD= Body Mass Index ...
  • Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice 

    Sorolla Bardají, Maria Alba; Rodríguez Colman, Maria José; Vall-llaura Espinosa, Núria; Vived Maza, Celia; Fernández Nogales, Marta; Lucas, José J.; Ferrer, Isidre; Cabiscol Català, Elisa (Springer Science, Business Media, 2016-06)
    Oxidative stress has been described as important to Huntington disease (HD) progression. In a previous HD study, we identified several carbonylated proteins, including pyridoxal kinase and antiquitin, both of which are ...
  • The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system 

    Pérez Sampietro, María; Serra Cardona, Albert; Canadell, David; Casas Herranz, Celia; Ariño Carmona, Joaquín; Herrero Perpiñán, Enrique (Scientific Reports, 2016)
    The yeast Saccharomyces cerevisiae is employed as a model to study the cellular mechanisms of toxicity and defense against selenite, the most frequent environmental selenium form. We show that yeast cells lacking Aft2, a ...
  • Development of a sequential workflow based on LC-PRM for the verification of endometrial cancer protein biomarkers in uterine aspirate samples 

    Martínez García, Elena; Lesur, Antoine; Devis, Laura; Rosa Campos, Alexandre; Cabrera, Silvia; Oostrum, Jan van; Matias-Guiu, Xavier; Gil Moreno, Antonio; Reventós, Jaume; Colas, Eva; Domon, Bruno (Impact Journals, 2016)
    About 30% of endometrial cancer (EC) patients are diagnosed at an advanced stage of the disease, which is associated with a drastic decrease in the 5-year survival rate. The identification of biomarkers in uterine aspirate ...
  • Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism 

    Jové Font, Mariona; Gatius, Sònia; Yeramian Hakim, Andree; Portero Otín, Manuel; Eritja Sánchez, Núria; Santacana Espasa, Maria; Colas, Eva; Ruiz, Maria; Pamplona Gras, Reinald; Matias-Guiu, Xavier (Impact Journals, 2016)
    Metabolomics, an essential technique in precision medicine, contributes to the molecular fingerprinting of tumours, further helping to understand their pathogenesis. In this work, using a LC-ESI-QTOF-MS/MS platform, we ...
  • Computer-assisted initial diagnosis of rare diseases 

    Alves, Rui; Piñol, Marc; Vilaplana, Jordi; Teixidó Torrelles, Ivan; Cruz, Joaquim; Comas, Jorge; Vilaprinyo Terré, Ester; Sorribas Tello, Albert; Solsona Tehàs, Francesc (PeerJ, 2016)
    Introduction. Most documented rare diseases have genetic origin. Because of their low individual frequency, an initial diagnosis based on phenotypic symptoms is not always easy, as practitioners might never have been exposed ...

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