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  • Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease 

    Gomez Pastor, Rocio; Burchfiel, Eileen T.; Neef, Daniel W.; Jaeger, Alex M.; Cabiscol Català, Elisa; McKinstry, Spencer U.; Doss, Argenia; Aballay, Alejandro; Lo, Donald C.; Akimov, Sergey S.; Ross, Christopher A.; Eroglu, Cagla; Thiele, Dennis J. (Nature, 2017)
    Huntington’s Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death. Expression of the cellular protein folding and pro-survival machinery ...
  • Neuroprotection by neurotrophic factors and membrane depolarization is regulated by calmodulin kinase IV 

    Pérez García, María José; Gou Fàbregas, Myriam; Pablo Llavall, Yolanda de; Llovera i Tomàs, Marta; Comella i Carnicé, Joan Xavier; Soler i Tatché, Rosa Ma (American Society for Biochemistry and Molecular Biology, 2008)
    Neurotrophic factors promote motoneuron (MN) survival through increased intracellular calcium (Ca(2+)) and regulation of the phosphatidylinositol (PI) 3-kinase/protein kinase B (PKB) pathway by calmodulin (CaM). Activation ...
  • Mtl1 is required to activate general stress response through Tor1 and Ras2 inhibition under conditions of glucose starvation and oxidative stress 

    Petkova, Mima Ivanova; Pujol Carrión, Núria; Arroyo, J.; Garcia-Cantalejo, J.; Torre Ruiz, M. A. de la (American Society for Biochemistry and Molecular Biology, 2010)
    Mtl1 is a member of the cell wall integrity (CWI) pathway of Saccharomyces cerevisiae, which functions as a cell wall sensor for oxidative stress. Genome-wide transcriptional analysis revealed a cluster of genes that were ...
  • Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer 

    Eritja Sánchez, Núria; Chen, Bo-Juen; Rodríguez Barrueco, Ruth; Santacana Espasa, Maria; Gatius, Sònia; Vidal, August; Martí, Maria Dolores; Ponce, Jordi; Bergadà Bertran, Laura; Yeramian Hakim, Andree; Encinas, Mario; Ribera i Calvet, Joan; Reventós, Jaume; Boyd, Jeff; Villanueva, Alberto; Matias Guiu, Xavier; Dolcet Roca, Xavier; Llobet Navàs, David (Taylor & Francis, 2017)
    Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in complete tumor remission and are frequently challenged by the appearance of refractory cell clones, eventually resulting in disease ...
  • Glutaredoxins Grx4 and Grx3 of Saccharomyces cerevisiae Play a Role in Actin Dynamics through Their Trx Domains, Which Contributes to Oxidative Stress Resistance 

    Pujol Carrión, Núria; Torre Ruiz, M. A. de la (American Society for Microbiology, 2010)
    Grx3 and Grx4 are two monothiol glutaredoxins of Saccharomyces cerevisiae that have previously been characterized as regulators of Aft1 localization and therefore of iron homeostasis. In this study, we present data showing ...
  • The MAP Kinase Slt2 Is Involved in Vacuolar Function and Actin Remodeling in Saccharomyces cerevisiae Mutants Affected by Endogenous Oxidative Stress 

    Pujol Carrión, Núria; Petkova, Mima Ivanova; Serrano Endolz, Luis; Torre Ruiz, M. A. de la (American Society for Microbiology, 2013)
    Oxidative stress causes transient actin cytoskeleton depolarization and also provokes vacuole fragmentation in wild-type cells. Under conditions of oxidative stress induced by hydrogen peroxide, the Slt2 protein is required ...
  • Tenosynovitis with rice body formation presenting as a cutaneous abscess 

    Moreno, Sara; Forcada Calvet, Pau; Soria, Xavier; Altemir, Victoria; Gatius, Sònia; Gil, Mabel; Matias-Guiu, Xavier; Casanova i Seuma, Josep M. (Josep Manel); Martí Laborda, Rosa Ma. (John Wiley & Sons, 2014)
    A 62-year-old woman with a past medical history of rheumatoid arthritis was referred to the Department of Dermatology because of an enlarging cutaneous lesion on the right thumb which resembled a soft tissue infection. ...
  • Sgs1’s roles in DNA end resection, HJ dissolution, and crossover suppression require a two-step SUMO regulation dependent on Smc5/6 

    Bermúdez López, Marcelino; Villoria, María Teresa; Esteras, Miguel; Jarmuz, Adam; Torres Rosell, Jordi; Clemente Blanco, Andrés; Aragón, Luis (Cold Spring Harbor Laboratory Press, 2016)
    The RecQ helicase Sgs1 plays critical roles during DNA repair by homologous recombination, fromend resection to Holliday junction (HJ) dissolution. Sgs1 has both pro- and anti-recombinogenic roles, and therefore its ...
  • Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis 

    Bozić Stanojević, Milica; Guzmán, Carla; Benet, Marta; Sánchez-Campos, Sonia; García-Monzón, Carmelo; Garí Marsol, Eloi; Gatius, Sònia; Valdivielso Revilla, José Manuel; Jover, Ramiro (Elsevier, 2016)
    Background & Aims The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote ...
  • Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination 

    De Piccoli, Giacomo; Cortes Ledesma, Felipe; Ira, Gregory; Torres Rosell, Jordi; Uhle, Stefan; Farmer, Sarah; Hwang, Ji-Young; Machin, Felix; Ceschia, Audrey; McAleenan, Alexandra; Cordon Preciado, Violeta; Clemente Blanco, Andrés; Vilella Mitjana, Felipe; Ullal, Pranav; Jarmuz, Adam; Leitao, Beatriz; Bressan, Debra; Dotiwala, Farokh; Papusha, Alma; Zhao, Xiaolan; Myung, Kyungjae; Haber, James E.; Aguilera, Andrés; Aragón, Luis (Nature, 2006)
    DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that the ...
  • Bck2 is a phase-independent activator of cell cycle-regulated genes in yeast 

    Ferrezuelo, Francisco; Aldea, Martí; Futcher, Bruce (Landes Bioscience, 2009)
    During the cell division cycle of the yeast Saccharomyces cerevisiae, the G1-to-S transition depends upon the activation of two transcription factors (SBF and MBF), which are responsible for the cell cycle-regulated ...
  • Cyclin Cln3 is retained at the ER and released by the J chaperone Ydj1 in late G1 to trigger cell cycle entry 

    Vergés, Emili; Colomina i Gabarrella, Neus; Garí Marsol, Eloi; Gallego, Carme; Aldea, Martí (Elsevier, 2007)
    G1 cyclin Cln3 plays a key role in linking cell growth and proliferation in budding yeast. It is generally assumed that Cln3, which is present throughout G1, accumulates passively in the nucleus until a threshold is reached ...
  • 1,25-Dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter 

    Cardús i Figueras, Anna; Panizo García, Sara; Encinas Martín, Mario; Dolcet Roca, Xavier; Gallego, Carme; Aldea, Martí; Fernandez, Elvira; Valdivielso Revilla, José Manuel (Elsevier, 2009)
    In previous studies we have demonstrated that the active form of vitamin D (1,25(OH)2D3) increases vascular endothelial growth factor (VEGF) expression and release in vascular smooth muscle cells (VSMC) in vitro. However, ...
  • Unilateral milia-type intradermal tophi associated with underlying urate subcutaneous deposition: an uncommon cutaneous presentation of gout 

    Aguayo Ortiz, Rafael; Baradad Brusau, Manuel; Soria, Xavier; Abal Diaz, Leandro; Sanmartín Novell, Verònica; Egido Garcia, Ramon Maria; Gallel Vicente, María del Pilar; Casanova i Seuma, Josep M. (Josep Manel); Martí Laborda, Rosa Ma. (Wiley online library, 2013)
    Tophi develop during the most advanced clinical stage of gout, and are usually located on or around the joints. However, unusual skin features caused by intradermal and/or subcutaneous deposition of tophaceous material ...
  • Identification of line-specific strategies for improving carotenoid production in synthetic maize through data-driven mathematical modeling 

    Comas, Jorge; Benfeitas, Rui; Vilaprinyo Terré, Ester; Sorribas, Albert; Solsona, Francesc; Farré Martinez, Gemma; Berman Quintana, Judit; Zorrilla López, Uxue; Capell Capell, Teresa; Sandmann, Gerhard; Zhu, Changfu; Christou, Paul; Alves, Rui (Wiley online library, 2016)
    Plant synthetic biology is still in its infancy. However, synthetic biology approaches have been used to manipulate and improve the nutritional and health value of staple food crops such as rice, potato and maize. With ...
  • Control of cell cycle and cell growth by molecular chaperones 

    Aldea, Martí; Garí Marsol, Eloi; Colomina i Gabarrella, Neus (Taylor & Francis, 2007)
    Cells adapt their size to both intrinsic and extrinsic demands and, among them, those that stem from growth and proliferation rates are crucial for cell size homeostasis. Here we revisit mechanisms that regulate cell cycle ...
  • Whi3 regulates morphogenesis in budding yeast by enhancing Cdk functions in apical growth 

    Colomina i Gabarrella, Neus; Ferrezuelo, Francisco; Vergés, Emili; Aldea, Martí; Garí Marsol, Eloi (Landes Bioscience, 2009)
    The Whi3 protein is associated with the endoplasmic reticulum, interacts with Cdc28, the budding-yeast Cdk, binds the mRNA of cyclin CLN3 and prevents accumulation of the Cdc28-Cln3 in the nucleus until late G1. Besides ...
  • Erk1/2 activation in stromal fibroblasts from sporadic basal cell carcinomas 

    Aguayo Ortiz, Rafael; Rafel i Borrell, Marta; Santacana Espasa, Maria; Pérez Fusté, Noel; Garí Marsol, Eloi (American Society for Dermatologic Surgery, 2015)
    BACKGROUND Constitutive activation of the Erk pathway can lead to oncogenic transformation. However, the Erk pathway is not activated in human basal cell carcinomas (BCCs); although in animal models, this seems to be ...
  • Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model 

    Gou Fabregas, Myriam; Ramírez-Núñez, Omar; Cacabelos Barral, Daniel; Bahi i Pla, Núria; Portero Otín, Manuel; Garcera, Ana; Soler i Tatché, Rosa M. (Elsevier, 2014)
    Amyotrophic Lateral Sclerosis (ALS), a severe neurodegenerative disease, affects the upper and lower motor neurons in the brain and spinal cord. In some studies, ALS disease progression has been associatedwith an increase ...
  • Influencia del manguito de isquemia en la profilaxis antibiótica en prótesis total de rodilla 

    Prats Gispert, Laura; Valls Marsal, Joan; Ros Salvador, Joaquim; Jover, Alfredo; Pérez Villar, Ferran; Fernández Martínez, José Juan (Elsevier, 2015)
    Objetivo: Existe evidencia científica grado iv de la importancia que el antibiótico administradopreoperatoriamente tiene en la prevención de la infección protésica.Hay controversia en si la isquemia aplicada en la cirugía ...

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